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Cited by 102Retinal Diseases and TreatmentsAlcohol Consumption and Health EffectsRetinal Imaging and Analysis

The DOI matches its Crossref record; 39 of the 39 references it cites were found in a registry or an index.

Prospective Study of Alcohol Consumption and the Risk of Age-Related Macular Degeneration

Cho, Eunyoung·2000·Archives of Ophthalmology
DOI 10.1001/archopht.118.5.681
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Abstract

OBJECTIVE: To describe the relationship between alcohol consumption and the incidence of age-related macular degeneration (AMD). METHODS: We conducted a prospective study among female nurses between 1980 and 1994 and among male health professionals between 1986 and 1994. We included 32764 women and 29488 men who were 50 years or older, without a diagnosis of AMD or cancer at baseline, and added additional subjects to the analysis as they reached 50 years of age. Their alcohol intake was assessed at baseline and updated during follow-up evaluations using a validated semiquantitative food-frequency questionnaire. After separate analyses for women and men, pooled estimates of the relationship of alcohol to the risk of AMD were calculated. RESULTS: Age-related macular degeneration associated with a visual acuity loss of 20/30 or worse, including the early and dry and wet types, was diagnosed in 298 women (from 697498 person-years of follow-up) and 153 men (229 180 person-years) by 1994, the end of follow-up. After controlling for age, smoking, and other risk factors, the pooled relative risks (RRs) and 95% confidence intervals (CIs) for AMD compared with nondrinkers were 1.0 (0.7-1.2) for drinkers who consumed 0.1 to 4.9 g/d of alcohol; 0.9 (0.6-1.4) for 5 to 14.9 g/d; 1.1 (0.7-1.7) for 15 to 29.9 g/d; and 1.3 (0.9-1.8) for 30 g/d or more. Among women, there was a suggestion of a modest increased risk of the disease in drinkers who consumed 30 g/d or more (RR, 1.5; 95% CI, 1.0-2.4); this was limited to an increased risk of the early and dry form (RR, 2.0; 95% CI, 1.2-3.4). No specific type of alcohol provided protection against AMD. CONCLUSION: This prospective study does not support an inverse relationship between moderate alcohol consumption and risk of AMD.

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Metadata

Authors
Cho, E.
Affiliations
Harvard University (US)
Corresponding author
Cho, Eunyoung
ORCID
Cho, Eunyoung
Venue
Archives of Ophthalmology
Publisher
American Medical Association (AMA)
Published
2000-05-01
Volume
118
Issue
5
Pages
681
ISSN
0003-9950 (ISSN-L)
DOI
10.1001/archopht.118.5.681
OpenAlex
W1576497894
Cited by
102
References
39
Citations by year
2026: 2 · 2025: 1 · 2023: 2 · 2022: 2 · 2021: 15 · 2020: 2 · 2019: 2 · 2018: 2 · 2017: 1 · 2016: 1 · 2015: 3 · 2014: 4 · 2013: 4 · 2012: 2
FWCI
3.80
Type
journal article
Language
en
Open access
closed
Locations
  • Archives of Ophthalmology (publishedVersion)
  • PubMed (publishedVersion)
Funders
  • National Eye Institute (R01EY009611, EY09611)
  • National Cancer Institute (CA-55075, CA-40356)
Topics
  • Health Sciences › Medicine › Ophthalmology › Retinal Diseases and Treatments
  • Health Sciences › Medicine › Pathology and Forensic Medicine › Alcohol Consumption and Health Effects
  • Health Sciences › Medicine › Radiology, Nuclear Medicine and Imaging › Retinal Imaging and Analysis
Keywords
age-related macular degeneration, alcohol consumption, visual acuity loss, dry age-related macular degeneration, neovascular age-related macular degeneration, sex differences, moderate drinking, risk factors
MeSH terms
Aged, Alcohol Drinking, Female, Health Personnel, Humans, Macular Degeneration, Male, Massachusetts, Middle Aged, Prospective Studies, Surveys and Questionnaires, Risk Factors, Visual Acuity, Incidence

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