Dietary fatty acids and the 5-year incidence of age-related maculopathy
Abstract
OBJECTIVE: To assess longitudinal associations between dietary fat and incident age-related maculopathy (ARM) in an older, population-based, historical cohort. METHODS: A total of 3654 persons, 49 years or older, participated in the Blue Mountains Eye Study (1992-1994); 2335 (75.1% of survivors) were reexamined after 5 years (1997-1999). Dietary data were collected from 2895 people (79%) at baseline by means of a semiquantitative food frequency questionnaire to calculate dietary fat intakes. Presence of ARM was graded from retinal photographs (Wisconsin ARM Grading System). Logistic regression adjusted for age, sex, vitamin C intake, and smoking. RESULTS: Participants with the highest vs lowest quintiles of n-3 polyunsaturated fat intake had lower risk of incident early ARM (odds ratio [95% confidence interval], 0.41 [0.22-0.75). A 40% reduction of incident early ARM was associated with fish consumption at least once a week (odds ratio [95% confidence interval], 0.58 [0.37-0.90]), whereas fish consumption at least 3 times per week could reduce the incidence of late ARM (odds ratio [95% confidence interval], 0.25 [0.06-1.00]). We found no association between incident ARM and butter, margarine, or nut consumption. CONCLUSIONS: A regular diet high in n-3 polyunsaturated fat, especially from fish, suggests protection against early and late ARM in this older Australian cohort. Our study could not confirm deleterious effects of higher polyunsaturated fat intakes reported by other clinic-based studies.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
The Blue Mountains Eye Study showed that a reduction in incident early changes of age-related macular degeneration and the eating of fish three times per week could reduce the risk of advanced age-related macular degeneration.
“The Blue Mountains Eye Study showed that a reduction in incident early changes of age-related macular degeneration and the eating of fish three times per week could reduce the risk of advanced age-related macular degeneration.108”
From Age-related macular degeneration (2008) · cites this paper as [108]
Cites
The Wisconsin Age-related Maculopathy Grading System
Klein, R., Davis, M. D., Magli, Y. L., Segał, P., Klein, R., & Hubbard, L. D. (1991) · Ophthalmology · doi:10.1016/s0161-6420(91)32186-9 · Cited by 1,188 · see citing works
The Five-year Incidence and Progression of Age-related Maculopathy
Klein, R., Klein, R., Jensen, S. C., & Meuer, S. M. (1997) · Ophthalmology · doi:10.1016/s0161-6420(97)30368-6 · Cited by 1,148 · see citing works
Dietary Guidelines for Americans 2005
SKOLNIK, N., & King, M. (2005) · Family Practice News · doi:10.1016/s0300-7073(05)71075-6 · Cited by 1,071 · see citing works
Current concepts in the pathogenesis of age-related macular degeneration
Zarbin, M. A. (2004) · Archives of Ophthalmology · doi:10.1001/archopht.122.4.598 · Cited by 1,006 · see citing works
The role of omega-3 long-chain polyunsaturated fatty acids in health and disease of the retina
SanGiovanni, J. P., & Chew, E. Y. (2004) · Progress in Retinal and Eye Research · doi:10.1016/j.preteyeres.2004.06.002 · Cited by 882 · see citing works
THE USE OF A SELF-ADMINISTERED QUESTIONNAIRE TO ASSESS DIET FOUR YEARS IN THE PAST
Willett, W. C., SAMPSON, L., Browne, M. L., Stampfer, M. J., ROSNER, B. A., Hennekens, C. H., & Speizer, F. E. (1988) · American Journal of Epidemiology · doi:10.1093/oxfordjournals.aje.a114780 · Cited by 801 · see citing works
Dietary fat and risk of coronary heart disease in men: cohort follow up study in the United States
Ascherio, A., Rimm, E. B., Giovannucci, E. L., Spiegelman, D. L., Stampfer, M. J., & Willett, W. C. (1996) · BMJ · doi:10.1136/bmj.313.7049.84 · Cited by 732 · see citing works
Risk factors for incident age-related macular degeneration
Tomany, S. C., Wang, J. J., van Leeuwen, R., Klein, R., Mitchell, P., Vingerling, J. R., Klein, B. E. K., Smith, W., & de Jong, P. T. V. M. (2004) · Ophthalmology · doi:10.1016/j.ophtha.2003.11.010 · Cited by 621 · see citing works
Dietary fat and risk for advanced age-related macular degeneration
Seddon, J. M. (2001) · Archives of Ophthalmology · doi:10.1001/archopht.119.8.1191 · Cited by 408 · see citing works
Seddon, J. M. (2003) · Archives of Ophthalmology · doi:10.1001/archopht.121.12.1728 · Cited by 384 · see citing works
Prospective study of dietary fat and the risk of age-related macular degeneration
Cho, E., Hung, S., Willett, W. C., Spiegelman, D., Rimm, E. B., Seddon, J. M., Colditz, G. A., & Hankinson, S. E. (2001) · The American Journal of Clinical Nutrition · doi:10.1093/ajcn/73.2.209 · Cited by 350 · see citing works
A Hemodynamic Model of the Pathogenesis of Age-related Macular Degeneration
Friedman, E. (1997) · American Journal of Ophthalmology · doi:10.1016/s0002-9394(14)70906-7 · Cited by 265 · see citing works
Blood Pressure, Atherosclerosis, and the Incidence of Age-Related Maculopathy: The Rotterdam Study
van Leeuwen, R., Ikram, M. K., Vingerling, J. R., Witteman, J. C. M., Albert Hofman, D., & de Jong, P. T. V. M. (2003) · Investigative Ophthalmology & Visual Science · doi:10.1167/iovs.03-0121 · Cited by 263 · see citing works
Five-year incidence of age-related maculopathy lesions
Mitchell, P., Wang, J. J., Foran, S., & Smith, W. (2002) · Ophthalmology · doi:10.1016/s0161-6420(02)01055-2 · Cited by 251 · see citing works
Validity and reproducibility of a self-administered food frequency questionnaire in older people
Smith, W. T., Mitchell, P., Reay, E. M., Webb, K., & Harvey, P. W. (1998) · Australian and New Zealand Journal of Public Health · doi:10.1111/j.1467-842x.1998.tb01414.x · Cited by 239 · see citing works
Dietary Fat and Fish Intake and Age-Related Maculopathy
Smith, W. T. (2000) · Archives of Ophthalmology · doi:10.1001/archopht.118.3.401 · Cited by 211 · see citing works
Reduced or modified dietary fat for preventing cardiovascular disease.
Hooper, L., Summerbell, C., Thompson, R. L., Sills, D., Roberts, F. G., Moore, H., & Smith, G. D. (2012) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd002137.pub3 · Cited by 206 · see citing works
Rotstein, N. P., Politi, L. E., German, O. L., & Girotti, M. R. (2003) · Investigative Ophthalmology & Visual Science · doi:10.1167/iovs.02-0901 · Cited by 173 · see citing works
Trans Fatty Acids in Adipose Tissue and the Food Supply Are Associated with Myocardial Infarction
Clifton, P. M., Keogh, J. B., & Noakes, M. (2004) · Journal of Nutrition · doi:10.1093/jn/134.4.874 · Cited by 134 · see citing works
Flood, V., Smith, W., Wang, J. J., Manzi, F., Webb, K., & Mitchell, P. (2002) · Ophthalmology · doi:10.1016/s0161-6420(02)01263-0 · Cited by 109 · see citing works
Flood, V. M., Smith, W. T., Webb, K., & Mitchell, P. (2004) · Public Health Nutrition · doi:10.1079/phn2004604 · Cited by 62 · see citing works
Development of a database of fatty acids in Australian foods
Mann, N., Sinclair, A. J., Percival, P. W., et al. (2003) · RMIT Research Repository (RMIT University Library) · Cited by 53 · see citing works
Moriguchi, K., Yuri, T., Yoshizawa, K., Kiuchi, K., Takada, H., Inoue, Y., Hada, T., Matsumura, M., & Tsubura, A. (2003) · Experimental Eye Research · doi:10.1016/s0014-4835(03)00114-3 · Cited by 36 · see citing works
Fish Oil (Polyunsaturated Fatty Acid) Prevents Ischemic-induced Injury in the Mammalian Retina
Murayama, K., Yoneya, S., Miyauchi, O., et al. (2002) · Experimental Eye Research · doi:10.1006/exer.2002.1151 · Cited by 31 · see citing works
Food and nutrition: Australasia, Asia and the Pacific.
Wahlqvist, M. L. (2002) · Medical Entomology and Zoology · Cited by 16 · see citing works
Flagged first, then by citations
Cited by
Sorted by citations
Age-related macular degeneration
Coleman, H. R., Chan, C.-C., Ferris, F. L., & Chew, E. Y. (2008) · The Lancet · doi:10.1016/s0140-6736(08)61759-6 · Cited by 542 · see citing works
Chong, E. W.-T. (2008) · Archives of Ophthalmology · doi:10.1001/archopht.126.6.826 · Cited by 279 · see citing works
A new perspective on lipid research in age-related macular degeneration
van Leeuwen, E. M., Emri, E., Merle, B. M. J., Colijn, J. M., Kersten, E., Cougnard-Gregoire, A., Dammeier, S., Meester-Smoor, M., Pool, F. M., de Jong, E. K., et al. (2018) · Progress in Retinal and Eye Research · doi:10.1016/j.preteyeres.2018.04.006 · Cited by 247 · see citing works
Dietary ω-3 Fatty Acid and Fish Intake and Incident Age-Related Macular Degeneration in Women
Christen, W. G. (2011) · Archives of Ophthalmology · doi:10.1001/archophthalmol.2011.34 · Cited by 138 · see citing works
Prevalence of Age-Related Macular Degeneration in a Malay Population
Kawasaki, R., Wang, J. J., Aung, T., Tan, D. T. H., Mitchell, P., Sandar, M., Saw, S.-M., & Wong, T. Y. (2008) · Ophthalmology · doi:10.1016/j.ophtha.2008.02.012 · Cited by 104 · see citing works
Neuner, B., Komm, A., Wellmann, J., Dietzel, M., Pauleikhoff, D., Walter, J., Busch, M., & Hense, H.-W. (2009) · Addictive Behaviors · doi:10.1016/j.addbeh.2009.05.015 · Cited by 46 · see citing works
Gorusupudi, A., Rallabandi, R., Li, B., Arunkumar, R., Blount, J. D., Rognon, G. T., Chang, F.-Y., Wade, A., Lucas, S., Conboy, J. C., et al. (2021) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2017739118 · Cited by 33 · see citing works
- Authors
- Chua, B.
- Affiliations
- The University of Sydney (AU)
- Corresponding author
- Chua, Brian
- Venue
- Archives of Ophthalmology
- Publisher
- American Medical Association (AMA)
- Published
- 2006-07-01
- Volume
- 124
- Issue
- 7
- Pages
- 981
- ISSN
- 0003-9950 (ISSN-L)
- OpenAlex
- W2131253576
- Cited by
- 172
- References
- 25
- Citations by year
- 2026: 2 · 2025: 2 · 2024: 6 · 2023: 10 · 2022: 6 · 2021: 11 · 2020: 6 · 2019: 9 · 2018: 6 · 2017: 6 · 2016: 6 · 2015: 4 · 2014: 7 · 2013: 10 · 2012: 12
- FWCI
- 12.80
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Archives of Ophthalmology (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Ophthalmology › Retinal Diseases and Treatments
- Health Sciences › Nursing › Nutrition and Dietetics › Fatty Acid Research and Health
- Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Nutritional Studies and Diet
- Keywords
- age-related maculopathy, dietary fatty acids, omega-3 fatty acids, fish consumption, dietary fat intake, older adults, Blue Mountains Eye Study, nuts
- MeSH terms
- Aged, Ascorbic Acid, Dietary Fats, Unsaturated, Eating, Feeding Behavior, Female, Follow-Up Studies, Humans, Macular Degeneration, Male, Middle Aged, New South Wales, Surveys and Questionnaires, Risk Factors, Smoking, Urban Population, Fatty Acids, Omega-3, Diet Records, Incidence, Odds Ratio
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
