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Cited by 104Retinal Diseases and TreatmentsRetinal Imaging and AnalysisOphthalmology and Visual Impairment Studies

Prevalence of Age-Related Macular Degeneration in a Malay Population

Kawasaki, Ryo, Wang, Jie Jin, Aung, Tin, Tan, Donald T.H., Mitchell, Paul, Sandar, Mya, Saw, Seang-Mei, Wong, Tien Y.·2008·Ophthalmology
DOI 10.1016/j.ophtha.2008.02.012
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Abstract

Objective To describe the prevalence of age-related macular degeneration (AMD) in an Asian Malay population.Design Population-based cross-sectional study.Participants An age-stratified random sample of Malay persons aged 40 to 80 years living in Singapore.Methods Participants were invited to a central clinic for a comprehensive examination.Main outcome measures Early and late AMD signs were graded from retinal photographs following the Wisconsin grading system.Results Of 3280 participants who participated (78.7% response rate), 3265 had photographs of sufficient quality for grading of AMD signs. Early and late AMD were present in 160 (4.9%) and 23 (0.70%) participants, respectively. After age standardization, the prevalence of early AMD in Malay persons aged 40 to 80 years was estimated to be 3.5% (95% confidence interval [CI], 2.9%-4.1%) and that of late AMD was 0.34% (95% CI, 0.20%-0.49%). Early AMD was more prevalent in men than in women (6.1% vs. 3.8%); this was significant despite adjusting for age and smoking (odds ratio [OR], 1.56; 95% CI, 1.11-2.20). Late AMD also was more prevalent in men than in women (1.0% vs. 0.4%), although this was not statistically significant after adjusting for age and smoking (OR, 1.39; 95% CI, 0.52-3.68). The prevalence of early and late AMD was similar to that reported in the Blue Mountains Eye Study among white persons.Conclusions The prevalence of AMD in Asian Malay people is similar to that in white persons from the Blue Mountains Eye Study. Early AMD signs were more frequent in men compared with women, an association that was not fully explained by the higher smoking rates in men.

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Authors
Kawasaki, R., Wang, J. J., Aung, T., Tan, D. T. H., Mitchell, P., Sandar, M., Saw, S.-M., & Wong, T. Y.
Affiliations
  • The University of Melbourne (AU)
  • The University of Sydney (AU)
  • National University of Singapore (SG)
  • Singapore Eye Research Institute (SG)
Corresponding author
Wong, Tien Y.
ORCID
Venue
Ophthalmology
Publisher
Elsevier BV
Published
2008-10
Volume
115
Issue
10
Pages
1735-1741
ISSN
0161-6420 (ISSN-L)
DOI
10.1016/j.ophtha.2008.02.012
OpenAlex
W1519656732
Cited by
104
References
29
Citations by year
2026: 3 · 2025: 1 · 2024: 2 · 2023: 2 · 2022: 1 · 2021: 2 · 2020: 4 · 2019: 8 · 2018: 1 · 2017: 9 · 2016: 3 · 2015: 11 · 2014: 13 · 2013: 15 · 2012: 6
FWCI
7.76
Type
journal article
Language
en
Open access
closed
Licence
Locations
  • Ophthalmology (publishedVersion)
  • PubMed (publishedVersion)
  • National University of Singapore (submittedVersion)
Topics
  • Health Sciences › Medicine › Ophthalmology › Retinal Diseases and Treatments
  • Health Sciences › Medicine › Radiology, Nuclear Medicine and Imaging › Retinal Imaging and Analysis
  • Health Sciences › Medicine › Epidemiology › Ophthalmology and Visual Impairment Studies
Keywords
age-related macular degeneration, prevalence, Malay population, early AMD, late AMD, sex differences, smoking, fundus images, Asian populations, Singapore
MeSH terms
Adult, Aged, Aged, 80 and over, Blood Pressure, Cross-Sectional Studies, Female, Humans, Cholesterol, HDL, Cholesterol, LDL, Macular Degeneration, Male, Middle Aged, Photography, Singapore, Visual Acuity, Comorbidity, Body Mass Index, Prevalence, Asian People

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