Cited by 306Retinal Diseases and TreatmentsAntioxidant Activity and Oxidative StressRetinal Imaging and Analysis

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Antioxidant Status and Neovascular Age-Related Macular Degeneration

·1993·Archives of Ophthalmology

DOI 10.1001/archopht.1993.01090010108035

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Abstract

We evaluated the hypothesis that higher serum levels of micronutrients with antioxidant capabilities may be associated with a decreased risk of neovascular age-related macular degeneration by comparing serum levels of carotenoids, vitamins C and E, and selenium in 421 patients with neovascular age-related macular degeneration and 615 controls. Subjects were classified by blood level of the micronutrient (low, medium, and high). Persons with carotenoid levels in the medium and high groups, compared with those in the low group, had markedly reduced risks of neovascular age-related macular degeneration, with levels of risk reduced to one half and one third, respectively. Although no statistically significant protective effect was found for vitamin C or E or selenium individually, an antioxidant index that combined all four micronutrient measurements showed statistically significant reductions of risk with increasing levels of the index. Although these results suggest that higher blood levels of micronutrients with antioxidant potential, in particular, carotenoids, may be associated with a decreased risk of the most visually disabling form of age-related macular degeneration, it would be premature to translate these findings into nutritional recommendations.

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Venue: Archives of Ophthalmology
Publisher: American Medical Association (AMA)
Published: 1993-01-01
Volume: 111
Issue: 1
Pages: 104
ISSN: 0003-9950 (ISSN-L)
DOI: 10.1001/archopht.1993.01090010108035
OpenAlex: W4247315918
Cited by: 304
References: 0
Citations by year: 2026: 1 · 2025: 1 · 2024: 3 · 2023: 4 · 2022: 8 · 2021: 7 · 2020: 10 · 2019: 3 · 2018: 4 · 2017: 9 · 2016: 6 · 2015: 9 · 2014: 7 · 2013: 8 · 2012: 15
FWCI: 13.98
Type: journal article
Language: en
Open access: closed
Locations: Archives of Ophthalmology (publishedVersion)
PubMed (publishedVersion)
Funders: National Eye Institute (N01-EY-5-2111, N01-EY-5-2109, N01-EY-5-2110)
Topics: Health Sciences › Medicine › Ophthalmology › Retinal Diseases and Treatments
Health Sciences › Medicine › Biochemistry (medical) › Antioxidant Activity and Oxidative Stress
Health Sciences › Medicine › Radiology, Nuclear Medicine and Imaging › Retinal Imaging and Analysis
Keywords: neovascular age-related macular degeneration, antioxidant status, carotenoids, vitamin C, vitamin E, selenium, micronutrients, antioxidant index, serum nutrient levels, disease risk
MeSH terms: Aged, Aged, 80 and over, Antioxidants, Ascorbic Acid, Carotenoids, Female, Humans, Macula Lutea, Macular Degeneration, Male, Middle Aged, Neovascularization, Pathologic, Risk Factors, Selenium, Vitamin E, Odds Ratio, Case-Control Studies

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Antioxidant Status and Neovascular Age-Related Macular Degeneration

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