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Cited by 344

The DOI matches its Crossref record; 31 of the 31 references it cites were found in a registry or an index.

Forecasting Age-Related Macular Degeneration Through the Year 2050: The Potential Impact of New Treatments

Rein, David B.·2009·Archives of Ophthalmology
DOI 10.1001/archophthalmol.2009.58
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Abstract

OBJECTIVE: To forecast age-related macular degeneration (AMD) and its consequences in the United States through the year 2050 with different treatment scenarios. METHODS: We simulated cases of early AMD, choroidal neovascularization (CNV), geographic atrophy (GA), and AMD-attributable visual impairment and blindness with 5 universal treatment scenarios: (1) no treatment; (2) focal laser and photodynamic therapy (PDT) for CNV; (3) vitamin prophylaxis at early-AMD incidence with focal laser/PDT for CNV; (4) no vitamin prophylaxis followed by focal laser treatment for extra and juxtafoveal CNV and anti-vascular endothelial growth factor treatment; and (5) vitamin prophylaxis at early-AMD incidence followed by CNV treatment, as in scenario 4. RESULTS: Cases of early AMD increased from 9.1 million in 2010 to 17.8 million in 2050 across all scenarios. In non-vitamin-receiving scenarios, cases of CNV and GA increased from 1.7 million in 2010 to 3.8 million in 2050 (25% lower in vitamin-receiving scenarios). Cases of visual impairment and blindness increased from 620 000 in 2010 to 1.6 million in 2050 when given no treatment and were 2.4%, 22.0%, 16.9%, and 34.5% lower in scenarios 2, 3, 4, and 5, respectively. CONCLUSION: Prevalence of AMD will increase substantially by 2050, but the use of new therapies can mitigate its effects.

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Metadata

Authors
Rein, D. B.
Venue
Archives of Ophthalmology
Publisher
American Medical Association (AMA)
Published
2009-04-01
Volume
127
Issue
4
Pages
533
ISSN
0003-9950 (ISSN-L)
DOI
10.1001/archophthalmol.2009.58
OpenAlex
W2144523453
Cited by
344
References
31
FWCI
21.86
Type
journal article
Language
en
Open access
closed

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CoChat. (2026). Citation check: Forecasting Age-Related Macular Degeneration Through the Year 2050: The Potential Impact of New Treatments. https://app.cochat.ai/papers/10.1001/archophthalmol.2009.58
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Rein, D. B. (2009). Forecasting Age-Related Macular Degeneration Through the Year 2050: The Potential Impact of New Treatments. Archives of Ophthalmology. https://doi.org/10.1001/archophthalmol.2009.58

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