Causes and Prevalence of Visual Impairment Among Adults in the UnitedStates
Open accessAbstract
OBJECTIVES: To estimate the cause-specific prevalence and distribution of blindness and low vision in the United States by age, race/ethnicity, and gender, and to estimate the change in these prevalence figures over the next 20 years. METHODS: Summary prevalence estimates of blindness (both according to the US definition of < or =6/60 [< or =20/200] best-corrected visual acuity in the better-seeing eye and the World Health Organization standard of < 6/120 [< 20/400]) and low vision (< 6/12 [< 20/40] best-corrected vision in the better-seeing eye) were prepared separately for black, Hispanic, and white persons in 5-year age intervals starting at 40 years. The estimated prevalences were based on recent population-based studies in the United States, Australia, and Europe. These estimates were applied to 2000 US Census data, and to projected US population figures for 2020, to estimate the number of Americans with visual impairment. Cause-specific prevalences of blindness and low vision were also estimated for the different racial/ethnic groups. RESULTS: Based on demographics from the 2000 US Census, an estimated 937 000 (0.78%) Americans older than 40 years were blind (US definition). An additional 2.4 million Americans (1.98%) had low vision. The leading cause of blindness among white persons was age-related macular degeneration (54.4% of the cases), while among black persons, cataract and glaucoma accounted for more than 60% of blindness. Cataract was the leading cause of low vision, responsible for approximately 50% of bilateral vision worse than 6/12 (20/40) among white, black, and Hispanic persons. The number of blind persons in the US is projected to increase by 70% to 1.6 million by 2020, with a similar rise projected for low vision. CONCLUSIONS: Blindness or low vision affects approximately 1 in 28 Americans older than 40 years. The specific causes of visual impairment, and especially blindness, vary greatly by race/ethnicity. The prevalence of visual disabilities will increase markedly during the next 20 years, owing largely to the aging of the US population.
AI snapshot
Written from the paper’s full text.
TL;DR
This pooled analysis estimates that in 2000, 937,000 Americans older than 40 years were blind by the US definition and an additional 2.4 million had low vision, with prevalence projected to rise substantially by 2020. Causes varied by race/ethnicity: age-related macular degeneration led among white persons, while cataract and glaucoma accounted for most blindness among black persons.
Key findings
- In 2000, an estimated 937,000 Americans older than 40 years were blind by the US definition (0.78%; 95% CI, 0.63%-0.94%), and 2.4 million had low vision (1.98%; 95% CI, 1.74%-2.21%), totaling 3.3 million visually impaired Americans (2.76%; 95% CI, 2.48%-3.04%).
- The leading cause of blindness among white persons was age-related macular degeneration (54.4% of cases); among black persons, cataract and open-angle glaucoma accounted for slightly over 60% of cases; among Hispanic persons, open-angle glaucoma was the most common cause (28.6%), based on 4 bilaterally blind persons from glaucoma.
- Cataract was the leading cause of low vision, responsible for approximately 50% of bilateral vision worse than 6/12 (20/40) among white, black, and Hispanic persons.
- The number of blind persons older than 40 years was projected to increase by approximately 70% to 1.6 million (prevalence 1.1%) by 2020; low vision was projected at 3.9 million (2.5%), for a total of 5.5 million visually impaired Americans (3.6%).
Methods
- Population-based studies of blindness and low vision conducted in North America, Western Europe, and Australia, published in English after 1990 and up to May 2001, were included; data were standardized for blindness definitions (WHO <6/120 [<20/400]; US ≤6/60 [≤20/200]) and low vision (<6/12 [<20/40] best-corrected vision in the better-seeing eye).
- Age-, race/ethnicity-, and gender-specific prevalences were pooled using minimum variance linear estimation and logistic regression models fit separately for black, white, and Hispanic persons.
- Modeled prevalences were applied to 2000 US Census data and to 2020 census projections, assuming constant age- and race/ethnicity-specific prevalences over the period.
Limitations
- The paper states that estimates for white persons rely partly on data from Australia and Europe, where clinical and surgical practices and access to care may differ from the United States; Hispanic estimates are based on a single study of persons of Mexican descent; and black estimates are based on only 2 studies from the same state.
- The paper states that diagnostic criteria for causes of blindness and low vision differed among studies, and that estimates are based on best-corrected visual acuity, so they do not reflect visual impairment due to uncorrected refractive error; if Melbourne Visual Impairment Project estimates applied, the true number of visually impaired Americans might be as high as 8 million.
- Evident from the text: cause-specific estimates for Hispanic blindness are based on very few cases (e.g., 4 persons blind from glaucoma), and the 2020 projections assume constant age- and race/ethnicity-specific prevalences.
Model-written summary. Check it against the paper before relying on it.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
0 of 26 cited sources checked · 0 supported · 0 flagged
- Findingreasoning
Blindness or low vision affects approximately 1 in 28 Americans older than 40 years.
“Blindness or low vision affects approximately 1 in 28 Americans older than 40 years.”
Quote in the paperSubstantial claim - Findingown data
There was a high degree of similarity in age-specific blindness prevalence among the 6 studies of European-derived individuals on which the study estimates are based.
“It is reassuring to note the high degree of similarity in agespecific blindness prevalence among the 6 studies of European-derived individuals on which our study estimates are based (Figure 1A).”
Quote in the paperSubstantial claim - Findingcitation
The authors' estimates of the number of Americans with visual impairment are slightly lower than those reported in NHANES I-A, which reported 7.7% of African American and 4.1% of non-Hispanic white subjects with binocular visual acuities of 6/15 (20/50) or worse.
“Our estimates of the number of Americans with visual impairment are slightly lower than those given in NHANES I-A (NHANES Augmentation Study I), which re-ported that 7.7% of African American and 4.1% of non-Hispanic white subjects had binocular visual acuities of 6/15 (20/50) or worse.19”
Quote in the paperNot a substantial claim0 of 1 sources checked- cites [19]
Not checked in the free run.
- Findingown data
Age-specific blindness prevalence was higher for black persons compared with white persons (OR=2.77; 95% CI, 1.56-4.92).
“Age-specific blindness prevalence was higher for black persons compared with white persons (odds ratio [OR] = 2.77; 95% CI, 1.56-4.92)”
Quote in the paperSubstantial claim - Findingown data
The proportion of low vision due to cataract was more than twice the proportion due to any other condition.
“This was more than twice the proportion of any other condition (Figure 3).”
Quote in the paperNot a substantial claim
- Findingreasoning
In 2000, a total of 3.3 million Americans aged 40 years and older had visual impairment.
“for a total of 3.3 million Americans aged 40 years and older with visual impairment (Table 2).”
Quote in the paperNot a substantial claim - Findingown data
The prevalence of low vision among Hispanic persons was higher than that for black persons (OR=1.90; 95% CI, 1.28-2.83).
“and black persons (OR=1.90;95% CI, 1.28-2.83)”
Quote in the paperNot a substantial claim - Findingnone given
Differences in the observed age-specific prevalence of low vision among studies are more prominent.
“Differences in the observed agespecific prevalence of low vision among studies are more prominent.”
Quote in the paperNot a substantial claim - Findingown data
Among black persons, cataract and open-angle glaucoma accounted for slightly over 60% of blindness cases.
“while among black persons, cataract and glaucoma accounted for more than 60% of blindness.”
- Also stated in: § RESULTS · plain
“The leading causes of blindness among black persons were more evenly distributed than among white persons, with cataract and open-angle glaucoma (OAG) accounting for slightly over 60% of the cases.”
Quote in the paperNot a substantial claim - Also stated in: § RESULTS · plain
- Findingown data
Estimated blindness by US definition among Australians older than 40 years in 2000 was 55,000 (0.7%).
“blindness (US definition of Յ6/60 [Յ20/200] best-corrected visual acuity in the better-seeing eye) 55 000 (0.7%)”
Quote in the paperNot a substantial claim - Findingown data
Age-specific blindness prevalence was higher for black persons compared with Hispanic persons (OR=3.13; 95% CI, 2.29-4.29).
“or Hispanic persons (OR=3.13;95% CI, 2.29-4.29)”
Quote in the paperSubstantial claim - Findingown data
The prevalence of low vision among Hispanic persons was higher than that for white persons (OR=1.39; 95% CI, 1.24-1.56).
“while the prevalence of low vision among Hispanic persons was higher than that for white persons OR=1.39; 95% CI, 1.24-1.56)”
Quote in the paperSubstantial claim - Findingnone given
Cataract was the leading cause of low vision, responsible for approximately 50% of bilateral vision worse than 6/12 (20/40) among white, black, and Hispanic persons.
“Cataract was the leading cause of low vision, responsible for approximately 50% of bilateral vision worse than 6/12 (20/40) among white, black, and Hispanic persons.”
Quote in the paperSubstantial claim - Findingown data
Age-related macular degeneration was the leading cause of blindness in all 6 population-based studies of European-derived populations on which the current article is based.
“Agerelated macular degeneration was also the leading cause of blindness in all 6 population-based studies of Europeanderived populations on which the current article is based.”
Quote in the paperNot a substantial claim - Findingcitation
Cataract is identified as the leading cause of low vision among Hispanic persons in our estimates, based on 43 persons with cataract from a total of 92 with visual acuity worse than 6/12.
“Estimates of low vision among Hispanic persons are somewhat more robust; cataract is identified as the leading cause of low vision among Hispanic persons in our estimates, based on 43 persons with cataract from a total of 92 with visual acuity worse than 6/12 (Ͻ20/40).9”
Quote in the paperNot a substantial claim0 of 1 sources checked- cites [9]
Not checked in the free run.
- Findingcitation
OAG is indicated as the leading cause of blindness among Hispanic persons in our estimates, based on 4 persons blind from glaucoma, compared with 2 each from diabetic retinopathy, cataract, and AMD in the Proyecto VER study.
“This is most apparent for blindness estimates; OAG is indicated as the leading cause of blindness among Hispanic persons in our estimates (Figure 1) on the basis of 4 persons blind from glaucoma, compared with 2 each from diabetic retinopathy, cataract, and AMD in the Proyecto VER study.9”
Quote in the paperNot a substantial claim0 of 1 sources checked- cites [9]
Not checked in the free run.
- Interpretationown data
The lack of an increased burden of blindness among white women is counter to a recent report from a large, older, white population in England that women are at greater age-adjusted risk for blindness than men.
“The lack of an increased burden of blindness among white women is counter to a recent report from a large, older, white population in England that women are at greater age-adjusted risk for blindness than men.14”
Quote in the paperNot a substantial claim0 of 1 sources checked- cites [14]
Not checked in the free run.
- Interpretationown data
The finding of higher age-adjusted blindness prevalence among black men than black women runs contrary to a recent meta-analytic study reporting a significant age-adjusted excess of blindness among women.
“Our finding of a higher age-adjusted blindness prevalence among black men as opposed to black women runs contrary to the results of a recent meta-analytic study that reported a significant age-adjusted excess of blindness among women in population-based studies throughout Africa, Asia, and the developed world.13”
Quote in the paperNot a substantial claim0 of 1 sources checked- cites [13]
Not checked in the free run.
- Premisecitation
The British study reported presenting as opposed to best-corrected visual acuity.
“Once again, however, the British study reported presenting as opposed to best-corrected visual acuity.”
Quote in the paperNot a substantial claim0 of 1 sources checked- cites [20]
Not checked in the free run.
- Study design and conductown data
Low numbers of cases in some 5-year age and gender intervals were insufficient to provide robust pooled gender-specific estimates, so these estimates were collapsed over gender.
“The low numbers of cases in some 5-year age and gender intervals were insufficient to provide robust, pooled, gender-specific estimates, so these estimates were collapsed over gender.”
Quote in the paperSubstantial claim - Premisecitation
Population-based studies of ocular disease in the United States are potentially limited in generalizability by local variations in the populations studied, accessibility of eye care, and patterns of surgical practice.
“Population-based studies of ocular disease that have been carried out in the United States [6][7][8][9] are potentially limited in their generalizability by local variations in the populations studied, accessibility of eye care, and patterns of surgical practice.”
Quote in the paperSubstantial claim0 of 1 sources checked- cites [6][7][8][9]
Not checked in the free run.
- Interpretationown data
The specific causes of visual impairment, and especially blindness, vary greatly by race/ethnicity.
“The specific causes of visual impairment, and especially blindness, vary greatly by race/ethnicity.”
Quote in the paperSubstantial claim - Premisereasoning
Few population-based studies of national scope have been carried out in the United States to estimate the prevalence of visual impairment.
“Because of the cost and logistical difficulty of carrying out an appropriate sampling scheme, few populationbased studies of national scope have been carried out in the United States to estimate the prevalence of visual impairment.”
Quote in the paperSubstantial claim - Interpretationreasoning
The number of blind persons older than 40 years in the United States was projected to increase by approximately 70% to 1.6 million (prevalence 1.1%) by 2020.
“It was estimated that the number of blind persons older than 40 years in the United States would increase by approximately 70% to 1.6 million (prevalence of 1.1%) by 2020.”
Quote in the paperSubstantial claim- The authors state this as an assumption: Constant age- and race/ethnicity-specific prevalences for blindness and low vision were assumed over the period from 2000 to 2020.
- Study design and conductcitation
Hispanic estimates in the study are based on a single study, Proyecto VER, based in Nogales and Tucson, Arizona.
“Although our study gives estimates for the prevalence of visual impairment among Hispanic persons, these data are based on a single study, Proyecto VER (Vision Evaluation Research), based in Nogales and Tucson, Ariz.9”
Quote in the paperSubstantial claim0 of 1 sources checked- cites [9]
Not checked in the free run.
- Interpretationcitation
The Hispanic estimates may be susceptible to local patterns of medical and surgical practice, which vary greatly by region and patient insurance type.
“These estimates may be susceptible to local patterns of medical and surgical practice, which are known to vary greatly by region 29 and patient insurance type.30”
Quote in the paperNot a substantial claim0 of 2 sources checked- cites [29]
Not checked in the free run.
- cites [30]
Not checked in the free run.
- Premisecitation
The risk for development of diabetic retinopathy seems to be higher among black persons who have diabetes mellitus.
“The risk for development of diabetic retinopathy also seems to be higher among black persons who have diabetes mellitus.26,27”
Quote in the paperSubstantial claim0 of 2 sources checked- cites [26]
Not checked in the free run.
- cites [27]
Not checked in the free run.
- Premisecitation
The Visual Acuity Impairment Survey carried out by the National Eye Institute in the 1980s suffered limitations because of the absence of photographic documentation and the large proportion of persons who could not be examined.
“The Visual Acuity Impairment Survey carried out by the National Eye Institute in the 1980s suffered similar limitations because of the absence of photographic documentation and the large proportion of persons who could not be examined.5”
Quote in the paperNot a substantial claim0 of 1 sources checked- cites [5]
Not checked in the free run.
- Interpretationreasoning
The number of persons with low vision was projected to be 3.9 million (2.5%) by 2020.
“The number of persons with low vision was projected to be 3.9 million (2.5%)”
Quote in the paperNot a substantial claim- The authors state this as an assumption: Constant age- and race/ethnicity-specific prevalences for blindness and low vision were assumed over the period from 2000 to 2020.
- Interpretationreasoning
The higher burden of cataract, OAG, and diabetic retinopathy may explain the higher age-specific prevalence of blindness among black compared with white persons observed in our estimates.
“The higher burden of cataract, OAG, and diabetic retinopathy may also explain the higher age-specific prevalence of blindness among black compared white persons observed in our estimates.”
Quote in the paperSubstantial claim - Interpretationreasoning
A total of 5.5 million Americans were projected to be visually impaired (3.6%) by 2020.
“for a total of 5.5 million visually impaired Americans (3.6%).”
Quote in the paperNot a substantial claim- The authors state this as an assumption: Constant age- and race/ethnicity-specific prevalences for blindness and low vision were assumed over the period from 2000 to 2020.
- Study design and conductreasoning
Our approach has allowed such differences to be eliminated.
“Our approach has allowed such differences to be eliminated.”
Quote in the paperSubstantial claim - Study design and conductreasoning
Our estimates for white persons rely in part on data from Australia and Europe, where clinical and surgical practices and access to care may differ from the United States.
“Our estimates for white persons rely in part on data from Australia and Europe, where clinical and surgical practices and access to care may differ from the United States.”
Quote in the paperSubstantial claim - Study design and conductown data
The estimates for overall and cause-specific visual impairment in Hispanic persons are based on a few cases.
“Furthermore, the estimates for overall and cause-specific visual impairment in Hispanic persons are based on a few cases.”
Quote in the paperNot a substantial claim - Interpretationreasoning
The projection of a large increase in the prevalence of blindness and low vision in the United States during the next 2 decades is driven largely by the fact that the prevalence of visual impairment increases sharply in persons older than 65 years.
“The projection of a large increase in the prevalence of blindness and low vision in the United States during the next 2 decades is driven largely by the fact that the prevalence of visual impairment increases sharply in persons older than 65 years.”
Quote in the paperSubstantial claim - Interpretationreasoning
National estimates derived in this way may not be representative of the American Hispanic population as a whole, which comprises Cuban Americans, Puerto Ricans, and Central Americans in addition to Mexican Americans.
“National estimates derived in this way may not be representative of the American Hispanic population as a whole, which comprises Cuban Americans, Puerto Ricans, and Central Americans in addition to Mexican Americans.”
Quote in the paperSubstantial claim
- Classified as probably not a substantial claim. 16
- May combine two claims. 24
Probably not a substantial claim: may not pass S3 (load-bearing).
Findingown dataEstimated blindness by WHO standard among Australians older than 40 years in 2000 was 35,000 (0.4%).
“blindness (WHO standard of Ͻ6/120 [Ͻ20/400] best-corrected visual acuity in the better-seeing eye) 35 000 (0.4%)”
Quote in the paperNot a substantial claimMay combine two claims.
Findingown dataBased on the 2000 US Census, an estimated 937,000 Americans older than 40 years were blind by the US definition, a prevalence of 0.78% (95% CI, 0.63%-0.94%).
“Based on demographics from the 2000 US Census, an estimated 937000 (0.78%) Americans older than 40 years were blind (US definition).”
- Also stated in: § RESULTS · hedged
“In 2000, there were an estimated 937000 blind Americans who were older than 40 years (US definition), a prevalence of 0.78% (95% confidence interval [CI], 0.63%-0.94%).”
Quote in the paperSubstantial claim- Also stated in: § RESULTS · hedged
May combine two claims.
Findingown dataOverall, blindness was significantly (P=.004) more common in white women than white men, but the difference was no longer significant after adjustment for age (P>.10).
“Overall, blindness was significantly (P=.004) more common in white women than white men, but the difference was no longer significant after adjustment for age (PϾ.10).”
Quote in the paperSubstantial claimMay combine two claims.
Findingown dataAn estimated additional 2.4 million Americans older than 40 years had low vision, a prevalence of 1.98% (95% CI, 1.74%-2.21%).
“An additional 2.4 million Americans (1.98%) had low vision.”
- Also stated in: § RESULTS · hedged
“The number of persons with low vision was estimated to be an additional 2.4 million (1.98%; 95% CI, 1.74%-2.21%)”
Quote in the paperSubstantial claim- Also stated in: § RESULTS · hedged
May combine two claims.
Findingown dataThe Baltimore Eye Survey is at the lowest end of the range of low vision prevalence, and the Beaver Dam Eye Study toward the highest end; both are American studies.
“However, the Baltimore Eye Survey, Baltimore, Md, is at the lowest end of this range, and the Beaver Dam Eye Study toward the highest end (Figure 1C); these are both American studies.”
Quote in the paperNot a substantial claimMay combine two claims.
Findingown dataBoth low vision and blindness increased significantly with age for all races/ethnicities (P<.001 for both).
“Both low vision and blindness increased significantly with age for all races/ethnicities (PϽ.001 for all races/ethnicities for both blindness and low vision) (Table 3).”
- Also stated in: § COMMENT · boosted
“Our results were consistent with those of the participating studies in demonstrating that the prevalence of visual impairment increases with increasing age.”
Quote in the paperSubstantial claim- Also stated in: § COMMENT · boosted
May combine two claims.
Findingown dataAmong Hispanic persons, open-angle glaucoma was the most common cause of blindness, accounting for 28.6% of cases, based on 4 persons bilaterally blind from glaucoma.
“Among Hispanic persons, OAG was the most common cause of blindness (28.6% of the cases), although this is based on a total of only 4 persons bilaterally blind from glaucoma.”
Quote in the paperNot a substantial claimMay combine two claims.
Findingown dataThe age-adjusted prevalence of low vision was significantly higher for women among white persons (P=.01) but did not differ significantly by gender among black (P=.96) or Hispanic persons (P=.11).
“The age-adjusted prevalence of low vision was significantly higher for women among white persons (P=.01) but did not differ significantly by gender among black (P=.96) or Hispanic persons (P=.11).”
- Also stated in: § COMMENT · hedged
“White women did appear to be at an increased risk of low vision in the current study.”
Quote in the paperNot a substantial claim- Also stated in: § COMMENT · hedged
May combine two claims.
Findingown dataThe leading cause of blindness among white Americans in 2000 was age-related macular degeneration, accounting for 54% of all blindness.
“The leading cause of blindness among white persons was age-related macular degeneration (54.4% of the cases)”
- Also stated in: § RESULTS · plain
“accounting for 54% of all blindness, as opposed to 9% for cataract, the next most common cause”
Quote in the paperSubstantial claim- Also stated in: § RESULTS · plain
May combine two claims.
FindingcitationPrevalence of visual impairment in the British sample (WHO low vision standard <6/18) was 3.1% for persons aged 65 through 74 years, as opposed to 1.47% for Americans aged 65 through 69 years, and 2.61% for those aged 70 through 74 years.
“Prevalence of visual impairment in the British sample (WHO low vision standard Ͻ6/18 [20/60]) was 3.1% for persons aged 65 through 74 years, as opposed to 1.47% for Americans aged 65 through 69 years, and 2.61% for those aged 70 through 74 years.”
Quote in the paperNot a substantial claim0 of 1 sources checked- cites [20]
Not checked in the free run.
Probably not a substantial claim: may not pass S3 (load-bearing).
FindingreasoningEstimated blindness by US definition in Western Europe in 2000 was 1.38 million (0.7%).
“blindness (US definition); 1.38 million (0.7%)”
Quote in the paperNot a substantial claimProbably not a substantial claim: may not pass S3 (load-bearing).
FindingreasoningEstimated low vision prevalence in Western Europe in 2000 was 3.64 million (2.0%).
“low vision, 3.64 million (2.0%)”
Quote in the paperNot a substantial claimProbably not a substantial claim: may not pass S3 (load-bearing).
FindingreasoningEstimated low vision prevalence among Australians older than 40 years in 2000 was 143,000 (1.8%).
“low vision 143 000 (1.8%)”
Quote in the paperNot a substantial claimMay combine two claims.
Findingown dataMen had a significantly higher age-adjusted prevalence of blindness than women among black persons (P=.002), but not among white (P=.20) or Hispanic persons (P=.64).
“Men had a significantly higher age-adjusted prevalence of blindness than women among black persons (P=.002), but not among white (P=.20) or Hispanic persons (P=.64).”
Quote in the paperNot a substantial claimProbably not a substantial claim: may not pass S3 (load-bearing).
FindingreasoningEstimated blindness by WHO standard in Western Europe in 2000 was 879,000 (0.5%).
“blindness (WHO standard), 879000 (0.5%)”
Quote in the paperNot a substantial claimProbably not a substantial claim: may not pass S3 (load-bearing).
FindingcitationThe proportion of persons older than 65 years with blindness and low vision in the United States seems to be somewhat lower than that reported among a population-based sample of similar-aged British persons.
“The proportion of persons older than 65 years with blindness and low vision in the United States seems to be somewhat lower than that reported among a population-based sample of similar-aged British persons.20”
Quote in the paperNot a substantial claim0 of 1 sources checked- cites [20]
Not checked in the free run.
May combine two claims.
Findingown dataPersons aged 80 years and older made up only 7.7% of the population in our study but accounted for 69% of observed blindness.
“Persons aged 80 years and older made up only 7.7% of the population in our study but accounted for 69% of observed blindness.”
Quote in the paperSubstantial claimMay combine two claims.
PremisecitationThe NHANES I-A results are for presenting rather than best-corrected visual acuity, and they included only persons aged 25 to 74 years.
“However, the NHANES I-A results are for presenting rather than best-corrected visual acuity as in our analysis, and they included only persons aged 25 to 74 years.”
Quote in the paperNot a substantial claim0 of 1 sources checked- cites [19]
Not checked in the free run.
May combine two claims.
Interpretationown dataBlindness prevalence rises rapidly among the oldest segment of the population beyond 85 years, suggested by a highly significant quadratic term and a rapid apparent increase in estimated prevalence above age 85.
“Although limited data did not permit us to make robust estimates in the age range beyond 85 years, a highly significant quadratic term in our models, together with a rapid apparent increase in estimated blindness prevalence above the age of 85 years, suggests that blindness prevalence rises rapidly among the oldest segment of the population.”
Quote in the paperSubstantial claimProbably not a substantial claim: may not pass S3 (load-bearing).
PremisecitationAge-related macular degeneration has been reported to be the leading cause of blindness in most recent population-based studies of persons of European descent.
“Age-related macular degeneration has been reported to be the leading cause of blindness in most recent population-based studies of persons of European descent.[6][7][8][15][16][17]”
Quote in the paperNot a substantial claim0 of 1 sources checked- cites [6][7][8][15][16][17]
Not checked in the free run.
May combine two claims.
Interpretationown dataDiseases of aging are the most common causes of blindness (AMD, cataract, and glaucoma) and of low vision (cataract).
“Diseases of aging are also the most common causes of blindness (AMD, cataract, and glaucoma) and of low vision (cataract).”
Quote in the paperSubstantial claimMay combine two claims.
InterpretationcitationThe higher risk of diabetic retinopathy among black persons with diabetes may be because of a combination of factors, including higher prevalence of hyperglycemia and hypertension, poor access to medical care, and reduced health literacy among black compared with white persons.
“This may be because of a combination of factors, including higher prevalence of hyperglycemia and hypertension, poor access to medical care, and reduced health literacy among black compared with white persons.28”
Quote in the paperNot a substantial claim0 of 1 sources checked- cites [28]
Not checked in the free run.
Probably not a substantial claim: may not pass S3 (load-bearing).
Premisenone givenNHANES vision data were collected more than 30 years ago.
“In addition, these data were collected more than 30 years ago.”
Quote in the paperNot a substantial claimMay combine two claims.
PremisecitationNHANES has collected national data on vision disabilities, but the lack of photographic documentation of ocular conditions limits the ability to assess causal associations.
“While The National Health and Nutrition Examination Survey (NHANES) has collected national data on vision disabilities, 4 the lack of photographic documentation of ocular conditions limits the ability to assess causal associations.”
Quote in the paperSubstantial claim0 of 1 sources checked- cites [4]
Not checked in the free run.
May combine two claims.
Interpretationown dataVisual impairment is highly prevalent in the United States and is projected to increase rapidly as the population ages.
“Visual impairment is highly prevalent in the United States and is projected to increase rapidly as the population ages.”
Quote in the paperNot a substantial claim- The authors state this as an assumption: Constant age- and race/ethnicity-specific prevalences for blindness and low vision were assumed over the period from 2000 to 2020.
May combine two claims.
InterpretationreasoningThe prevalence of visual disabilities will increase markedly during the next 20 years, owing largely to the aging of the US population.
“The prevalence of visual disabilities will increase markedly during the next 20 years, owing largely to the aging of the US population.”
Quote in the paperSubstantial claim- The authors state this as an assumption: Constant age- and race/ethnicity-specific prevalences for blindness and low vision were assumed over the period from 2000 to 2020.
May combine two claims.
Study design and conductcitationIn the case of Hispanic persons, estimates are based on data from a single study of persons of Mexican descent, which are likely to be influenced by local factors such as number, distribution, and practice patterns of ophthalmologists.
“In the case of Hispanic persons, an important and rapidly growing segment of the US population, estimates are based on data from a single study of persons of Mexican descent, 9 which are likely to be influenced by local factors such as number, distribution, and practice patterns of ophthalmologists.”
Quote in the paperSubstantial claim0 of 1 sources checked- cites [9]
Not checked in the free run.
Probably not a substantial claim: may not pass S3 (load-bearing), S4 (based). May combine two claims.
Interpretationnone givenMost of this blindness could be reversed with treatment or avoided by preventive efforts.
“Most of this blindness could be reversed with treatment or avoided by preventive efforts.”
Quote in the paperNot a substantial claimProbably not a substantial claim: may not pass S3 (load-bearing).
Study design and conductnone givenDiagnostic criteria for the various causes of blindness and low vision also differed among studies.
“Diagnostic criteria for the various causes of blindness and low vision also differed among studies.”
Quote in the paperNot a substantial claimMay combine two claims.
Study design and conductcitationThe estimates reported here are based on best-corrected visual acuity and do not reflect the burden of low vision and blindness due to uncorrected refractive error.
“Finally, and perhaps most importantly, the estimates reported here are based on best-corrected visual acuity.These figures do not reflect the burden of low vision and blindness due to uncorrected refractive error, potentially an important cause of visual impairment in the United States.36,37”
Quote in the paperSubstantial claim0 of 2 sources checked- cites [36]
Not checked in the free run.
- cites [37]
Not checked in the free run.
Probably not a substantial claim: may not pass S3 (load-bearing).
InterpretationcitationIf such estimates may accurately be applied in the United States, the true number of visually impaired Americans might be as high as 8 million.
“If such estimates may accurately be applied in the United States, the true number of visually impaired Americans might be as high as 8 million.”
Quote in the paperNot a substantial claim- The authors state this as an assumption: The estimates from the Melbourne Visual Impairment Project (almost 60% of visual impairment due to uncorrected refractive error) may accurately be applied in the United States.
Probably not a substantial claim: may not pass S3 (load-bearing).
Study design and conductown dataThese estimates of low vision and blindness prevalence among the US population are the first to take full advantage of the large number of population-based studies of vision carried out in the last decade.
“Nevertheless, these estimates of low vision and blindness prevalence among the US population are the first to take full advantage of the large number of populationbased studies of vision carried out in the last decade.”
Quote in the paperNot a substantial claimMay combine two claims.
InterpretationreasoningThus, the results of the current study provide useful estimates of the burden of visual impairment in the United States, its distribution by age, race/ethnicity, and sex, and its likely rapid future increase.
“Thus, the results of the current study provide useful estimates of the burden of visual impairment in the United States, its distribution by age, race/ethnicity, and sex, and its likely rapid future increase.”
Quote in the paperSubstantial claimClassified as probably not a substantial claim. May combine two claims.
Study design and conductnone givenThe estimates were derived from raw data provided directly by the study groups and were combined only after agreement had been reached on standard presentation of data.
“The estimates were derived from raw data provided directly by the study groups and were combined only after agreement had been reached on standard presentation of data.”
Quote in the paperSubstantial claimProbably not a substantial claim: may not pass S2 (checkable), S3 (load-bearing), S4 (based).
InterpretationreasoningThese factors might be expected to influence the prevalence and cause-specific distribution of visual impairment.
“These factors might be expected to influence the prevalence and causespecific distribution of visual impairment.”
Quote in the paperNot a substantial claimProbably not a substantial claim: may not pass S3 (load-bearing).
PremisecitationA recent report from the Melbourne Visual Impairment Project suggests that almost 60% of visual impairment may be due to uncorrected refractive error.
“A recent report from the Melbourne Visual Impairment Project 17 suggests that almost 60% of visual impairment may be due to uncorrected refractive error.”
Quote in the paperNot a substantial claim0 of 1 sources checked- cites [17]
Not checked in the free run.
Classified as probably not a substantial claim.
PremisecitationA recent review has cited differences in the definition of low vision and the age range of the oldest age category as the 2 most important sources of disagreement in estimates of visual impairment between studies.
“A recent review has cited differences in the definition of low vision and the age range of the oldest age category as the 2 most important sources of disagreement in estimates of visual impairment between studies.38”
Quote in the paperSubstantial claim0 of 1 sources checked- cites [38]
Not checked in the free run.
May combine two claims.
Study design and conductreasoningEstimates for black persons are based on data from only 2 studies, both from the same state, and may be similarly unstable.
“Estimates for black persons are based on data from only 2 studies, 7,8 both from the same state, and may be similarly unstable.”
Quote in the paperNot a substantial claim0 of 2 sources checked- cites [7]
Not checked in the free run.
- cites [8]
Not checked in the free run.
The authors state this as an assumption.
Constant age- and race/ethnicity-specific prevalences for blindness and low vision were assumed over the period from 2000 to 2020.
“Constant age-and race/ethnicity-specific prevalences were assumed over this period for both blindness and low vision.”
The paper relies on this without support.
Few national estimates exist for the prevalence of impaired best-corrected visual acuity.
“Few national estimates exist for the prevalence of impaired best-corrected visual acuity, as was used in the current study, presumably because of the difficulty and expense involved.”
The paper relies on this without support.
The very old (aged 80 years and older) represent the fastest-growing segment of the US population.
“It is this group, the very old, who represent the fastest-growing segment of the US population.”
The authors state this as an assumption.
The estimates from the Melbourne Visual Impairment Project (almost 60% of visual impairment due to uncorrected refractive error) may accurately be applied in the United States.
“If such estimates may accurately be applied in the United States, the true number of visually impaired Americans might be as high as 8 million.”
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
Age-related macular degeneration is the leading cause of blindness in elderly populations of European descent.
“Age-related macular degeneration is the leading cause of blindness in elderly populations of European descent.”
From Age-related macular degeneration (2008) · cites this paper as [1]
Age-related macular degeneration is the most common cause of visual impairment in individuals over the age of 55 years in developed countries.
“Age-related macular degeneration is the most common cause of visual impairment in individuals over the age of 55 years in developed countries.1”
From Age-related macular degeneration (2008) · cites this paper as [1]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
Each contradiction between two passages listed here was confirmed by an independent check.
The stated "1 in 28" prevalence conflicts with the reported overall prevalence
MajorTable 2 reports visual impairment in 2.76% of Americans aged 40 years and older. That is approximately 1 in 36, not 1 in 28.
Reported 28 · recomputed 36.231884
“Conclusions: Blindness or low vision affects approximately 1 in 28 Americans older than 40 years.”
Figure 2 excludes the blindness threshold used elsewhere
MinorFigure 2 defines blindness as visual acuity strictly worse than 6/60, whereas the paper's US definition includes acuity of exactly 6/60. Thus the figure caption describes a different threshold for its cause-specific results.
“Figure 2. Causes of blindness (best-corrected visual acuity Ͻ6/60 [Ͻ20/200] in the better-seeing eye) by race/ethnicity.”
“Blindness as defined by the US definition is the best-corrected visual acuity of 6/60 or worse (Յ20/200) in the better-seeing eye.”
Cites
(2001) · Archives of Ophthalmology · doi:10.1001/archopht.119.10.1417 · Cited by 3,285 · see citing works
Association of Health Literacy With Diabetes Outcomes
Schillinger, D. (2002) · JAMA · doi:10.1001/jama.288.4.475 · Cited by 1,944 · see citing works
Racial variations in the prevalence of primary open-angle glaucoma. The Baltimore Eye Survey
Tielsch, J. M. (1991) · JAMA · doi:10.1001/jama.266.3.369 · Cited by 1,264 · see citing works
Leibowitz, H. M., Krueger, D. E., Maunder, L. R., Milton, R. C., KINI, M. M., Kahn, H. A., Nickerson, R. J., Pool, J., Colton, T., Ganley, J. P., et al. (1980) · PubMed · Cited by 1,250 · see citing works
Age-Specific Prevalence and Causes of Blindness and Visual Impairment in an Older Population
Klaver, C. C. W. (1998) · Archives of Ophthalmology · doi:10.1001/archopht.116.5.653 · Cited by 889 · see citing works
Visual Acuity and the Causes of Visual Loss in Australia
Attebo, K., Mitchell, P., & Smith, W. (1996) · Ophthalmology · doi:10.1016/s0161-6420(96)30684-2 · Cited by 800 · see citing works
The Prevalence of Refractive Errors Among Adults in the United States,Western Europe, and Australia
The Eye Diseases Prevalence Research Group* (2004) · Archives of Ophthalmology · doi:10.1001/archopht.122.4.495 · Cited by 665 · see citing works
Self-citationThe Beaver Dam Eye Study: Visual Acuity
Klein, R., Klein, R., Linton, K. L. P., & Mets, D. L. D. (1991) · Ophthalmology · doi:10.1016/s0161-6420(91)32137-7 · Cited by 663 · see citing works
Patz, A., Fine, S. L., Finkelstein, D., Prout, T., Aiello, L., Bradley, R. F., Briones, J. C., Myers, F. L., Bresnick, G. H., de Venecia, G., et al. (1978) · Ophthalmology · doi:10.1016/s0161-6420(78)35693-1 · Cited by 649 · see citing works
Muñoz, B. (2000) · Archives of Ophthalmology · doi:10.1001/archopht.118.6.819 · Cited by 521 · see citing works
* (1995) · Ophthalmology · doi:10.1016/s0161-6420(95)30973-6 · Cited by 446 · see citing works
West, S. K., Muñoz, B., Rubin, G. S., Schein, O. D., Bandeen‐Roche, K., Zeger, S. L., German, S., & Fried, L. P. (1997) · PubMed · Cited by 391 · see citing works
The Cause-specific Prevalence of Visual Impairment in an Urban Population
Rahmani, B., Tielsch, J. M., Katz, J., Gottsch, J. D., Quigley, H. A., Javitt, J. C., & Sommer, A. H. (1996) · Ophthalmology · doi:10.1016/s0161-6420(96)30435-1 · Cited by 327 · see citing works
Racial differences in the prevalence of age-related macular degeneration
Friedman, D. S., Katz, J., Bressler, N. M., Rahmani, B., & Tielsch, J. M. (1999) · Ophthalmology · doi:10.1016/s0161-6420(99)90267-1 · Cited by 304 · see citing works
Gender and blindness: a meta-analysis of population-based prevalence surveys
Abou-Gareeb, I., Lewallen, S., Bassett, K. L., & Courtright, P. (2001) · Ophthalmic Epidemiology · doi:10.1076/opep.8.1.39.1540 · Cited by 248 · see citing works
Age-related maculopathy in a multiracial United States population
Klein, R., Klein, B. E. K., Jensen, S. C., Mares-Perlman, J. A., Cruickshanks, K. J., & Palta, M. (1999) · Ophthalmology · doi:10.1016/s0161-6420(99)90255-5 · Cited by 227 · see citing works
Cause-specific prevalence of bilateral visual impairment in Victoria, Australia
VanNewkirk, M. R., Weih, L. M., McCarty, C. A., & Taylor, H. R. (2001) · Ophthalmology · doi:10.1016/s0161-6420(01)00554-1 · Cited by 210 · see citing works
Evans, J. R., FLETCHER, A. E., Wormald, R., Ng, E. S.-W., Stirling, S., Smeeth, L. L., Breeze, E., Bulpitt, C. J., Nunes, M., Jones, D., et al. (2002) · British Journal of Ophthalmology · doi:10.1136/bjo.86.7.795 · Cited by 198 · see citing works
The Relationship of Vision and Hearing Impairment to One-Year Mortality and Functional Decline
Laforge, R. G., Spector, W. D., & Sternberg, J. (1992) · Journal of Aging and Health · doi:10.1177/089826439200400108 · Cited by 192 · see citing works
Hyman, L., Wu, S., Connell, A. M. S., SCHACHAT, A. P., Nemesure, B. B., Hennis, A. J. M., & Leske, M. C. (2001) · Ophthalmology · doi:10.1016/s0161-6420(01)00590-5 · Cited by 190 · see citing works
Impairment and disability in the aged
Jette, A. M., & Branch, L. G. (1985) · Journal of Chronic Diseases · doi:10.1016/0021-9681(85)90008-6 · Cited by 186 · see citing works
Muñoz, B. E., West, S. K., Rodriguez, J., et al. (2002) · PubMed · Cited by 158 · see citing works
Attributable risk estimates for cataract to prioritize medical and public health action.
McCarty, C. A., Nanjan, M. B., & Taylor, H. R. (2000) · PubMed · Cited by 149 · see citing works
Causes of blindness and visual impairment in a population-based sample of U.S. Hispanics
Rodriguez, J., Sánchez, R., Muñoz, B. E., West, S. K., Broman, A. T., Snyder, R. W., Klein, R., & Quigley, H. A. (2002) · Ophthalmology · doi:10.1016/s0161-6420(01)01008-9 · Cited by 143 · see citing works
Visual acuity measurements in a national sample of British elderly people
van der Pols, J. C. (2000) · British Journal of Ophthalmology · doi:10.1136/bjo.84.2.165 · Cited by 113 · see citing works
Black-white differences in risk of developing retinopathy among individuals with type 2 diabetes.
Harris, E. L., Sherman, S. H., & Georgopoulos, A. (1999) · Diabetes Care · doi:10.2337/diacare.22.5.779 · Cited by 91 · see citing works
Variations in Cataract Extraction Rates in Medicare Prepaid and Fee-for-Service Settings
Goldzweig, C. L. (1997) · JAMA · doi:10.1001/jama.1997.03540460029028 · Cited by 85 · see citing works
A Model of the Prevalence and Incidence of Low Vision and Blindness among Adults in the U.S.
Massof, R. W. (2002) · Optometry and Vision Science · doi:10.1097/00006324-200201000-00010 · Cited by 81 · see citing works
Surgical Undertreatment of Glaucoma in Black Beneficiaries of Medicare
Devgan, U. (2000) · Archives of Ophthalmology · doi:10.1001/archopht.118.2.253 · Cited by 73 · see citing works
The Advanced Glaucoma Intervention Study, 6: Effect of Cataract on Visual Field and Visual Acuity
(2000) · Archives of Ophthalmology · doi:10.1001/archopht.118.12.1639 · Cited by 73 · see citing works
Escarce, J. J. (1993) · Medical Care · doi:10.1097/00005650-199312000-00004 · Cited by 54 · see citing works
Klaver, C., Wolfs, R. C. W., Vingerling, H., Albert Hofman, D., & Jong, P. D. (1998) · EUR Research Repository (Erasmus University Rotterdam) · Cited by 53 · see citing works
Arfken, C. L., Reno, P. L., Santiago, J. V., et al. (1998) · Diabetes Care · doi:10.2337/diacare.21.5.792 · Cited by 47 · see citing works
Survey of blindness and visual impairment in Bioko, Equatorial Guinea
Moser, C. L. (2002) · British Journal of Ophthalmology · doi:10.1136/bjo.86.3.257 · Cited by 32 · see citing works
Prevalence of Uncorrected Binocular Distance Visual Acuity in Hispanic and Non-Hispanic Adults
Lee, D. J., Gómez-Marı́n, O., & Lam, B. L. (1998) · Ophthalmology · doi:10.1016/s0161-6420(98)93042-1 · Cited by 17 · see citing works
Lam, B. L., Lee, D. J., & Gómez-Marı́n, O. (2000) · Ophthalmic Epidemiology · doi:10.1076/0928-6586(200003)711-2ft073 · Cited by 14 · see citing works
Variations in cataract extraction rates in Medicare prepaid and fee-for-service settings
Goldzweig, C. L. (1997) · JAMA · doi:10.1001/jama.277.22.1765 · Cited by 13 · see citing works
Flagged first, then by citations
Research works printed but not linked: 3
- West SK, Munoz B, Rubin GS, et al. Function and visual impairment in a population- based study of older adults. Invest Ophthalmol Vis Sci. 1997;38:72-82.
- Hyman L, Wu SY, Connell AM, et al. Prevalence and causes of visual impairment in the Barbados Eye Study. Ophthalmology. 2001;108:1751-1756.
- Early Treatment Diabetic Retinopathy Study Research Group. Photocoagulation for diabetic macular edema: Early Treatment Diabetic Retinopathy Study report number 1. Arch Ophthalmol. 1985;103:1796-1806.
Cited by
Sorted by citations
Pegaptanib for neovascular age-related macular degeneration
Gragoudas, E. S., Adamis, A. P., Cunningham, E. T., Feinsod, M., & Guyer, D. R. (2004) · New England Journal of Medicine · doi:10.1056/nejmoa042760 · Cited by 2,337 · see citing works
Age-related macular degeneration
Jager, R. D., Mieler, W. F., & Miller, J. W. (2008) · New England Journal of Medicine · doi:10.1056/nejmra0801537 · Cited by 1,379 · see citing works
FERRARA, N., DAMICO, L., SHAMS, N., LOWMAN, H., & KIM, R. (2006) · Retina · doi:10.1097/01.iae.0000242842.14624.e7 · Cited by 849 · see citing works
Clinical risk factors for age-related macular degeneration: a systematic review and meta-analysis
Chakravarthy, U., Wong, T. Y., Fletcher, A., Piault, E., Evans, C., Zlateva, G., Buggage, R., Pleil, A., & Mitchell, P. (2010) · BMC Ophthalmology · doi:10.1186/1471-2415-10-31 · Cited by 842 · see citing works
Subretinal electronic chips allow blind patients to read letters and combine them to words
Zrenner, E., Bartz-Schmidt, K. U., Benav, H., Besch, D., Bruckmann, A., Gabel, V.-P., Gekeler, F., Greppmaier, U., Harscher, A., Kibbel, S., et al. (2011) · Proceedings of the Royal Society B: Biological Sciences · doi:10.1098/rspb.2010.1747 · Cited by 819 · see citing works
Intravitreal Aflibercept Injection for Neovascular Age-related Macular Degeneration
Schmidt-Erfurth, U., Kaiser, P. K., Korobelnik, J.-F., Brown, D. M., Chong, V., Nguyen, Q. D., Ho, A. C., Ogura, Y., Simader, C., Jaffe, G. J., et al. (2014) · Ophthalmology · doi:10.1016/j.ophtha.2013.08.011 · Cited by 822 · see citing works
Fifteen-Year Cumulative Incidence of Age-Related Macular Degeneration
Klein, R., Klein, B. E. K., Knudtson, M. D., Meuer, S. M., Swift, M., & Gangnon, R. E. (2007) · Ophthalmology · doi:10.1016/j.ophtha.2006.10.040 · Cited by 638 · see citing works
At the interface of sensory and motor dysfunctions and Alzheimer’s disease.
Albers, M. W., Gilmore, G. C., Kaye, J., Murphy, C., Wingfield, A., Bennett, D. A., Boxer, A. L., Buchman, A. S., Cruickshanks, K. J., Devanand, D. P., et al. (2015) · Alzheimer's & Dementia · doi:10.1016/j.jalz.2014.04.514 · Cited by 589 · see citing works
Comorbidity of fetal alcohol spectrum disorder: a systematic review and meta-analysis
Popova, S., Lange, S., Shield, K., Mihic, A., Chudley, A. E., Mukherjee, R. A. S., Bekmuradov, D., & Rehm, J. (2016) · The Lancet · doi:10.1016/s0140-6736(15)01345-8 · Cited by 541 · see citing works
Age-related macular degeneration
Coleman, H. R., Chan, C.-C., Ferris, F. L., & Chew, E. Y. (2008) · The Lancet · doi:10.1016/s0140-6736(08)61759-6 · Cited by 542 · see citing works
Effects of aging and sensory loss on glial cells in mouse visual and auditory cortices
Tremblay, M., Zettel, M. L., Ison, J. R., Allen, P. D., & Majewska, A. K. (2012) · Glia · doi:10.1002/glia.22287 · Cited by 309 · see citing works
Heier, J. S. (2006) · Archives of Ophthalmology · doi:10.1001/archopht.124.11.1532 · Cited by 304 · see citing works
A Treat and Extend Regimen Using Ranibizumab for Neovascular Age-Related Macular Degeneration
Gupta, O. P., Shienbaum, G., Patel, A. H., Fecarotta, C., Kaiser, R. S., & Regillo, C. D. (2010) · Ophthalmology · doi:10.1016/j.ophtha.2010.02.032 · Cited by 272 · see citing works
Swaroop, A., Chew, E. Y., Bowes Rickman, C., & Abecasis, G. R. (2009) · Annual Review of Genomics and Human Genetics · doi:10.1146/annurev.genom.9.081307.164350 · Cited by 270 · see citing works
Pegaptanib Sodium for Neovascular Age-Related Macular Degeneration
D’Amico, D. J. (2006) · Ophthalmology · doi:10.1016/j.ophtha.2006.02.027 · Cited by 260 · see citing works
Y402H polymorphism of complement factor H affects binding affinity to C-reactive protein
Laine, M., Jarva, H., Seitsonen, S., Haapasalo, K., Lehtinen, M. J., Lindeman, N., Anderson, D. H., Johnson, P. T., Järvelä, I., Jokiranta, T. S., et al. (2007) · The Journal of Immunology · doi:10.4049/jimmunol.178.6.3831 · Cited by 246 · see citing works
Nrf2 signaling is impaired in the aging RPE given an oxidative insult
Sachdeva, M. M., Cano, M., & Handa, J. T. (2014) · Experimental Eye Research · doi:10.1016/j.exer.2013.10.024 · Cited by 207 · see citing works
“Age-relatedmacular degeneration (AMD) represents the leading cause of vision impairment in the elderly, accounting for 54% of blindness in Caucasian Americans (Congdon et al., 2004).”
Age-related eye disease and gender
Zetterberg, M. (2016) · Maturitas · doi:10.1016/j.maturitas.2015.10.005 · Cited by 185 · see citing works
Rakoczy, E. P., Lai, C.-M., Magno, A. L., Wikstrom, M. E., French, M. A., Pierce, C. M., Schwartz, S. D., Blumenkranz, M. S., Chalberg, T. W., Degli-Esposti, M. A., et al. (2015) · The Lancet · doi:10.1016/s0140-6736(15)00345-1 · Cited by 189 · see citing works
Retinal ultrastructure of murine models of dry age-related macular degeneration (AMD)
Ramkumar, H. L., Zhang, J., & Chan, C.-C. (2010) · Progress in Retinal and Eye Research · doi:10.1016/j.preteyeres.2010.02.002 · Cited by 163 · see citing works
How does the macula protect itself from oxidative stress?
Handa, J. T. (2012) · Molecular Aspects of Medicine · doi:10.1016/j.mam.2012.03.006 · Cited by 154 · see citing works
Conley, Y. P., Thalamuthu, A., Jakobsdottir, J., Weeks, D. E., Mah, T., Ferrell, R. E., & Gorin, M. B. (2005) · Human Molecular Genetics · doi:10.1093/hmg/ddi204 · Cited by 158 · see citing works
Conley, Y. P., Jakobsdottir, J., Mah, T., Weeks, D. E., Klein, R., Kuller, L., Ferrell, R. E., & Gorin, M. B. (2006) · Human Molecular Genetics · doi:10.1093/hmg/ddl396 · Cited by 157 · see citing works
Constable, I. J., Pierce, C. M., Lai, C.-M., Magno, A. L., Degli-Esposti, M. A., French, M. A., McAllister, I. L., Butler, S., Barone, S. B., Schwartz, S. D., et al. (2016) · EBioMedicine · doi:10.1016/j.ebiom.2016.11.016 · Cited by 152 · see citing works
Lee, K. S., Lin, S., Copland, D. A., Dick, A. D., & Liu, J. (2021) · Journal of Neuroinflammation · doi:10.1186/s12974-021-02088-0 · Cited by 150 · see citing works
Gustatory and olfactory dysfunction in older adults: a national probability study
Boesveldt, S., Lindau, S. T., McClintock, M. K., Hummel, T., & Lundstrom, J. N. (2011) · Rhinology journal · doi:10.4193/rhino10.155 · Cited by 142 · see citing works
Klein, R., Deng, Y., Klein, B. E. K., Hyman, L., Seddon, J., Frank, R. N., Wallace, R. B., Hendrix, S. L., Kuppermann, B. D., Langer, R. D., et al. (2007) · American Journal of Ophthalmology · doi:10.1016/j.ajo.2006.11.058 · Cited by 142 · see citing works
Geographic variation in the rate and timing of cataract surgery among US communities
Kauh, C. Y., Blachley, T. S., Lichter, P. R., Lee, P. P., & Stein, J. D. (2016) · JAMA Ophthalmology · doi:10.1001/jamaophthalmol.2015.5322 · Cited by 134 · see citing works
Complement component C5a activates ICAM-1 expression on human choroidal endothelial cells
Skeie, J. M., Fingert, J. H., Russell, S. R., Stone, E. M., & Mullins, R. F. (2010) · Investigative Opthalmology & Visual Science · doi:10.1167/iovs.10-5322 · Cited by 114 · see citing works
Lipids, oxidized lipids, oxidation-specific epitopes, and Age-related macular degeneration.
Handa, J. T., Cano, M., Wang, L., Datta, S., & Liu, T. (2017) · Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids · doi:10.1016/j.bbalip.2016.07.013 · Cited by 112 · see citing works
Overview of progress in the epidemiology of age-related macular degeneration
Klein, R. (2007) · Ophthalmic Epidemiology · doi:10.1080/09286580701344381 · Cited by 110 · see citing works
Vogt, S. D., Curcio, C. A., Wang, L., Li, C.-M., McGwin, G., Medeiros, N. E., Philp, N. J., Kimble, J. A., & Read, R. W. (2011) · Experimental Eye Research · doi:10.1016/j.exer.2011.06.002 · Cited by 104 · see citing works
Indaram, M., Ma, W., Zhao, L., Fariss, R. N., Rodriguez, I. R., & Wong, W. T. (2015) · Scientific Reports · doi:10.1038/srep09144 · Cited by 101 · see citing works
Retinal specialist versus artificial intelligence detection of retinal fluid from OCT
Keenan, T. D. L., Clemons, T. E., Domalpally, A., Elman, M. J., Havilio, M., Agrón, E., Benyamini, G., & Chew, E. Y. (2021) · Ophthalmology · doi:10.1016/j.ophtha.2020.06.038 · Cited by 93 · see citing works
Chew, E. Y., Klein, M. L., Clemons, T. E., Agrón, E., Ratnapriya, R., Edwards, A. O., Fritsche, L. G., Swaroop, A., & Abecasis, G. R. (2014) · Ophthalmology · doi:10.1016/j.ophtha.2014.05.008 · Cited by 94 · see citing works
A2E accumulation influences retinal microglial activation and complement regulation
Ma, W., Coon, S., Zhao, L., Fariss, R. N., & Wong, W. T. (2013) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2012.06.010 · Cited by 92 · see citing works
Holekamp, N. M., Liu, Y., Yeh, W.-S., Chia, Y., Kiss, S., Almony, A., & Kowalski, J. W. (2014) · American Journal of Ophthalmology · doi:10.1016/j.ajo.2013.12.018 · Cited by 88 · see citing works
Lotery, A., Griner, R., Ferreira, A., Milnes, F., & Dugel, P. (2017) · Eye · doi:10.1038/eye.2017.143 · Cited by 84 · see citing works
Schaumberg, D. A. (2007) · Archives of Ophthalmology · doi:10.1001/archopht.125.3.300 · Cited by 79 · see citing works
Exposure to Chlamydia pneumoniae infection and progression of age-related macular degeneration
Robman, L., Mahdi, O., McCarty, C., Dimitrov, P., Tikellis, G., McNeil, J., Byrne, G., Taylor, H., & Guymer, R. (2005) · American Journal of Epidemiology · doi:10.1093/aje/kwi130 · Cited by 77 · see citing works
Population-Based Studies in Ophthalmology
Wong, T. Y., & Hyman, L. (2008) · American Journal of Ophthalmology · doi:10.1016/j.ajo.2008.07.048 · Cited by 74 · see citing works
Interleukin gene polymorphisms in age-related macular degeneration
Tsai, Y.-Y., Lin, J.-M., Wan, L., Lin, H.-J., Tsai, Y., Lee, C.-C., Tsai, C.-H., Tsai, F.-J., & Tseng, S.-H. (2008) · Investigative Opthalmology & Visual Science · doi:10.1167/iovs.07-0125 · Cited by 69 · see citing works
Keenan, T. D. L., Pickford, C. E., Holley, R. J., Clark, S. J., Lin, W., Dowsey, A. W., Merry, C. L., Day, A. J., & Bishop, P. N. (2014) · Investigative Opthalmology & Visual Science · doi:10.1167/iovs.14-14126 · Cited by 65 · see citing works
Ross, R. J., Zhou, M., Shen, D., Fariss, R. N., Ding, X., Bojanowski, C. M., Tuo, J., & Chan, C.-C. (2008) · Experimental Eye Research · doi:10.1016/j.exer.2008.01.014 · Cited by 60 · see citing works
Orlin, A., Hadley, D., Chang, W., Ho, A. C., Brown, G., Kaiser, R. S., Regillo, C. D., Godshalk, A. N., Lier, A., Kaderli, B., et al. (2012) · Retina · doi:10.1097/iae.0b013e31822a2c7c · Cited by 60 · see citing works
Two-Photon Microscopy: Shedding Light on the Chemistry of Vision
Imanishi, Y., Lodowski, K. H., & Koutalos, Y. (2007) · Biochemistry · doi:10.1021/bi701055g · Cited by 58 · see citing works
Temporal interactions during paired-electrode stimulation in two retinal prosthesis subjects
Horsager, A., Boynton, G. M., Greenberg, R. J., & Fine, I. (2011) · Investigative Opthalmology & Visual Science · doi:10.1167/iovs.10-5282 · Cited by 48 · see citing works
Nork, T. M. (2011) · Archives of Ophthalmology · doi:10.1001/archophthalmol.2011.210 · Cited by 48 · see citing works
Correction: Systemic Complement Activation in Age-Related Macular Degeneration
Scholl, H. P. N., Charbel Issa, P., Walier, M., Janzer, S., Pollok-Kopp, B., Börncke, F., Fritsche, L. G., Chong, N. V., Fimmers, R., Wienker, T., et al. (2008) · PLoS ONE · doi:10.1371/annotation/32b9bc31-ed6d-4d31-9ce0-480407017bad · Cited by 39 · see citing works
Keenan, T. D. L., Kelly, S. P., Sallam, A., Mohamed, Q., Tufail, A., & Johnston, R. L. (2013) · British Journal of Ophthalmology · doi:10.1136/bjophthalmol-2013-303233 · Cited by 29 · see citing works
SanGiovanni, J. P., & Lee, P. H. (2013) · PLoS ONE · doi:10.1371/journal.pone.0071239 · Cited by 26 · see citing works
Tong, N., Jin, R., Zhou, Z., & Wu, X. (2019) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2019.00137 · Cited by 26 · see citing works
- Authors
- The Eye Diseases Prevalence Research Group*
- Corresponding author
- The Eye Diseases Prevalence Research Group*
- Venue
- Archives of Ophthalmology
- Publisher
- American Medical Association (AMA)
- Published
- 2004-04-01
- Volume
- 122
- Issue
- 4
- Pages
- 477
- ISSN
- 0003-9950 (ISSN-L)
- OpenAlex
- W1789824814
- Semantic Scholar
- e63937184c8bc856924c06a7c584c8c48c573fc8
- Cited by
- 2,616
- References
- 37
- Citations by year
- 2026: 63 · 2025: 61 · 2024: 79 · 2023: 88 · 2022: 88 · 2021: 126 · 2020: 120 · 2019: 112 · 2018: 141 · 2017: 139 · 2016: 151 · 2015: 160 · 2014: 172 · 2013: 179 · 2012: 151
- FWCI
- 64.67
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Archives of Ophthalmology (publishedVersion)
- PubMed (publishedVersion)
- EUR Research Repository (Erasmus University Rotterdam) (publishedVersion)
- EUR Research Repository (Erasmus University Rotterdam) (submittedVersion)
- Research Portal (Queen's University Belfast) (submittedVersion)
- Funders
- Johns Hopkins University
- Erasmus Medisch Centrum
- National Eye Institute
- Topics
- Health Sciences › Medicine › Epidemiology › Ophthalmology and Visual Impairment Studies
- Health Sciences › Medicine › Ophthalmology › Glaucoma and retinal disorders
- Health Sciences › Medicine › Ophthalmology › Retinal Diseases and Treatments
- Keywords
- blindness, low vision, visual impairment, prevalence, age-related macular degeneration, cataract, glaucoma, racial and ethnic disparities, population aging, population projections, adults
- MeSH terms
- Adult, Aged, Aged, 80 and over, Australia, Black or African American, Blindness, Cataract, Europe, Female, Glaucoma, Hispanic or Latino, Humans, Macular Degeneration, Male, Middle Aged, United States, Visual Acuity, Vision, Low, Causality, Prevalence, Age Distribution, Persons with Visual Disabilities, White People
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Claims read by deepseek-v4.1-flash under definition version 3 (extract-v3) on 2026-10-09.
Classified by jev-1.13-20260917 (gold-guideline-v0.2) on 2026-10-09.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review