The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.
Suicidality and 5-Hydroxyindoleacetic Acid Concentration Associated With a Tryptophan Hydroxylase Polymorphism
Abstract
BACKGROUND: To examine whether the tryptophan hydroxylase (TPH) gene, which codes for the rate-limiting enzyme in the biosynthesis of serotonin, may be a factor influencing serotonin turnover and behaviors controlled by serotonin. METHODS: Using a polymerase chain reaction-based method, TPH genotype was determined in DNA samples from 56 impulsive and 14 nonimpulsive, alcoholic, violent offenders and 20 healthy volunteers. RESULTS: In the behaviorally extreme impulsive group, we observed a significant association between TPH genotype and cerebrospinal fluid 5-hydroxyindoleacetic acid (5-HIAA) concentration. No association of TPH genotype with impulsive behavior was detected. The polymorphism was also associated with a history of suicide attempts in all violent offenders, independent of impulsivity status and cerebrospinal fluid 5-HIAA concentration. CONCLUSION: In some individuals, a genetic variant of the TPH gene may influence 5-HIAA concentration in the cerebrospinal fluid and predisposition to suicidal behavior.
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Cites
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Self-citationNeurobiology of Aggression and Violence
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Suicidal Behavior Runs in Families: A Controlled Family Study of Adolescent Suicide Victims
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Serotonergic genes and suicide: A systematic review
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The Genetics of Suicide: A Critical Review of Molecular Studies
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Metadata
- Authors
- Nielsen, D. A.
- Venue
- Archives of General Psychiatry
- Publisher
- American Medical Association (AMA)
- Published
- 1994-01-01
- Volume
- 51
- Issue
- 1
- Pages
- 34
- ISSN
- 0003-990X (ISSN-L)
- OpenAlex
- W2094445259
- Cited by
- 372
- References
- 1
- FWCI
- 6.36
- Type
- journal article
- Language
- en
- Open access
- closed
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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