Cited by 666Hallucinations in medical conditionsSchizophrenia research and treatmentMental Health and Psychiatry

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Mapping Auditory Hallucinations in Schizophrenia Using Functional Magnetic Resonance Imaging

Shergill, Sukhwinder S., Brammer, Michael J., Williams, Steven C. R., Murray, Robin M., McGuire, Philip K.·2000·Archives of General Psychiatry

DOI 10.1001/archpsyc.57.11.1033

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Abstract

BACKGROUND: Perceptions of speech in the absence of an auditory stimulus (auditory verbal hallucinations) are a cardinal feature of schizophrenia. Functional neuroimaging provides a powerful means of measuring neural activity during auditory hallucinations, but the results from previous studies have been inconsistent. This may reflect the acquisition of small numbers of images in each subject and the confounding effects of patients actively signaling when hallucinations occur. METHODS: We examined 6 patients with schizophrenia who were experiencing frequent auditory hallucinations, using a novel functional magnetic resonance imaging method that permitted the measurement of spontaneous neural activity without requiring subjects to signal when hallucinations occurred. Approximately 50 individual scans were acquired at unpredictable intervals in each subject while they were intermittently hallucinating. Immediately after each scan, subjects reported whether they had been hallucinating at that instant. Neural activity when patients were and were not experiencing hallucinations was compared in each subject and the group as a whole. RESULTS: Auditory hallucinations were associated with activation in the inferior frontal/insular, anterior cingulate, and temporal cortex bilaterally (with greater responses on the right), the right thalamus and inferior colliculus, and the left hippocampus and parahippocampal cortex (P<.0001). CONCLUSIONS: Auditory hallucinations may be mediated by a distributed network of cortical and subcortical areas. Previous neuroimaging studies of auditory hallucinations may have identified different components of this network.

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Co-Planar Stereotaxic Atlas of the Human Brain
Talairach, J., & Tournoux, P. (1988) · Medical Entomology and Zoology · Cited by 11,798
Brain magnetic resonance imaging with contrast dependent on blood oxygenation.
Ogawa, S., Lee, T. M., Kay, A. R., & Tank, D. W. (1990) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.87.24.9868 · Cited by 6,483
Processing strategies for time‐course data sets in functional mri of the human brain
Bandettini, P. A., Jesmanowicz, A., Wong, E. C., & Hyde, J. S. (1993) · Magnetic Resonance in Medicine · doi:10.1002/mrm.1910300204 · Cited by 1,762
The neuropsychology of schizophrenia
Gray, J. A., Feldon, J., Rawlins, J. N. P., Hemsley, D. R., & Smith, A. D. (1991) · Behavioral and Brain Sciences · doi:10.1017/s0140525x00065055 · Cited by 1,350
A functional neuroanatomy of hallucinations in schizophrenia
Silbersweig, D. A., Stern, E., Frith, C., Cahill, C., Holmes, A., Grootoonk, S., Seaward, J., McKenna, P., Chua, S. E., Schnorr, L., et al. (1995) · Nature · doi:10.1038/378176a0 · Cited by 906 · cited 2×
“Thus, our earlier work using SPET linked auditory hallucinations with activation in the left inferior frontal cortex,(15) while other studies, mainly using PET, respectively implicated the anterior cingulate gyrus,(16) the left(3,17) and the right temporal cortex,(2,3) the left parahippocampal region(18) and the thala…”
BackgroundResult
Patterns of Cerebral Blood Flow in Schizophrenia
Liddle, P. F., Friston, K. J., Frith, C., Hirsch, S. R., Jones, T., & Frackowiak, R. S. J. (1992) · The British Journal of Psychiatry · doi:10.1192/bjp.160.2.179 · Cited by 899
Activation of Heschl’s Gyrus during Auditory Hallucinations
Dierks, T., Linden, D. E. J., Jandl, M., Formisano, E., Goebel, R., Lanfermann, H., & Singer, W. (1999) · Neuron · doi:10.1016/s0896-6273(00)80715-1 · Cited by 752
The role of the right hemisphere in the interpretation of figurative aspects of language A positron emission tomography activation study
Bottini, G., Corcoran, R., Sterzi, R., Paulesu, E., Schenone, P., Scarpa, P., Frackowiak, R. S. J., & Frith, D. (1994) · Brain · doi:10.1093/brain/117.6.1241 · Cited by 660
The hippocampal formation participates in novel picture encoding: evidence from functional magnetic resonance imaging.
Stern, C. E., Corkin, S., González, R. G., Guimarães, A. R., Baker, J. R., Jennings, P. J., Carr, C. A., Sugiura, R., Vedantham, V., & Rosen, B. R. (1996) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.93.16.8660 · Cited by 645

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Fuentes-Claramonte, P., Soler-Vidal, J., Salgado-Pineda, P., Garcia-Leon, M., Ramiro, N., Santo-Angles, A., Torres, M. L., Tristany, J., Guerrero-Pedraza, A., Munuera, J., et al. (2021) · Scientific Reports · doi:10.1038/s41598-021-98269-1 · Cited by 14
Hallucinations in children and adolescents
Sosland, M. D., & Edelsohn, G. A. (2005) · Current Psychiatry Reports · doi:10.1007/s11920-005-0051-2 · Cited by 14
“This was consistent with several other studies that seem to indicate that auditory hallucinations are misidentified self-talk [ 52 ].”
Result
Auditory processing deficits in bipolar disorder with and without a history of psychotic features
Zenisek, R., Thaler, N. S., Sutton, G. P., Ringdahl, E. N., Snyder, J. S., & Allen, D. N. (2015) · Bipolar Disorders · doi:10.1111/bdi.12333 · Cited by 14
Abnormalities of the cingulate gyrus in bipolar disorder and other severe psychiatric illnesss: postmortem findings from the Stanley Foundation Neuropathology Consortium and literature review
Knable, M. B., Barci, B. M., Bartko, J. J., Webster, M. J., & Torrey, Ε. F. (2002) · Clinical Neuroscience Research · doi:10.1016/s1566-2772(02)00042-7 · Cited by 14
Attentional Modulation of Source Attribution in First-Episode Psychosis: A Functional Magnetic Resonance Imaging Study
Kambeitz‐Ilankovic, L., Hennig‐Fast, K., Benetti, S., Kambeitz, J. P., Pettersson‐Yeo, W., O’Daly, O., McGuire, P. K., & Allen, P. (2012) · Schizophrenia Bulletin · doi:10.1093/schbul/sbs101 · Cited by 13
Draining the pond and catching the fish: Uncovering the ecosystem of auditory verbal hallucinations
Looijestijn, J., Blom, J. D., Hoek, H. W., Renken, R. J., Liemburg, E. J., Sommer, I. E., Aleman, A., & Goekoop, R. (2018) · NeuroImage Clinical · doi:10.1016/j.nicl.2018.09.016 · Cited by 13
Thalamic Hyperperfusion in Verbal Hallucination of Parkinsonian Patients
Matsui, H., Nishinaka, K., Miyoshi, T., Hara, N., Oda, M., Kubori, T., & Udaka, F. (2007) · Internal Medicine · doi:10.2169/internalmedicine.46.0191 · Cited by 13
“Shergill et al disclosed right thalamus hyperactivation in shizophrenic patients with active auditory hallucinations (25) and Woodruff et al showed right dominant thalamus hyperactivation in one patient (26).”
Background
Timing of covert articulation: An fMRI study
Shergill, S. S., Tracy, D. K., Seal, M. L., Rubia, K., & McGuire, P. K. (2006) · Neuropsychologia · doi:10.1016/j.neuropsychologia.2006.04.005 · Cited by 16
Neuroanatomical and clinical correlates of prodromal dementia with Lewy bodies: a systematic literature review of neuroimaging findings
Conti, D., Gabrielli, G. B., Panigutti, M., Zazzaro, G., Bruno, G., Galati, G., & D’Antonio, F. (2024) · Journal of Neurology · doi:10.1007/s00415-024-12726-1 · Cited by 12
“Indeed, hippocampal hyperactivity has been implied in the generation of hallucinations (either auditory, visual, or multisensory) and other positive symptoms in the schizophrenia spectrum [66–75].”
Fiber Pathway Pathology, Synapse Loss and Decline of Cortical Function in Schizophrenia
Bennett, M. R., Farnell, L., & Gibson, W. G. (2013) · PLoS ONE · doi:10.1371/journal.pone.0060518 · Cited by 12
Brain mechanisms involved in processing unreal perceptions
Ku, J. H., Kim, J., Jung, Y., Park, I. H., Lee, H., Han, K., Yoon, K. J., Kim, I. Y., & Kim, S. I. (2008) · NeuroImage · doi:10.1016/j.neuroimage.2008.08.011 · Cited by 12
“Although the occurrence of hallucinations has been investigated by many researchers (Dierks et al., 1999; Ditman and Kuperberg, 2005; Laroi and Woodward, 2007; Shergill et al., 2000, 2004; Silbersweig et al., 1995), the process of copingwith the perception of unreal events remains to be elucidated.”
Clinical, cognitive and neural correlates of self-monitoring deficits in schizophrenia: an update
Raveendran, V., & Kumari, V. (2007) · Acta Neuropsychiatrica · doi:10.1111/j.1601-5215.2007.00151.x · Cited by 13
Identifying first-episode drug naïve patients with schizophrenia with or without auditory verbal hallucinations using whole-brain functional connectivity: A pattern analysis study
Huang, P., Cui, L., Li, X., Lu, Z., Zhu, X., Xi, Y., Wang, H., Baojuan Li, A., Hou, F., Miao, D., et al. (2018) · NeuroImage Clinical · doi:10.1016/j.nicl.2018.04.026 · Cited by 13
“…and diffusion tensor imaging-based approaches, including functional connectivity (Chang et al., 2017; Cui et al., 2016; Escartí et al., 2010; Shergill et al., 2000; Vercammen et al., 2010), effective connectivity (Cui et al., 2015; Li et al., 2017), voxel-mirrored homotopic connectivity…”
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Psychotic experiences in childhood are associated with increased structural integrity of the left arcuate fasciculus – A population-based case-control study
Dooley, N., O’Hanlon, E., Healy, C., Adair, A., McCandless, C., Coppinger, D., Kelleher, I., Clarke, M. C., Leemans, A., Frodl, T., et al. (2019) · Schizophrenia Research · doi:10.1016/j.schres.2019.08.022 · Cited by 11
Structural brain abnormalities in schizophrenia patients with a history and presence of auditory verbal hallucination
Sone, M., Koshiyama, D., Zhu, Y., Maikusa, N., Okada, N., Abe, O., Yamasue, H., Kasai, K., & Koike, S. (2022) · Translational Psychiatry · doi:10.1038/s41398-022-02282-5 · Cited by 12
“Furthermore, the caudal MFG is known to be associated with verbal working memory [43].”
Background
Disruption of medial prefrontal synchrony in the subchronic phencyclidine model of schizophrenia in rats
Young, A. M. J., Stubbendorff, C., Valencia, M., & Gerdjikov, T. V. (2014) · Neuroscience · doi:10.1016/j.neuroscience.2014.12.014 · Cited by 13
“This maps onto findings that positive symptomatology in human patients is associated with prefrontal hyperactivity (Shergill et al., 2000).”
Background
Treatment of auditory verbal hallucinations with transcranial magnetic stimulation in a patient with psychotic major depression: One-year follow-up
Freitas, C., PEARLMAN, C. A., & Pascual‐Leone, Á. (2011) · Neurocase · doi:10.1080/13554794.2010.547864 · Cited by 11
“The theoretical background for applying rTMS to the TPC is based on functional neuroimaging demonstrating hyperactivity in this region while the patients are hallucinating (e.g., Silbersweig et al., 1995; Shergill et al., 2000).”
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Identifying neural signatures mediating behavioral symptoms and psychosis onset: High-dimensional whole brain functional mediation analysis
Chén, O. Y., Cao, H., Phan, H., Nagels, G., Reinen, J., Gou, J., Qian, T., Di, J., Prince, J., Cannon, T. D., et al. (2020) · NeuroImage · doi:10.1016/j.neuroimage.2020.117508 · Cited by 12
The phenomenology of auditory verbal hallucinations in schizophrenia and the challenge from pseudohallucinations
López‐Silva, P., Álvaro Cavieres, F., & Humpston, C. S. (2022) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2022.826654 · Cited by 15
“Very recently, contradicting several earlier studies using the Symptom Capture Paradigm (78, 113), Fuentes-Claramonte et al. (114) found no evidence in their study suggesting that the experience of AVHs in schizophrenia is associated with auditory cortex activation.”
BackgroundResult
Neuropsychopharmacology of auditory hallucinations: insights from pharmacological functional MRI and perspectives for future research
Johnsen, E., Hugdahl, K., Fusar‐Poli, P., Kroken, R. A., & Kompus, K. (2012) · Expert Review of Neurotherapeutics · doi:10.1586/ern.12.147 · Cited by 13
Hallucinations et démences
Fénelon, G., & Mahieux, F. (2004) · Revue Neurologique · doi:10.1016/s0035-3787(04)70942-x · Cited by 11
True Lies: Delusions and Lie-Detection Technology
Langleben, D. D., Dattilio, F. M., & Guthei, T. G. (2006) · The Journal of Psychiatry & Law · doi:10.1177/009318530603400305 · Cited by 11
Animal Models of Hallucinations Observed Through the Modern Lens
Robbins, T. W. (2016) · Schizophrenia Bulletin · doi:10.1093/schbul/sbw134 · Cited by 10
Impaired motor-to-sensory transformation mediates auditory hallucinations
Yang, F., Zhu, H., Cao, X., Li, H., Fang, X., Yu, L., Li, S., Wu, Z., Li, C., Zhang, C., et al. (2024) · PLoS Biology · doi:10.1371/journal.pbio.3002836 · Cited by 11
Impact of low-frequency rTMS on functional connectivity of the dentate nucleus subdomains in schizophrenia patients with auditory verbal hallucination.
Xie, Y.-J., He, Y., Guan, M.-Z., Zhou, G.-P., Wang, Z.-H., Ma, Z.-J., Wang, H.-N., & Yin, H. (2022) · Journal of Psychiatric Research · doi:10.1016/j.jpsychires.2022.02.030 · Cited by 10
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Harvey, P. D. (2013) · Cambridge University Press eBooks · doi:10.1017/cbo9781139003872.002 · Cited by 10
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Huang, Y.-R., Shih, J.-M., Chang, K., Huang, C. L., Wu, Y.-L., & Chen, C. (2012) · Nuclear Medicine and Biology · doi:10.1016/j.nucmedbio.2012.01.005 · Cited by 10
“hypothalamus, substantia nigra, the temporal and anterior cingulate cortex) in drug-naïve schizophrenic patients [17,29–31], and there had been an [I]epidepride SPECT study that reported significantly lower D2/D3 values in themidbrain of patients with schizophrenia [32].”
Result
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“…de la Universidad de Chile, Chile Reviewed by: Christopher Schmidt, Pfizer, Inc., USA Bernhard J. Mitterauer, Volitronics-Institute for Basic Research Psychopathology and Brain Philosophy, Austria *Correspondence: Kunjumon I. Vadakkan, Division of Neurology, Department of Internal Medicine,…”
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AUDITORY HALLUCINATIONS ELICIT SIMILAR BRAIN ACTIVATION IN PSYCHOTIC AND NON-PSYCHOTIC INDIVIDUALS
Sommer, I. E. (2012) · Schizophrenia Research · doi:10.1016/s0920-9964(12)70250-5 · Cited by 10
Self-Awareness of Psychopathology and Brain Volume in Patients With First Episode Psychosis
Kim, J.-Y., Jeon, H., Kwon, A., Jin, M. J., Lee, S., & Chung, Y. (2019) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2019.00839 · Cited by 11
Processing of linguistic deixis in people with schizophrenia, with and without auditory verbal hallucinations
Fuentes‐Claramonte, P., Soler‐Vidal, J., Salgado‐Pineda, P., Ramiro, N., García‐León, M. Á., Cano, R., Arévalo, A., Munuera, J., Portillo, F., Panicali, F., et al. (2022) · NeuroImage Clinical · doi:10.1016/j.nicl.2022.103007 · Cited by 10
Psychiatric neuroimaging: Joining forces with epidemiology
Glahn, D. C., Reichenberg, A., Frangou, S., & Ormel, H. (2008) · European Psychiatry · doi:10.1016/j.eurpsy.2007.09.014 · Cited by 10
“Neuroimaging has perhaps contributed the most in the investigation functional neural activity associated with auditory hallucinations within an extensive network of cortical and sub-cortical areas including the inferior frontal cortex, the anterior cingulate gyrus, the right lateral temporal cortex, the left parahippo…”
Background
Everything you wanted to know about neuroimaging and psychiatry, but were afraid to ask
Martinelli, C., & Shergill, S. S. (2015) · BJPsych Advances · doi:10.1192/apt.bp.114.013763 · Cited by 12
“…in schizophrenia, demonstrating that both speech generation areas and speech perception areas are active during auditory hallucinations (Shergill 2000) and that mechanistic treatments such as transcranial direct current stimulation (tDCS) or repetitive transcranial magnetic stimulation…”
Background
The Hyperactivity of Efferent Auditory System in Patients with Schizophrenia: A Transient Evoked Otoacoustic Emissions Study
Wahab, N. A. A., Wahab, S. B., Rahman, A. H. A., Sidek, D., & Zakaria, M. N. (2016) · Psychiatry Investigation · doi:10.4306/pi.2016.13.1.82 · Cited by 10
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Dahò, M., & Monzani, D. (2025) · Cognitive Neuropsychology · doi:10.1080/02643294.2025.2527983 · Cited by 12
“Heschl’s gyrus was selected by the authors because, although it is not conventionally regarded as part of any inner speech system, it has been linked to auditory processing and imagery (Shergill et al., 2000; Zatorre & Halpern, 2005).”
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O’Daly, O., Joyce, D. W., Tracy, D. K., Stephan, K. E., Murray, R. M., & Shergill, S. S. (2014) · Journal of Psychopharmacology · doi:10.1177/0269881114527360 · Cited by 9
“, 1992), a proposal supported by imaging data (Shergill et al., 2000) and evidence that antipsychotics blunt this over-activity.”
Background
Auditory Verbal Experience and Agency in Waking, Sleep Onset, REM, and Non‐REM Sleep
Speth, J., Harley, T. A., & Speth, C. (2016) · Cognitive Science · doi:10.1111/cogs.12363 · Cited by 9
Explications cognitives des hallucinations acoustico-verbales dans la schizophrénie : un article de synthèse de la littérature scientifique
Livet, A., & Salomé, F. (2020) · L Encéphale · doi:10.1016/j.encep.2019.11.010 · Cited by 9
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Foucher, J., Luck, D., Chassagnon, S., Offerlin-Meyer, I., & Pham, B.-T. (2007) · L Encéphale · doi:10.1016/j.encep.2007.06.002 · Cited by 8
Consciousness, Memory, and Hallucinations
Behrendt, R. (2011) · Springer eBooks · doi:10.1007/978-1-4614-0959-5_3 · Cited by 8
[Functional neuroimaging of auditory hallucinations in schizophrenia].
Font, M. S., Parellada, E., Fernández-Egea, E., Bernardo, M., & Lomeña, F. (2003) · PubMed · Cited by 8
Direct eye gaze enhances the ventriloquism effect
Lavan, N., Chan, W. Y., Zhuang, Y., Mareschal, I., & Shergill, S. S. (2022) · Attention Perception & Psychophysics · doi:10.3758/s13414-022-02468-5 · Cited by 7
“the patient’s experience of their inner speech—are perceived to be coming from a specific location in space (Plaze et al., 2011; Shergill et al., 2000).”
Background
Transcranial Electrical Stimulation (tES) for the Treatment of Neuropsychiatric Disorders Across Lifespan
Pérez, C., Leite, J., Carvalho, S., & Fregni, F. (2016) · European Psychologist · doi:10.1027/1016-9040/a000252 · Cited by 6
Behavioral and Auditory Electrophysiological Rebound as a Compensatory Response to the Reinforcing Effects of Morphine
Paliarin, F., Incrocci, R. M., & Nobre, M. J. (2018) · Neuroscience · doi:10.1016/j.neuroscience.2018.09.025 · Cited by 7
Elevation of EGR1/zif268, a Neural Activity Marker, in the Auditory Cortex of Patients with Schizophrenia and its Animal Model
Iwakura, Y., Kawahara‐Miki, R., Kida, S., Sotoyama, H., Gabdulkhaev, R., Takahashi, H., Kunii, Y., Hino, M., Nagaoka, A., Izumi, R., et al. (2022) · Neurochemical Research · doi:10.1007/s11064-022-03599-9 · Cited by 8
Suppression of verbal hallucinations and changes in regional cerebral blood flow after intravenous lidocaine: A case report
Plewnia, C., Bischof, F., & Reimold, M. (2006) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2006.08.014 · Cited by 7
Transcranial Magnetic Stimulation for the Treatment of Pharmacoresistant Nondelusional Auditory Verbal Hallucinations in Dementia
Marras, A., & Pallanti, S. (2013) · Case Reports in Psychiatry · doi:10.1155/2013/930304 · Cited by 10
Neural Signature for Auditory Hallucinations in Schizophrenia: A High-Resolution Positron Emission Tomography Study with Fludeoxyglucose (18F)
Kim, J.-H., Son, Y., Kim, J.-H., Lee, H.-J., Kang, N.-I., Chung, G., Park, J.-I., Cui, Y., Kim, W.-S., & Chung, Y.-C. (2018) · Clinical Psychopharmacology and Neuroscience · doi:10.9758/cpn.2018.16.3.324 · Cited by 6
Aberrant cerebellar-default-mode functional connectivity underlying auditory verbal hallucinations in schizophrenia revealed by multi-voxel pattern analysis of resting-state functional connectivity MRI data
Itahashi, T., Mimura, M., Hasegawa, S., Tani, M., Kato, N., & Hashimoto, R. (2018) · Schizophrenia Research · doi:10.1016/j.schres.2018.02.013 · Cited by 7
Unilateral auditory hallucinations in schizophrenia after damage to the right hippocampus
TAKEBAYASHI, H., Takei, N., SUZUKI, S., & MORI, N. (2002) · Schizophrenia Research · doi:10.1016/s0920-9964(01)00399-1 · Cited by 7
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Seifritz, E., Salle, F. D., Bilecen, D., Radue, E. W., & Scheffler, K. (2001) · Neuroimaging Clinics of North America · doi:10.1016/s1052-5149(25)00706-3 · Cited by 7
Neurokognitive Grundlagen schizophrener Symptome:
Kathmann, N. (2001) · Zeitschrift für Klinische Psychologie und Psychotherapie · doi:10.1026//1616-3443.30.4.241 · Cited by 7
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Distinguishing the voice of self from others: The self-monitoring hypothesis of auditory hallucination
Asai, T., & Tanno, Y. (2010) · The Japanese journal of psychology · doi:10.4992/jjpsy.81.247 · Cited by 6
Associations of resting-state perfusion and auditory verbal hallucinations with and without emotional content in schizophrenia
Conring, F., Gangl, N., Derome, M., Wiest, R., Federspiel, A., Walther, S., & Stegmayer, K. (2023) · NeuroImage: Clinical · doi:10.1016/j.nicl.2023.103527 · Cited by 7
“…2016), the superior frontal gyrus (Kompus et al., 2011), the precentral gyrus (Jardri et al., 2011; van Lutterveld et al., 2013; Zmigrod et al., 2016), and the anterior cingulate gyrus (Lennox et al., 2000; Raij et al., 2009; Shergill et al., 2000; Silbersweig et al., 1995; Sommer et al., 2008).”
Background
Intracortical circuitry: One of psychiatry?s missing assumptions
Casanova, M. F. (2004) · European Archives of Psychiatry and Clinical Neuroscience · doi:10.1007/s00406-004-0457-6 · Cited by 6
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Schulz, T., Berger, C., Krecklow, B., Kurth, J., Schwarzenboeck, S. M., Foley, P. B., Thome, J., Krause, B. J., & Hoeppner, J. (2014) · Journal of Neural Transmission · doi:10.1007/s00702-013-1151-5 · Cited by 6
“Many of the neuroimaging studies have observed prominent activation in the right as well as in the left hemisphere during AVH (Lennox et al. 1999; Shergill et al. 2000; Woodruff 2004), with considerable intersubject variation with respect to region (Copolov et al. 2003; Lennox et al. 2000; see also…”
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“Furthermore, a number of studies in imaging techniques have allowed us to study the phenomenon live, as it occurs, collecting various new data (Shergill et al., 2000).”
Background
Psychotische Störungen und Schizophrenie
Rey, E.-R. (2011) · Springer-Lehrbuch · doi:10.1007/978-3-642-13018-2_38 · Cited by 6
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Mitelman, S. A., Zhang, J., & Buchsbaum, M. S. (2010) · Cambridge University Press eBooks · doi:10.1017/cbo9780511789977.006 · Cited by 6
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“Retrospective self-report (Shergill et al. 2000) is one alternative, but only for discrete symptoms such as hallucinations, and only where there is insight.”
Background
Mediation of the Relationship between Inner Voice Experiences and Health-Related Quality of Life
England, M. (2005) · Perspectives In Psychiatric Care · doi:10.1111/j.0031-5990.2005.00006.x · Cited by 6
Disconnected Networks During Auditory Hallucinations and Dreams: A Topological Problem for Neuroimaging?
Gómez, J. F. (2002) · Archives of General Psychiatry · doi:10.1001/archpsyc.59.5.468 · Cited by 6
Control of Functional Connectivity in Cerebral Cortex by Basal Ganglia Mediated SynchronizationPreprint
Pouzzner, D. (2017) · arXiv (Cornell University) · doi:10.48550/arxiv.1708.00779 · Cited by 6
Structural aging of human neurons is opposite of the changes in schizophrenia
Mizutani, R., Saiga, R., Yamamoto, Y., Uesugi, M., Takeuchi, A., Uesugi, K., Terada, Y., Suzuki, Y., Andrade, V. D., Carlo, F. D., et al. (2023) · PLoS ONE · doi:10.1371/journal.pone.0287646 · Cited by 5
An ontogenetic role for Broca's and related speech areas in schizophrenic auditory hallucinations? Evidence from sulcal pits analysis
Salgado‐Pineda, P., Barbosa, L., Hostalet, N., García‐León, M. Á., Fuentes‐Claramonte, P., Soler‐Vidal, J., Bucur, L., Alemán‐Gómez, Y., Karuk, A., Ramiro, N., et al. (2025) · Psychiatry Research · doi:10.1016/j.psychres.2025.116502 · Cited by 5
Le rôle des anomalies structurelles et fonctionnelles du cortex insulaire dans l’altération de la perception du corps chez les patients schizophrènes
The, J. T. (2021) · L Encéphale · doi:10.1016/j.encep.2020.11.004 · Cited by 5
EEG Theta Power and Coherence to Octave Illusion in First-Episode Paranoid Schizophrenia with Auditory Hallucinations
Zheng, L., Chai, H., Yu, S., Xu, Y., Chen, W., & Wang, W. (2014) · Psychopathology · doi:10.1159/000366104 · Cited by 5
Management of Auditory Hallucinations as a Sequela of Traumatic Brain Injury
Dobry, Y., Novakovic, V., Barkin, R. L., & Sundaram, V. K. (2013) · American Journal of Therapeutics · doi:10.1097/mjt.0b013e31825e3a80 · Cited by 5
“In schizophrenia, dysregulation and dysfunction of frontotemporal areas, demonstrated by data from positron emission tomography studies, has been associated with auditory hallucination.(33,34) Our patient’s MRI showed profound injury to left frontotemporal region of the cortex, an area that shows the strongest associa…”
Background
Prelimbic NMDA receptors stimulation mimics the attenuating effects of clozapine on the auditory electrophysiological rebound induced by ketamine withdrawal
Incrocci, R. M., Paliarin, F., & Nobre, M. J. (2018) · NeuroToxicology · doi:10.1016/j.neuro.2018.08.013 · Cited by 5
Activation of the motivation-related ventral striatum during delusional experience
Raij, T. T., Riekki, T. J. J., Rikandi, E., Mäntylä, T. J. S., Kieseppä, T., & Suvisaari, J. (2018) · Translational Psychiatry · doi:10.1038/s41398-018-0347-8 · Cited by 5
Musical Hallucinations in Chronic Pain: The Anterior Cingulate Cortex Regulates Internally Generated Percepts
Schmitgen, A., Saal, J., Sankaran, N., Desai, M., Joseph, I., Starr, P. A., Chang, E. F., & Shirvalkar, P. R. (2021) · Frontiers in Neurology · doi:10.3389/fneur.2021.669172 · Cited by 5
“This has been evidenced by coactivation of ACC and auditory cortex during silence seen with positron emission tomography (71) and concordant ACC activation during auditory hallucinations (72).”
Background
Interdependent Concepts and their Independent Uses: Mental Imagery and Hallucinations
Smith, E. T. (2018) · Perspectives on Science · doi:10.1162/posc_a_00278 · Cited by 5
Neuroimaging and Psychopathological Domains
Mucci, A., Galderisi, S., Amodio, A., & Dierks, T. (2019) · Springer eBooks · doi:10.1007/978-3-319-97307-4_2 · Cited by 6
An Epistemological Approach: History of Concepts and Ideas About Hallucinations in Classical Psychiatry
Peyroux, É., & Nicolas Franck, B. (2012) · Springer eBooks · doi:10.1007/978-1-4614-4121-2_1 · Cited by 5
Functional Brain Imaging of Hallucinations: Symptom Capture Studies
Jardri, R., & Sommer, I. E. (2012) · Springer eBooks · doi:10.1007/978-1-4614-4121-2_20 · Cited by 5
Brain Functioning When the Voices Are Silent: Aberrant Default Modes in Auditory Verbal Hallucinations
van de Ven, V. G. (2012) · Springer eBooks · doi:10.1007/978-1-4614-4121-2_21 · Cited by 5
“In addition, symptom mapping studies in hallucinating schizophrenia patients showed increased hippocampal activity during auditory (Dierks et al. 1999; Shergill et al. 2000) as well as visual hallucinations (Oertel et al. 2007).”
BackgroundInfluential
Distinct neural responses used to gain insight into hallucinatory perception in patients with schizophrenia
Kim, J., Ku, J. H., Lee, H., Choi, S. H., & Kim, I. Y. (2012) · Journal of Psychiatric Research · doi:10.1016/j.jpsychires.2012.06.012 · Cited by 5
“Several studies have demonstrated the presence of additional top-down functions in the processing of hallucinatory perceptions that include wide-spread brain regions such as the limbic system and perception-related regions (Tiihonen et al., 1992; Silbersweig et al., 1995; Shergill et al., 2000).”
Background
Ressonância magnética funcional e sua contribuição para o estudo da cognição em esquizofrenia
Arcuri, S. M., & McGuire, P. K. (2001) · Brazilian Journal of Psychiatry · doi:10.1590/s1516-44462001000500012 · Cited by 5
“Pode-se também provocar o aparecimento do sintoma em indivíduos sadios através do uso de drogas(19) ou captar sintomas ativos em pacientes que os apresentam em curso praticamente contínuo numa fase aguda da doença.(20) Outra abordagem é a de estudar pacientes com diagnósticos diferentes, porém com o mesmo sintoma.”
Background
Human functional brain imaging
Bushnell, M. C., Duncan, G. H., & Hofbauer, R. K. (1999) · Pain Forum · doi:10.1016/s1082-3174(99)70023-1 · Cited by 5
Disrupted cholinergic modulation can underlie abnormal gamma rhythms in schizophrenia and auditory hallucination
Lee, J. H. (2017) · Journal of Computational Neuroscience · doi:10.1007/s10827-017-0666-4 · Cited by 5
Hearing voices or hearing the self in disguise? Revealing the neural correlates of auditory hallucinations in schizophrenia
Fu, C. H. Y., & McGuire, P. K. (2003) · Cambridge University Press eBooks · doi:10.1017/cbo9780511543708.021 · Cited by 5
The Neural Mechanisms of Private Speech in Second Language Learners’ Oral Production: An fNIRS Study
Jiang, R., Xiao, Z., Jiang, Y.-H., & Jiang, X. (2025) · Brain Science · doi:10.3390/brainsci15050451 · Cited by 5
“Compared to in‑ ner speech, outer speech engages many of the same language‑related areas but with varying activation strengths, including Broca’s area [25], motor areas [25,26], and the supramarginal gyrus (SMG) [26,27].”
Auditory Cortex Thickness Is Associated With N100 Amplitude in Schizophrenia Spectrum Disorders
Slapø, N. B., Nerland, S., Jørgensen, K. N., Mørch-Johnsen, L. E., Pettersen, J. H., Roelfs, D., Parker, N., Valstad, M., Pentz, A. B., Timpe, C. M. F., et al. (2023) · Schizophrenia Bulletin Open · doi:10.1093/schizbullopen/sgad015 · Cited by 4
Effective stimulation sites and networks for substantia nigra pars reticulata deep brain stimulation for auditory verbal hallucinations in schizophrenia
Kim, M. J., Butala, A., Salimpour, Y., Sawa, A., Figee, M., Choi, K. S., Shen, A., Schretlen, D. J., Mills, K. A., & Cascella, N. G. (2026) · Translational Psychiatry · doi:10.1038/s41398-026-04298-7 · Cited by 4
Computer-Aided Prognosis: Accurate Prediction of Patients with Neurologic and Psychiatric Diseases via Multi-modal MRI Analysis
He, H., Wen, H., Dai, D., & Wang, J. (2018) · Intelligent systems reference library · doi:10.1007/978-3-319-68843-5_10 · Cited by 4
Event-related potentials elicited by the Deutsch “high-low” word illusion in the patients with first-episode schizophrenia with auditory hallucinations
Xu, Y., Chai, H., Zhang, B.-R., Gao, Q.-Q., Fan, H., Zheng, L.-L., Mao, H.-J., Zhang, Y., & Wang, W. (2016) · BMC Psychiatry · doi:10.1186/s12888-016-0747-3 · Cited by 4
“The areas activated during hallucinations were the temporal and prefrontal cortical areas [21, 22], or the inferior frontal/ insular, anterior cingulate, temporal as well as some subcortical regions [23, 24].”
Background
Functional imaging localization of complex organic hallucinations
Bernal, B., Guillen, M. R., Ragheb, J. R., Altman, N. R., Ibrahim, G. M., LaPlante, P., Padilla, A. F., & DUCHOWNY, M. S. (2019) · Neurocase · doi:10.1080/13554794.2019.1611866 · Cited by 4
Hallucinations
Franck, N., & Thibaut, F. (2004) · Encyclopédie médico-chirurgicale. Psychiatrie · doi:10.1016/s0246-1072(03)00104-4 · Cited by 4
Neuroimaging Studies of Nonpsychotic First-Degree Relatives of People With Schizophrenia
Seidman, L. J., Wencel, H. E., McDonald, C., Murray, R. M., & Tsuang, M. T. (2004) · Humana Press eBooks · doi:10.1007/978-1-59259-729-1_9 · Cited by 4
Hallucinatory disorder: Preliminary data for a clinical diagnostic proposal
Mauri, M. C., Valli, I., Ferrari, V. M. S., Regispani, F., Cerveri, G., & INVERNIZZI, G. (2006) · Cognitive Neuropsychiatry · doi:10.1080/13546800544000037 · Cited by 4
“Hallucinating subjects have shown a reduced activation of cortical areas implicated in verbal self-monitoring (Fu et al., 2001; McGuire et aI., 1996; Shergill et al., 2000) and processing of external auditory stimuli (Allen et al., 2003; David et al., 1996; Woodruff et al., 1997).”
Background
Neuroimaging studies in schizophrenia: An overview of research from Asia
Narayanaswamy, J. C., Venkatasubramanian, G., & Gangadhar, B. N. (2012) · International Review of Psychiatry · doi:10.3109/09540261.2012.704872 · Cited by 4
“An association between middle and superior temporal lobe activity during speech processing and positive symptoms such as auditory hallucinations is also noteworthy (Han et al., 2007; Shergill et al., 2000).”
Background
Modeling the Positive Symptoms of Schizophrenia
Alkam, T., & Nabeshima, T. (2015) · Handbook of behavioral neuroscience · doi:10.1016/b978-0-12-800981-9.00004-3 · Cited by 4
Thought and language disorders in very early onset schizophrenia, schizoaffective disorder and bipolar disorder
Pantano, T., Lee Fu, I., Curatolo, E., Martins, C. B., & Elkis, H. (2016) · Archives of Clinical Psychiatry (São Paulo) · doi:10.1590/0101-60830000000087 · Cited by 4
“77 Age of onset 11,37 (3,34) 8,37 (4,65) 12,43 (3,04) F = 3.”
Schizophrenie und verwandte Störungen — Neurobiologie
Arolt, V., Ohrmann, P., & Rothermundt, M. (2006) · Springer eBooks · doi:10.1007/3-540-30887-3_7 · Cited by 3
We’re not in Kansas anymore: ectopic dopaminergic terminals as an explanation for the positive symptoms in psychiatric pathology
Avramescu, R. G., & Flores, C. (2023) · Journal of Psychiatry and Neuroscience · doi:10.1503/jpn.230015 · Cited by 4
Pharmacological Applications of fMRI
Matthews, P. M. (2009) · Neuromethods · doi:10.1007/978-1-60327-919-2_25 · Cited by 3
Auditory Hallucinations: An Audiological Horizon?
Musiek, F. E., Morris, S., Ichiba, K., Clark, L., & Davidson, A. J. (2021) · Journal of the American Academy of Audiology · doi:10.1055/s-0041-1722989 · Cited by 3

Authors: Shergill, S. S., Brammer, M. J., Williams, S. C. R., Murray, R. M., & McGuire, P. K.
Affiliations: King's College London (GB)
ORCID: Shergill, Sukhwinder S.
Brammer, Michael J.
Williams, Steven C. R.
Murray, Robin M.
McGuire, Philip K.
Venue: Archives of General Psychiatry
Publisher: American Medical Association (AMA)
Published: 2000-11-01
Volume: 57
Issue: 11
Pages: 1033
ISSN: 0003-990X (ISSN-L)
DOI: 10.1001/archpsyc.57.11.1033
OpenAlex: W2022503841
Cited by: 666
References: 36
Citations by year: 2026: 11 · 2025: 13 · 2024: 12 · 2023: 18 · 2022: 20 · 2021: 14 · 2020: 13 · 2019: 17 · 2018: 22 · 2017: 20 · 2016: 22 · 2015: 20 · 2014: 28 · 2013: 30 · 2012: 43
FWCI: 11.08
Type: journal article
Language: en
Open access: closed
Locations: Archives of General Psychiatry (publishedVersion)
PubMed (publishedVersion)
Research Portal (King's College London) (submittedVersion)
Topics: Life Sciences › Neuroscience › Cognitive Neuroscience › Hallucinations in medical conditions
Health Sciences › Medicine › Psychiatry and Mental health › Schizophrenia research and treatment
Social Sciences › Arts and Humanities › Philosophy › Mental Health and Psychiatry
Keywords: auditory verbal hallucinations, schizophrenia, spontaneous neuronal activity, inferior frontal cortex, insula, anterior cingulate cortex, thalamus, inferior colliculus, hippocampus, parahippocampal cortex, temporal cortex, distributed neural networks
MeSH terms: Auditory Perception, Brain Mapping, Hallucinations, Humans, Magnetic Resonance Imaging, Schizophrenia, Schizophrenic Psychology

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Mapping Auditory Hallucinations in Schizophrenia Using Functional Magnetic Resonance Imaging

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