The DOI matches its Crossref record; 14 of the 14 references it cites were found in a registry or an index.
Roles for Ghrelin in the Regulation of Appetite and Body Weight
Abstract
besity is a global epidemic that has proven daunting to prevent and treat.The prevalences of obesity (body mass index [BMI] Ͼ30) and morbid obesity (BMI Ͼ40) among American adults are about 30% and 5%, respectively. 1Obesity is so strongly associated with medical comorbidities and mortality that it has begun to overtake infectious diseases as the most significant contributor to ill health worldwide. 2,3Overweight persons are also frequently stigmatized and consequently suffer from low self-esteem.Their motivation to achieve and maintain weight loss is often Herculean.In 1 study of 47 patients who had durably lost 45 kg or more after bariatric surgery, 100% preferred to be deaf, dyslexic, diabetic, or have heart disease rather than be obese again; leg amputation and blindness were preferred by 91.5% and 89.4%, respectively. 4The traditional treatment paradigm of diet, exercise, and medication generally achieves no more than a 5% to 10% reduction in body weight, 5,6 and recidivism after such weight loss exceeds 90% within 5 years. 7,80][11] The molecular mediators of these compensatory responses to weight loss are potential targets for antiobesity treatments.Ghrelin is a potent orexigenic (appetite-stimulating) peptide that seems to participate in the adaptive response to weight loss.Therefore, ghrelin holds promise as a target for both medical and surgical approaches to obesity.
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Cites
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“Almost all arcuate NPY/AgRP neurons express the ghrelin receptor and can be stimulated by ghrelin, as judged by increases in the firing rate and the expression of c-Fos, NPY, and AgRP in these cells.(41,43,55-60) Pharmacologic blockade of either NPY or AgRP attenuates the orexigenic actions of ghrelin.”
BackgroundA preprandial rise in plasma ghrelin levels suggests a role in meal initiation in humans
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Cited by
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Ghrelin and the short- and long-term regulation of appetite and body weight
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Self-citationGastric Bypass for Obesity: Mechanisms of Weight Loss and Diabetes Resolution
Cummings, D. E., Overduin, J., & Foster-Schubert, K. E. (2004) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2004-0433 · Cited by 503
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The TNF-α System: Functional Aspects in Depression, Narcolepsy and Psychopharmacology
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A Twin Study of Sleep Duration and Body Mass Index
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Nocturnal levels of ghrelin and leptin and sleep in chronic insomnia
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The neurological effects of ghrelin in brain diseases: Beyond metabolic functions
Jiao, Q., Du, X., Li, Y., Gong, B., Shi, L., Tang, T., & Jiang, H. (2017) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2016.12.010 · Cited by 62
Sadeghian, M., Hosseini, S. A., Zare Javid, A., Ahmadi Angali, K., & Mashkournia, A. (2021) · Obesity Surgery · doi:10.1007/s11695-020-05202-y · Cited by 35
Ghrelin’s Role as a Major Regulator of Appetite and Its Other Functions in Neuroendocrinology
Lim, C. T., Kola, B., Korbonits, M., & Grossman, A. B. (2010) · Progress in Brain Research · doi:10.1016/s0079-6123(10)82008-4 · Cited by 34
Metabolic Adaptations to Weight Loss: A Brief Review
Martínez-Gómez, M. G., & Roberts, B. M. (2022) · Journal of Strength & Conditioning Research · doi:10.1519/jsc.0000000000003991 · Cited by 32
Metadata
- Authors
- Cummings, D. E.
- Venue
- Archives of Surgery
- Publisher
- American Medical Association (AMA)
- Published
- 2003-04-01
- Volume
- 138
- Issue
- 4
- Pages
- 389
- ISSN
- 0004-0010 (ISSN-L)
- OpenAlex
- W2093709895
- Cited by
- 285
- References
- 14
- FWCI
- 9.88
- Type
- journal article
- Language
- en
- Open access
- closed
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