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Heavy Smokers, Smoking Cessation, and Clonidine: Results of a Double-blind, Randomized Trial
Abstract
Seventy-one heavy smokers who had failed in previous attempts to stop smoking participated in a randomized clinical trial to test the efficacy of clonidine as an aid in smoking cessation. The success rate in clonidine-treated subjects (verified by serum cotinine concentration) was more than twice that in the placebo-treated subjects. When the data were stratified by gender, a strong effect present in women was not apparent in men. After six months, cessation rates remained significantly higher among smokers treated with clonidine than those receiving placebo. The data also revealed an unexpectedly high prevalence (61%) of a history of major depression in this sample and a significant negative effect of such a history on cessation regardless of treatment. These findings, highly suggestive of an important role of clonidine in smoking cessation, warrant further studies to establish the long-term (greater than or equal to 12 months) efficacy of this drug and to replicate the association between nicotine dependence and depression.
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“a majority of smokers enrolled in smoking cessation programs have a history of depressive episodes (Dalack, Glassman, Rivelli, Covey, & Stetner, 1995; Glassman et al., 1988; Lerman et al., 1996)”
From Nicotine addiction and psychiatric disorders (2015) · cites this paper as Glassman et al., 1988
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A randomized trial of nortriptyline combined with transdermal nicotine for smoking cessation
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Comorbidity, Smoking Behavior and Treatment Outcome
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Depression and Smoking Cessation in Older Adults: A Longitudinal Study
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“We focused on lifetime history of depressive or dysthymic disorder to see if we would replicate previous findings that lifetime diagnostic status predicts abstinence rates (Glassman et al., 1988) using our RMLCA approach.”
A smoke-free chemical dependency unit. The Cleveland Clinic experience.
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Metadata
- Authors
- Glassman, A. H.
- Corresponding author
- Glassman, Alexander H.
- Venue
- JAMA
- Publisher
- American Medical Association (AMA)
- Published
- 1988-05-20
- Volume
- 259
- Issue
- 19
- Pages
- 2863
- ISSN
- 0002-9955 (ISSN-L)
- 0098-7484
- OpenAlex
- W7214164996
- Cited by
- 0
- References
- 0
- FWCI
- 0.00
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- JAMA (publishedVersion)
- Topics
- Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Smoking Behavior and Cessation
- Health Sciences › Medicine › Epidemiology › Substance Abuse Treatment and Outcomes
- Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Chronic Obstructive Pulmonary Disease (COPD) Research
- Keywords
- heavy smoking, smoking cessation, clonidine, nicotine dependence, tobacco use
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