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Cited by 70Smoking Behavior and CessationTreatment of Major DepressionAnxiety, Depression, Psychometrics, Treatment, Cognitive Processes

Mood, major depression, and fluoxetine response in cigarette smokers

Gregory W. Dalack, Alexander H. Glassman, Sarah K. Rivelli, Lirio S. Covey, Fay Stetner·1995·American Journal of Psychiatry
DOI 10.1176/ajp.152.3.398
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Abstract

OBJECTIVE: Two smoking cessation studies provided venues to 1) look for differences in affective symptoms between cigarette smokers with and without a history of major depression or other psychiatric diagnoses who were not currently depressed and 2) evaluate the efficacy of fluoxetine in ameliorating affective symptoms in smokers with a history of major depression but not currently depressed. METHOD: Part I: Three hundred sixty-eight smokers who enrolled in a smoking cessation treatment study completed baseline self-rating scales. The relationship between the scale scores and a history of major depression and other psychiatric diagnoses was examined. Part II: Thirty-nine smokers with a history of major depression were enrolled in a randomized, double-blind study that examined the utility of fluoxetine as an aid to smoking cessation. Self-rated scales were compared at baseline and after 3 weeks of medication treatment before the attempt to quit. RESULTS: A history of major depression had significant main effects across all scale scores; subjects with such a history rated themselves as more symptomatic. The effects of other psychiatric diagnoses were neither as pervasive nor as robust. There were no differences in baseline scores between the fluoxetine- and placebo-treated groups and no change within the placebo group after 3 weeks. There was significant improvement from baseline in several subscale scores for the group treated with fluoxetine. However, comparison of the score changes for the placebo and fluoxetine groups did not show a statistically significant difference, which limited the ability to conclude that active treatment was better than placebo. CONCLUSIONS: Subjects with a history of major depression, but without current affective illness, reported themselves to be more symptomatic than those without such-a history. Furthermore, in a group of smokers with a history of major depression, affective symptoms, without concurrent syndromal illness, may be ameliorated by treatment with fluoxetine.

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Crossref · 10.1176/ajp.152.3.398

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  • A majority of smokers enrolled in smoking cessation programs have a history of depressive episodes.

    “a majority of smokers enrolled in smoking cessation programs have a history of depressive episodes (Dalack, Glassman, Rivelli, Covey, & Stetner, 1995; Glassman et al., 1988; Lerman et al., 1996)”

    From Nicotine addiction and psychiatric disorders (2015) · cites this paper as Dalack et al., 1995

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Authors
Dalack, G. W., Glassman, A. H., Rivelli, S. K., Covey, L. S., & Stetner, F.
Affiliations
Columbia University (US)
ORCID
Gregory W. Dalack
Venue
American Journal of Psychiatry
Publisher
American Psychiatric Association Publishing
Published
1995-03-01
Volume
152
Issue
3
Pages
398-403
ISSN
  • 0002-953X (ISSN-L)
  • 1535-7228
DOI
10.1176/ajp.152.3.398
OpenAlex
W2398471897
Cited by
70
References
18
Citations by year
2023: 1 · 2021: 2 · 2020: 1 · 2019: 2 · 2015: 2 · 2014: 2 · 2013: 2 · 2012: 1
FWCI
3.32
Type
journal article
Language
en
Open access
closed
Locations
  • American Journal of Psychiatry (publishedVersion)
  • PubMed (publishedVersion)
Funders
  • National Institutes of Health (5r01da004732-04)
  • National Institute of Mental Health (MH-15144, T32MH015144)
  • National Institute on Drug Abuse (DA-04732)
Topics
  • Health Sciences › Medicine › Physiology › Smoking Behavior and Cessation
  • Health Sciences › Medicine › Pharmacology › Treatment of Major Depression
  • Social Sciences › Psychology › Experimental and Cognitive Psychology › Anxiety, Depression, Psychometrics, Treatment, Cognitive Processes
Keywords
cigarette smoking, major depressive disorder, fluoxetine, smoking cessation, mood, affective symptoms, psychiatric comorbidity, placebo response
MeSH terms
Smoking Prevention, Adult, Affective Symptoms, Depressive Disorder, Double-Blind Method, Female, Fluoxetine, Humans, Male, Personality Inventory, Placebos, Psychiatric Status Rating Scales, Smoking, Comorbidity, Smoking Cessation, Treatment Outcome

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