Depression and nicotine: preclinical and clinical evidence for common mechanisms
Abstract
Updated findings on the relationship between nicotine and depression are presented. Clinical and preclinical research on nicotine use and depression suggests that nicotine may have some properties in common with antidepressants. Updated findings involve the comorbidity of smoking and major depressive disorder (MDD), the influence of depression during withdrawal on failure to quit smoking, the course of MDD without nicotine and the neurobiology of smoking and depression.
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Clinical studies have demonstrated an increased rate of smoking in individuals with depression, a tendency for depressive symptoms to develop in the context of smoking cessation, and the capacity for nicotine to improve depressive symptoms, even in non-smokers.
“Clinical studies have demonstrated an increased rate of smoking in individuals with depression (Diwan et al., 1998), a tendency for depressive symptoms to develop in the context of smoking cessation (Laje et al., 2001), and the capacity for nicotine to improve depressive symptoms, even in non-smokers (McClernon et al., 2006; Salin-Pascual et al., 1996).”
From Mood and anxiety regulation by nicotinic acetylcholine receptors: A potential pathway to modulate aggression and related behavioral states (2015) · cites this paper as Laje et al., 2001
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Psychische Störungen und Verhaltensstörungen durch psychotrope Substanzen
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ANÁLISE DA SAÚDE MENTAL DE TABAGISTAS NA ATENÇÃO PRIMÁRIA A SAÚDE
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ТРЕВОЖНО-ДЕПРЕССИВНЫЕ РАССТРОЙСТВА У ПАЦИЕНТОВ С АЛКОГОЛИЗМОМ, ОСЛОЖНЕННЫМ НИКОТИНОВОЙ ЗАВИСИМОСТЬЮ
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- Authors
- Laje, R. P., Berman, J. A., & Glassman, A. H.
- Affiliations
- Columbia University (US)
- Venue
- Current Psychiatry Reports
- Published
- 2001-11
- Volume
- 3
- Issue
- 6
- Pages
- 470-474
- ISSN
- 1523-3812 (ISSN-L)
- 1535-1645
- OpenAlex
- W2027647710
- Cited by
- 74
- References
- 45
- Citations by year
- 2026: 2 · 2025: 2 · 2024: 7 · 2023: 3 · 2021: 2 · 2020: 2 · 2018: 2 · 2017: 1 · 2016: 3 · 2015: 3 · 2014: 3 · 2013: 3 · 2012: 2
- FWCI
- 0.17
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Current Psychiatry Reports (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Physiology › Smoking Behavior and Cessation
- Health Sciences › Medicine › Pharmacology › Treatment of Major Depression
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Nicotinic Acetylcholine Receptors Study
- Keywords
- nicotine, depression, major depressive disorder, smoking, nicotine withdrawal, smoking cessation, comorbidities
- MeSH terms
- Antidepressive Agents, Major Depressive Disorder, Humans, Nicotine, Receptors, Cholinergic, Receptors, Nicotinic, Smoking, Comorbidity, Smoking Cessation
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