Cited by 75Smoking Behavior and CessationTreatment of Major DepressionNicotinic Acetylcholine Receptors Study

Depression and nicotine: preclinical and clinical evidence for common mechanisms

Laje, Rene P., Berman, Joshua A., Glassman, Alexander H.·2001·Current Psychiatry Reports

Abstract

Updated findings on the relationship between nicotine and depression are presented. Clinical and preclinical research on nicotine use and depression suggests that nicotine may have some properties in common with antidepressants. Updated findings involve the comorbidity of smoking and major depressive disorder (MDD), the influence of depression during withdrawal on failure to quit smoking, the course of MDD without nicotine and the neurobiology of smoking and depression.

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Crossref · 10.1007/s11920-001-0040-z

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47 of 47 references verified0 citation errors · 0 not checkable

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  • Clinical studies have demonstrated an increased rate of smoking in individuals with depression, a tendency for depressive symptoms to develop in the context of smoking cessation, and the capacity for nicotine to improve depressive symptoms, even in non-smokers.

    “Clinical studies have demonstrated an increased rate of smoking in individuals with depression (Diwan et al., 1998), a tendency for depressive symptoms to develop in the context of smoking cessation (Laje et al., 2001), and the capacity for nicotine to improve depressive symptoms, even in non-smokers (McClernon et al., 2006; Salin-Pascual et al., 1996).”

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Authors
Laje, R. P., Berman, J. A., & Glassman, A. H.
Affiliations
Columbia University (US)
Venue
Current Psychiatry Reports
Published
2001-11
Volume
3
Issue
6
Pages
470-474
ISSN
  • 1523-3812 (ISSN-L)
  • 1535-1645
OpenAlex
W2027647710
Cited by
74
References
45
Citations by year
2026: 2 · 2025: 2 · 2024: 7 · 2023: 3 · 2021: 2 · 2020: 2 · 2018: 2 · 2017: 1 · 2016: 3 · 2015: 3 · 2014: 3 · 2013: 3 · 2012: 2
FWCI
0.17
Type
journal article
Language
en
Open access
closed
Locations
  • Current Psychiatry Reports (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Physiology › Smoking Behavior and Cessation
  • Health Sciences › Medicine › Pharmacology › Treatment of Major Depression
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Nicotinic Acetylcholine Receptors Study
Keywords
nicotine, depression, major depressive disorder, smoking, nicotine withdrawal, smoking cessation, comorbidities
MeSH terms
Antidepressive Agents, Major Depressive Disorder, Humans, Nicotine, Receptors, Cholinergic, Receptors, Nicotinic, Smoking, Comorbidity, Smoking Cessation

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