Cited by 1,226Dementia and Cognitive Impairment ResearchAlzheimer's disease research and treatmentsAging, Health, and Disability

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Prevalence of Alzheimer's Disease in a Community Population of Older Persons: Higher Than Previously Reported

Evans, Denis A.·1989·JAMA

DOI 10.1001/jama.1989.03430180093036

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Abstract

Clinically diagnosed Alzheimer's disease and other dementing illnesses were assessed in a geographically defined US community. Of 3623 persons (80.8% of all community residents over 65 years of age) who had brief memory testing in their homes, a stratified sample of 467 persons underwent neurological, neuropsychological, and laboratory examination. Prevalence rates of Alzheimer's disease were calculated for the community population from the sample undergoing clinical evaluation. Of those over the age of 65 years, an estimated 10.3% (95% confidence limits, 8.1% and 12.5%) had probable Alzheimer's disease. This prevalence rate was strongly associated with age. Of those 65 to 74 years old, 3.0% (95% confidence limits, 0.8 and 5.2) had probable Alzheimer's disease, compared with 18.7% (95% confidence limits, 13.2 and 24.2) of those 75 to 84 years old and 47.2% (95% confidence limits, 37.0 and 63.2) of those over 85 years. Other dementing conditions were uncommon. Of community residents with moderate or severe cognitive impairment, 84.1% had clinically diagnosed Alzheimer's disease as the only probable diagnosis. These data suggest that clinically diagnosed Alzheimer's disease is a common condition and that its public health impact will continue to increase with increasing longevity of the population. (JAMA. 1989;262:2551-2556)

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Wang, W. ‐., Liao, Y., Wu, S.-L., Tsai, F., Lee, C. ‐., & Hua, C. ‐. (2005) · European Journal of Neurology · doi:10.1111/j.1468-1331.2005.01033.x · Cited by 34
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Background
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Background
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Background
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Background
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BackgroundInfluential
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McBee, W. L., Dailey, M. E., Dugan, E., & Shumaker, S. A. (1997) · Endocrinology and Metabolism Clinics of North America · doi:10.1016/s0889-8529(05)70250-4 · Cited by 28
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Graves, A. B., Larson, E. B., White, L. R., Teng, E. L., & Homma, A. (1994) · International Psychogeriatrics · doi:10.1017/s1041610294001778 · Cited by 28
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Ishii, H., Meguro, K., Ishizaki, J., Shimada, M., Yamaguchi, S., Sano, I., Ambo, H., Ohtake, H., Shimada, Y., Someya, K., et al. (2000) · Archives of Gerontology and Geriatrics · doi:10.1016/s0167-4943(99)00038-2 · Cited by 28
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Harris, P. B., & Long, S. (1993) · Journal of Cross-Cultural Gerontology · doi:10.1007/bf00971563 · Cited by 28
A double‐blind, placebo‐controlled, enriched population study of tacrine in patients with Alzheimer's disease
Forette, F., Hoover, T. M., Gracon, S. I., de Rotrou, J., Hervy, M. P., Lechevalier, B., Micas, M., Petit, H., Orgogozo, J., Guard, O., et al. (1995) · European Journal of Neurology · doi:10.1111/j.1468-1331.1995.tb00124.x · Cited by 27
The Differentiation Between Depression and Dementia in the Very Old
Helmchen, H., & Linden, M. (1993) · Ageing and Society · doi:10.1017/s0144686x00001379 · Cited by 28
Thalamic volume loss as an early sign of amnestic mild cognitive impairment
Zidan, M., Boban, J. M., Bjelan, M., Todorović, A., Stankov, T. V., Semnic, M. D., Boban, N., & Kozic, D. B. (2019) · Journal of Clinical Neuroscience · doi:10.1016/j.jocn.2019.07.004 · Cited by 27
Thinking About Dementia
Leibing, A., & Cohen, L. (2020) · Rutgers University Press eBooks · doi:10.36019/9780813539270 · Cited by 27
Coenzyme Q10 and its effects in the treatment of neurodegenerative diseases
dos Santos, G. C., Antunes, L. M. G., dos Santos, A. C., & Bianchi, M. D. L. P. (2009) · Brazilian Journal of Pharmaceutical Sciences · doi:10.1590/s1984-82502009000400002 · Cited by 28
Incidence and Documentation of Cognitive Impairment Among Older Adults With Severe Mental Illness in a Community Mental Health Setting
Mackin, R. S., & Areán, P. A. (2009) · American Journal of Geriatric Psychiatry · doi:10.1097/jgp.0b013e31818cd3e5 · Cited by 27
The role of estrogen replacement therapy in Alzheimer’s disease
Panidis, D., Matalliotakis, I., Rousso, D., Kourtis, A., & Koumantakis, E. E. (2001) · European Journal of Obstetrics & Gynecology and Reproductive Biology · doi:10.1016/s0301-2115(00)00373-0 · Cited by 27
Diagnostic Significance of Cortical Superficial Siderosis for Alzheimer Disease in Patients with Cognitive Impairment
Inoue, Y., Nakajima, M., Uetani, H., Hirai, T., Ueda, M., Kitajima, M., Utsunomiya, D., Watanabe, M. J. L., Hashimoto, M., Ikeda, M., et al. (2015) · American Journal of Neuroradiology · doi:10.3174/ajnr.a4496 · Cited by 29
Enhanced Detection Specificity and Sensitivity of Alzheimer’s Disease Using Amyloid-β-Targeted Quantum Dots
Quan, L. N., Wu, J., Lane, L. A., Wang, J., Lu, Q., Gu, Z., & Wang, Y. (2016) · Bioconjugate Chemistry · doi:10.1021/acs.bioconjchem.6b00019 · Cited by 27
Longitudinal Relationships between Caloric Expenditure and Gray Matter in the Cardiovascular Health Study
Raji, C. A., Merrill, D. A., Eyre, H. A., Mallam, S., Torosyan, N., Erickson, K. I., López, O. L., Becker, J. T., Carmichael, O. T., Gach, H. M., et al. (2016) · Journal of Alzheimer s Disease · doi:10.3233/jad-160057 · Cited by 33
“Importantly, this decrease in physical activity occurs when this population is at risk for dementia, namely AD [6].”
Amylin Enhances Amyloid-β Peptide Brain to Blood Efflux Across the Blood-Brain Barrier
Mohamed, L. A., Zhu, H., Mousa, Y. M., Wang, E., Qiu, W. Q., & Kaddoumi, A. (2017) · Journal of Alzheimer s Disease · doi:10.3233/jad-160800 · Cited by 27
“While the number of AD patients grows rapidly in the US [1, 2], there are no effective treatments for the disease.”
Body temperature as a risk factor for Alzheimer’s disease
Holtzman, A. H., & Simon, E. W. (2000) · Medical Hypotheses · doi:10.1054/mehy.2000.1085 · Cited by 26
Screening recommendations for the elderly.
Beers, M. H., Fink, A., & Beck, J. C. (1991) · American Journal of Public Health · doi:10.2105/ajph.81.9.1131 · Cited by 27
Cognitive Impairment and Problem Behaviors as Risk Factors for Institutionalization
Kasper, J. D., & Shore, A. D. (1994) · Journal of Applied Gerontology · doi:10.1177/073346489401300403 · Cited by 27
Mental and somatic health and need for care in octo- and nonagenerians
Meller, I., Fichter, M. M., Schröppel, H., & Beck-Eichinger, M. (1993) · European Archives of Psychiatry and Clinical Neuroscience · doi:10.1007/bf02190388 · Cited by 27
Biomedical Research Involving Older Human Subjects
Sachs, G. A., & Cassel, C. K. (1990) · Law Medicine and Health Care · doi:10.1111/j.1748-720x.1990.tb00026.x · Cited by 27
The Role of Misdirected Plasticity in Plaque Biogenesis and Alzheimer’s Disease Pathology
Cotman, C. W., Cummings, B. J., & Whitson, J. S. (1991) · Springer eBooks · doi:10.1007/978-3-642-46722-6_19 · Cited by 27
Awareness impairment in Alzheimer’s disease and frontotemporal dementia: a systematic MRI review
Leocadi, M., Canu, E., Paldino, A., Agosta, F., & Filippi, M. (2022) · Journal of Neurology · doi:10.1007/s00415-022-11518-9 · Cited by 26
“In fact, sarcastic intent is straightforward to manipulate, and its detection can be reliably assessed [59].”
Background
Machine learning techniques to discover genes with potential prognosis role in Alzheimer’s disease using different biological sources
Martínez-Ballesteros, M., García-Heredia, J. M., Nepomuceno-Chamorro, I. A., & Riquelme, J. C. (2016) · Information Fusion · doi:10.1016/j.inffus.2016.11.005 · Cited by 24

Authors: Evans, D. A.
Corresponding author: Evans, Denis A.
ORCID: Evans, Denis A.
Venue: JAMA
Publisher: American Medical Association (AMA)
Published: 1989-11-10
Volume: 262
Issue: 18
Pages: 2551
ISSN: 0002-9955 (ISSN-L)
0098-7484
DOI: 10.1001/jama.1989.03430180093036
OpenAlex: W2129678592
Cited by: 1,226
References: 0
Citations by year: 2026: 6 · 2025: 11 · 2024: 13 · 2023: 15 · 2022: 9 · 2021: 20 · 2020: 22 · 2019: 17 · 2018: 20 · 2017: 18 · 2016: 28 · 2015: 23 · 2014: 17 · 2013: 32 · 2012: 25
FWCI: 44.57
Type: journal article
Language: en
Open access: closed
Locations: JAMA (publishedVersion)
DigitalGeorgetown (Georgetown University Library) (submittedVersion)
Funders: National Institute on Aging (N01-AG02107, N01‐AG‐1‐2106, AG 06789)
Topics: Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Alzheimer's disease research and treatments
Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Aging, Health, and Disability
Keywords: Alzheimer's disease, prevalence, older adults, dementia, age-related cognitive decline, community-dwelling older adults, cognitive impairment, age differences in prevalence, public health impact

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Prevalence of Alzheimer's Disease in a Community Population of Older Persons: Higher Than Previously Reported

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