Cited by 1,226Dementia and Cognitive Impairment ResearchAlzheimer's disease research and treatmentsAging, Health, and Disability

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Prevalence of Alzheimer's Disease in a Community Population of Older Persons: Higher Than Previously Reported

Evans, Denis A.·1989·JAMA

DOI 10.1001/jama.1989.03430180093036

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Abstract

Clinically diagnosed Alzheimer's disease and other dementing illnesses were assessed in a geographically defined US community. Of 3623 persons (80.8% of all community residents over 65 years of age) who had brief memory testing in their homes, a stratified sample of 467 persons underwent neurological, neuropsychological, and laboratory examination. Prevalence rates of Alzheimer's disease were calculated for the community population from the sample undergoing clinical evaluation. Of those over the age of 65 years, an estimated 10.3% (95% confidence limits, 8.1% and 12.5%) had probable Alzheimer's disease. This prevalence rate was strongly associated with age. Of those 65 to 74 years old, 3.0% (95% confidence limits, 0.8 and 5.2) had probable Alzheimer's disease, compared with 18.7% (95% confidence limits, 13.2 and 24.2) of those 75 to 84 years old and 47.2% (95% confidence limits, 37.0 and 63.2) of those over 85 years. Other dementing conditions were uncommon. Of community residents with moderate or severe cognitive impairment, 84.1% had clinically diagnosed Alzheimer's disease as the only probable diagnosis. These data suggest that clinically diagnosed Alzheimer's disease is a common condition and that its public health impact will continue to increase with increasing longevity of the population. (JAMA. 1989;262:2551-2556)

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Jack, C. R., Marjańska, M., Wengenack, T. M., Reyes, D. A., Curran, G. L., Lin, J., Preboske, G. M., Poduslo, J. F., & Garwood, M. (2007) · The Neuroscientist · doi:10.1177/1073858406295610 · Cited by 76
Risk Factors for Alzheimer’s Disease: Role of Multiple Antioxidants, Non-Steroidal Anti-inflammatory and Cholinergic Agents Alone or in Combination in Prevention and Treatment
Prasad, K. N., Cole, W. C., & Prasad, K. C. (2002) · Journal of the American College of Nutrition · doi:10.1080/07315724.2002.10719249 · Cited by 76
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An examination of Alzheimer's disease case definitions using Medicare claims and survey data
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Teel, C. S., & Carson, P. (2003) · Journal of Family Nursing · doi:10.1177/1074840702239490 · Cited by 76
“Alzheimer’s disease (AD) is the most common cause of dementia among the older population, comprising about 75% of all dementia cases (Celsis, 2000) and affecting up to half of Americans 85 and older (Cummings & Jeste, 1999; Evans et al., 1989; Leon, Cheng, & Neumann, 1998).”
Background
Research with Alzheimer's Disease Subjects: Informed Consent and Proxy Decision Making
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“Older age and apolipoprotein E (APOE) are the 2 most robust risk factors for late life cognitive decline, MCI, and dementia (Corder et al., 1993; Dubé et al., 2013; Evans et al., 1989; Karlamangla et al., 2009; Lipnicki et al., 2013).”
Background
Multiple Antioxidants in the Prevention and Treatment of Alzheimer Disease: Analysis of Biologic Rationale
Prasad, K. N., Hovland, A. R., Cole, W. C., Prasad, K. C., Nahreini, P., Edwards‐Prasad, J., & Andreatta, C. P. (2000) · Clinical Neuropharmacology · doi:10.1097/00002826-200001000-00002 · Cited by 75
Weight Loss in Alzheimer’s Disease: An International Review of the Literature
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A PIN1 polymorphism that prevents its suppression by AP4 associates with delayed onset of Alzheimer's disease
Ma, S. L., Tang, N. L. S., Tam, C. W. C., Lui, V. W.-C., LAM, L. C. W., Chiu, H. F. K., Driver, J. A., Pastorino, L., & Lu, K. P. (2010) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2010.05.018 · Cited by 74
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Alcohol‐Related Dementia in the Institutionalized Elderly
Carlen, P. L., McAndrews, M. P., Weiss, R., Dongier, M., Hill, J., Menzano, E., Farcnik, K. D., Abarbanel, J. M., & Eastwood, M. R. (1994) · Alcoholism Clinical and Experimental Research · doi:10.1111/j.1530-0277.1994.tb01432.x · Cited by 73
Beyond the Signal Sequence: Protein Routing in Health and Disease
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“AD is, at present, an incurable neurodegenerative disease and the most common form of dementia (156).”
Background
Epidemiology of Dementia in Rochester, Minnesota
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“This prevalence rate is strongly associated with age: of those 65–74 years old, only 3% is AD patients, compared with those over 85 years old, nearly 50% of which suffer from AD (Evans et al., 1989).”
Background

Authors: Evans, D. A.
Corresponding author: Evans, Denis A.
ORCID: Evans, Denis A.
Venue: JAMA
Publisher: American Medical Association (AMA)
Published: 1989-11-10
Volume: 262
Issue: 18
Pages: 2551
ISSN: 0002-9955 (ISSN-L)
0098-7484
DOI: 10.1001/jama.1989.03430180093036
OpenAlex: W2129678592
Cited by: 1,226
References: 0
Citations by year: 2026: 6 · 2025: 11 · 2024: 13 · 2023: 15 · 2022: 9 · 2021: 20 · 2020: 22 · 2019: 17 · 2018: 20 · 2017: 18 · 2016: 28 · 2015: 23 · 2014: 17 · 2013: 32 · 2012: 25
FWCI: 44.57
Type: journal article
Language: en
Open access: closed
Locations: JAMA (publishedVersion)
DigitalGeorgetown (Georgetown University Library) (submittedVersion)
Funders: National Institute on Aging (N01-AG02107, N01‐AG‐1‐2106, AG 06789)
Topics: Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Alzheimer's disease research and treatments
Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Aging, Health, and Disability
Keywords: Alzheimer's disease, prevalence, older adults, dementia, age-related cognitive decline, community-dwelling older adults, cognitive impairment, age differences in prevalence, public health impact

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Prevalence of Alzheimer's Disease in a Community Population of Older Persons: Higher Than Previously Reported

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