Cited by 2,613Atrial Fibrillation Management and OutcomesCardiac electrophysiology and arrhythmiasAcute Ischemic Stroke Management

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Independent Risk Factors for Atrial Fibrillation in a Population-Based Cohort: The Framingham Heart Study

Benjamin, Emelia J.·1994·JAMA

DOI 10.1001/jama.1994.03510350050036

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Abstract

Objective. —To determine the independent risk factors for atrial fibrillation. Design. —Cohort study. Setting. —The Framingham Heart Study. Subjects. —A total of 2090 men and 2641 women members of the original cohort, free of a history of atrial fibrillation, between the ages of 55 and 94 years. Main Outcome Measures. —Sex-specific multiple logistic regression models to identify independent risk factors for atrial fibrillation, including age, smoking, diabetes, electrocardiographic left ventricular hypertrophy, hypertension, myocardial infarction, congestive heart failure, and valve disease. Results. —During up to 38 years of follow-up, 264 men and 298 women developed atrial fibrillation. After adjusting for age and other risk factors for atrial fibrillation, men had a 1.5 times greater risk of developing atrial fibrillation than women. In the full multivariable model, the odds ratio (OR) of atrial fibrillation for each decade of advancing age was 2.1 for men and 2.2 for women (P<.0001). In addition, after multivariable adjustment, diabetes (OR, 1.4 for men and 1.6 for women), hypertension (OR, 1.5 for men and 1.4 for women), congestive heart failure (OR, 4.5 for men and 5.9 for women), and valve disease (OR, 1.8 for men and 3.4 for women) were significantly associated with risk for atrial fibrillation in both sexes. Myocardial infarction (OR, 1.4) was significantly associated with the development of atrial fibrillation in men. Women were significantly more likely than men to have valvular heart disease as a risk factor for atrial fibrillation. The multivariable models were largely unchanged after eliminating subjects with valvular heart disease. Conclusion. —In addition to intrinsic cardiac causes such as valve disease and congestive heart failure, risk factors for cardiovascular disease also predispose to atrial fibrillation. Modification of risk factors for cardiovascular disease may have the added benefit of diminishing the incidence of atrial fibrillation. (JAMA. 1994;271:840-844)

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Authors: Benjamin, E. J.
Corresponding author: Benjamin, Emelia J.
ORCID: Benjamin, Emelia J.
Venue: JAMA
Publisher: American Medical Association (AMA)
Published: 1994-03-16
Volume: 271
Issue: 11
Pages: 840
ISSN: 0002-9955 (ISSN-L)
0098-7484
DOI: 10.1001/jama.1994.03510350050036
OpenAlex: W4294236164
Cited by: 2,613
References: 0
Citations by year: 2026: 62 · 2025: 84 · 2024: 108 · 2023: 126 · 2022: 123 · 2021: 160 · 2020: 155 · 2019: 142 · 2018: 144 · 2017: 134 · 2016: 163 · 2015: 149 · 2014: 139 · 2013: 145 · 2012: 121
FWCI: 5.68
Type: journal article
Language: en
Open access: closed
Locations: JAMA (publishedVersion)
Funders: National Heart, Lung, and Blood Institute (N01-HC-38038)
National Institute of Neurological Disorders and Stroke (2-R01-NS-17950-11)
Topics: Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Atrial Fibrillation Management and Outcomes
Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiac electrophysiology and arrhythmias
Health Sciences › Medicine › Clinical Neurology › Acute Ischemic Stroke Management
Keywords: atrial fibrillation, risk factors, sex differences, age, diabetes mellitus, hypertension, congestive heart failure, valvular heart disease, myocardial infarction, left ventricular hypertrophy, cardiovascular disease, Framingham Heart Study

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Independent Risk Factors for Atrial Fibrillation in a Population-Based Cohort: The Framingham Heart Study

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