Cited by 150SARS-CoV-2 and COVID-19 ResearchAnimal Virus Infections StudiesCOVID-19 Clinical Research Studies

Neutralizing Antibodies Against SARS-CoV-2 Variants After Infection and Vaccination

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Edara, Venkata Viswanadh, Hudson, William H., Xie, Xuping, Ahmed, Rafi, Suthar, Mehul S.·2021·JAMA

Abstract

Serum neutralizing antibodies rapidly appear after SARS-CoV-2 infection 1 and vaccination 2 and are maintained for several months.3,4 The emergence of SARS-CoV-2 variants has raised concerns about the breadth of neutralizingantibody responses.We compared the neutralizing-antibody response to 4 variants in infected and vaccinated individuals to determine how mutations within the spike protein are associated with virus neutralization.

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Crossref · 10.1001/jama.2021.4388

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  • In the live-virus FRNT neutralization assay, titers to WA1 were higher than those to D614G.

    “By contrast, using the live-virus FRNT neutralization assay (Fig. 1B and Fig. 2B), titers to WA1 were higher than those to D614G, consistent with previous studies of that assay (19).”

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Authors
Edara, V. V., Hudson, W. H., Xie, X., Ahmed, R., & Suthar, M. S.
Affiliations
  • Emory University (US)
  • The University of Texas Medical Branch at Galveston (US)
Corresponding author
Suthar, Mehul S.
Venue
JAMA
Published
2021-05-11
Volume
325
Issue
18
Pages
1896
ISSN
  • 0002-9955 (ISSN-L)
  • 0098-7484
OpenAlex
W3136247297
Cited by
150
References
7
Citations by year
2026: 3 · 2025: 12 · 2024: 9 · 2023: 20 · 2022: 55 · 2021: 51
FWCI
10.68
Type
journal article
Language
en
Open access
Locations
  • JAMA (publishedVersion)
  • Europe PMC (PubMed Central) (publishedVersion)
  • PubMed Central (publishedVersion)
  • PubMed (publishedVersion)
Funders
  • Emory University
  • Children's Healthcare of Atlanta
  • National Institutes of Health (COVID-19, P51OD011132)
  • National Institute on Aging (R00AG049092)
  • National Institute of Allergy and Infectious Diseases (COVID-19, R24AI120942, K99AI153736, U19AI090023, R01AI148378, U01AI150747, R01AI127799, UM1AI148684, U19AI057266)
Topics
  • Health Sciences › Medicine › Infectious Diseases › SARS-CoV-2 and COVID-19 Research
  • Life Sciences › Agricultural and Biological Sciences › Animal Science and Zoology › Animal Virus Infections Studies
  • Health Sciences › Medicine › Infectious Diseases › COVID-19 Clinical Research Studies
Keywords
SARS-CoV-2, neutralizing antibodies, SARS-CoV-2 variants, spike protein mutations, vaccine-induced immunity, natural infection, antibody breadth, virus neutralization
MeSH terms
Immunogenicity, Vaccine, COVID-19, SARS-CoV-2, COVID-19 Vaccines, COVID-19 Serological Testing, Antibodies, Viral, Humans, Antibodies, Neutralizing

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