Neutralizing Antibodies Against SARS-CoV-2 Variants After Infection and Vaccination
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Serum neutralizing antibodies rapidly appear after SARS-CoV-2 infection 1 and vaccination 2 and are maintained for several months.3,4 The emergence of SARS-CoV-2 variants has raised concerns about the breadth of neutralizingantibody responses.We compared the neutralizing-antibody response to 4 variants in infected and vaccinated individuals to determine how mutations within the spike protein are associated with virus neutralization.
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In the live-virus FRNT neutralization assay, titers to WA1 were higher than those to D614G.
“By contrast, using the live-virus FRNT neutralization assay (Fig. 1B and Fig. 2B), titers to WA1 were higher than those to D614G, consistent with previous studies of that assay (19).”
From Durability of mRNA-1273 vaccine–induced antibodies against SARS-CoV-2 variants (2021) · cites this paper as [19]
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- Authors
- Edara, V. V., Hudson, W. H., Xie, X., Ahmed, R., & Suthar, M. S.
- Affiliations
- Emory University (US)
- The University of Texas Medical Branch at Galveston (US)
- Corresponding author
- Suthar, Mehul S.
- Venue
- JAMA
- Publisher
- American Medical Association (AMA)
- Published
- 2021-05-11
- Volume
- 325
- Issue
- 18
- Pages
- 1896
- ISSN
- 0002-9955 (ISSN-L)
- 0098-7484
- PMC
- PMC7980146
- OpenAlex
- W3136247297
- Cited by
- 150
- References
- 7
- Citations by year
- 2026: 3 · 2025: 12 · 2024: 9 · 2023: 20 · 2022: 55 · 2021: 51
- FWCI
- 10.68
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- JAMA (publishedVersion)
- Europe PMC (PubMed Central) (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Emory University
- Children's Healthcare of Atlanta
- National Institutes of Health (COVID-19, P51OD011132)
- National Institute on Aging (R00AG049092)
- National Institute of Allergy and Infectious Diseases (COVID-19, R24AI120942, K99AI153736, U19AI090023, R01AI148378, U01AI150747, R01AI127799, UM1AI148684, U19AI057266)
- Topics
- Health Sciences › Medicine › Infectious Diseases › SARS-CoV-2 and COVID-19 Research
- Life Sciences › Agricultural and Biological Sciences › Animal Science and Zoology › Animal Virus Infections Studies
- Health Sciences › Medicine › Infectious Diseases › COVID-19 Clinical Research Studies
- Keywords
- SARS-CoV-2, neutralizing antibodies, SARS-CoV-2 variants, spike protein mutations, vaccine-induced immunity, natural infection, antibody breadth, virus neutralization
- MeSH terms
- Immunogenicity, Vaccine, COVID-19, SARS-CoV-2, COVID-19 Vaccines, COVID-19 Serological Testing, Antibodies, Viral, Humans, Antibodies, Neutralizing
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