The DOI matches its Crossref record; 21 of the 21 references it cites were found in a registry or an index.
Drug-Induced QT Prolongation in Women During the Menstrual Cycle
Abstract
CONTEXT: Women have a higher incidence of torsades de pointes than men, but it is not known if the risk of drug-induced torsades de pointes varies during the menstrual cycle. OBJECTIVES: To determine if the degree of QT prolongation in response to ibutilide varies with the menstrual cycle phase and to compare QT prolongation between women and men. DESIGN AND SETTING: Cohort study of men and women who received the same intervention conducted between November 1998 and November 2000 at a general clinical research center of a university hospital. PARTICIPANTS: A volunteer sample of 58 healthy adults (38 men and 20 women) aged 21 to 40 years. INTERVENTION: A low dose of ibutilide (0.003 mg/kg), infused intravenously for 10 minutes. Subjects were monitored for 120 minutes. Women received the intervention on 3 separate occasions to correspond with menstrual cycle phases, which were verified by using hormonal assays. MAIN OUTCOME MEASURE: QT interval, recorded from electrocardiogram at timed intervals during and after ibutilide infusion and standardized for variations in heart rate (QTc). RESULTS: Maximum (mean [SD]) millisecond increase in QTc after ibutilide infusion was greater for women during menses (63 [13]) and the ovulatory phase (59 [17]) compared with women during the luteal phase (53 [14]) and compared with men (46 [16]; P =.002 vs menses and P =.007 vs ovulation). Progesterone (r = -0.40) and progesterone-to-estradiol ratio (r = -0.41), but not estradiol (r = 0.14) or testosterone (r = 0.09), were inversely correlated with ibutilide-induced QT prolongation. CONCLUSIONS: Menstrual cycle and sex differences exist in QTc responses to ibutilide, with the greatest increase in QTc corresponding to the first half of the menstrual cycle.
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Die Systolendauer im Elektrokardiogramm bei normalen Menschen und bei Herzkranken
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Makkar, R. R. (1993) · JAMA: The Journal of the American Medical Association · doi:10.1001/jama.1993.03510210076031 · Cited by 971
Sex differences in the evolution of the electrocardiographic QT interval with age.
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Sex Difference in Risk of Torsade de Pointes With d,l- Sotalol
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Influence of Pregnancy on the Risk for Cardiac Events in Patients With Hereditary Long QT Syndrome
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Gender Difference in the Cycle Length-Dependent QT and Potassium Currents in Rabbits
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Gender differences in drug responses
FRANCONI, F., BRUNELLESCHI, S., STEARDO, L., & CUOMO, V (2007) · Pharmacological Research · doi:10.1016/j.phrs.2006.11.001 · Cited by 454
Chapter 1 Gender Differences in Pharmacological Response
Anderson, G. D. (2008) · International Review of Neurobiology · doi:10.1016/s0074-7742(08)00001-9 · Cited by 347
Anderson, G. D. (2005) · Journal of Women's Health · doi:10.1089/jwh.2005.14.19 · Cited by 321
Gender differences in the effects of cardiovascular drugs
Tamargo, J., Rosano, G., Walther, T., Duarte, J., Niessner, A., Kaski, J., Ceconi, C., Drexel, H., Kjeldsen, K., Savarese, G., et al. (2017) · European Heart Journal - Cardiovascular Pharmacotherapy · doi:10.1093/ehjcvp/pvw042 · Cited by 317
Nakamura, H., Kurokawa, J., Bai, C.-X., Asada, K., Xu, J., Oren, R. V., Zhu, Z. I., Clancy, C. E., Isobe, M., & Furukawa, T. (2007) · Circulation · doi:10.1161/circulationaha.107.702407 · Cited by 190
Metadata
- Authors
- Rodriguez, I.
- Venue
- JAMA
- Publisher
- American Medical Association (AMA)
- Published
- 2001-03-14
- Volume
- 285
- Issue
- 10
- Pages
- 1322
- ISSN
- 0002-9955 (ISSN-L)
- 0098-7484
- OpenAlex
- W1969839521
- Cited by
- 311
- References
- 21
- FWCI
- 11.34
- Type
- journal article
- Language
- en
- Open access
- closed
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