Cited by 264Air Quality and Health ImpactsIndoor Air Quality and Microbial ExposureChronic Obstructive Pulmonary Disease (COPD) Research

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Association of Ozone Exposure With Cardiorespiratory Pathophysiologic Mechanisms in Healthy Adults

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Day, Drew B., Xiang, Jianbang, Mo, Jinhan, Li, Feng, Chung, Mingkei, Gong, Jicheng, Weschler, Charles J., Ohman-Strickland, Pamela A., Sundell, Jan, Weng, Wenguo, Zhang, Yinping, Zhang, Junfeng (Jim)·2017·JAMA Internal Medicine

DOI 10.1001/jamainternmed.2017.2842PMC PMC5710579

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Abstract

Importance: Exposure to ozone has been associated with cardiovascular mortality, but the underlying biological mechanisms are not yet understood. Objective: To examine the association between ozone exposure and cardiopulmonary pathophysiologic mechanisms. Design, Setting, and Participants: A longitudinal study involving 89 healthy adult participants living on a work campus in Changsha City, China, was conducted from December 1, 2014, to January 31, 2015. This unique quasiexperimental setting allowed for better characterization of air pollutant exposure effects because the participants spent most of their time in controlled indoor environments. Concentrations of indoor and outdoor ozone, along with the copollutants particulate matter, nitrogen dioxide, and sulfur dioxide, were monitored throughout the study period and then combined with time-activity information and filtration conditions of each residence and office to estimate 24-hour and 2-week combined indoor and outdoor mean exposure concentrations. Associations between each exposure measure and outcome measure were analyzed using single-pollutant and 2-pollutant linear mixed models controlling for ambient temperature, secondhand smoke exposure, and personal-level time-varying covariates. Main Outcomes and Measures: Biomarkers indicative of inflammation and oxidative stress, arterial stiffness, blood pressure, thrombotic factors, and spirometry were measured at 4 sessions. Results: Of the 89 participants, 25 (28%) were women and the mean (SD) age was 31.5 (7.6) years. The 24-hour ozone exposure concentrations ranged from 1.4 to 19.4 parts per billion (ppb), corresponding to outdoor concentrations ranging from 4.3 to 47.9 ppb. Within this range, in models controlling for a second copollutant and other potential confounders, a 10-ppb increase in 24-hour ozone was associated with mean increases of 36.3% (95% CI, 29.9%-43.0%) in the level of platelet activation marker soluble P-selectin, 2.8% (95% CI, 0.6%-5.1%) in diastolic blood pressure, 18.1% (95% CI, 4.5%-33.5%) in pulmonary inflammation markers fractional exhaled nitric oxide, and 31.0% (95% CI, 0.2%-71.1%) in exhaled breath condensate nitrite and nitrate as well as a -9.5% (95% CI, -17.7% to -1.4%) decrease in arterial stiffness marker augmentation index. A 10-ppb increase in 2-week ozone was associated with increases of 61.1% (95% CI, 37.8%-88.2%) in soluble P-selectin level and 126.2% (95% CI, 12.1%-356.2%) in exhaled breath condensate nitrite and nitrate level. Other measured biomarkers, including spirometry, showed no significant associations with either 24-hour ozone or 2-week ozone exposures. Conclusions and Relevance: Short-term ozone exposure at levels not associated with lung function changes was associated with platelet activation and blood pressure increases, suggesting a possible mechanism by which ozone may affect cardiovascular health.

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Benjamini, Y., & Yekutieli, D. (2001) · The Annals of Statistics · doi:10.1214/aos/1013699998 · Cited by 10,490
Lung cancer, cardiopulmonary mortality, and long-term exposure to fine particulate air pollution
Pope III, C. A. (2002) · JAMA · doi:10.1001/jama.287.9.1132 · Cited by 8,447
Expert consensus document on arterial stiffness: methodological issues and clinical applications
Laurent, S., Cockcroft, J., Van Bortel, L., Boutouyrie, P., Giannattasio, C., Hayoz, D., Pannier, B., Vlachopoulos, C., Wilkinson, I., Struijker-Boudier, H., et al. (2006) · European Heart Journal · doi:10.1093/eurheartj/ehl254 · Cited by 6,077
Clinical application of C-reactive protein for cardiovascular disease detection and prevention
Ridker, P. M. (2003) · Circulation · doi:10.1161/01.cir.0000053730.47739.3c · Cited by 2,513
Long-term ozone exposure and mortality
Jerrett, M., Burnett, R. T., Pope, C. A., Ito, K., Thurston, G., Krewski, D., Shi, Y., Calle, E., & Thun, M. (2009) · New England Journal of Medicine · doi:10.1056/nejmoa0803894 · Cited by 1,602
Review of relationship between indoor and outdoor particles: I/O ratio, infiltration factor and penetration factor
Chen, C., & Zhao, B. (2010) · Atmospheric Environment · doi:10.1016/j.atmosenv.2010.09.048 · Cited by 993
Long-term ozone exposure and mortality in a large prospective study
Turner, M. C., Jerrett, M., Pope, C. A., Krewski, D., Gapstur, S. M., Diver, W. R., Beckerman, B. S., Marshall, J. D., Su, J., Crouse, D. L., et al. (2016) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/rccm.201508-1633oc · Cited by 938
Lung Cancer and Cardiovascular Disease Mortality Associated with Ambient Air Pollution and Cigarette Smoke: Shape of the Exposure–Response Relationships
Pope, C. A., Burnett, R. T., Turner, M. C., Cohen, A., Krewski, D. R., Jerrett, M., Gapstur, S. M., & Thun, M. J. (2011) · Environmental Health Perspectives · doi:10.1289/ehp.1103639 · Cited by 764
Ozone in Indoor Environments: Concentration and Chemistry
Weschler, C. J. (2000) · Indoor Air · doi:10.1034/j.1600-0668.2000.010004269.x · Cited by 762
The effect of urban air pollution on inflammation, oxidative stress, coagulation, and autonomic dysfunction in young adults
Chuang, K.-J., Chan, C.-C., Su, T.-C., Lee, C.-T., & Tang, C.-S. (2007) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/rccm.200611-1627oc · Cited by 685

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[11]Brown J, Bowman C. Integrated Science Assessment for Ozone and Related Photochemical Oxidants. Washington, DC: US Environmental Protection Agency; 2013. [Google Scholar]
[32]US Environmental Protection Agency . Policy Assessment for the Review of the Ozone National Ambient Air Quality Standards. Research Triangle Park, NC: US Environmental Protection Agency, Office of Air and Radiation, Office of Air Quality Planning and Standards, Health and Environmental Impacts Division, Ambient Standards Group; 2014. [Google Scholar]

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Ozone exposure and prothrombosis: Mechanistic insights from a randomized controlled exposure trial
Niu, Y., Li, H., Wang, W., Wang, C., Liu, C., Du, X., Zhang, Q., Li, J., Shi, S., Meng, X., et al. (2022) · Journal of Hazardous Materials · doi:10.1016/j.jhazmat.2022.128322 · Cited by 36
Nitrated Polycyclic Aromatic Hydrocarbons and Arachidonic Acid Metabolisms Relevant to Cardiovascular Pathophysiology: Findings from a Panel Study in Healthy Adults
He, L., Lin, Y., Day, D. B., Teng, Y., Wang, X., Liu, X. L., Yan, E., Gong, J., Qin, J., Wang, X., et al. (2021) · Environmental Science & Technology · doi:10.1021/acs.est.0c08150 · Cited by 36
Associations of long-term exposure to ambient ozone with hypertension, blood pressure, and the mediation effects of body mass index: A national cross-sectional study of middle-aged and older adults in China
Niu, Z., Duan, Z., Wei, J., Wang, F., Han, D., Zhang, K., Jing, Y., Wen, W., Qin, W., & Yang, X. (2022) · Ecotoxicology and Environmental Safety · doi:10.1016/j.ecoenv.2022.113901 · Cited by 38
The effect of ambient ozone on glucose-homoeostasis: A prospective study of non-diabetic older adults in Beijing
Li, A., Mei, Y., Zhao, M., Xu, J., Seery, S., Li, R., Zhao, J., Zhou, Q., Ge, X., & Xu, Q. (2020) · The Science of The Total Environment · doi:10.1016/j.scitotenv.2020.143308 · Cited by 34
Sulfur dioxide may predominate in the adverse effects of ambient air pollutants on semen quality among the general population in Hefei, China
Zhang, F., Li, H., Xu, W., Song, G., Wang, Z., Mao, X., Wei, Y., Dai, M., Zhang, Y., Shen, Q., et al. (2023) · The Science of The Total Environment · doi:10.1016/j.scitotenv.2023.161472 · Cited by 34
The impact of short-lived climate pollutants on the human health
Mathew, N., Somanathan, A., Tirpude, A., & Arfin, T. (2024) · Environmental Pollution and Management · doi:10.1016/j.epm.2024.04.001 · Cited by 37
Associations of ambient fine particulate matter and its constituents with serum complement C3 in a panel study of older adults in China
Pei, L., Zhao, M., Xu, J., Li, A., Luo, K., Li, R., Yang, M., & Xu, Q. (2019) · Environmental Pollution · doi:10.1016/j.envpol.2019.05.096 · Cited by 33
Impacts of implementing Healthy Building guidelines for daily PM2.5 limit on premature deaths and economic losses in urban China: A population-based modeling study
Xiang, J., Seto, E., Mo, J., Zhang, J. J., & Zhang, Y. (2021) · Environment International · doi:10.1016/j.envint.2020.106342 · Cited by 32
Effect of ozone aging on light absorption and fluorescence of brown carbon in soot particles: The important role of polycyclic aromatic hydrocarbons
Kuang, Y., Shang, J., & Chen, Q. (2021) · Journal of Hazardous Materials · doi:10.1016/j.jhazmat.2021.125406 · Cited by 34
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Agarwala, R., Wang, P., Bishop, H. L., Dissanayake, A., & Calhoun, B. H. (2021) · IEEE Journal of Solid-State Circuits · doi:10.1109/jssc.2021.3057229 · Cited by 32
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Li, J., Liu, F., Liang, F., Yang, Y., Lu, X., & Gu, D. (2023) · Environmental Science and Pollution Research · doi:10.1007/s11356-023-25156-9 · Cited by 33
Effects of air purification of indoor PM 2.5 on the cardiorespiratory biomarkers in young healthy adults
Wang, Y., Zhao, Y., Xue, L., Wu, S., Wang, B., Li, G., Huang, J., & Guo, X. (2021) · Indoor Air · doi:10.1111/ina.12815 · Cited by 30
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Qiu, H., Chuang, K.-J., Bai, C., Fan, Y., Chang, T.-P., Yim, S. H. L., Wong, T.-W., & Ho, K. (2021) · Environment International · doi:10.1016/j.envint.2021.106634 · Cited by 28
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Association of long-term ozone air pollution and age-related macular degeneration in older Chinese population
Jia, H., Guo, Y., Luo, H., Meng, X., Zhang, L., Yu, K., Zheng, X., Sun, Y., Hu, W., Wu, Z., et al. (2023) · The Science of The Total Environment · doi:10.1016/j.scitotenv.2023.169145 · Cited by 29
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Moshammer, H. M., Panholzer, J., Ulbing, L., Udvarhelyi, E., Ebenbauer, B., & Peter, S. (2019) · International Journal of Environmental Research and Public Health · doi:10.3390/ijerph16050788 · Cited by 31
Associations between short-term ambient ozone exposure and cause-specific mortality in rural and urban areas of Jiangsu, China
Lin, C., Ma, Y., Liu, R., Shao, Y., Ma, Z., Zhou, L., Jing, Y., Bell, M. L., & Chen, K. (2022) · Environmental Research · doi:10.1016/j.envres.2022.113098 · Cited by 29
Ozone Reaction Products Associated with Biomarkers of Cardiorespiratory Pathophysiology
He, L., Weschler, C. J., Zhang, Y., Li, F., Bergin, M., Black, M. S., & Zhang, J. J. (2023) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/rccm.202212-2203le · Cited by 29
The association between ozone and years of life lost from stroke, 2013–2017: A retrospective regression analysis in 48 major Chinese cities
Li, J., Huang, J., Cao, R., Yin, P., Wang, L., Liu, Y., Pan, X., Li, G., & Zhou, M. (2020) · Journal of Hazardous Materials · doi:10.1016/j.jhazmat.2020.124220 · Cited by 28
Contribution of Bacillus cereus ERBP in ozone detoxification by Zamioculcas zamiifolia plants: Effect of ascorbate peroxidase, catalase and total flavonoid contents for ozone detoxification
Pheomphun, P., Treesubsuntorn, C., Jitareerat, P., & Thiravetyan, P. (2019) · Ecotoxicology and Environmental Safety · doi:10.1016/j.ecoenv.2019.01.028 · Cited by 28
Associations of ozone exposure with urinary metabolites of arachidonic acid
He, L., Lin, Y., Wang, X., Liu, X., Wang, Y., Qin, J., Wang, X., Day, D. B., Xiang, J., Mo, J., et al. (2020) · Environment International · doi:10.1016/j.envint.2020.106154 · Cited by 27
Green Design Studio: A modular-based approach for high-performance building design
Shen, J., Krietemeyer, B., Bartosh, A., Gao, Z. J., & Zhang, J. “. (2020) · Building Simulation · doi:10.1007/s12273-020-0728-9 · Cited by 27
Cardiorespiratory Effects of Indoor Ozone Exposure Associated with Changes in Metabolic Profiles among Children: A Repeated-Measure Panel Study
Liu, S., Huang, Q., Zhang, X., Dong, W., Zhang, W., Wu, S., Yang, D., Nan, B., Zhang, J., Shen, H., et al. (2021) · The Innovation · doi:10.1016/j.xinn.2021.100087 · Cited by 27
Associations between time-weighted personal air pollution exposure and amino acid metabolism in healthy adults
Hu, X., Yan, M., He, L., Qiu, X., Zhang, J. J., Zhang, Y., Mo, J., Day, D. B., Xiang, J., & Gong, J. (2021) · Environment International · doi:10.1016/j.envint.2021.106623 · Cited by 27
Effects of personal air pollutant exposure on oxidative stress: Potential confounding by natural variation in melatonin levels
He, L., Cui, X., Xia, Q., Li, F., Mo, J., Gong, J., Zhang, Y., & Zhang, J. J. (2019) · International Journal of Hygiene and Environmental Health · doi:10.1016/j.ijheh.2019.09.012 · Cited by 27
Short-term effects of air pollution and temperature on cattle mortality in the Netherlands
Egberts, V., Schaik, G. V., Brunekreef, B., & Hoek, G. (2019) · Preventive Veterinary Medicine · doi:10.1016/j.prevetmed.2019.03.021 · Cited by 26
Low-Level Air Pollution Associated With Death: Policy and Clinical Implications
Zhang, J. (2017) · JAMA · doi:10.1001/jama.2017.18948 · Cited by 24
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Liu, S., Shu, L., Zhu, L., Song, Y., Sun, W., Chen, Y., Wang, D., Pu, D., Li, X., Sun, S., et al. (2024) · Earth s Future · doi:10.1029/2023ef003937 · Cited by 25
Joint Effect of Short-Term Exposure to Fine Particulate Matter and Ozone on Mortality: A Time Series Study in 272 Chinese Cities
Xu, C., Yin, P., Jiang, Y., Lin, X., Shi, S., Li, X., Chen, J., Jiang, Y., Meng, X., & Zhou, M. (2024) · Environmental Science & Technology · doi:10.1021/acs.est.3c10951 · Cited by 24
Effect of environmental air pollutants on placental function and pregnancy outcomes: a molecular insight
Singh, S. K., Goel, I., Tripathi, S., Ahirwar, A. K., Kumar, M., Rana, A., Dhar, R., & Karmakar, S. (2024) · Environmental Science and Pollution Research · doi:10.1007/s11356-024-35016-9 · Cited by 26
Acute ozone exposure can cause cardiotoxicity: Mitochondria play an important role in mediating myocardial apoptosis
Tian, L., Chu, N., Yang, H., Yan, J., Lin, B., Zhang, W., Li, K., Lai, W., Bian, L., Liu, H., et al. (2020) · Chemosphere · doi:10.1016/j.chemosphere.2020.128838 · Cited by 24
Adverse short-term effects of ozone on cardiovascular mortalities modified by season and temperature: a time-series study
Gao, P., Wu, Y., He, L., Li, W., Fu, Y., Chen, J., Zhang, F., Krafft, T., & Martens, P. (2023) · Frontiers in Public Health · doi:10.3389/fpubh.2023.1182337 · Cited by 26
Association between short-term exposure to ambient air pollutants and biomarkers indicative of inflammation and oxidative stress: a cross-sectional study using KoGES-HEXA data
Kim, J. H., Woo, H. D., Lee, J., Song, D. S., & Lee, K. (2024) · Environmental Health and Preventive Medicine · doi:10.1265/ehpm.23-00199 · Cited by 25
Fine particulate matter control performance of a new kind of suspended fan filter unit for use in office buildings
Ren, J., & Liu, J. (2018) · Building and Environment · doi:10.1016/j.buildenv.2018.12.047 · Cited by 22

Authors: Day, D. B., Xiang, J., Mo, J., Li, F., Chung, M., Gong, J., Weschler, C. J., Ohman-Strickland, P. A., Sundell, J., Weng, W., Zhang, Y., & Zhang, J. (.
Affiliations: Duke University (US)
Tsinghua University (CN)
Shanghai Jiao Tong University (CN)
Global Health Research Center, Duke Kunshan University, Kunshan, Jiangsu Province, China
Rutgers, The State University of New Jersey (US)
Environmental and Occupational Health Sciences Institute, Rutgers University, Piscataway, New Jersey
Corresponding author: Zhang, Junfeng (Jim)
ORCID: Day, Drew B.
Xiang, Jianbang
Mo, Jinhan
Li, Feng
Gong, Jicheng
Weschler, Charles J.
Sundell, Jan
Weng, Wenguo
Zhang, Yinping
Zhang, Junfeng (Jim)
Venue: JAMA Internal Medicine
Publisher: American Medical Association (AMA)
Published: 2017-09-01
Volume: 177
Issue: 9
Pages: 1344
ISSN: 2168-6106 (ISSN-L)
DOI: 10.1001/jamainternmed.2017.2842
PMC: PMC5710579
OpenAlex: W2736092386
Cited by: 264
References: 50
Citations by year: 2026: 19 · 2025: 31 · 2024: 39 · 2023: 23 · 2022: 37 · 2021: 29 · 2020: 33 · 2019: 34 · 2018: 15 · 2017: 3
FWCI: 12.54
Type: journal article
Language: en
Open access: green
www.ncbi.nlm.nih.gov
Locations: JAMA Internal Medicine (publishedVersion)
Europe PMC (PubMed Central) (publishedVersion)
PubMed Central (publishedVersion)
PubMed (publishedVersion)
Topics: Physical Sciences › Environmental Science › Health, Toxicology and Mutagenesis › Air Quality and Health Impacts
Physical Sciences › Environmental Science › Health, Toxicology and Mutagenesis › Indoor Air Quality and Microbial Exposure
Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Chronic Obstructive Pulmonary Disease (COPD) Research
Keywords: ozone exposure, air pollution health effects, oxidative stress, inflammation, arterial stiffness, blood pressure, platelet activation, soluble P-selectin, exhaled nitric oxide, lung function, spirometry, particulate matter, nitrogen dioxide, sulfur dioxide
MeSH terms: Adult, Air Pollution, Breath Tests, Cardiovascular Diseases, China, Environmental Exposure, Female, Humans, Male, Nitrates, Nitrites, Nitrogen Dioxide, Ozone, Pneumonia, Prothrombin Time, Spirometry, Oxidative Stress, Vascular Stiffness

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Association of Ozone Exposure With Cardiorespiratory Pathophysiologic Mechanisms in Healthy Adults

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