Magnetic Resonance Imaging Alteration of the Brain in a Patient With Coronavirus Disease 2019 (COVID-19) and Anosmia
Open accessAbstract
This case report describes a 25-year-old female radiographer with no significant medical history who had been working in a coronavirus disease 2019 (COVID-19) ward who presented with a mild dry cough that lasted for 1 day, followed by persistent severe anosmia and dysgeusia.
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Image studies and postmortem examination of the brain of COVID-19 patients revealed hemorrhagic lesions accompanied by neuronal injury and neuroinflammation signals.
“Image studies [12, 13] and postmortem examination [14] of the brain of COVID-19 patients also revealed hemorrhagic lesions accompanied by neuronal injury and neuroinflammation signals.”
From Hyperactivation of P2X7 receptors as a culprit of COVID-19 neuropathology (2021) · cites this paper as [12]
Two anosmic COVID-19 patients had fMRI-identified hyperintensity in both olfactory bulbs that reverted to normal after resolution of anosmia, consistent with central involvement in at least some cases.
“Two anosmic COVID-19 patients have presented with fMRI-identified hyperintensity in both OBs that reverted to normal after resolution of the anosmia (58, 59), consistent with central involvement in at least some cases.”
From Non-neuronal expression of SARS-CoV-2 entry genes in the olfactory system suggests mechanisms underlying COVID-19-associated anosmia (2020) · cites this paper as [58]
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COVID-19-Related Anosmia: The Olfactory Pathway Hypothesis and Early Intervention
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- Authors
- Politi, L. S., Salsano, E., & Grimaldi, M.
- Affiliations
- Boston Children's Hospital (US)
- Fondazione IRCCS Istituto Neurologico Carlo Besta (IT)
- Humanitas University (IT)
- Corresponding author
- Politi, Letterio S.
- Venue
- JAMA Neurology
- Publisher
- American Medical Association (AMA)
- Published
- 2020-08-01
- Volume
- 77
- Issue
- 8
- Pages
- 1028
- ISSN
- 2168-6149 (ISSN-L)
- OpenAlex
- W3031398513
- Cited by
- 369
- References
- 6
- Citations by year
- 2026: 5 · 2025: 10 · 2024: 21 · 2023: 29 · 2022: 74 · 2021: 127 · 2020: 100 · 2018: 3
- FWCI
- 35.72
- Type
- journal article
- Language
- en
- Open access
- Licence
- other-oa
- Locations
- JAMA Neurology (publishedVersion)
- PubMed (publishedVersion)
- The Journal of the American Medical Association (JAMA) Network (American Medical Association) (submittedVersion)
- BOA (University of Milano-Bicocca) (submittedVersion)
- INFM-OAR (INFN Catania) (submittedVersion, other-oa)
- Zenodo (CERN European Organization for Nuclear Research) (other-oa)
- Topics
- Health Sciences › Medicine › Neurology › Long-Term Effects of COVID-19
- Life Sciences › Neuroscience › Sensory Systems › Olfactory and Sensory Function Studies
- Health Sciences › Medicine › Infectious Diseases › COVID-19 Clinical Research Studies
- Keywords
- COVID-19 pandemic, anosmia, dysgeusia, brain MRI abnormalities, olfactory dysfunction, neuroimaging findings
- MeSH terms
- Betacoronavirus, COVID-19, SARS-CoV-2, Adult, Olfaction Disorders, Brain, Female, Humans, Magnetic Resonance Imaging, Pneumonia, Viral, Coronavirus Infections, Pandemics
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