Cited by 152Tryptophan and brain disordersNeuroinflammation and Neurodegeneration MechanismsStress Responses and Cortisol

Therapeutic Implications of Brain–Immune Interactions: Treatment in Translation

Open access
Miller, Andrew H, Haroon, Ebrahim, Felger, Jennifer C·2017·Neuropsychopharmacology

Abstract

A wealth of data has been amassed that details a complex, yet accessible, series of pathways by which the immune system, notably inflammation, can influence the brain and behavior. These data have opened the window to a diverse array of novel targets whose potential efficacy is tied to specific neurotransmitters and neurocircuits as well as specific behaviors. What is clear is that the impact of inflammation on the brain cuts across psychiatric disorders and engages dopaminergic and glutamatergic pathways that regulate motivation and motor activity as well as the sensitivity to threat. Given the ability to identify patient populations with increased inflammation, the precision of interventions can be further tuned, in conjunction with the ability to establish target engagement in the brain through the use of multiple neuroimaging strategies. After a brief overview of the mechanisms by which inflammation affects the brain and behavior, this review examines the extant literature on the efficacy of anti-inflammatory treatments, while forging guidelines for future intelligent clinical trial design. An examination of the most promising therapeutic strategies is also provided, along with some of the most exciting clinical trials that are currently being planned or underway.

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

A few free checks a day · papers already verified open instantly · results are public

Integrity signals

Registry

Crossref · 10.1038/npp.2016.167

Cites

241 of 241 references verified0 citation errors · 0 not checkable

Statistics

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

A few free checks a day · papers already verified open instantly · results are public

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

Cites

Flagged first, then by citations

Research works printed but not linked: 2

  1. REVIEW ................................................................................................................................................... Neuropsychopharmacology REVIEWS
  2. REVIEW ................................................................................................................................................... Neuropsychopharmacology REVIEWS

Cited by

Sorted by citations

Authors
Miller, A. H., Haroon, E., & Felger, J. C.
Affiliations
Emory University (US)
Corresponding author
Miller, Andrew H
Venue
Neuropsychopharmacology
Published
2016-08-24
Volume
42
Issue
1
Pages
334-359
ISSN
  • 0893-133X (ISSN-L)
  • 1740-634X
OpenAlex
W2507921187
Cited by
152
References
241
Citations by year
2026: 13 · 2025: 16 · 2024: 8 · 2023: 10 · 2022: 25 · 2021: 19 · 2020: 18 · 2019: 10 · 2018: 20 · 2017: 10 · 2016: 3
FWCI
0.86
Type
journal article
Language
en
Open access
Locations
  • Neuropsychopharmacology (publishedVersion)
  • PubMed Central (publishedVersion)
  • PubMed (publishedVersion)
Funders
  • National Institutes of Health (UL1TR000454, UL1TR002378)
  • National Institute of Mental Health (R21MH077172, R01MH083746, R01MH112076, R21MH106904, R03MH100273, R01MH109637, R01MH107033, R01MH087604, R21MH105897)
  • National Cancer Institute (P30CA138292)
  • National Center for Research Resources (UL1RR025008)
Topics
  • Life Sciences › Neuroscience › Biological Psychiatry › Tryptophan and brain disorders
  • Life Sciences › Neuroscience › Neurology › Neuroinflammation and Neurodegeneration Mechanisms
  • Life Sciences › Neuroscience › Behavioral Neuroscience › Stress Responses and Cortisol
Keywords
neuroimmune interactions, neuroinflammation, anti-inflammatory therapy, mental illness, dopaminergic pathways, glutamatergic pathways, motivation, threat sensitivity, neuroimaging, clinical trial design, translational research
MeSH terms
Animals, Mental Disorders, Brain, Humans, Inflammation, Neurotransmitter Agents

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review