Cited by 331Musculoskeletal pain and rehabilitationPain Management and TreatmentPain Management and Placebo Effect

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Effect of Pain Reprocessing Therapy vs Placebo and Usual Care for Patients With Chronic Back Pain: A Randomized Clinical Trial

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Ashar, Yoni K., Gordon, Alan, Schubiner, Howard, Uipi, Christie, Knight, Karen, Anderson, Zachary, Carlisle, Judith, Polisky, Laurie, Geuter, Stephan, Flood, Thomas F., Kragel, Philip A., Dimidjian, Sona, Lumley, Mark A., Wager, Tor D.·2022·JAMA Psychiatry

DOI 10.1001/jamapsychiatry.2021.2669PMC PMC8482298

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Abstract

Importance: Chronic back pain (CBP) is a leading cause of disability, and treatment is often ineffective. Approximately 85% of cases are primary CBP, for which peripheral etiology cannot be identified, and maintenance factors include fear, avoidance, and beliefs that pain indicates injury. Objective: To test whether a psychological treatment (pain reprocessing therapy [PRT]) aiming to shift patients' beliefs about the causes and threat value of pain provides substantial and durable pain relief from primary CBP and to investigate treatment mechanisms. Design, Setting, and Participants: This randomized clinical trial with longitudinal functional magnetic resonance imaging (fMRI) and 1-year follow-up assessment was conducted in a university research setting from November 2017 to August 2018, with 1-year follow-up completed by November 2019. Clinical and fMRI data were analyzed from January 2019 to August 2020. The study compared PRT with an open-label placebo treatment and with usual care in a community sample. Interventions: Participants randomized to PRT participated in 1 telehealth session with a physician and 8 psychological treatment sessions over 4 weeks. Treatment aimed to help patients reconceptualize their pain as due to nondangerous brain activity rather than peripheral tissue injury, using a combination of cognitive, somatic, and exposure-based techniques. Participants randomized to placebo received an open-label subcutaneous saline injection in the back; participants randomized to usual care continued their routine, ongoing care. Main Outcomes and Measures: One-week mean back pain intensity score (0 to 10) at posttreatment, pain beliefs, and fMRI measures of evoked pain and resting connectivity. Results: At baseline, 151 adults (54% female; mean [SD] age, 41.1 [15.6] years) reported mean (SD) pain of low to moderate severity (mean [SD] pain intensity, 4.10 [1.26] of 10; mean [SD] disability, 23.34 [10.12] of 100) and mean (SD) pain duration of 10.0 (8.9) years. Large group differences in pain were observed at posttreatment, with a mean (SD) pain score of 1.18 (1.24) in the PRT group, 2.84 (1.64) in the placebo group, and 3.13 (1.45) in the usual care group. Hedges g was -1.14 for PRT vs placebo and -1.74 for PRT vs usual care (P < .001). Of 151 total participants, 33 of 50 participants (66%) randomized to PRT were pain-free or nearly pain-free at posttreatment (reporting a pain intensity score of 0 or 1 of 10), compared with 10 of 51 participants (20%) randomized to placebo and 5 of 50 participants (10%) randomized to usual care. Treatment effects were maintained at 1-year follow-up, with a mean (SD) pain score of 1.51 (1.59) in the PRT group, 2.79 (1.78) in the placebo group, and 3.00 (1.77) in the usual care group. Hedges g was -0.70 for PRT vs placebo (P = .001) and -1.05 for PRT vs usual care (P < .001) at 1-year follow-up. Longitudinal fMRI showed (1) reduced responses to evoked back pain in the anterior midcingulate and the anterior prefrontal cortex for PRT vs placebo; (2) reduced responses in the anterior insula for PRT vs usual care; (3) increased resting connectivity from the anterior prefrontal cortex and the anterior insula to the primary somatosensory cortex for PRT vs both control groups; and (4) increased connectivity from the anterior midcingulate to the precuneus for PRT vs usual care. Conclusions and Relevance: Psychological treatment centered on changing patients' beliefs about the causes and threat value of pain may provide substantial and durable pain relief for people with CBP. Trial Registration: ClinicalTrials.gov Identifier: NCT03294148.

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Figure 1. CONSORT Participant Flow Diagram MRI indicates magnetic resonance imaging.CC BY · PubMed Central

Figure 2. Clinical Outcomes A, Shading indicates standard error. B, Dots represent individual participants; thick lines represent the group mean. C, Percentage of patients reporting pain scores of 0 or 1 of 10 (ie, pain-free or nearly pain-free) at posttreatment and at 1-year follow-up. PRT indicates pain reprocessing therapy.CC BY · PubMed Central

Figure 3. Effects of Treatment on Evoked and Spontaneous Back Pain and Related Brain Function A, Error bars show standard error. B, Coordinates and statistics for activations provided in eTable 7 in Supplement 2; analyses conducted within a mask of regions of interest; eFigure 1 in Supplement 2. C, Decreased evoked pain-related activity was observed in anterior midcingulate (aMCC) and anterior prefrontal regions for PRT vs placebo and left anterior insula for PRT vs usual care. D, Error bars show standard error. E, PRT vs control conditions increased aPFC-seeded (red clusters) and aIns-seeded (green clusters) connectivity with primary somatosensory cortex (permutation test, P < .05). Inset shows seed regions, derived from evoked pain analyses; magenta outlines, PRT vs placebo; black outlines, PRT vs usual care. F, PRT vs usual care increased connectivity between an aMCC seed (yellow; derived from evoked back pain analyses) and the precuneus (orange). Connectivity analyses were conducted within primary somatosensory cortex and medial default mode network masks. aP < .001. bP < .05.CC BY · PubMed Central

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Research works printed but not linked: 1

Schubiner, 2010, Unlearn Your Pain

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See all 331

Authors: Ashar, Y. K., Gordon, A., Schubiner, H., Uipi, C., Knight, K., Anderson, Z., Carlisle, J., Polisky, L., Geuter, S., Flood, T. F., Kragel, P. A., Dimidjian, S., Lumley, M. A., & Wager, T. D.
Affiliations: University of Colorado Boulder (US)
Pain Psychology Center, Los Angeles, California
Ascension Providence Hospital (US)
Panorama Orthopedics and Spine Center, Golden, Colorado
Northwestern University (US)
Johns Hopkins University (US)
Brigham and Women's Hospital (US)
Emory University (US)
Wayne State University (US)
Dartmouth College (US)
Corresponding author: Ashar, Yoni K.
Wager, Tor D.
ORCID: Ashar, Yoni K.
Schubiner, Howard
Uipi, Christie
Anderson, Zachary
Carlisle, Judith
Geuter, Stephan
Flood, Thomas F.
Kragel, Philip A.
Dimidjian, Sona
Lumley, Mark A.
Wager, Tor D.
Venue: JAMA Psychiatry
Publisher: American Medical Association (AMA)
Published: 2022-01-01
Volume: 79
Issue: 1
Pages: 13
ISSN: 2168-622X (ISSN-L)
DOI: 10.1001/jamapsychiatry.2021.2669
PMC: PMC8482298
OpenAlex: W3204387157
Cited by: 331
References: 82
Citations by year: 2026: 87 · 2025: 80 · 2024: 85 · 2023: 45 · 2022: 32
FWCI: 23.94
Type: journal article
Language: en
Open access: hybrid
doi.org
Licence: cc-by
Locations: JAMA Psychiatry (publishedVersion, cc-by)
PubMed Central (publishedVersion, cc-by)
PubMed (publishedVersion)
Funders: Deutsche Forschungsgemeinschaft
National Institutes of Health (TL1TR002386)
National Institute of Mental Health (R01MH076136)
National Institute on Drug Abuse (R01DA035484)
National Center for Advancing Translational Sciences
Topics: Health Sciences › Health Professions › Physical Therapy, Sports Therapy and Rehabilitation › Musculoskeletal pain and rehabilitation
Health Sciences › Medicine › Anesthesiology and Pain Medicine › Pain Management and Treatment
Life Sciences › Neuroscience › Cognitive Neuroscience › Pain Management and Placebo Effect
Keywords: chronic back pain, pain beliefs, fear avoidance, placebo effect, psychological intervention, telemedicine, evoked pain, resting-state functional connectivity, therapeutic mechanisms, pain intensity, disability, treatment durability, fear-avoidance beliefs, pain catastrophizing, pain-related guilt, pain-related shame, pain-related hopelessness
MeSH terms: Adult, Back Pain, Disability Evaluation, Female, Humans, Male, Middle Aged, Pain, Treatment Outcome, Pain Management

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Effect of Pain Reprocessing Therapy vs Placebo and Usual Care for Patients With Chronic Back Pain: A Randomized Clinical Trial

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