The somatosensory link in fibromyalgia: functional connectivity of the primary somatosensory cortex is altered by sustained pain and is associated with clinical/autonomic dysfunction
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Objective: Fibromyalgia (FM) is a chronic functional pain syndrome characterized by widespread pain, significant pain catastrophizing, sympathovagal dysfunction, and amplified temporal summation for evoked pain. While several studies have demonstrated altered resting brain connectivity in FM, studies have not specifically probed the somatosensory system and its role in both somatic and nonsomatic FM symptoms. Our objective was to evaluate resting primary somatosensory cortex (S1) connectivity and to explore how sustained, evoked deep tissue pain modulates this connectivity. Methods: We acquired functional magnetic resonance imaging and electrocardiography data on FM patients and healthy controls during rest (the rest phase) and during sustained mechanical pressure–induced pain over the lower leg (the pain phase). Functional connectivity associated with different S1 subregions was calculated, while S1 leg connectivity (representation of the leg in the primary somatosensory cortex) was contrasted between the rest phase and the pain phase and was correlated with clinically relevant measures in FM. Results: During the rest phase, FM patients showed decreased connectivity between multiple ipsilateral and cross‐hemispheric S1 subregions, which was correlated with clinical pain severity. Compared to the rest phase, the pain phase produced increased S1 leg connectivity to the bilateral anterior insula in FM patients, but not in healthy controls. Moreover, in FM patients, sustained pain–altered S1 leg connectivity to the anterior insula was correlated with clinical/behavioral pain measures and autonomic responses. Conclusion: Our study demonstrates that both somatic and nonsomatic dysfunction in FM, including clinical pain, pain catastrophizing, autonomic dysfunction, and amplified temporal summation, are closely linked with the degree to which evoked deep tissue pain alters S1 connectivity to salience/affective pain‐processing regions. Additionally, diminished connectivity between S1 subregions during the rest phase in FM may result from ongoing widespread clinical pain.
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Women report using catastrophizing, behavioral activities, positive self-statements, social and emotional support, and problem-focused coping more often than men.
“compared to men, women have endorsed more frequent use of catastrophizing, behavioral activities, positive self-statements, social and emotional support, and problem-focused coping 148, 201–204.”
From Evaluating psychosocial contributions to chronic pain outcomes (2018) · cites this paper as [201]
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An inventory for measuring depression
BECK, A. T. (1961) · Archives of General Psychiatry · doi:10.1001/archpsyc.1961.01710120031004 · Cited by 38,032 · see citing works
Heart Rate Variability: Standards of Measurement, Physiological Interpretation, and Clinical Use
Electrophysiology, T. F. O. T. E. S. O. C. T. N. A. (1996) · Circulation · doi:10.1161/01.cir.93.5.1043 · Cited by 17,159 · see citing works
Heart rate variability: Standards of measurement, physiological interpretation, and clinical use
Malik, M., Bigger, J. T., Camm, A. J., Kleiger, R. E., Malliani, A., Moss, A. J., & Schwartz, P. J. (1996) · European Heart Journal · doi:10.1093/oxfordjournals.eurheartj.a014868 · Cited by 15,289 · see citing works
The Pain Catastrophizing Scale: Development and validation.
Sullivan, M. J. L., Bishop, S. R., & Pivik, J. (1995) · Psychological Assessment · doi:10.1037//1040-3590.7.4.524 · Cited by 8,227 · see citing works
Dissociable intrinsic connectivity networks for salience processing and executive control
Seeley, W. W., Menon, V., Schatzberg, A. F., Keller, J., Glover, G. H., Kenna, H., Reiss, A. L., & Greicius, M. D. (2007) · The Journal of Neuroscience · doi:10.1523/jneurosci.5587-06.2007 · Cited by 7,426 · see citing works
How do you feel — now? The anterior insula and human awareness
(Bud) Craig, A. D. (2009) · Nature Reviews Neuroscience · doi:10.1038/nrn2555 · Cited by 6,657 · cited 1× · see citing works
“The anterior insula is also known to control autonomic response for both internally driven processes and external sensory stimuli (44, 45), and is a core component of the central autonomic network for both sympathetic and parasympathetic modulation(46).”
BackgroundFunctional connectivity in the resting brain: a network analysis of the default mode hypothesis
Greicius, M. D., Krasnow, B., Reiss, A. L., & Menon, V. (2003) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0135058100 · Cited by 6,358 · see citing works
Wolfe, F., Clauw, D. J., Fitzcharles, M., Goldenberg, D. L., Katz, R. S., Mease, P., Russell, A. S., Russell, I. J., Winfield, J. B., & Yunus, M. B. (2010) · Arthritis Care & Research · doi:10.1002/acr.20140 · Cited by 3,952 · see citing works
Accurate and robust brain image alignment using boundary-based registration
Greve, D. N., & Fischl, B. R. (2009) · NeuroImage · doi:10.1016/j.neuroimage.2009.06.060 · Cited by 3,553 · see citing works
Neural systems supporting interoceptive awareness
Critchley, H. D., Wiens, S., Rotshtein, P., Öhman, A., & Dolan, R. J. (2004) · Nature Neuroscience · doi:10.1038/nn1176 · Cited by 3,406 · cited 1× · see citing works
“The anterior insula is also known to control autonomic response for both internally driven processes and external sensory stimuli (44, 45), and is a core component of the central autonomic network for both sympathetic and parasympathetic modulation(46).”
BackgroundKubios HRV–heart rate variability analysis software.
Tarvainen, M. P., Niskanen, J.-P., Lipponen, J. A., Ranta-aho, P. O., & Karjalainen, P. A. (2014) · Computer Methods and Programs in Biomedicine · doi:10.1016/j.cmpb.2013.07.024 · Cited by 2,720 · cited 1× · see citing works
“HRV estimation was performed using the previously validated Kubios-HRV software (19).”
MethodThe influence of head motion on intrinsic functional connectivity MRI
Van Dijk, K. R. A., Sabuncu, M. R., & Buckner, R. L. (2012) · NeuroImage · doi:10.1016/j.neuroimage.2011.07.044 · Cited by 2,344 · see citing works
Van Dijk, K. R. A., Hedden, T., Venkataraman, A., Evans, K. C., Lazar, S. W., & Buckner, R. L. (2010) · Journal of Neurophysiology · doi:10.1152/jn.00783.2009 · Cited by 1,844 · see citing works
Fibromyalgia: A Clinical Review
Clauw, D. J. (2014) · JAMA · doi:10.1001/jama.2014.3266 · Cited by 1,674 · see citing works
Validation of the Brief Pain Inventory for chronic nonmalignant pain
Tan, G., Jensen, M. P., Thornby, J. I., & Shanti, B. F. (2004) · The Journal of Pain · doi:10.1016/j.jpain.2003.12.005 · Cited by 1,416 · see citing works
Beissner, F., Meissner, K., Bar, K.-J., & Napadow, V. (2013) · Journal of Neuroscience · doi:10.1523/jneurosci.1103-13.2013 · Cited by 920 · see citing works
Self-citationOpportunities and limitations of intrinsic functional connectivity MRI
Buckner, R. L., Krienen, F. M., & Yeo, B. T. T. (2013) · Nature Neuroscience · doi:10.1038/nn.3423 · Cited by 912 · see citing works
Pain catastrophizing and neural responses to pain among persons with fibromyalgia
Gracely, R. H. (2004) · Brain · doi:10.1093/brain/awh098 · Cited by 892 · see citing works
Malik, M., & Camm, A. J. (1990) · Clinical Cardiology · doi:10.1002/clc.4960130811 · Cited by 722 · see citing works
Influence of heart rate on the BOLD signal: The cardiac response function
Chang, C. E., Cunningham, J. P., & Glover, G. H. (2008) · NeuroImage · doi:10.1016/j.neuroimage.2008.09.029 · Cited by 652 · see citing works
Intrinsic brain connectivity in fibromyalgia is associated with chronic pain intensity
Napadow, V., LaCount, L., Park, K., As‐Sanie, S., Clauw, D. J., & Harris, R. E. (2010) · Arthritis & Rheumatism · doi:10.1002/art.27497 · Cited by 645 · see citing works
Self-citationForebrain emotional asymmetry: a neuroanatomical basis?
Craig, A. D. (. (2005) · Trends in Cognitive Sciences · doi:10.1016/j.tics.2005.10.005 · Cited by 626 · see citing works
Anterior insula integrates information about salience into perceptual decisions about pain
Wiech, K., Lin, C.-S., Brodersen, K. H., Bingel, U., Ploner, M., & Tracey, I. (2010) · The Journal of Neuroscience · doi:10.1523/jneurosci.2087-10.2010 · Cited by 470 · see citing works
Cohen, H., Neumann, L., Shore, M., Amir, M., Cassuto, Y., & Buskila, D. (2000) · Seminars in Arthritis and Rheumatism · doi:10.1016/s0049-0172(00)80010-4 · Cited by 339 · see citing works
Default mode network connectivity encodes clinical pain: An arterial spin labeling study
Loggia, M. L., Kim, J., Gollub, R. L., Vangel, M. G., Kirsch, I., Kong, J., Wasan, A. D., & Napadow, V. (2012) · Pain · doi:10.1016/j.pain.2012.07.029 · Cited by 314 · see citing works
Self-citationHyperexcitable C nociceptors in fibromyalgia
Serra, J., Collado, A., Solà, R., Antonelli, F., Torres, X., Salgueiro, M., Quiles, C., & Bostock, H. (2014) · Annals of Neurology · doi:10.1002/ana.24065 · Cited by 295 · see citing works
The Cortical Rhythms of Chronic Back Pain
Baliki, M. N., Baria, A. T., & Apkarian, A. V. (2011) · Journal of Neuroscience · doi:10.1523/jneurosci.1984-11.2011 · Cited by 288 · see citing works
Napadow, V., Kim, J., Clauw, D. J., & Harris, R. E. (2012) · Arthritis & Rheumatism · doi:10.1002/art.34412 · Cited by 276 · see citing works
Self-citationHarris, R. E., Napadow, V., Huggins, J. P., Pauer, L., Kim, J., Hampson, J. P., Sundgren, P. C., Foerster, B. R., Petrou, M., Schmidt‐Wilcke, T., et al. (2013) · Anesthesiology · doi:10.1097/aln.0000000000000017 · Cited by 253 · see citing works
Self-citationStaud, R. M., Robinson, M. E., & Price, D. D. (2007) · Journal of Pain · doi:10.1016/j.jpain.2007.06.006 · Cited by 232 · see citing works
Differentiation of Visceral and Cutaneous Pain in the Human Brain
Strigo, I. A., Duncan, G. H., Boivin, M., & Bushnell, M. C. (2003) · Journal of Neurophysiology · doi:10.1152/jn.01048.2002 · Cited by 231 · see citing works
Meeus, M., Goubert, D., Backer, F. D., Struyf, F., Hermans, L., Coppieters, I., Wandele, I. D., Silva, H. D., & Calders, P. (2013) · Seminars in Arthritis and Rheumatism · doi:10.1016/j.semarthrit.2013.03.004 · Cited by 213 · see citing works
Disrupted Functional Connectivity of the Pain Network in Fibromyalgia
Cifré, I., Sitges, C., Fraiman, D., Muñoz, M. Á., Balenzuela, P., González‐Roldán, A. M., Martínez-Jauand, M., Birbaumer, N., Chialvo, D. R., & Montoya, P. (2011) · Psychosomatic Medicine · doi:10.1097/psy.0b013e3182408f04 · Cited by 212 · see citing works
Lateralization of affective processing in the insula
Duerden, E. G., Arsalidou, M., Lee, M., & Taylor, M. J. (2013) · NeuroImage · doi:10.1016/j.neuroimage.2013.04.014 · Cited by 204 · see citing works
Staud, R. M., Craggs, J. G., Perlstein, W. M., Robinson, M. E., & Price, D. D. (2008) · European Journal of Pain · doi:10.1016/j.ejpain.2008.02.002 · Cited by 187 · see citing works
Aberrant temporal and spatial brain activity during rest in patients with chronic pain
Malinen, S., Vartiainen, N. V., Hlushchuk, Y., Koskinen, M., Ramkumar, P., Forss, N., Kalso, E. A., & Hari, R. (2010) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1001504107 · Cited by 186 · see citing works
Disrupted Brain Circuitry for Pain‐Related Reward/Punishment in Fibromyalgia
Loggia, M. L., Berna, C., Kim, J., Cahalan, C. M., Gollub, R. L., Wasan, A. D., Harris, R. E., Edwards, R. R., & Napadow, V. (2013) · Arthritis & Rheumatology · doi:10.1002/art.38191 · Cited by 178 · see citing works
Self-citationSomatotopic organization of human somatosensory cortices for pain: a single trial fMRI study
Bingel, U., Lorenz, J., Glauche, V., Knab, R., Gläscher, J. P., Weiller, C., & Büchel, C. (2004) · NeuroImage · doi:10.1016/j.neuroimage.2004.05.021 · Cited by 174 · see citing works
Somatosensory cortical plasticity in carpal tunnel syndrome treated by acupuncture
Napadow, V., Liu, J., Li, M., Kettner, N. W., Ryan, A., Kwong, K. K., Hui, K. K. S., & Audette, J. F. (2006) · Human Brain Mapping · doi:10.1002/hbm.20261 · Cited by 151 · see citing works
Self-citationPujol, J., Macià, D., Garcia‐Fontanals, A., Blanco‐Hinojo, L., López‐Solà, M., Garcia-Blanco, S., Poca‐Dias, V., Harrison, B. J., Contreras‐Rodríguez, O., Monfort, J., et al. (2014) · Pain · doi:10.1016/j.pain.2014.04.028 · Cited by 122 · see citing works
del Paso, G. A. R., Garrido, S., Pulgar, Á., Martín‐Vázquez, M., & Duschek, S. (2010) · Psychosomatic Medicine · doi:10.1097/psy.0b013e3181da91f1 · Cited by 121 · see citing works
Caro, X. J., & Winter, E. F. (2014) · Arthritis & Rheumatology · doi:10.1002/art.38662 · Cited by 117 · see citing works
Peak and End Effects in Patients' Daily Recall of Pain and Fatigue: A Within-Subjects Analysis
Schneider, S., Stone, A. A., Schwartz, J. E., & Broderick, J. E. (2011) · The Journal of Pain · doi:10.1016/j.jpain.2010.07.001 · Cited by 114 · see citing works
Lloyd, D. M., Findlay, G. F. G., Roberts, N., & Nurmikko, T. J. (2008) · Spine · doi:10.1097/brs.0b013e3181734a8a · Cited by 101 · see citing works
Spatial and temporal aspects of deep tissue pain assessed by cuff algometry
Polianskis, R., Graven‐Nielsen, T., & Arendt‐Nielsen, L. (2002) · Pain · doi:10.1016/s0304-3959(02)00162-8 · Cited by 95 · see citing works
Verhoeven, K., Damme, S. V., Eccleston, C., Ryckeghem, D. M. L. V., Legrain, V., & Crombez, G. (2011) · European Journal of Pain · doi:10.1016/j.ejpain.2011.01.009 · Cited by 87 · see citing works
Polianskis, R., Graven‐Nielsen, T., & Arendt‐Nielsen, L. (2002) · Journal of Pain · doi:10.1054/jpai.2002.27140 · Cited by 76 · see citing works
Journal of pain : official journal of the American Pain Society.
ScienceDirect (2000) · Cited by 76 · see citing works
Frontoparietal mechanisms supporting attention to location and intensity of painful stimuli
Lobanov, O. V., Quevedo, A. S., Hadsel, M. S., Kraft, R. A., & Coghill, R. C. (2013) · Pain · doi:10.1016/j.pain.2013.05.030 · Cited by 65 · see citing works
Sustained deep-tissue pain alters functional brain connectivity
Kim, J., Loggia, M. L., Edwards, R. R., Wasan, A. D., Gollub, R. L., & Napadow, V. (2013) · Pain · doi:10.1016/j.pain.2013.04.016 · Cited by 61 · see citing works
Self-citationSegmentally arranged somatotopy within the face representation of human primary somatosensory cortex
Moulton, E. A., Pendse, G., Morris, S., Aiello‐Lammens, M. E., Becerra, L. R., & Borsook, D. (2008) · Human Brain Mapping · doi:10.1002/hbm.20541 · Cited by 59 · see citing works
Riedl, V., Valet, M., Wöller, A. A., Sorg, C., Vogel, D., Sprenger, T., Boecker, H., Wohlschläger, A. M., & Tölle, T. R. (2011) · NeuroImage · doi:10.1016/j.neuroimage.2011.04.011 · Cited by 54 · see citing works
Temporal summation of heat pain in humans: Evidence supporting thalamocortical modulation
Tran, T. D., Wang, H., Tandon, A. A., Hernández-García, L., & Casey, K. L. (2010) · Pain · doi:10.1016/j.pain.2010.04.001 · Cited by 47 · see citing works
Terry, R. H., Brodie, E. E., & Niven, C. A. (2007) · Journal of Pain · doi:10.1016/j.jpain.2006.12.006 · Cited by 24 · see citing works
Kim, J., Dijk, K. R. A. V., Libby, A., & Napadow, V. (2013) · Brain Connectivity · doi:10.1089/brain.2013.0153 · Cited by 19 · see citing works
Self-citationGlover (2000) · doi:10.1002/1522-2594(200007)44:1
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Evaluating psychosocial contributions to chronic pain outcomes
Meints, S. M., & Edwards, R. R. (2018) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2018.01.017 · Cited by 719 · see citing works
Self-citationAn Inflammation-Centric View of Neurological Disease: Beyond the Neuron
Skaper, S. D., Facci, L., Zusso, M., & Giusti, P. (2018) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2018.00072 · Cited by 461 · see citing works
Ashar, Y. K., Gordon, A., Schubiner, H., Uipi, C., Knight, K., Anderson, Z., Carlisle, J., Polisky, L., Geuter, S., Flood, T. F., et al. (2022) · JAMA Psychiatry · doi:10.1001/jamapsychiatry.2021.2669 · Cited by 331 · see citing works
Deciphering nociplastic pain: clinical features, risk factors and potential mechanisms
Kaplan, C. M., Kelleher, E. M., Irani, A., Schrepf, A., Clauw, D. J., & Harte, S. E. (2024) · Nature Reviews Neurology · doi:10.1038/s41582-024-00966-8 · Cited by 231 · see citing works
Meints, S. M., Mawla, I., Napadow, V., Kong, J., Gerber, J. A., Chan, S., Wasan, A. D., Kaptchuk, T. J., McDonnell, C., Carrière, J. S., et al. (2018) · Pain · doi:10.1097/j.pain.0000000000001461 · Cited by 166 · see citing works
Self-citationRewiring the primary somatosensory cortex in carpal tunnel syndrome with acupuncture
Maeda, Y., Kim, H., Kettner, N. W., Kim, J., Cina, S., Malatesta, C., Gerber, J. A., McManus, C., Ong-Sutherland, R., Mezzacappa, P., et al. (2017) · Brain · doi:10.1093/brain/awx015 · Cited by 153 · see citing works
Self-citationSmith, S. M., Dworkin, R. H., Turk, D. C., Baron, R., Polydefkis, M. J., Tracey, I., Borsook, D., Edwards, R. R., Harris, R. E., Wager, T. D., et al. (2017) · Journal of Pain · doi:10.1016/j.jpain.2017.02.429 · Cited by 151 · see citing works
Self-citationLazaridou, A., Kim, J., Cahalan, C. M., Loggia, M. L., Franceschelli, O., Berna, C., Schur, P. H., Napadow, V., & Edwards, R. R. (2016) · Clinical Journal of Pain · doi:10.1097/ajp.0000000000000422 · Cited by 136 · see citing works
Self-citationGarcia, R. G., Lin, R. L., Lee, J., Kim, J., Barbieri, R., Sclocco, R., Wasan, A. D., Edwards, R. R., Rosen, B. R., Hadjikhani, N. K., et al. (2017) · Pain · doi:10.1097/j.pain.0000000000000930 · Cited by 137 · see citing works
Self-citationLee, J., Mawla, I., Kim, J., Loggia, M. L., Ortiz, A., Jung, C. J., Chan, S., Gerber, J. A., Schmithorst, V. J., Edwards, R. R., et al. (2018) · Pain · doi:10.1097/j.pain.0000000000001417 · Cited by 133 · see citing works
Self-citationCoppieters, I., Meeus, M., Kregel, J., Caeyenberghs, K., Pauw, R. D., Goubert, D., & Cagnie, B. J. (2016) · Journal of Pain · doi:10.1016/j.jpain.2016.04.005 · Cited by 120 · see citing works
Kim, J., Mawla, I., Kong, J., Lee, J., Gerber, J. A., Ortiz, A., Kim, H., Chan, S., Loggia, M. L., Wasan, A. D., et al. (2019) · Pain · doi:10.1097/j.pain.0000000000001541 · Cited by 116 · see citing works
Self-citationEdwards, R. R., Schreiber, K. L., Dworkin, R. H., Turk, D. C., Baron, R., Freeman, R. L., Jensen, T. S., Latrémolière, A., Markman, J. D., Rice, A. S. C., et al. (2022) · Journal of Pain · doi:10.1016/j.jpain.2022.08.010 · Cited by 103 · see citing works
Self-citationThe problem in differentiation between psoriatic-related polyenthesitis and fibromyalgia
Marchesoni, A., Marco, G. D., Merashli, M., McKenna, F., Tinazzi, I., Marzo‐Ortega, H., & McGonagle, D. (2017) · Rheumatology · doi:10.1093/rheumatology/kex079 · Cited by 93 · see citing works
Ellingsen, D., Isenburg, K., Jung, C. J., Lee, J., Gerber, J. A., Mawla, I., Sclocco, R., Jensen, K. B., Edwards, R. R., Kelley, J. M., et al. (2020) · Science Advances · doi:10.1126/sciadv.abc1304 · Cited by 83 · see citing works
Self-citationThe effect of induced and chronic pain on attention
Moore, D. J., Meints, S. M., Lazaridou, A., Johnson, D., Franceschelli, O., Cornelius, M., Schreiber, K., & Edwards, R. R. (2019) · The Journal of Pain · doi:10.1016/j.jpain.2019.05.004 · Cited by 83 · see citing works
Self-citationPharmacologic attenuation of cross-modal sensory augmentation within the chronic pain insula
Harte, S. E., Ichesco, E., Hampson, J. P., Peltier, S., Schmidt‐Wilcke, T., Clauw, D. J., & Harris, R. E. (2016) · Pain · doi:10.1097/j.pain.0000000000000593 · Cited by 83 · see citing works
Self-citationInsular balance of glutamatergic and GABAergic signaling modulates pain processing
Watson, C. J. (2016) · Pain · doi:10.1097/j.pain.0000000000000615 · Cited by 80 · see citing works
Fibromyalgia is characterized by altered frontal and cerebellar structural covariance brain networks
Kim, H., Kim, J., Loggia, M. L., Cahalan, C., Garcia, R. G., Vangel, M. G., Wasan, A. D., Edwards, R. R., & Napadow, V. (2015) · NeuroImage Clinical · doi:10.1016/j.nicl.2015.02.022 · Cited by 74 · see citing works
Self-citationControversies and challenges in fibromyalgia: a review and a proposal
Cohen, H. (2017) · Therapeutic Advances in Musculoskeletal Disease · doi:10.1177/1759720x17699199 · Cited by 70 · see citing works
Encoding of Self‐Referential Pain Catastrophizing in the Posterior Cingulate Cortex in Fibromyalgia
Lee, J., Protsenko, E., Lazaridou, A., Franceschelli, O., Ellingsen, D., Mawla, I., Isenburg, K., Berry, M. P., Galenkamp, L., Loggia, M. L., et al. (2018) · Arthritis & Rheumatology · doi:10.1002/art.40507 · Cited by 66 · see citing works
Self-citationDifferential dopamine function in fibromyalgia
Albrecht, D., MacKie, P., Kareken, D. A., Hutchins, G. D., Chumin, E. J., Christian, B. T., & Yoder, K. K. (2015) · Brain Imaging and Behavior · doi:10.1007/s11682-015-9459-4 · Cited by 63 · see citing works
Mawla, I., Ichesco, E., Zöllner, H. J., Edden, R. A. E., Chenevert, T. L., Buchtel, H. A., Bretz, M. D., Sloan, H., Kaplan, C. M., Harte, S. E., et al. (2020) · Arthritis & Rheumatology · doi:10.1002/art.41620 · Cited by 61 · see citing works
Self-citationEllingsen, D., Beißner, F., Alsady, T. M., Lazaridou, A., Paschali, M., Berry, M., Isaro, L., Grahl, A., Lee, J., Wasan, A. D., et al. (2020) · Pain · doi:10.1097/j.pain.0000000000002134 · Cited by 62 · see citing works
Self-citationPinto, A. M., Luís, M., Geenen, R., Palavra, F., Lumley, M. A., Ablin, J. N., Amris, K., Branco, J., Buskila, D., Castelhano, J., et al. (2023) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2023.105235 · Cited by 68 · see citing works
New Insights into the Pathophysiology and Treatment of Fibromyalgia
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Giorno, R. D., Skaper, S. D., Paladini, A., Varrassi, G., & Coaccioli, S. (2015) · Pain and Therapy · doi:10.1007/s40122-015-0038-6 · Cited by 56 · see citing works
Schreiber, K. L., Loggia, M. L., Kim, J., Cahalan, C. M., Napadow, V., & Edwards, R. R. (2017) · The Journal of Pain · doi:10.1016/j.jpain.2017.02.437 · Cited by 54 · see citing works
Self-citationToschi, N., Kim, J., Sclocco, R., Duggento, A., Barbieri, R., Kuo, B., & Napadow, V. (2016) · Autonomic Neuroscience · doi:10.1016/j.autneu.2016.10.003 · Cited by 54 · see citing works
Self-citationSclocco, R., Beißner, F., Desbordes, G., Polimeni, J. R., Wald, L. L., Kettner, N. W., Kim, J., Garcia, R. G., Renvall, V., Bianchi, A. M., et al. (2016) · Philosophical Transactions of the Royal Society A Mathematical Physical and Engineering Sciences · doi:10.1098/rsta.2015.0189 · Cited by 53 · see citing works
Self-citationEllingsen, D., Isenburg, K., Jung, C. J., Lee, J., Gerber, J. A., Mawla, I., Sclocco, R., Grahl, A., Anzolin, A., Edwards, R. R., et al. (2023) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2212910120 · Cited by 51 · see citing works
Self-citationLabrenz, F., Icenhour, A., Schlamann, M. U., Forsting, M., Bingel, U., & Elsenbruch, S. (2016) · NeuroImage · doi:10.1016/j.neuroimage.2016.01.064 · Cited by 46 · see citing works
Scheich, B., Vincze, P., Szőke, É., Borbély, É., Hunyady, Á., Szolcsányi, J., Dénes, Á., Környei, Z., Gaszner, B., & Helyes, Z. (2017) · European Journal of Pain · doi:10.1002/ejp.1043 · Cited by 48 · see citing works
Functional connectivity of music-induced analgesia in fibromyalgia
Pando‐Naude, V., Barrios, F. A., Alcauter, S., Pasaye, E. H., Vase, L., Brattico, E., Vuust, P., & Garza‐Villarreal, E. A. (2019) · Scientific Reports · doi:10.1038/s41598-019-51990-4 · Cited by 47 · see citing works
Berry, M. P., Lutz, J., Schuman-Olivier, Z., Germer, C., Pollak, S., Edwards, R. R., Gardiner, P., Desbordes, G., & Napadow, V. (2020) · Pain Medicine · doi:10.1093/pm/pnaa178 · Cited by 45 · see citing works
Self-citationClinical Manifestations of Body Memories: The Impact of Past Bodily Experiences on Mental Health
Gentsch, A., & Kuehn, E. (2022) · Brain Sciences · doi:10.3390/brainsci12050594 · Cited by 55 · see citing works
Fibromyalgia: A misconnection in a multiconnected world?
Perrot, S. (2019) · European Journal of Pain · doi:10.1002/ejp.1367 · Cited by 51 · see citing works
Li, T., Zhang, S., & Kurata, J. (2018) · Journal of Anesthesia · doi:10.1007/s00540-018-2561-1 · Cited by 43 · see citing works
Aberrant Salience? Brain Hyperactivation in Response to Pain Onset and Offset in Fibromyalgia
Hubbard, C. S., Lazaridou, A., Cahalan, C. M., Kim, J., Edwards, R. R., Napadow, V., & Loggia, M. L. (2020) · Arthritis & Rheumatology · doi:10.1002/art.41220 · Cited by 40 · see citing works
Self-citationKlein, A. N., & Schankin, C. J. (2021) · Headache The Journal of Head and Face Pain · doi:10.1111/head.14213 · Cited by 42 · see citing works
The Amplification of Symptoms in the Medically Ill
BARSKY, A. J., & Silbersweig, D. (2022) · Journal of General Internal Medicine · doi:10.1007/s11606-022-07699-8 · Cited by 41 · see citing works
Dorado, K., Schreiber, K. L., Koulouris, A., Edwards, R. R., Napadow, V., & Lazaridou, A. (2018) · Health Psychology Open · doi:10.1177/2055102918807406 · Cited by 37 · see citing works
Self-citationEllingsen, D., Garcia, R. G., Lee, J., Lin, R. L., Kim, J., Thurler, A. H., Castel, S., Dimisko, L., Rosen, B. R., Hadjikhani, N. K., et al. (2016) · Neurogastroenterology & Motility · doi:10.1111/nmo.13004 · Cited by 40 · see citing works
Self-citationArgaman, Y., Granovsky, Y., Sprecher, E., Sinai, A., Yarnitsky, D., & Weissman‐Fogel, I. (2021) · Journal of Pain · doi:10.1016/j.jpain.2021.11.001 · Cited by 37 · see citing works
The effects of catastrophizing on central motor activity
Henderson, L. A., Akhter, R., Youssef, A. M., Reeves, J. M., Peck, C. C., Murray, G. M., & Svensson, P. J. (2015) · European Journal of Pain · doi:10.1002/ejp.781 · Cited by 34 · see citing works
Dynamic Functional Brain Connectivity Underlying Temporal Summation of Pain in Fibromyalgia
Cheng, J. C., Anzolin, A., Berry, M., Honari, H., Paschali, M., Lazaridou, A., Lee, J., Ellingsen, D., Loggia, M. L., Grahl, A., et al. (2021) · Arthritis & Rheumatology · doi:10.1002/art.42013 · Cited by 35 · see citing works
Self-citationBrain Responses to Noxious Stimuli in Patients With Chronic Pain
Xu, A., Larsen, B., Henn, A. T., Baller, E. B., Scott, J. C., Sharma, V., Adebimpe, A., Basbaum, A. I., Corder, G. F., Dworkin, R. H., et al. (2021) · JAMA Network Open · doi:10.1001/jamanetworkopen.2020.32236 · Cited by 32 · see citing works
Self-citationElectrochemical Skin Conductance and Quantitative Sensory Testing on Fibromyalgia
Pickering, G. P., Achard, A., Corriger, A., Sickout‐Arondo, S., Macian, N., Leray, V., Lucchini, C., Cardot, J., & Pereira, B. (2019) · Pain Practice · doi:10.1111/papr.12857 · Cited by 32 · see citing works
When thinking about pain contributes to suffering: the example of pain catastrophizing
Haythornthwaite, J. A., Campbell, C. M., & Edwards, R. R. (2024) · Pain · doi:10.1097/j.pain.0000000000003372 · Cited by 32 · see citing works
Self-citationPei, Y., Zhang, Y., Zhu, Y., Zhao, Y., Zhou, F., Huang, M., Wu, L., & Gong, H. (2020) · Journal of Pain Research · doi:10.2147/jpr.s242807 · Cited by 31 · see citing works
A Randomized Controlled Neuroimaging Trial of Cognitive Behavioral Therapy for Fibromyalgia Pain
Lee, J., Lazaridou, A., Paschali, M., Loggia, M. L., Berry, M. P., Ellingsen, D., Isenburg, K., Anzolin, A., Grahl, A., Wasan, A. D., et al. (2023) · Arthritis & Rheumatology · doi:10.1002/art.42672 · Cited by 36 · see citing works
Self-citationIoachim, G., Warren, H. J. M., Powers, J. M., Staud, R. M., Pukall, C. F., & Stroman, P. W. (2022) · Frontiers in Neurology · doi:10.3389/fneur.2022.862976 · Cited by 32 · see citing works
Čeko, M., Baeuerle, T., Webster, L. R., Wager, T. D., & Lumley, M. A. (2024) · Pain · doi:10.1097/j.pain.0000000000003198 · Cited by 28 · see citing works
Meeker, T. J., Schmid, A., Keaser, M. L., Khan, S. A., Gullapalli, R. P., Dorsey, S. G., Greenspan, J. D., & Seminowicz, D. A. (2022) · NeuroImage · doi:10.1016/j.neuroimage.2022.119278 · Cited by 30 · see citing works
Functional brain reconfiguration during sustained pain
Lee, J., Lee, S., Lee, D. H., & Woo, C. (2022) · eLife · doi:10.7554/elife.74463 · Cited by 27 · see citing works
Reduced insula habituation associated with amplification of trigeminal brainstem input in migraine
Lee, J., Lin, R. L., Garcia, R. G., Kim, J., Kim, H., Loggia, M. L., Mawla, I., Wasan, A. D., Edwards, R. R., Rosen, B. R., et al. (2016) · Cephalalgia · doi:10.1177/0333102416665223 · Cited by 27 · see citing works
Self-citationLee, J., Eun, S., Kim, J., Lee, J., & Park, K. (2019) · Frontiers in Neuroscience · doi:10.3389/fnins.2019.01062 · Cited by 26 · see citing works
Self-citationMawla, I., Huang, Z., Kaplan, C. M., Ichesco, E., Waller, N., Larkin, T. E., Zöllner, H. J., Edden, R. A. E., Harte, S. E., Clauw, D. J., et al. (2023) · Pain · doi:10.1097/j.pain.0000000000002973 · Cited by 26 · see citing works
Self-citationZempsky, W. T., Stevens, M. C. G., Santanelli, J. P., Gaynor, A. M., & Khadka, S. (2017) · Clinical Journal of Pain · doi:10.1097/ajp.0000000000000492 · Cited by 24 · see citing works
Testing the effects of gentle vibrotactile stimulation on symptom relief in fibromyalgia
Pujol, J., Ramos‐López, D., Blanco‐Hinojo, L., Pujol, G., Ortiz, H., Martínez‐Vilavella, G., Blanch‐Rubió, J., Monfort, J., & Deus, J. (2019) · Arthritis Research & Therapy · doi:10.1186/s13075-019-1932-9 · Cited by 22 · see citing works
Behavioral, Psychological, Neurophysiological, and Neuroanatomic Determinants of Pain
Meints, S. M., Edwards, R. R., Gilligan, C. J., & Schreiber, K. L. (2020) · Journal of Bone and Joint Surgery · doi:10.2106/jbjs.20.00082 · Cited by 23 · see citing works
Self-citationHuman Posterior Insula Functional Connectivity Differs Between Electrical Pain and the Resting State
Vogt, K. M., Becker, C. J., Wasan, A. D., & Ibinson, J. W. (2016) · Brain Connectivity · doi:10.1089/brain.2016.0436 · Cited by 21 · see citing works
Self-citationLim, M., Kim, D. J., Nascimento, T. D., Ichesco, E., Kaplan, C. M., Harris, R. E., & DaSilva, A. F. M. (2021) · Neuromodulation Technology at the Neural Interface · doi:10.1111/ner.13512 · Cited by 20 · see citing works
Self-citationMarks, D. F. (2023) · Biomedicines · doi:10.3390/biomedicines11010180 · Cited by 20 · see citing works
Lee, C., Liptan, G. L., Kantorovich, S., Sharma, M., & Brenton, A. (2018) · BMC Rheumatology · doi:10.1186/s41927-018-0045-4 · Cited by 20 · see citing works
Iwamoto, S., Tamura, M., Sasaki, A., & Nawano, M. (2021) · Scientific Reports · doi:10.1038/s41598-021-81067-0 · Cited by 18 · see citing works
Temporal Summation in Fibromyalgia Patients: Comparing Phasic and Tonic Paradigms
Castelo-Branco, L., Cardenas‐Rojas, A., Rebello‐Sanchez, I., Pacheco‐Barrios, K., de Melo, P. S., Gonzalez‐Mego, P., Marduy, A., Vásquez-Ávila, K., Cortez, P. C., Parente, J., et al. (2022) · Frontiers in Pain Research · doi:10.3389/fpain.2022.881543 · Cited by 18 · see citing works
Tong, H., Maloney, T., Payne, M. F., Suñol, M., Dudley, J. A., King, C. D., Ting, T. V., Kashikar‐Zuck, S., Coghill, R. C., & López‐Solà, M. (2023) · Pain · doi:10.1097/j.pain.0000000000002933 · Cited by 20 · see citing works
Wu, J., Lu, Y.-C., Hua, X., Ma, S., & Xu, J. (2018) · World Neurosurgery · doi:10.1016/j.wneu.2018.02.173 · Cited by 18 · see citing works
Ciaramella, A., Silvestri, S., Pozzolini, V., Federici, M., & Carli, G. (2020) · Scandinavian Journal of Pain · doi:10.1515/sjpain-2020-0103 · Cited by 17 · see citing works
Chronic generalized pain disrupts whole brain functional connectivity in mice
Nasseef, M. T., Ma, W., Singh, J. P., Dozono, N., Lançon, K., Séguéla, P., Darcq, E., Ueda, H., & Kieffer, B. L. (2021) · Brain Imaging and Behavior · doi:10.1007/s11682-020-00438-9 · Cited by 17 · see citing works
Pujol, J., Blanco‐Hinojo, L., Doreste, A., Ojeda, F., Martínez‐Vilavella, G., Pérez, V., Deus, J., & Monfort, J. (2022) · Arthritis Research & Therapy · doi:10.1186/s13075-022-02942-3 · Cited by 17 · see citing works
Liu, X., Xu, Y. K., Sun, W., Wang, J., Gao, Y., Wang, L., Xu, W., Wang, S., Jiu, S., & Zhang, C. (2023) · Frontiers in Plant Science · doi:10.3389/fpls.2023.1092654 · Cited by 17 · see citing works
Terry, E. L., Tanner, J. J., Cardoso, J. S., Sibille, K. T., Lai, S., Deshpande, H., DEUTSCH, G., Price, C. C., Staud, R. M., Goodin, B. R., et al. (2022) · Journal of Neuroscience Research · doi:10.1002/jnr.25018 · Cited by 16 · see citing works
Cambios en la resonancia magnética cerebral asociados al síndrome de fibromialgia
Murga, Í., Guillén, V., & Lafuente, J. V. (2017) · Medicina Clínica · doi:10.1016/j.medcli.2017.01.034 · Cited by 16 · see citing works
Woodbury, A., Krishnamurthy, V., Gebre, M., Napadow, V., Bicknese, C., Liu, M., Lukemire, J., Kalangara, J. P., Cui, X., Guo, Y., et al. (2020) · Pain Medicine · doi:10.1093/pm/pnaa317 · Cited by 16 · see citing works
Self-citationWarren, H. J. M., Ioachim, G., Powers, J. M., & Stroman, P. W. (2021) · Journal of Pain Research · doi:10.2147/jpr.s290795 · Cited by 16 · see citing works
Suñol, M., Dudley, J. A., Payne, M. F., Tong, H., Ting, T. V., Kashikar‐Zuck, S., Coghill, R. C., & López‐Solà, M. (2023) · Arthritis & Rheumatology · doi:10.1002/art.42691 · Cited by 16 · see citing works
Cerebral magnetic resonance changes associated with fibromyalgia syndrome
Murga, Í., Guillén, V., & Lafuente, J. V. (2017) · Medicina Clínica (English Edition) · doi:10.1016/j.medcle.2017.05.011 · Cited by 14 · see citing works
Oxygenation alleviates waterlogging-caused damages to cherry rootstocks
Wang, Y., Xu, Y., Xu, J., Sun, W., Lv, Z., Manzoor, M. A., Liu, X., Shen, Z., Wang, J., Liu, R., et al. (2023) · Molecular Horticulture · doi:10.1186/s43897-023-00056-1 · Cited by 13 · see citing works
Delon‐Martin, C., Lefaucheur, J., Hodaj, E., Sorel, M., Dumolard, A., Payen, J., & Hodaj, H. (2023) · Neuromodulation Technology at the Neural Interface · doi:10.1016/j.neurom.2023.05.005 · Cited by 13 · see citing works
Aoe, T., Kawanaka, R., Ohsone, F., Hara, A., & Yokokawa, T. (2024) · Scientific Reports · doi:10.1038/s41598-024-60993-9 · Cited by 14 · see citing works
Jiu, S., Xu, Y., Xie, X., Wang, J., Xu, J., Liu, X., Sun, W., Xu, W., Wang, S., & Zhang, C. (2021) · Environmental and Experimental Botany · doi:10.1016/j.envexpbot.2021.104667 · Cited by 13 · see citing works
Zarei, A. A., Jensen, W., Jadidi, A. F., Lontis, R., & Atashzar, S. F. (2022) · Journal of Neural Engineering · doi:10.1088/1741-2552/ac59a1 · Cited by 13 · see citing works
Pei, Y., Peng, J., Zhang, Y., Huang, M., & Zhou, F. (2022) · Scientific Reports · doi:10.1038/s41598-022-10238-4 · Cited by 12 · see citing works
Jamison, R. N., Curran, S., Wan, L., Ross, E. L., Gilligan, C. J., & Edwards, R. R. (2021) · Neuromodulation Technology at the Neural Interface · doi:10.1111/ner.13463 · Cited by 13 · see citing works
Self-citationWank, I., Niedermair, T., Kronenberg, D., Stange, R., Brochhausen, C., Heß, A., & Grässel, S. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms24010510 · Cited by 12 · see citing works
Xu, Y., Wang, Y., Xu, J., Lv, Z., Manzoor, M. A., Mao, J., Zhang, X., Liu, R., Wang, S., Whiting, M. D., et al. (2023) · Scientia Horticulturae · doi:10.1016/j.scienta.2023.111827 · Cited by 12 · see citing works
Diagnosis and treatment of medically unexplained symptoms and chronic functional syndromes.
Clarke, D. D. (2016) · Families Systems & Health · doi:10.1037/fsh0000228 · Cited by 12 · see citing works
Sex, Neural Networks, and Behavioral Symptoms Among Adolescents With Multisite Pain
Hidalgo‐Lopez, E., Smith, T., Angstadt, M., Becker, H. C., Schrepf, A., Clauw, D. J., Harte, S. E., Heitzeg, M. M., Mindell, J. A. A., Kaplan, C. M., et al. (2025) · JAMA Network Open · doi:10.1001/jamanetworkopen.2025.5364 · Cited by 13 · see citing works
Recent strategies for drug development in fibromyalgia syndrome
Blumenthal, D. E., & Malemud, C. J. (2016) · Expert Review of Neurotherapeutics · doi:10.1080/14737175.2016.1207531 · Cited by 11 · see citing works
Lee, J., Andronesi, O. C., Torrado-Carvajal, Á., Ratai, E., Loggia, M. L., Weerasekera, A., Berry, M. P., Ellingsen, D., Isaro, L., Lazaridou, A., et al. (2021) · European Journal of Pain · doi:10.1002/ejp.1820 · Cited by 11 · see citing works
Self-citationESSOMM European core curriculum and principles of manual medicine
Locher, H. A., Bernardotto, M., Beyer, L., ESSOMM Rome Consensus Group, Acarkan, T., Barth, F., Borgstrøm, H., Bultman, H., Buzhov, B., Okur, S. Ç., et al. (2022) · Manuelle Medizin · doi:10.1007/s00337-022-00886-y · Cited by 11 · see citing works
Lee, Y., Fine, A., Protsenko, E., Massarotti, E. M., Edwards, R. R., Mawla, I., Napadow, V., & Loggia, M. L. (2018) · Arthritis Care & Research · doi:10.1002/acr.23601 · Cited by 11 · see citing works
Self-citationvan der Schaaf, M. E., Geerligs, L., Toni, I., Knoop, H., & Oosterman, J. M. (2024) · Psychological Medicine · doi:10.1017/s0033291723003690 · Cited by 10 · see citing works
Alves, R. L., Zortéa, M., Serrano, P. V., Laranjeira, V. D. S., Tocchetto, B. F., Ramalho, L., Alves, C. F. D. S., Tomedi, R. B., de Almeida, R. P., Bruck, S. M., et al. (2024) · PLoS ONE · doi:10.1371/journal.pone.0288830 · Cited by 13 · see citing works
Catastrophizing and Fibromyalgia: A Mini-Review
Conversano, C., Marchi, L., Ciacchini, R., Mirabelli, V., & Angelo, G. (2018) · Journal of Translational Neurosciences · doi:10.21767/2573-5349.100020 · Cited by 12 · see citing works
Zhao, G., Zhang, C., Zhan, Y., & He, L. (2022) · Disease Markers · doi:10.1155/2022/2623179 · Cited by 9 · see citing works
RetractedChen, T., & Lin, C. (2023) · Journal of Oral Rehabilitation · doi:10.1111/joor.13526 · Cited by 9 · see citing works
Quantitative Sensory Testing in Fibromyalgia Syndrome: A Scoping Review
Carneiro, A. M., Dalle, C., Salvetti, M. D. G., & da Silva, V. A. (2025) · Biomedicines · doi:10.3390/biomedicines13040988 · Cited by 7 · see citing works
- Authors
- Kim, J., Loggia, M. L., Cahalan, C. M., Harris, R. E., Beissner, F., Garcia, R. G., Kim, H., Barbieri, R., Wasan, A. D., Edwards, R. R., & Napadow, V.
- Affiliations
- Harvard University (US)
- Brigham and Women's Hospital (US)
- University of Michigan (US)
- University of Pittsburgh (US)
- Corresponding author
- Kim, Jieun
- ORCID
- Venue
- Arthritis & Rheumatology
- Publisher
- Wiley
- Published
- 2015-04-27
- Volume
- 67
- Issue
- 5
- Pages
- 1395-1405
- ISSN
- 2326-5191 (ISSN-L)
- 2326-5205
- PMC
- PMC4414820
- OpenAlex
- W2132125609
- Cited by
- 161
- References
- 57
- Citations by year
- 2026: 11 · 2025: 10 · 2024: 16 · 2023: 17 · 2022: 23 · 2021: 18 · 2020: 13 · 2019: 9 · 2018: 13 · 2017: 13 · 2016: 14 · 2015: 4
- FWCI
- 11.92
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Arthritis & Rheumatology (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Deep Blue (University of Michigan) (submittedVersion)
- Virtual Community of Pathological Anatomy (University of Castilla La Mancha) (submittedVersion, other-oa)
- Digital Access to Scholarship at Harvard (DASH) (Harvard University) (submittedVersion, cc-by)
- Repositorio Universidad de Santander (submittedVersion, cc-by-nc-nd)
- Funders
- National Center for Complementary and Alternative Medicine, NIH (P01-AT-006663, R01-AT-007550, R01-AR-064367, R21-AR-057920)
- Korea Institute of Oriental Medicine (K14290)
- German Research Foundation (BE4677/1-1)
- Arthritis Foundation and American College of Rheumatology
- Topics
- Health Sciences › Medicine › Psychiatry and Mental health › Fibromyalgia and Chronic Fatigue Syndrome Research
- Life Sciences › Neuroscience › Cognitive Neuroscience › Functional Brain Connectivity Studies
- Health Sciences › Medicine › Psychiatry and Mental health › Psychosomatic Disorders and Their Treatments
- Keywords
- fibromyalgia, primary somatosensory cortex, resting-state functional connectivity, sustained pain, anterior insula, pain catastrophizing, temporal summation, autonomic dysfunction
- MeSH terms
- Adult, Cerebral Cortex, Electrocardiography, Female, Fibromyalgia, Humans, Magnetic Resonance Imaging, Male, Middle Aged, Neural Pathways, Pain, Pain Measurement, Pressure, Severity of Illness Index, Somatosensory Cortex, Case-Control Studies, Primary Dysautonomias, Functional Neuroimaging
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