The DOI matches its Crossref record; 23 of the 23 references it cites were found in a registry or an index.
Modulation of lead toxicity bySpirulina fusiformis
Abstract
In this study, we examined whether in vivo keishi-bukuryo-gan (a Kampo formulation) could prevent the progression of atherosclerosis in cholesterol-fed rabbits, an animal model for hypercholesterolaemia. Sixteen male Japanese white rabbits (2 kg body weight) were divided into two groups. Group A (n = 8) was fed standard rabbit chow containing 1% cholesterol for 8 weeks. Group B (n = 8) was fed standard rabbit chow containing 1% cholesterol and 1% keishi-bukuryo-gan for 8 weeks. At the end of the experiment, average plasma concentrations of total-cholesterol and IDL-cholesterol were 2055.9 +/- 201.8 mg/dL and 408.1 +/- 62.6 mg/dL in group A and 1950.5 +/- 126.3 mg/dL and 407.6 +/- 56.6 mg/dL in group B, respectively. The percentage of the surface area of the total thoracic aorta with visible plaque was significantly reduced by keishi-bukuryo-gan administration; group A was 33.2% +/- 5.3% and group B was 14.3% +/- 2.9%. beta-very low density lipoprotein (VLDL) and low density lipoprotein (LDL) isolated from cholesterol fed rabbits treated with keishi-bukuryo-gan (group B) were shown to be highly resistant to oxidative modification by cupric ion. Sera isolated from rabbits administered keishi-bukuryo-gan had reduced lipid peroxide formation compared with those from rabbits without keishi-bukuryo-gan. Thus, keishi-bukuryo-gan prevents the progression of atherosclerosis in cholesterol-fed rabbits in vivo by limiting oxidative LDL modification.
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“The modulatory effect of Arthrospira platensis on lead toxicity may be due its high content of flavonoids which are powerful antioxidants, β-carotene, iron, γ-linolenic acid, other carotenoids, phycocyanins and vitamins [136,137,138].”
From Application of Arthrospira platensis for Medicinal Purposes and the Food Industry: A Review of the Literature (2023) · cites this paper as [137]
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Phytotherapy in the management of diabetes: A review
Governa, P., Baini, G., Borgonetti, V., Cettolin, G., Giachetti, D., Magnano, A., Miraldi, E., & Biagi, M. (2018) · Molecules · doi:10.3390/molecules23010105 · Cited by 182
Gentscheva, G., Nikolova, K., Panayotova, V., Peycheva, K., Makedonski, L., Slavov, P., Radusheva, P., Petrova, P., & Yotkovska, I. (2023) · Life · doi:10.3390/life13030845 · Cited by 106
Song, X., Wang, T., Guo, L., Jin, Y., Wang, J., Yin, G., Jiang, K., Wang, L., Huang, H., & Zeng, L. (2020) · Evidence-based Complementary and Alternative Medicine · doi:10.1155/2020/2804849 · Cited by 8
Metadata
- Authors
- Shastri, D., Kumar, M., & Kumar, A.
- Venue
- Phytotherapy Research
- Published
- 1999
- References
- 23
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