The DOI matches its Crossref record; 240 of the 242 references it cites were found in a registry or an index.
Protein and energy supplementation in elderly people at risk from malnutrition
Open accessAbstract
BACKGROUND: Evidence for the effectiveness of nutritional supplements containing protein and energy, often prescribed for older people, is limited. Malnutrition is more common in this age group and deterioration of nutritional status can occur during illness. It is important to establish whether supplementing the diet is an effective way of improving outcomes for older people at risk from malnutrition. OBJECTIVES: This review examined trials for improvement in nutritional status and clinical outcomes when extra protein and energy were provided, usually as commercial 'sip-feeds'. SEARCH STRATEGY: We searched The Cochrane Library, MEDLINE, EMBASE, Healthstar, CINAHL, BIOSIS, CAB abstracts. We also hand searched nutrition journals and reference lists and contacted 'sip-feed' manufacturers. SELECTION CRITERIA: Randomised and quasi-randomised controlled trials of oral protein and energy supplementation in older people, with the exception of groups recovering from cancer treatment or in critical care. DATA COLLECTION AND ANALYSIS: Two reviewers independently assessed trials prior to inclusion and independently extracted data and assessed trial quality. Authors of trials were contacted for further information as necessary. MAIN RESULTS: Sixty-two trials with 10,187 randomised participants have been included in the review. Maximum duration of intervention was 18 months. Most included trials had poor study quality. The pooled weighted mean difference (WMD) for percentage weight change showed a benefit of supplementation of 2.2% (95% confidence interval (CI) 1.8 to 2.5) from 42 trials. There was no significant reduction in mortality in the supplemented compared with control groups (relative risk (RR) 0.92, CI 0.81 to 1.04) from 42 trials. Mortality results were statistically significant when limited to trials in which participants (N = 2461) were defined as undernourished (RR 0.79, 95% CI 0.64 to 0.97).The risk of complications was reduced in 24 trials (RR 0.86, 95% CI 0.75 to 0.99). Few trials were able to suggest any functional benefit from supplementation. The WMD for length of stay from 12 trials also showed no statistically significant effect (-0.8 days, 95% CI -2.8 to 1.3). Adverse effects included nausea or diarrhoea. AUTHORS' CONCLUSIONS: Supplementation produces a small but consistent weight gain in older people. Mortality may be reduced in older people who are undernourished. There may also be a beneficial effect on complications which needs to be confirmed. However, this updated review found no evidence of improvement in functional benefit or reduction in length of hospital stay with supplements. Additional data from large-scale multi-centre trials are still required.
Overview
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In the citing paper
“The latest Cochrane update from 2009 indicates that protein-energy supplementation reduces mortality, especially in older, undernourished subjects and in patients with geriatric conditions.74”
From Evidence-Based Recommendations for Optimal Dietary Protein Intake in Older People: A Position Paper From the PROT-AGE Study Group (2013) · cites this paper as [74]
In the citing paper
“Considerable evidence supports the concept that supplemental protein or higher dietary protein intake by older people hospitalized for hip fracture could reduce risk for complications, 74,84,85 improve bone mineral density, 86,87 and reduce rehabilitation time (Table 4).86”
From Evidence-Based Recommendations for Optimal Dietary Protein Intake in Older People: A Position Paper From the PROT-AGE Study Group (2013) · cites this paper as [74]
In the citing paper
“Reduced mortality risk has been reported in undernourished, hospitalized geriatric patients where supplementation (at least 400 kcal/d) may assume a therapeutic role.74”
From Evidence-Based Recommendations for Optimal Dietary Protein Intake in Older People: A Position Paper From the PROT-AGE Study Group (2013) · cites this paper as [74]
In the citing paper
“Milne et al 74 reviewed a total of 62 studies on protein and energy supplementation in older people.”
From Evidence-Based Recommendations for Optimal Dietary Protein Intake in Older People: A Position Paper From the PROT-AGE Study Group (2013) · cites this paper as [74]
In the citing paper
“However, findings from 3 comprehensive reviews/meta-analyses 73,74,84 and 2 recently published clinical trials 227,228 may suggest some beneficial effects, especially in individuals who are older, malnourished, frailer, and with interventions used for at least 3 months (Table 8).”
From Evidence-Based Recommendations for Optimal Dietary Protein Intake in Older People: A Position Paper From the PROT-AGE Study Group (2013) · cites this paper as [74]
In the citing paper
“Overall results showed that the risk of complications was reduced in 24 trials (relative risk [RR] 0.86, 95% CI 0.75e0.99),but few supported functional benefits from supplementation.”
From Evidence-Based Recommendations for Optimal Dietary Protein Intake in Older People: A Position Paper From the PROT-AGE Study Group (2013) · cites this paper as [74]
In the citing paper
“Nutrition, especially dietary protein intake, is known to affect overall function of the body.73,74,84,208e212”
From Evidence-Based Recommendations for Optimal Dietary Protein Intake in Older People: A Position Paper From the PROT-AGE Study Group (2013) · cites this paper as [74]
In the citing paper
“Overall results showed that the risk of complications was reduced in 24 trials (relative risk [RR] 0.86, 95% CI 0.75e0.99),but few supported functional benefits from supplementation.”
From Evidence-Based Recommendations for Optimal Dietary Protein Intake in Older People: A Position Paper From the PROT-AGE Study Group (2013) · cites this paper as [74]
In the citing paper
“This effect was no longer observed in the updated review in 2009 (119), and this issue was not addressed in other SLRs.”
From ESPEN practical guideline: Clinical nutrition and hydration in geriatrics (2022) · cites this paper as [119]
In the citing paper
“Subgroup analyses in the largest available SLR including 62 RCTs (119) regarding mortality were consistently statistically significant when limited to trials where 400 kcal J o u r n a l P r e -p r o o f or more was provided per day by ONS.”
From ESPEN practical guideline: Clinical nutrition and hydration in geriatrics (2022) · cites this paper as [119]
In the citing paper
“Altogether, positive effects of ONS on dietary intake (115, 116, 119, 121) and BW (115, 116, 119, 121), and reduced risk of complications (121) and readmissions (115, 120, 121) were reported, whereas the length of hospital stay (114, 115, 121) and mortality risk (114-116, 119, 121) were not significantly reduced.”
From ESPEN practical guideline: Clinical nutrition and hydration in geriatrics (2022) · cites this paper as [119]
In the citing paper
“The most comprehensive review included 62 randomized or quasi-randomized clinical trials in older persons in a variety of settings and varying nutritional states (119).”
From ESPEN practical guideline: Clinical nutrition and hydration in geriatrics (2022) · cites this paper as [119]
In the citing paper
“A systematic literature search found six high-quality SLRs that have assessed the efficacy of ONS versus usual care in older persons (114-121).”
From ESPEN practical guideline: Clinical nutrition and hydration in geriatrics (2022) · cites this paper as [119]
Citations
Cites
Measuring inconsistency in meta-analyses
Higgins, J. P. T., Thompson, S. G., Deeks, J. J., & Altman, D. G. (2003) · BMJ · doi:10.1136/bmj.327.7414.557 · Cited by 63,139
(1965) · PubMed · Cited by 14,925
The Timed “Up & Go”: A Test of Basic Functional Mobility for Frail Elderly Persons
Podsiadlo, D., & Richardson, S. (1991) · Journal of the American Geriatrics Society · doi:10.1111/j.1532-5415.1991.tb01616.x · Cited by 14,418
Functional evaluation : Barthel index
Mahonery, F. I. (1965) · Medical Entomology and Zoology · Cited by 12,762
Exercise training and nutritional supplementation for physical frailty in very elderly people
Fiatarone, M. A., O'Neill, E. F., Ryan, N. D., Clements, K. M., Solares, G. R., Nelson, M. E., Roberts, S. B., Kehayias, J. J., Lipsitz, L. A., & Evans, W. J. (1994) · New England Journal of Medicine · doi:10.1056/nejm199406233302501 · Cited by 2,857
Katz, S. (1963) · JAMA · doi:10.1001/jama.1963.03060120024016 · Cited by 2,421
THE BIOLOGY OF HUMAN STARVATION
Keys, A., BROŽEK, J., & Henschel, A. (1951) · The Medical Journal of Australia · doi:10.5694/j.1326-5377.1951.tb56499.x · Cited by 2,135
The Biology of Human Starvation: Volume I
KEYS, A., BROŽEK, J., HENSCHEL, A., MICKELSEN, O., & TAYLOR, H. L. (1950) · doi:10.5749/j.ctv9b2tqv · Cited by 2,039
Incidence and recognition of malnutrition in hospital
McWhirter, J. P., & Pennington, C. R. (1994) · BMJ · doi:10.1136/bmj.308.6934.945 · Cited by 1,504
Epidoxorubicin In, A., Cascinu, S., Labianca, R., Barone, C., Santoro, O., Carnaghi, C., Frontini, L., Aitini, E., Rota, S., Torri, V., et al. (2009) · Springer eBooks · doi:10.1007/978-0-387-78665-0_6514 · Cited by 1,394
Flagged first, then by citations
2 of the 242 references couldn’t be matched to a known paper.
Research works printed but not linked: 33
- Brown, 1992, Effect of nutrition on recovery after fractured femur, Medical Audit News, 2, 10
- Brown, 1992, Nutritional influences on recovery and length of hospital stay in elderly women following femoral fracture, Proceedings of the Nutrition Society, 51, 132A
- Deletter, 1991, A nutritional intervention for persons with chronic airflow limitation [PhD thesis]
- Edington, 2004, A prospective randomised controlled trial of nutritional supplementation in malnourished elderly in the community: clinical and health economic outcomes, Proceedings of the Nutrition Society, 63, 9A
- Gegerle, 1986, Dietary survey on the effect of an oral nutritional supplement after femoral neck fracture, Schweizerishe Rundschau fur Medizin Praxis, 75, 933
- Hankins C Dietary supplementation with sustagen in elderly patients with fractured neck of femur (PhD Thesis) Sydney University 1996
- Madigan C Benefits of dietary supplementation in elderly patients with fractured neck of femur (MSc dissertation) MSc dissertation 1994
- McWhirter, 1996, The influence of supplemental feeding and a comparison of methods in malnourished hospital patients, Jpen: Journal of Enteral and Parenteral Nutrition, 20, 73
- Payette, 2002, Efficacy of nutritional intervention in the free-living frail elderly, American Journal of Clinical Nutrition, 75, 340S
- Potter, 1998, Randomised controlled trial of protein energy supplementation in elderly emergency admissions (abstract), Age and Ageing, 27 Suppl 2, 39
- Potter, 1998, A evaluation of protein energy supplementation in medically ill admissions to a geriatric unit, Proceedings of the Nutrition Society, 57, 88A
- Salas, 2004, Effect of a whole formula diet on nutritional status in institutionalized patients with alzheimer disease, Clinical Nutrition, 23, 769
- Tidermark, 2002, Liquid supplementation and nandrolone to elderly women, Clinical Nutrition, 21 Suppl 1, 40
- Bean, 1994, Double-blind pilot trial in elderly women with fractured femur of ornithine alpha-ketoglutarate versus a defined formula peptide oral supplement, Proceedings of the Nutrition Society, 53, 203A
- Campbell, 1994, Dietary protein intake influences resistance training-induced changes in whole-body protein turnover, FASEB: Federation of American societies for experimental biology, 8, A428
- Danhof, 1982, Nutritional support of geriatric patients, Jpen: Journal of Parenteral & Enteral Nutrition, 6, 588
- Gallagher, 1992, Aggressive early management of malnutrition in hip fracture patients, Journal of Parenteral & Enteral Nutrition, 16, 19S
- Kiel, 1992, Enhancing weight gain in long-term care residents through a protein-calorie supplemented mechanically altered diet, Journal of the American Dietetic Association, 92 Suppl, A91
- Kretser, 2000, Improving nutritional and functional outcomes in homebound elders via an aggressive 21 meal per week home delivery program, Journal of the American Dietetic Association, 100, A91
- Neumann, 2004, Journal of Parenteral and Enteral Nutrition, 28, S30
- Nickerson, 1998, Oral and metabolic tolerance of supplemental arginine in elderly nursing home residents with pressure ulcers, Journal of Parenteral & Enteral Nutrition, 22 Suppl, 75
- Pardy, 1986, Supplemental nutrition does not alter respiratory muscle strength (RMS) or endurance (RME) in ambulatory COPD, American Review of Respiratory Disease, 133, A204
- Pupim, 2002, Review of Brasilian Medicine, 59, 55
- Bonjour, 1997, Protein Intake, IGF-1 and osteoporosis, Osteoporosis International, 7 Suppl 3, S36, 10.1007/BF03194340 · DOI
- Schurch, 1996, Protein supplements increase serum IGF-1 and decrease proximal femur bone loss in patients with recent hip fracture, 327
- Stauffer, 1986, Effects of diet supplementation on anthropometric and laboratory nutritional parameters in malnourished ambulatory patients with severe chronic obstructive pulmonary disease (COPD), American Review of Respiratory Disease, 133, A204
- Vargas, 1995, Effects of an inspiratory muscle training program and nutritional support in patients with chronic obstructive lung disease, Revista Medica De Chile, 123, 1225
- Driver, 1994, Evaluation of supplemental nutrition in elderly orthopaedic patients [PhD thesis]
- Driver, 1990, A controlled trial of sip-feed supplements and compliance, Proceedings of the Nutrition Society, 49, 173A
- Williams, 1988, The use of a nutritional risk score in identifying patients who may benefit from sip-feed supplementation in hospital, Proceedings of the Nutrition Society, 47, 135A
- Lennard-Jones, 1992, A positive approach to nutrition as treatment
- National Collaborating Centre for Acute Care, 2006, Nutrition support in adults. Oral nutrition support, enteral tube feeding and parenteral nutrition
- Peake, 1998, Nutritional supplementation: how much do people drink?, Proceedings of the Nutrition Society, 57, 94A
Cited by
Sorted by citations
Items 201–300 of 846
Rapid Geriatric Assessment: A Tool for Primary Care Physicians
Morley, J. E., Little, M. O., & Berg‐Weger, M. (2017) · Journal of the American Medical Directors Association · doi:10.1016/j.jamda.2016.11.017 · Cited by 57
Schüetz, P., Fehr, R., Baechli, V., Geiser, M., Gomes, F., Kutz, A., Tribolet, P., Bregenzer, T., Hoess, C., Pavlicek, V., et al. (2018) · International Journal of Clinical Trials · doi:10.18203/2349-3259.ijct20182085 · Cited by 57
Bjorkman, M. P., Suominen, M. H., Kautiainen, H., Jyväkorpi, S. K., Finne-Soveri, H. U., Strandberg, T. E., Pitkälä, K. H., & Tilvis, R. S. (2019) · Journal of the American Medical Directors Association · doi:10.1016/j.jamda.2019.09.006 · Cited by 57
Edwards, D. J., Carrier, J., & Hopkinson, J. B. (2017) · International Journal of Nursing Studies · doi:10.1016/j.ijnurstu.2017.01.013 · Cited by 57
Atalay, B. G., Yağmur, C., Nursal, T. Z., Atalay, H., & Noyan, T. (2008) · Journal of Parenteral and Enteral Nutrition · doi:10.1177/0148607108314369 · Cited by 57
Xu, Z., Tan, Z., Zhang, Q., Gui, Q., & Yang, Y. (2014) · PLoS ONE · doi:10.1371/journal.pone.0109141 · Cited by 60
Beelen, J., de Roos, N. M., & de Groot, C. P. G. M. (2016) · The journal of nutrition health & aging · doi:10.1007/s12603-016-0733-y · Cited by 56
Tamang, M. K., Yadav, U. N., Hosseinzadeh, H., Kafle, B., Paudel, G., Khatiwada, S., & Sekaran, V. C. (2019) · BMC Research Notes · doi:10.1186/s13104-019-4282-4 · Cited by 56
Trabal, J., & Farran-Codina, A. (2015) · Nutrition Reviews · doi:10.1093/nutrit/nuv023 · Cited by 55
Kaegi-Braun, N., Tribolet, P., Gomes, F., Fehr, R., Baechli, V., Geiser, M., Deiss, M., Kutz, A., Bregenzer, T., Hoess, C., et al. (2021) · Clinical Nutrition · doi:10.1016/j.clnu.2020.08.019 · Cited by 55
Rasmussen, N. M. L., Belqaid, K., Lugnet, K., Nielsen, A. L., Rasmussen, H. H., & Beck, A. M. (2018) · Clinical Nutrition ESPEN · doi:10.1016/j.clnesp.2018.07.002 · Cited by 55
van der Meij, B. S., Wijnhoven, H. A. H., Finlayson, G., Oosten, B. S. H., & Visser, M. (2015) · Appetite · doi:10.1016/j.appet.2015.03.011 · Cited by 55
Leucine and citrulline modulate muscle function in malnourished aged rats
Faure, C., Raynaud-Simon, A., Ferry, A., Daugé, V., Cynober, L., Aussel, C., & Moinard, C. (2011) · Amino Acids · doi:10.1007/s00726-011-0841-2 · Cited by 59
Musculoskeletal health and frailty
McGuigan, F. E., Bartosch, P., & Åkesson, K. (2017) · Best Practice & Research Clinical Rheumatology · doi:10.1016/j.berh.2017.11.002 · Cited by 56
Calvani, R., Martone, A. M., Marzetti, E., Onder, G., Savera, G., Lorenzi, M., Serafini, E., Bernabei, R., & Landi, F. (2014) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2014.00269 · Cited by 54
Health System Quality Improvement
Meehan, A. J., Loose, C., Bell, J., Partridge, J. S., Nelson, J. L., & Goates, S. (2016) · Journal of Nursing Care Quality · doi:10.1097/ncq.0000000000000177 · Cited by 54
Endevelt, R., Lemberger, J., Bregman, J., Kowen, G., Berger-Fecht, I., Lander, H., Karpati, T., & Shahar, D. R. (2011) · The journal of nutrition health & aging · doi:10.1007/s12603-011-0074-9 · Cited by 54
Vulnerable patients with a fractured neck of femur: nutritional status and support in hospital
Nematy, M., Hickson, M., Brynes, A. E., Ruxton, C. H. S., & Frost, G. S. (2006) · Journal of Human Nutrition and Dietetics · doi:10.1111/j.1365-277x.2006.00692.x · Cited by 54
Ahn, S.-H., Lee, J.-H., & Lee, J.-W. (2020) · Lipids in Health and Disease · doi:10.1186/s12944-020-01414-4 · Cited by 44
Nykänen, I., Rissanen, T., Sulkava, R. O., & Hartikainen, S. A. (2013) · The journal of nutrition health & aging · doi:10.1007/s12603-013-0342-y · Cited by 53
Lundin, H. R., Sääf, M., Strender, L.-E., Mollasaraie, H. A., & Salminen, H. (2012) · European Journal of Clinical Nutrition · doi:10.1038/ejcn.2012.100 · Cited by 53
Garwe, T., Albrecht, R. M., Stoner, J. A., Mitchell, S., & Motghare, P. N. (2015) · The American Journal of Surgery · doi:10.1016/j.amjsurg.2015.06.013 · Cited by 53
Barriers to and Facilitators of the Consumption of Animal-Based Protein-Rich Foods in Older Adults
Appleton, K. M. (2016) · Nutrients · doi:10.3390/nu8040187 · Cited by 57
Targeting Frailty in Heart Failure
Joseph, S. M., & Rich, M. W. (2017) · Current Treatment Options in Cardiovascular Medicine · doi:10.1007/s11936-017-0527-5 · Cited by 53
van Asselt, D. Z. B., de van der Schueren, M. A. E., van der Cammen, T. J. M., Disselhorst, L. G. M., Janse, A., Lonterman, S., Maas, H. A. A. M., Popescu, M. E., Schölzel-Dorenbos, C. J. M., Sipers, W. M. W. H., et al. (2012) · Age and Ageing · doi:10.1093/ageing/afs005 · Cited by 52
House Staff Member Awareness of Older Inpatients' Risks for Hazards of Hospitalization
Fernandez, H. M. (2008) · Archives of Internal Medicine · doi:10.1001/archinternmed.2007.87 · Cited by 52
Freijer, K., Nuijten, M. J. C., & Schols, J. M. G. A. (2012) · Frontiers in Pharmacology · doi:10.3389/fphar.2012.00078 · Cited by 51
O’Connell, M. B., Jensen, P. S., Andersen, S. L., Fernbrant, C., Nørholm, V., & Petersen, H. V. (2017) · Journal of Clinical Nursing · doi:10.1111/jocn.14020 · Cited by 51
Skaar, E., Eide, L. S. P., Norekvål, T. M., Ranhoff, A. H., Nordrehaug, J. E., Forman, D. E., Schoenenberger, A. W., Hufthammer, K. O., Kuiper, K. K. J., Bleie, Ø., et al. (2018) · European Heart Journal - Quality of Care and Clinical Outcomes · doi:10.1093/ehjqcco/qcy044 · Cited by 51
Suominen, M. H., Puranen, T. M., Jyväkorpi, S. K., Eloniemi-Sulkava, U. R., Kautiainen, H., Siljamäki-Ojansuu, U., & Pitkälä, K. H. (2015) · The journal of nutrition health & aging · doi:10.1007/s12603-015-0558-0 · Cited by 51
Nutrition and Dementia: a review of available research.
Guerchet, M., Albanese, E., Prina, M. A., Prince, M. J., Siervo, M., & Acosta, D. M. (2014) · HAL · Cited by 51
Lilamand, M., Kelaiditi, E., Demougeot, L., Rolland, Y., Vellas, B. J., & Cesari, M. (2014) · The journal of nutrition health & aging · doi:10.1007/s12603-014-0533-1 · Cited by 50
Beelen, J., Vasse, E., Janssen, N., Janse, A., de Roos, N. M., & de Groot, C. P. G. M. (2017) · Clinical Nutrition · doi:10.1016/j.clnu.2017.05.010 · Cited by 50
Young, A. M., Banks, M. D., & Mudge, A. M. (2018) · Clinical Nutrition ESPEN · doi:10.1016/j.clnesp.2017.12.009 · Cited by 50
Sanz‐París, A., Camprubí-Robles, M., López-Pedrosa, J. M., Pereira, S. L., Rueda, R., Ballesteros-Pomar, M. D., Almeida, J. M. G., & Cruz-Jentoft, A. J. (2018) · The journal of nutrition health & aging · doi:10.1007/s12603-018-0995-7 · Cited by 50
Lang, P. O., Meyer, N., Heitz, D., Dramé, M., Jovenin, N., Ankri, J., Somme, D., Novella, J., Gauvain, J., Couturier, P., et al. (2007) · European Journal of Epidemiology · doi:10.1007/s10654-007-9150-1 · Cited by 50
Kramer, C. S., Groenendijk, I., Beers, S., Wijnen, H. H., van de Rest, O., & de Groot, C. P. G. M. (2022) · Current Developments in Nutrition · doi:10.1093/cdn/nzac007 · Cited by 50
Clinical practice in nursing homes as a key for progress
Morley, J. E. (2010) · The journal of nutrition health & aging · doi:10.1007/s12603-010-0039-4 · Cited by 49
Cost-effectiveness of nutrition interventions in nursing home residents: A pilot intervention
Simmons, S. F., Zhuo, X., & Keeler, E. (2010) · The journal of nutrition health & aging · doi:10.1007/s12603-010-0082-1 · Cited by 49
Ziylan, C., Haveman‐Nies, A., van Dongen, E. J. I., Kremer, S., & de Groot, C. P. G. M. (2015) · BMC Nutrition · doi:10.1186/s40795-015-0034-6 · Cited by 49
de van der Schueren, M. A. E., Wijnhoven, H. A. H., Kruizenga, H. M., & Visser, M. (2015) · Clinical Nutrition · doi:10.1016/j.clnu.2015.12.013 · Cited by 49
Beck, A. M., Dent, E., & Baldwin, C. (2016) · Journal of Human Nutrition and Dietetics · doi:10.1111/jhn.12382 · Cited by 49
Effects of Nutritional Status on 6-Month Outcome of Hip Fractures in Elderly Patients
Miu, D. K. Y., & Lam, P. S. (2017) · Annals of Rehabilitation Medicine · doi:10.5535/arm.2017.41.6.1005 · Cited by 49
Seematter‐Bagnoud, L., & Büla, C. (2018) · Public health reviews · doi:10.1186/s40985-018-0086-7 · Cited by 49
ESPEN practical guideline: Nutritional support for polymorbid medical inpatients
Wunderle, C., Gomes, F., Schüetz, P., Stumpf, F., Austin, P. D., Ballesteros-Pomar, M. D., Cederholm, T., Fletcher, J. M., Laviano, A., Norman, K., et al. (2024) · Clinical Nutrition · doi:10.1016/j.clnu.2024.01.008 · Cited by 51
Weight Loss Strategies in the Elderly: A Clinical Conundrum
Coker, R. H., & Wolfe, R. R. (2018) · Obesity · doi:10.1002/oby.21961 · Cited by 47
Cachexia: a nutritional syndrome?
Anker, S. D., & Morley, J. E. (2015) · Journal of Cachexia Sarcopenia and Muscle · doi:10.1002/jcsm.12088 · Cited by 47
Effects of oral nutrition supplements in persons with dementia: A systematic review
Tangvik, R. J., Bruvik, F. K., Drageset, J., Kyte, K., & Hunskår, I. (2020) · Geriatric Nursing · doi:10.1016/j.gerinurse.2020.12.005 · Cited by 47
Nutrition Care after Discharge from Hospital: An Exploratory Analysis from the More-2-Eat Study
Laur, C. V., Curtis, L., Dubin, J. A., McNicholl, T., Valaitis, R. F., Douglas, P., Bell, J., Bernier, P., & Keller, H. (2018) · Healthcare · doi:10.3390/healthcare6010009 · Cited by 46
Séguy, D., Hubert, H., Robert, J., Meunier, J., Guérin, O., & Raynaud-Simon, A. (2019) · Clinical Nutrition · doi:10.1016/j.clnu.2019.08.005 · Cited by 47
Kennelly, S., Kennedy, N. P., Rughoobur, G. F., Slattery, C. G., & Sugrue, S. (2010) · Journal of Human Nutrition and Dietetics · doi:10.1111/j.1365-277x.2010.01111.x · Cited by 46
Beck, A. M., Damkjær, K., & Sørbye, L. W. (2010) · Archives of Gerontology and Geriatrics · doi:10.1016/j.archger.2009.05.018 · Cited by 45
Stow, R., Ives, N. J., Smith, C. H., Rick, C., & Rushton, A. (2015) · Trials · doi:10.1186/s13063-015-0952-2 · Cited by 46
Avelino‐Silva, T. J., & Jaluul, O. (2017) · International journal of gerontology · doi:10.1016/j.ijge.2016.11.002 · Cited by 45
Malnutrition in the elderly and its effects on bone health – A review
Siddique, N., O'Donoghue, M., Casey, M. C., & Walsh, J. B. (2017) · Clinical Nutrition ESPEN · doi:10.1016/j.clnesp.2017.06.001 · Cited by 45
Huang, C., Martins, B. A., Okada, K., Matsushita, E., Uno, C., Satake, S., & Kuzuya, M. (2020) · Clinical Nutrition · doi:10.1016/j.clnu.2020.05.013 · Cited by 49
Sharma, Y., Thompson, C. H., Kaambwa, B., Shahi, R., Hakendorf, P., & Miller, M. (2017) · QJM: An International Journal of Medicine · doi:10.1093/qjmed/hcx095 · Cited by 45
Nutritional guidelines for older people in Finland
Suominen, M. H., Jyvakorpi, S. K., Pitkala, K. H., Finne-Soveri, H., Hakala, P., Mannisto, S., Soini, H., & Sarlio-Lahteenkorva, S. (2014) · The Journal of nutrition, health and aging · doi:10.1007/s12603-014-0509-1 · Cited by 44
An open-ended question: Alzheimer’s disease and involuntary weight loss: which comes first?
Inelmen, E. M., Sergi, G., Coin, A., Girardi, A., & Manzato, E. (2010) · Aging Clinical and Experimental Research · doi:10.1007/bf03324796 · Cited by 44
Nutrition and older people: special considerations relating to nutrition and ageing
Gariballa, S. (2004) · Clinical Medicine · doi:10.7861/clinmedicine.4-5-411 · Cited by 44
Bretscher, C., Buergin, M., Gurzeler, G., Kägi‐Braun, N., Gressies, C., Tribolet, P., Lobo, D. N., Evans, D. C., Stanga, Z., Mueller, B., et al. (2023) · Journal of Parenteral and Enteral Nutrition · doi:10.1002/jpen.2470 · Cited by 44
Jobse, I., Liao, Y., Bartram, M., Delantonio, K., Uter, W. J. C., Stehle, P., Sieber, C. C., & Volkert, D. (2014) · The journal of nutrition health & aging · doi:10.1007/s12603-014-0544-y · Cited by 43
Integrated Therapies for Osteoporosis and Sarcopenia: From Signaling Pathways to Clinical Trials
Girgis, C. M. (2015) · Calcified Tissue International · doi:10.1007/s00223-015-9956-x · Cited by 43
Clinical Update on Nursing Home Medicine: 2009
Messinger‐Rapport, B. J., Thomas, D. R., Gammack, J. K., & Morley, J. E. (2009) · Journal of the American Medical Directors Association · doi:10.1016/j.jamda.2009.08.001 · Cited by 45
Undernutrition: who cares? Perspectives of dietitians and older adults on undernutrition
Beelen, J., Vasse, E., Ziylan, C., Janssen, N., de Roos, N. M., & de Groot, C. P. G. M. (2017) · BMC Nutrition · doi:10.1186/s40795-017-0144-4 · Cited by 43
Phillips, S. M., Lau, K. J., D'Souza, A. C., & Nunes, E. A. (2022) · Journal of Cachexia, Sarcopenia and Muscle · doi:10.1002/jcsm.13030 · Cited by 42
Marshall, S., Bauer, J., Capra, S., & Isenring, E. (2013) · The Journal of nutrition, health and aging · doi:10.1007/s12603-013-0341-z · Cited by 42
Munk, T., Svendsen, J. A., Knudsen, A. W., Østergaard, T. B., Thomsen, T., Olesen, S. S., Rasmussen, H. H., & Beck, A. M. (2021) · Clinical Nutrition · doi:10.1016/j.clnu.2021.09.029 · Cited by 42
Nutritional care; do process and structure indicators influence malnutrition prevalence over time?
Meijers, J. M. M., Tan, F. E. S., Schols, J. M. G. A., & Halfens, R. J. G. (2013) · Clinical Nutrition · doi:10.1016/j.clnu.2013.06.015 · Cited by 42
Oral strategies to supplement older adults’ dietary intakes: comparing the evidence
Silver, H. J. (2008) · Nutrition Reviews · doi:10.1111/j.1753-4887.2008.00131.x · Cited by 42
Body mass index, age and in-hospital mortality: The NutritionDay multinational survey
Cereda, E., Klersy, C., Hiesmayr, M., Schindler, K., Singer, P., Laviano, A., & Caccialanza, R. (2016) · Clinical Nutrition · doi:10.1016/j.clnu.2016.05.001 · Cited by 44
Schuetz, P. (2015) · Swiss Medical Weekly · doi:10.4414/smw.2015.14132 · Cited by 42
Lim, W. S., Wong, C. H., Ding, Y. Y., Rockwood, K. J., & Lien, C. T. C. (2019) · Annals of the Academy of Medicine Singapore · doi:10.47102/annals-acadmedsg.v48n1p25 · Cited by 42
Littbrand, H., Carlsson, M., Lundin‐Olsson, L., Lindelöf, N., Håglin, L., Gustafson, Y., & Rosendahl, E. (2011) · Journal of the American Geriatrics Society · doi:10.1111/j.1532-5415.2011.03484.x · Cited by 42
Prasad, K., Kaul, S., Padma, M., Gorthi, S. P., Khurana, D., & Bakshi, A. (2011) · Annals of Indian Academy of Neurology · doi:10.4103/0972-2327.83084 · Cited by 42
Ferrer, A., Badía, T., Formiga, F., Gil, A., Padrós, G., Sarró, M., Almeda, J., & Pujol, R. (2010) · Revista Española de Geriatría y Gerontología · doi:10.1016/j.regg.2009.10.013 · Cited by 41
Wright, J., & Baldwin, C. (2017) · Clinical Nutrition · doi:10.1016/j.clnu.2017.09.004 · Cited by 41
Atten, M. N. V. D.-V., Haveman‐Nies, A., van Bakel, M. M., Ferry, M., Franco, M., de Groot, C. P. G. M., & de Vries, J. H. M. (2018) · British Journal Of Nutrition · doi:10.1017/s0007114518000843 · Cited by 41
Closing the Osteoporosis Care Gap
Åkesson, K., & McGuigan, F. E. (2021) · Current Osteoporosis Reports · doi:10.1007/s11914-020-00644-w · Cited by 41
Chen, C., Tang, S. T., Wang, C. I., & Huang, G. (2009) · Journal of Clinical Nursing · doi:10.1111/j.1365-2702.2009.02932.x · Cited by 41
Pedersen, J. L., Pedersen, P. U., & Damsgaard, E. M. (2016) · The Journal of nutrition, health and aging · doi:10.1007/s12603-015-0629-2 · Cited by 40
Lindhardt, T., & Nielsen, M. H. (2017) · International Journal of Medical Informatics · doi:10.1016/j.ijmedinf.2016.10.017 · Cited by 40
Fragility Fracture Nursing: Holistic Care and Management of the Orthogeriatric Patient
(2018) · Perspectives in Nursing Management and Care for Older Adults · doi:10.1007/978-3-319-76681-2 · Cited by 40
Cawood, A. L., Burden, S. T., Smith, T. R., & Stratton, R. J. (2023) · Ageing Research Reviews · doi:10.1016/j.arr.2023.101953 · Cited by 40
Liljeberg, E., Andersson, A., Malmberg, K. B., & Nydahl, M. C. (2019) · Nutrition in Clinical Practice · doi:10.1002/ncp.10243 · Cited by 40
Rasheed, S., & Woods, B. T. (2013) · Journal of Nutrition in Gerontology and Geriatrics · doi:10.1080/21551197.2012.753772 · Cited by 39
Skates, J. J., & Anthony, P. S. (2012) · Journal of Gerontological Nursing · doi:10.3928/00989134-20120207-50 · Cited by 39
Considerations for the Development of Innovative Foods to Improve Nutrition in Older Adults
Mariane Lutz, R., Petzold, G., & Cecilia Albala, B. (2019) · Nutrients · doi:10.3390/nu11061275 · Cited by 40
Giha, H. A., Sater, M. S., & Alamin, O. A. O. (2022) · Acta Diabetologica · doi:10.1007/s00592-022-01860-9 · Cited by 39
Campbell, K. L., Webb, L., Vivanti, A., Varghese, P. N., & Ferguson, M. L. (2013) · Nutrition & Dietetics · doi:10.1111/1747-0080.12008 · Cited by 39
Self-citationRegion-Specific Fat Mass and Muscle Mass and Mortality in Community-Dwelling Older Men and Women
Wijnhoven, H. A. H., Snijder, M. B., de van der Schueren, M. A. E., Deeg, D. J. H., & Visser, M. (2011) · Gerontology · doi:10.1159/000324027 · Cited by 38
Soenen, S., Giezenaar, C., Hutchison, A. T., Horowitz, M., Chapman, I. M., & Luscombe‐Marsh, N. D. (2014) · American Journal of Clinical Nutrition · doi:10.3945/ajcn.114.087981 · Cited by 41
Schilp, J., Kruizenga, H. M., Wijnhoven, H. A. H., van Binsbergen, J. J., & Visser, M. (2013) · European Journal of Nutrition · doi:10.1007/s00394-013-0495-9 · Cited by 38
Lindroos, E., Saarela, R. K. T., Soini, H., Muurinen, S., Suominen, M. H., & Pitkälä, K. H. (2014) · The journal of nutrition health & aging · doi:10.1007/s12603-014-0467-7 · Cited by 38
Perspectives on the causes of undernutrition of community-dwelling older adults: A qualitative study
van der Pols-Vijlbrief, R., Wijnhoven, H. A. H., & Visser, M. (2017) · The journal of nutrition health & aging · doi:10.1007/s12603-017-0872-9 · Cited by 37
Rinninella, E., Cintoni, M., LORENZO, A. D., Addolorato, G., Vassallo, G. A., Moroni, R., Miggiano, G. A. D., Gasbarrini, A., & Mele, M. C. (2018) · Internal and Emergency Medicine · doi:10.1007/s11739-018-1884-0 · Cited by 37
Yamamoto, K., Tsuchihashi‐Makaya, M., Kinugasa, Y., Iida, Y., Kamiya, K., Kihara, Y., Kono, Y., Sato, Y., Suzuki, N., Takeuchi, H., et al. (2020) · Circulation Journal · doi:10.1253/circj.cj-20-0322 · Cited by 37
Nutritional care of medical inpatients: a health technology assessment
Lassen, K. Ø., Olsen, J., Grinderslev, E., Kruse, F., & Bjerrum, M. B. (2006) · BMC Health Services Research · doi:10.1186/1472-6963-6-7 · Cited by 37
den Uijl, L. C., Kremer, S., Jager, G., van der Stelt, A. J., de Graaf, C., Gibson, P., Godfrey, J., & Lawlor, J. (2015) · Appetite · doi:10.1016/j.appet.2015.01.016 · Cited by 37
Whey protein supplementation in nursing home residents. A randomized controlled trial
Bjorkman, M. P., Finne‐Soveri, H., & Tilvis, R. S. (2012) · European Geriatric Medicine · doi:10.1016/j.eurger.2012.03.010 · Cited by 37
Metadata
- Authors
- Milne, A. C., Potter, J., Vivanti, A., & Avenell, A.
- Affiliations
- Stonelea, Prospect Terrace, Port Elphinstone, Inverurie Aberdeen Aberdeenshire, Scotland UK AB51 3UN
- South East Sydney and Illawarra Area Health Service; Aged Care Southern Hospital Network; LMB 8808 South Coast Mail Centre Wollongong New South Wales Australia 2521
- Princess Alexandra Hospital (AU)
- University of Aberdeen (GB)
- Venue
- Cochrane Database of Systematic Reviews
- Publisher
- Wiley
- Published
- 2009-04-15
- Issue
- 2
- Pages
- CD003288-CD003288
- ISSN
- 1361-6137 (ISSN-L)
- 1465-1858
- PMC
- PMC7144819
- OpenAlex
- W1578200161
- Cited by
- 849
- References
- 242
- Citations by year
- 2026: 8 · 2025: 14 · 2024: 20 · 2023: 32 · 2022: 41 · 2021: 44 · 2020: 34 · 2019: 35 · 2018: 56 · 2017: 58 · 2016: 63 · 2015: 64 · 2014: 64 · 2013: 63 · 2012: 52
- FWCI
- 6.28
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Cochrane Database of Systematic Reviews (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Physiology (medical) › Nutrition and Health in Aging
- Health Sciences › Nursing › Nutrition and Dietetics › Clinical Nutrition and Gastroenterology
- Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Nutrition and Health Studies
- Keywords
- protein supplementation, energy supplementation, malnutrition, older adults, nutritional status, weight gain, mortality, complications, length of hospital stay, adverse effects, nausea, diarrhea, functional outcome, clinical outcomes, heterogeneity of results, publication bias, risk of bias assessment, conflicts of interest
- MeSH terms
- Aged, Energy Intake, Dietary Proteins, Humans, Length of Stay, Randomized Controlled Trials as Topic, Dietary Supplements, Malnutrition
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
