Cited by 924Antioxidant Activity and Oxidative StressVitamin C and Antioxidants ResearchNutrition and Health Studies

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Antioxidant supplements for prevention of mortality in healthy participants and patients with various diseases

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Bjelakovic, Goran, Nikolova, Dimitrinka, Gluud, Lise Lotte, Simonetti, Rosa G, Gluud, Christian·2012·Cochrane Database of Systematic Reviews

DOI 10.1002/14651858.cd007176.pub2PMC PMC8407395

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Abstract

BACKGROUND: Our systematic review has demonstrated that antioxidant supplements may increase mortality. We have now updated this review. OBJECTIVES: To assess the beneficial and harmful effects of antioxidant supplements for prevention of mortality in adults. SEARCH METHODS: We searched The Cochrane Library, MEDLINE, EMBASE, LILACS, the Science Citation Index Expanded, and Conference Proceedings Citation Index-Science to February 2011. We scanned bibliographies of relevant publications and asked pharmaceutical companies for additional trials. SELECTION CRITERIA: We included all primary and secondary prevention randomised clinical trials on antioxidant supplements (beta-carotene, vitamin A, vitamin C, vitamin E, and selenium) versus placebo or no intervention. DATA COLLECTION AND ANALYSIS: Three authors extracted data. Random-effects and fixed-effect model meta-analyses were conducted. Risk of bias was considered in order to minimise the risk of systematic errors. Trial sequential analyses were conducted to minimise the risk of random errors. Random-effects model meta-regression analyses were performed to assess sources of intertrial heterogeneity. MAIN RESULTS: Seventy-eight randomised trials with 296,707 participants were included. Fifty-six trials including 244,056 participants had low risk of bias. Twenty-six trials included 215,900 healthy participants. Fifty-two trials included 80,807 participants with various diseases in a stable phase. The mean age was 63 years (range 18 to 103 years). The mean proportion of women was 46%. Of the 78 trials, 46 used the parallel-group design, 30 the factorial design, and 2 the cross-over design. All antioxidants were administered orally, either alone or in combination with vitamins, minerals, or other interventions. The duration of supplementation varied from 28 days to 12 years (mean duration 3 years; median duration 2 years). Overall, the antioxidant supplements had no significant effect on mortality in a random-effects model meta-analysis (21,484 dead/183,749 (11.7%) versus 11,479 dead/112,958 (10.2%); 78 trials, relative risk (RR) 1.02, 95% confidence interval (CI) 0.98 to 1.05) but significantly increased mortality in a fixed-effect model (RR 1.03, 95% CI 1.01 to 1.05). Heterogeneity was low with an I(2)- of 12%. In meta-regression analysis, the risk of bias and type of antioxidant supplement were the only significant predictors of intertrial heterogeneity. Meta-regression analysis did not find a significant difference in the estimated intervention effect in the primary prevention and the secondary prevention trials. In the 56 trials with a low risk of bias, the antioxidant supplements significantly increased mortality (18,833 dead/146,320 (12.9%) versus 10,320 dead/97,736 (10.6%); RR 1.04, 95% CI 1.01 to 1.07). This effect was confirmed by trial sequential analysis. Excluding factorial trials with potential confounding showed that 38 trials with low risk of bias demonstrated a significant increase in mortality (2822 dead/26,903 (10.5%) versus 2473 dead/26,052 (9.5%); RR 1.10, 95% CI 1.05 to 1.15). In trials with low risk of bias, beta-carotene (13,202 dead/96,003 (13.8%) versus 8556 dead/77,003 (11.1%); 26 trials, RR 1.05, 95% CI 1.01 to 1.09) and vitamin E (11,689 dead/97,523 (12.0%) versus 7561 dead/73,721 (10.3%); 46 trials, RR 1.03, 95% CI 1.00 to 1.05) significantly increased mortality, whereas vitamin A (3444 dead/24,596 (14.0%) versus 2249 dead/16,548 (13.6%); 12 trials, RR 1.07, 95% CI 0.97 to 1.18), vitamin C (3637 dead/36,659 (9.9%) versus 2717 dead/29,283 (9.3%); 29 trials, RR 1.02, 95% CI 0.98 to 1.07), and selenium (2670 dead/39,779 (6.7%) versus 1468 dead/22,961 (6.4%); 17 trials, RR 0.97, 95% CI 0.91 to 1.03) did not significantly affect mortality. In univariate meta-regression analysis, the dose of vitamin A was significantly associated with increased mortality (RR 1.0006, 95% CI 1.0002 to 1.001, P = 0.002). AUTHORS' CONCLUSIONS: We found no evidence to support antioxidant supplements for primary or secondary prevention. Beta-carotene and vitamin E seem to increase mortality, and so may higher doses of vitamin A. Antioxidant supplements need to be considered as medicinal products and should undergo sufficient evaluation before marketing.

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Susceptibility of human LDL to oxidative modification. Effects of variations in beta-carotene concentration and oxygen tension.
Reaven, P. D., Ferguson, E., Navab, M., et al. (1994) · Arteriosclerosis and Thrombosis A Journal of Vascular Biology · doi:10.1161/01.atv.14.7.1162 · Cited by 72
Chemoprevention of oral leukoplakia and chronic esophagitis in an area of high incidence of oral and esophageal cancer
Заридзе, Д. Г., Evstifeeva, T. V., & Boyle, P. (1993) · Annals of Epidemiology · doi:10.1016/1047-2797(93)90023-w · Cited by 72
Introduction to artificial neural networks for physicians: Taking the lid off the black box
Rodvold, D. M., McLeod, D. G. R., Brandt, J. M., Snow, P. B., & Murphy, G. P. (2001) · The Prostate · doi:10.1002/1097-0045(200101)46:1 · Cited by 72
Statistical design and monitoring of the carotene and retinol efficacy trial (CARET)
Thornquist, M. D., Omenn, G. S., Goodman, G. E., Grizzle, J. E., Rosenstock, L., Barnhart, S., Anderson, G. L., Hammar, S. P., Balmes, J. R., Cherniack, M. G., et al. (1993) · Controlled Clinical Trials · doi:10.1016/0197-2456(93)90228-6 · Cited by 72
Morphometric evaluation of gastric antral atrophy: improvement after cure of Helicobacter pylori infection
Ruiz, B. A., Garay, J., Corréa, P., et al. (2001) · The American Journal of Gastroenterology · doi:10.1111/j.1572-0241.2001.05326.x · Cited by 71
Vitamins in aging, health, and longevity
Thomas, D. R. (2006) · Clinical Interventions in Aging · doi:10.2147/ciia.2006.1.1.81 · Cited by 71
Effect of Low-Dose Aspirin on the Occurrence of Venous Thromboembolism
Glynn, R. J., Ridker, P. M., Goldhaber, S. Z., & Buring, J. E. (2007) · Annals of Internal Medicine · doi:10.7326/0003-4819-147-8-200710160-00004 · Cited by 71
Effectiveness of vitamin E for treatment of long-term tardive dyskinesia
Dabiri, L., Pasta, D. J., Darby, J. K., et al. (1994) · American Journal of Psychiatry · doi:10.1176/ajp.151.6.925 · Cited by 71
Long-Term Combined Supplementations with α-Tocopherol and Vitamin C Have No Detectable Anti-Inflammatory Effects in Healthy Men
Bruunsgaard, H., Pedersen, B. K., Poulsen, H. E., Nyyssönen, K., Kaikkonen, J., & Salonen, J. T. (2003) · The Journal of Nutrition · doi:10.1093/jn/133.4.1170 · Cited by 70
Improvement of endothelial vasomotor dysfunction by treatment with alpha-tocopherol in patients with high remnant lipoproteins levels
Kugiyama, K., Motoyama, T., Doi, H., Kawano, H., Hirai, N., Soejima, H., Miyao, Y., Takazoe, K., Moriyama, Y., Mizuno, Y., et al. (1999) · Journal of the American College of Cardiology · doi:10.1016/s0735-1097(99)00057-1 · Cited by 70
A Randomized, Double-Blind Placebo-Controlled Trial Evaluating the Effects of Vitamin E and Selenium on Arsenic-Induced Skin Lesions in Bangladesh
Verret, W. J., Chen, Y., Ahmed, A., Islam, T., Parvez, F., Kibriya, M. G., Graziano, J. H., & Ahsan, H. (2005) · Journal of Occupational and Environmental Medicine · doi:10.1097/01.jom.0000183095.45050.97 · Cited by 70
Visual Acuity Outcomes after Cataract Surgery in Patients with Age-Related Macular Degeneration: Age-Related Eye Disease Study Report No. 27
Forooghian, F., Agrón, E., Clemons, T. E., Ferris, F. L., & Chew, E. Y. (2009) · Ophthalmology · doi:10.1016/j.ophtha.2009.04.033 · Cited by 70
Comparison of Self-Reported Diagnosis of Connective Tissue Disease with Medical Records in Female Health Professionals: The Women's Health Cohort Study
Karison, E. W., Lee, I.-M., Cook, N. R., et al. (1999) · American Journal of Epidemiology · doi:10.1093/oxfordjournals.aje.a010064 · Cited by 70
Antioxidant supplements for preventing gastrointestinal cancers
Bjelaković, G., Nikolova, D., Simonetti, R., & Gluud, C. N. (2004) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd004183.pub2 · Cited by 70
Self-citation
Vitamin E and Donepezil for the Treatment of Mild Cognitive Impairment
Barnes, D. E., & Yaffe, K. S. (2005) · New England Journal of Medicine · doi:10.1056/nejmc051856 · Cited by 69
Antioxidant supplementation enhances antioxidant capacity and mitigates oxidative damage following acute ischaemic stroke
Ullegaddi, R., Powers, H. J., & Gariballa, S. (2005) · European Journal of Clinical Nutrition · doi:10.1038/sj.ejcn.1602248 · Cited by 69
The HOPE (Heart Outcomes Prevention Evaluation) Study and its Consequences
McQueen, M., Lonn, E., Gerstein, H. C., Bosch, J., & Yusuf, S. (2005) · Scandinavian Journal of Clinical and Laboratory Investigation · doi:10.1080/00365510500236366 · Cited by 69
Vitamin E Supplementation in Patients With Carotid Atherosclerosis
Micheletta, F., Natoli, S., Misuraca, M., Sbarigia, E., Diczfalusy, U., & Iuliano, L. (2003) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/01.atv.0000104028.07929.72 · Cited by 69
Influence of selenium-enriched yeast supplementation on biomarkers of oxidative damage and hormone status in healthy adult males: a clinical pilot study.
El‐Bayoumy, K., Richie, J. P., Boyiri, T., Komninou, D., Prokopczyk, B., Trushin, N., Kleinman, W. A., Cox, J., Pittman, B. P., & Colosimo, S. (2002) · PubMed · Cited by 69
Does multivitamin supplementation prevent infections in healthy elderly subjects? A controlled trial.
Chavance, M., Herbeth, B., Lemoine, A., & Zhu, B. (1993) · PubMed · Cited by 69
Retinoids in prevention of skin cancer
Moon, T. E., Levine, N. S., Cartmel, B., et al. (1997) · Cancer Letters · doi:10.1016/s0304-3835(97)04663-6 · Cited by 68
Does selegiline delay progression of Parkinson's disease? A critical re-evaluation of the DATATOP study.
Ward, C. D. (1994) · Journal of Neurology Neurosurgery & Psychiatry · doi:10.1136/jnnp.57.2.217 · Cited by 68
Interobserver Agreement in the Classification of Stroke in the Physicians’ Health Study
Berger, K., Kase, C. S., & Buring, J. E. (1996) · Stroke · doi:10.1161/01.str.27.2.238 · Cited by 68
Effects of Antioxidant Therapy in Women Exposed to Eccentric Exercise
Bloomer, R. J. (2004) · International Journal of Sport Nutrition and Exercise Metabolism · doi:10.1123/ijsnem.14.4.377 · Cited by 68
Effect of a Single Bout of Exercise and β-Carotene Supplementation on the Urinary Excretion of 8-Hydroxy-deoxyguanosine in Humans
Sumida, S., Doi, T., Sakurai, M., Yoshioka, Y., & Okamura, K. (1997) · Free Radical Research · doi:10.3109/10715769709097864 · Cited by 67
Randomized double-blind trial of beta-carotene and vitamin C in women with minor cervical abnormalities
Mackerras, D., Irwig, L. M., Simpson, J. M., et al. (1999) · British Journal of Cancer · doi:10.1038/sj.bjc.6690231 · Cited by 67
Summary Results and Recommendations From the Age-Related Eye Disease Study
Chew, E. Y. (2009) · Archives of Ophthalmology · doi:10.1001/archophthalmol.2009.312 · Cited by 67
Effect of 3 months vitamin E supplementation on indices of the cellular and humoral immune response in elderly subjects
Waart, F. G. D., Portengen, L., Doekes, G., Verwaal, C. J., & Kok, F. J. (1997) · British Journal Of Nutrition · doi:10.1079/bjn19970193 · Cited by 67
A randomized, double‐blind, placebo‐controlled trial of supplementary vitamins E, C and their combination for treatment of haemodialysis cramps
Khajehdehi, P., Mojerlou, M., Behzadi, S., & Rais-Jalali, G. A. (2001) · Nephrology Dialysis Transplantation · doi:10.1093/ndt/16.7.1448 · Cited by 67
Treatment with Taurine, Diltiazem, and Vitamin E Retards the Progressive Visual Field Reduction in Retinitis Pigmentosa: A 3-Year Follow-Up Study
Pasantes‐Morales, H., Quiroz, H., & Quesada, O. (2002) · Metabolic Brain Disease · doi:10.1023/a:1019926122125 · Cited by 67
Effects of alpha-tocopherol and beta-carotene supplementation on gastric cancer incidence in male smokers (ATBC Study, Finland)
Malila, N. K., Taylor, P. R., Virtanen, M. J., et al. (2002) · Cancer Causes & Control · doi:10.1023/a:1019556227014 · Cited by 66
Adherence to nutritional recommendations and subsequent cognitive performance: findings from the prospective Supplementation with Antioxidant Vitamins and Minerals 2 (SU.VI.MAX 2) study
Kesse‐Guyot, E., Amieva, H., Castetbon, K., Henegar, A., Ferry, M., Jeandel, C., Herçberg, S., & Galan, P. (2010) · American Journal of Clinical Nutrition · doi:10.3945/ajcn.2010.29761 · Cited by 66
Some Aspects of Antioxidant Status in Blood from Alcoholics
Bjørneboe, G. A., Johnsen, J. T., Bjørneboe, A., et al. (1988) · Alcoholism Clinical and Experimental Research · doi:10.1111/j.1530-0277.1988.tb01350.x · Cited by 66
Effects of supplementation with tocotrienol-rich fraction on immune response to tetanus toxoid immunization in normal healthy volunteers
Mahalingam, D., Radhakrishnan, A. K., Amom, Z., Ibrahim, N., & Nesaretnam, K. (2010) · European Journal of Clinical Nutrition · doi:10.1038/ejcn.2010.184 · Cited by 66
The effect of pharmacological supplementation with vitamin C on low‐density lipoprotein oxidation
Wen, Y., Cooke, T., & Feely, J. (1997) · British Journal of Clinical Pharmacology · doi:10.1046/j.1365-2125.1997.00623.x · Cited by 66
Cognitive performance in relation to vitamin status in healthy elderly German women—the effect of 6-month multivitamin supplementation
Wolters, M., Hickstein, M., Flintermann, A., Tewes, U., & Hahn, A. (2005) · Preventive Medicine · doi:10.1016/j.ypmed.2004.11.007 · Cited by 66
β-Carotene Supplementation Increases Antioxidant Capacity of Plasma in Older Women , ,
Meydani, M., Martin, A., Ribaya‐Mercado, J. D., Gong, J., Blumberg, J. B., & Russell, R. M. (1994) · Journal of Nutrition · doi:10.1093/jn/124.12.397 · Cited by 65
The Protective Effect of Beta-Carotene and Retinol on Ventilatory Function in an Asbestos-Exposed Cohort
Chuwers, P., Barnhart, S., Blanc, P. D., Brodkin, C. A., Cullen, M. R., Kelly, T. N., Keogh, J. P., Omenn, G. S., Williams, J., & Balmes, J. R. (1997) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/ajrccm.155.3.9116988 · Cited by 65
Adjuvant Treatment of Recent Onset Rheumatoid Arthritis by Selenium Supplementation: Preliminary Observations
PERETZ, A., Nève, J., DUCHATEAU, J., & Famaey, J. P. (1992) · Lara D. Veeken · doi:10.1093/rheumatology/31.4.281 · Cited by 65
The effect of micronutrient supplementation on treatment outcome in patients with pulmonary tuberculosis: a randomized controlled trial in Mwanza, Tanzania
Range, N. S., Andersen, Å. B., Magnussen, P., Mugomela, A., & Friis, H. (2005) · Tropical Medicine & International Health · doi:10.1111/j.1365-3156.2005.01463.x · Cited by 65
Cost Implications of the Use of Ramipril in High-Risk Patients Based on the Heart Outcomes Prevention Evaluation (HOPE) Study
Lamy, A. L., Yusuf, S., Pogue, J. M., et al. (2003) · Circulation · doi:10.1161/01.cir.0000050600.49419.25 · Cited by 65
Diet supplementation with vitamin E, vitamin C and β-carotene cocktail enhances basal neutrophil antioxidant enzymes in athletes
Tauler, P., Aguiló, A., Fuentespina, E., Tur, J., & Pons, A. (2002) · Pflügers Archiv - European Journal of Physiology · doi:10.1007/s00424-001-0770-0 · Cited by 65
A Randomized, Double-Blind, Controlled Trial of Vitamin C in the Management of Hypertension and Lipids
Hajjar, I. M., George, V. T., Sasse, E. A., & Kochar, M. S. (2002) · American Journal of Therapeutics · doi:10.1097/00045391-200207000-00005 · Cited by 65
The effect of probucol and vitamin E treatment on the oxidation of low‐density lipoprotein and forearm vascular responses in humans
McDowell, I. F. W., Brennan, G., McEneny, J., Young, I. S., Nicholls, D., McVeigh, G. E., Bruce, I. N., Trimble, E. R., & Johnston, G. D. (1994) · European Journal of Clinical Investigation · doi:10.1111/j.1365-2362.1994.tb01073.x · Cited by 65
Impact of cancer occurrence on health-related quality of life: a longitudinal pre-post assessment.
Boini, S., Briançon, S., Guillemin, F., Galan, P., & Herçberg, S. (2004) · Health and Quality of Life Outcomes · doi:10.1186/1477-7525-2-4 · Cited by 65
Multicenter ophthalmic and nutritional age-related macular degeneration study--part 2: antioxidant intervention and conclusions.
Richer, S. (1996) · PubMed · Cited by 64
The effect of a polynutrient supplement on fatigue and physical activity of patients with chronic fatigue syndrome: a double-blind randomized controlled trial
Brouwers, F. M. (2002) · QJM · doi:10.1093/qjmed/95.10.677 · Cited by 64
A randomized, double blind, Phase III trial using oral beta-carotene supplementation for women with high-grade cervical intraepithelial neoplasia.
Keefe, K. A., Schell, M. J., Brewer, C., et al. (2001) · PubMed · Cited by 64
Preventing the common cold with a vitamin C supplement: A double-blind, placebo-controlled survey
Van Straten, M., & Josling, P. (2002) · Advances in Therapy · doi:10.1007/bf02850271 · Cited by 64
Physical activity and risk of colon cancer: the Physicians‘ Health Study (United States)
Lee, I.-M. M., Manson, J. E., Ajani, U. A., Paffenbarger, R. S., Hennekens, C. H., & Buring, J. E. (1997) · Cancer Causes & Control · doi:10.1023/a:1018438228410 · Cited by 63
Supplementation with 3 compositionally different tocotrienol supplements does not improve cardiovascular disease risk factors in men and women with hypercholesterolemia
Mustad, V. A., Smith, C. A., Ruey, P., Edens, N. K., & DeMichele, S. J. (2002) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/76.6.1237 · Cited by 63
Effect of antioxidant supplementation on urine and blood markers of oxidative stress during extended moderate-altitude training
Pfeiffer, J. M., Askew, E. W., Roberts, D. E., Wood, S. M., Benson, J. E., Johnson, S. C., & Freedman, M. S. (1999) · Wilderness and Environmental Medicine · doi:10.1580/1080-6032(1999)010[0066:eoasou]2.3.co;2 · Cited by 63
The Effect of Antioxidant Vitamin Supplementation on Traditional Cardiovascular Risk Factors
Miller, E. R., Appel, L. J., Levander, O. A., et al. (1997) · European Journal of Cardiovascular Prevention & Rehabilitation · doi:10.1177/174182679700400104 · Cited by 63
Alpha tocopherol in CSF of subjects taking high‐dose vitamin E in the DATATOP study
Vatassery, G. T., Fahn, S., & Kuskowski, M. A. (1998) · Neurology · doi:10.1212/wnl.50.6.1900 · Cited by 63
Effects of organic and inorganic selenium supplementation on selenoenzyme activity in blood lymphoctyes, granulocytes, platelets and erythrocytes
Brown, K., Pickard, K., Nicol, F., et al. (2000) · Clinical Science · doi:10.1042/cs19990276 · Cited by 63
Effect of Micronutrient Supplementation on Mood in Nursing Home Residents
Gosney, M., Hammond, M. F., Shenkin, A., & Allsup, S. J. (2008) · Gerontology · doi:10.1159/000131886 · Cited by 62
Rationale and Design of a Multicenter Study of Selegiline and α-Tocopherol in the Treatment of Alzheimer Disease Using Novel Clinical Outcomes
Sano, M., Ernesto, C., Klauber, M. R., Schafer, K. A., Woodbury, P., Thomas, R. G., Grundman, M., Growdon, J. H., & Thal, L. J. (1996) · Alzheimer Disease & Associated Disorders · doi:10.1097/00002093-199601030-00004 · Cited by 62
Increased serum and low-density-lipoprotein antioxidant potential after antioxidant supplementation in endurance athletes
Vasankari, T., Kujala, U. M., Vasankari, T., Vuorimaa, T., & Ahotupa, M. O. (1997) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/65.4.1052 · Cited by 62
DNA repair phenotype and dietary antioxidant supplementation
Guarnieri, S., Loft, S. H., Riso, P., et al. (2007) · British Journal Of Nutrition · doi:10.1017/s0007114507842796 · Cited by 62
The Effect of Supplementation with Selenium and Vitamin E in Psoriasis
Fairris, G. M., Lloyd, B., Hinks, L. J., et al. (1989) · Annals of Clinical Biochemistry International Journal of Laboratory Medicine · doi:10.1177/000456328902600113 · Cited by 62
Some considerations in the design of a nutrition intervention trial in Linxian, People's Republic of China.
Blot, W. J., & Li, J. (1985) · PubMed · Cited by 62
Comparison of baseline characteristics and mortality experience of participants and nonparticipants in a randomized clinical trial
Sesso, H. D., Gaziano, J. M., VanDenburgh, M., et al. (2002) · Controlled Clinical Trials · doi:10.1016/s0197-2456(02)00235-0 · Cited by 61
Vitamin E and benign breast "disease": a double-blind, randomized clinical trial.
Ernster, V. L., Goodson, W. H., Hunt, T. K., et al. (1985) · PubMed · Cited by 61
Effects of interaction of RRR-alpha-tocopheryl acetate and fish oil on low-density-lipoprotein oxidation in postmenopausal women with and without hormone-replacement therapy
Wander, R. C., Du, S., Ketchum, S., & Rowe, K. (1996) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/63.2.184 · Cited by 61
Effects of supplementation with folic acid and antioxidant vitamins on homocysteine levels and LDL oxidation in coronary patients
Bunout, D. C., Argelia Garrido, G., Suazo, M., et al. (2000) · Nutrition · doi:10.1016/s0899-9007(99)00248-8 · Cited by 61
Selenium Supplementation Reduced Oxidative DNA Damage in Adnexectomized BRCA1 Mutations Carriers
Dziaman, T., Huzarski, T., Gackowski, D., et al. (2009) · Cancer Epidemiology Biomarkers & Prevention · doi:10.1158/1055-9965.epi-09-0529 · Cited by 61
Effect of n-3 Fatty Acids and Antioxidants on Oxidative Stress after Exercise
McAnulty, S. R., Nieman, D. C., Fox-Rabinovich, M., Duran, V., McAnulty, L. S., Henson, D. A., Jin, F., & Landram, M. J. (2010) · Medicine & Science in Sports & Exercise · doi:10.1249/mss.0b013e3181d85bd1 · Cited by 61
Effect of supplementation with organic selenium on mercury status as measured by mercury in pubic hair
Seppänen, K., Kantola, M., Laatikainen, R., et al. (2000) · Journal of Trace Elements in Medicine and Biology · doi:10.1016/s0946-672x(00)80035-8 · Cited by 61
Antioxidant diet supplementation enhances aerobic performance in amateur sportsmen
Aguiló, A., Tauler, P., Sureda, A., Cases, N., Tur, J. A., & Pons, A. (2007) · Journal of Sports Sciences · doi:10.1080/02640410600951597 · Cited by 61
Vitamin E in the primary prevention of rheumatoid arthritis: The women's health study
Karlson, E. W., Shadick, N. A., Cook, N. R., Buring, J. E., & Lee, I.-M. M. (2008) · Arthritis Care & Research · doi:10.1002/art.24194 · Cited by 60
The effect of 2 weeks vitamin C supplementation on immunoendocrine responses to 2.5 h cycling exercise in man
Davison, G., & Gleeson, M. (2006) · European Journal of Applied Physiology · doi:10.1007/s00421-006-0196-7 · Cited by 60
Effects of combined administration of vitamins C and E on reactive hyperemia and inflammatory process in chronic smokers
Tousoulis, D. (2003) · Atherosclerosis · doi:10.1016/s0021-9150(03)00250-8 · Cited by 60
Effect of Ramipril in Reducing Sudden Deaths and Nonfatal Cardiac Arrests in High-Risk Individuals Without Heart Failure or Left Ventricular Dysfunction
Teo, K. K., Mitchell, L. B., Pogue, J., Bosch, J., Dagenais, G. R., & Yusuf, S. (2004) · Circulation · doi:10.1161/01.cir.0000141729.01918.d4 · Cited by 60
Centrum Use and Progression of Age-Related Cataract in the Age-Related Eye Disease Study
Milton, R. C., Sperduto, R. D., Clemons, T. E., & Ferris, F. L. (2006) · Ophthalmology · doi:10.1016/j.ophtha.2006.02.054 · Cited by 59
Use of antioxidants to treat pain in chronic pancreatitis.
Castano, G. D. L. H., de la Paz, A. G., Fernández, M. D., et al. (2000) · PubMed · Cited by 59
Influence of vitamin C on markers of oxidative stress in the earliest period of ischemic stroke
Łagowska-Lenard, M., Stelmasiak, Z., & Bartosik-Psujek, H. (2010) · Pharmacological Reports · doi:10.1016/s1734-1140(10)70334-0 · Cited by 59
Supplementation of ascorbic acid and alpha-tocopherol is useful to preventing bone loss linked to oxidative stress in elderly
Ruíz-Ramos, M., Vargas, L. A., van der Goes, T. I. F., Cervantes‐Sandoval, A., & Mendoza-Nú`nez, V. M. (2010) · The journal of nutrition health & aging · doi:10.1007/s12603-010-0099-5 · Cited by 59
An intervention trial to inhibit the progression of precancerous gastric lesions: compliance, serum micronutrients and S-allyl cysteine levels, and toxicity
You, W., CHANG, Y. S., Heinrich, J., Ma, J. L., Liu, W., Zhang, L., Brown, L. M., Yang, C. S., Gail, M. H., Fraumeni, J. F., et al. (2001) · European Journal of Cancer Prevention · doi:10.1097/00008469-200106000-00009 · Cited by 59
Contribution of Ready-to-Eat Cereals to Nutrition Intakes in French Adults and Relations with Corpulence
Bertrais, S., Luque, M. L. P., Preziosi, P., Fieux, B., de Flot, M. T., Galan, P., & Herçberg, S. (2000) · Annals of Nutrition and Metabolism · doi:10.1159/000046692 · Cited by 59
The effects of vitamin C supplementation on symptoms of delayed onset muscle soreness.
Connolly, D. A. J., Lauzon, C. D., Agnew, J., Dunn, M., & Reed, B. V. (2006) · PubMed · Cited by 58
Dietary Supplementation and Quality of Life of Older Patients: A Randomized, Double‐Blind, Placebo‐Controlled Trial
Gariballa, S., & Forster, S. (2007) · Journal of the American Geriatrics Society · doi:10.1111/j.1532-5415.2007.01435.x · Cited by 58
Effect of long-term beta-carotene and vitamin A on serum cholesterol and triglyceride levels among participants in the Carotene and Retinol Efficacy Trial (CARET)
Redlich, C. A., Chung, J. S., Cullen, M. R., Blaner, W. S., van Bennekum, A. M., & Berglund, L. (1999) · Atherosclerosis · doi:10.1016/s0021-9150(99)00266-x · Cited by 58
Lack of acute effects of ascorbic acid on spirometry and airway responsiveness to histamine in subjects with asthma
Jl, M., Cartier, A., Pineau, L., et al. (1986) · Journal of Allergy and Clinical Immunology · doi:10.1016/0091-6749(86)90265-4 · Cited by 58
Selenium supplementation improves mood in a double-blind crossover trial
Benton, D., & Cook, R. (1990) · Psychopharmacology · doi:10.1007/bf02247139 · Cited by 58
The effect of a selenium supplementation on the outcome of patients with severe systemic inflammation, burn and trauma
Gärtner, R., Albrich, W. C., & Angstwurm, M. (2001) · BioFactors · doi:10.1002/biof.5520140125 · Cited by 58
Relationship of electrocardiographic left ventricular hypertrophy to mortality and cardiovascular morbidity in high-risk patients
Lonn, E., Mathew, J., Pogue, J. M., Johnstone, D. E., Danisa, K., Bosch, J., Baird, M. G., Dagenais, G. R., Sleight, P., Yusuf, S., et al. (2003) · European Journal of Cardiovascular Prevention & Rehabilitation · doi:10.1097/01.hjr.0000106836.977722.cf · Cited by 58
Antioxidant status and risk of cancer in the SU.VI.MAX study: is the effect of supplementation dependent on baseline levels?
Galan, P., Briançon, S., Favier, A. E., Bertrais, S., Preziosi, P., Faure, H., Arnaud, J., Arnault, N., Czernichow, S., Mennen, L. I., et al. (2005) · British Journal Of Nutrition · doi:10.1079/bjn20051462 · Cited by 58
High dose ascorbic acid in Nigerian asthmatics
Anah, C. O., Jarike, L. N., & Baig, H. (1980) · PubMed · doi:10.5281/zenodo.13912251 · Cited by 57
Effect of long-term therapy with ramipril in high-risk women
Lonn, E., Roccaforte, R., Yi, Q., Dagenais, G. R., Sleight, P., Bosch, J., Suhan, P. S., Micks, M., Probstfield, J. L., Bernstein, V., et al. (2002) · Journal of the American College of Cardiology · doi:10.1016/s0735-1097(02)02035-1 · Cited by 57
Vitamin E and selenium supplementation in geriatric patients
Tolonen, M., Halme, M., & Sarna, S. J. (1985) · Biological Trace Element Research · doi:10.1007/bf02916538 · Cited by 57
Vitamin-E supplements and their effect on vitamin-E status in blood and genetic damage rate in peripheral blood lymphocytes
Fenech, M. F. (1997) · Carcinogenesis · doi:10.1093/carcin/18.2.359 · Cited by 57
The use of computerised 24 h dietary recalls in the French SU.VI.MAX Study: number of recalls required
Mennen, L., Bertrais, S., Galan, P., Arnault, N., de Courcy, G. P., & Herçberg, S. (2002) · European Journal of Clinical Nutrition · doi:10.1038/sj.ejcn.1601374 · Cited by 57
Cerebrospinal Fluid Homovanillic Acid in the DATATOP Study on Parkinson's Disease
Parkinson Study Group (1995) · Archives of Neurology · doi:10.1001/archneur.1995.00540270025015 · Cited by 57
The association between participant characteristics and serum concentrations of beta-carotene, retinol, retinyl palmitate, and alpha-tocopherol among participants in the Carotene and Retinol Efficacy Trial (CARET) for prevention of lung cancer.
Goodman, G. E., Thornquist, M. D., Kestin, M., Metch, B. J., Anderson, G. L., & Omenn, G. S. (1996) · PubMed · Cited by 56
Is Antioxidant and n–3 Supplementation Able to Improve Functional Status in Poststroke Patients? Results from the Nutristroke Trial
Garbagnati, F., Cairella, G., Martino, A. D., Multari, M., Scognamiglio, U., Venturiero, V., & Paolucci, S. (2009) · Cerebrovascular Diseases · doi:10.1159/000207441 · Cited by 56
Antioxidant Vitamin Supplements
Maxwell, S. R. J. (1999) · Drug Safety · doi:10.2165/00002018-199921040-00002 · Cited by 56
Epidemiologic determinants of skin photoaging: Baseline data of the SU.VI.MAX. cohort
Malvy, D. J.-M., Guinot, C., Preziosi, P., Vaillant, L., Tenenhaus, M., Galan, P., Herçberg, S., & Tschachler, E. (2000) · Journal of the American Academy of Dermatology · doi:10.1016/s0190-9622(00)90008-2 · Cited by 56
Vitamin E Supplementation and Plasma 8‐Isoprostane and Adiponectin in Overweight Subjects
Sutherland, W. H. F., Manning, P. J., Walker, R. J., de Jong, S. A., Ryalls, A. R., & Berry, E. A. (2007) · Obesity · doi:10.1038/oby.2007.546 · Cited by 56
Platelet function in type I diabetes: effects of supplementation with large doses of vitamin E
Colette, C., Parés-Herbute, N., Monnier, L., & Cartry, E. (1988) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/47.2.256 · Cited by 56
Alterations of the lipid profile after 7.5 years of low‐dose antioxidant supplementation in the SU.VI.MAX study
Herçberg, S., Bertrais, S., Czernichow, S., et al. (2005) · Lipids · doi:10.1007/s11745-006-1391-3 · Cited by 55
Pro-oxidant effect of alpha-tocopherol in patients with type 2 diabetes after an oral glucose tolerance test--a randomised controlled trial.
Winterbone, M. S., Sampson, M., Saha, S., Hughes, J. C., & Hughes, D. A. (2007) · Cardiovascular Diabetology · doi:10.1186/1475-2840-6-8 · Cited by 55
Multivitamin and dietary supplements, body weight and appetite: results from a cross-sectional and a randomised double-blind placebo-controlled study
Major, G. C., Doucet, É., Jacqmain, M., St-Onge, M., Bouchard, C., & Tremblay, A. (2007) · British Journal Of Nutrition · doi:10.1017/s0007114507853335 · Cited by 55
Ascorbic Acid Supplement During Luteal Phase in IVF
Griesinger, G., Franke, K., Kinast, C., Kutzelnigg, A., Riedinger, S., Kulin, S., Kaali, S. G., & Feichtinger, W. (2002) · Journal of Assisted Reproduction and Genetics · doi:10.1023/a:1014837811353 · Cited by 54
Donepezil Versus Vitamin E in Alzheimer's Disease Part 2: Mild Versus Moderate–Severe Alzheimer's Disease
ONOFRJ, M. C., Thomas, A., Luciano, A. L., Iacono, D., Rollo, A. D., D’Andreamatteo, G., & Iorio, A. D. (2002) · Clinical Neuropharmacology · doi:10.1097/00002826-200207000-00004 · Cited by 54
PROTECTIVE EFFECTS OF ANTIOXIDANT SUPPLEMENTATION ON PLASMA LIPID PEROXIDATION IN SMOKERS
Kim, H. S., & Lee, B. M. (2001) · Journal of Toxicology and Environmental Health · doi:10.1080/152873901316857761 · Cited by 54
Effects of Supplementation with a Combination of Antioxidant Vitamins and Trace Elements, at Nutritional Doses, on Biochemical Indicators and Markers of the Antioxidant System in Adult Subjects
Preziosi, P., Galán, P., Herbeth, B., et al. (1998) · Journal of the American College of Nutrition · doi:10.1080/07315724.1998.10718754 · Cited by 54
Physical Activity in Relation to All-Site and Lung Cancer Incidence and Mortality in Current and Former Smokers
Alfano, C. M., Klesges, R. C., Murray, D. M., Bowen, D. J., McTiernan, A., Weg, M. W. V., Robinson, L. A., Cartmel, B., Thornquist, M. D., Barnett, M. J., et al. (2004) · Cancer Epidemiology Biomarkers & Prevention · doi:10.1158/1055-9965.2233.13.12 · Cited by 54
Antioxidant supplementation does not attenuate oxidative stress at high altitude.
Subudhi, A. W., Jacobs, K. A., Hagobian, T. A., Fattor, J. A., Fulco, C. S., Muza, S. R., Rock, P. B., Hoffman, A. R., Cymerman, A., & Friedlander, A. L. (2004) · PubMed · Cited by 54
GISSI-Prevenzione trial
Jialal, I., Devaraj, S., Huet, B., & Traber, M. G. (1999) · The Lancet · doi:10.1016/s0140-6736(99)90191-5 · Cited by 53
Vitamin E improves arterial compliance in middle-aged men and women
Mottram, P. M., Shige, H., & Nestel, P. J. (1999) · Atherosclerosis · doi:10.1016/s0021-9150(99)00073-8 · Cited by 53
The effect of 5‐year vitamin C supplementation on serum pepsinogen level and Helicobacter pylori infection
Sasazuki, S., Sasaki, S., Tsubono, Y., Okubo, S., Hayashi, M., Kakizoe, T., & Tsugane, S. (2003) · Cancer Science · doi:10.1111/j.1349-7006.2003.tb01450.x · Cited by 53
Relation between beta-carotene intake and plasma and adipose tissue concentrations of carotenoids and retinoids
Johnson, E., Suter, P., Sahyoun, N. R., Ribaya‐Mercado, J. D., & Russell, R. (1995) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/62.3.598 · Cited by 53
[Diabetes mellitus--a free radical-associated disease. Results of adjuvant antioxidant supplementation].
Kähler, W., Kuklinski, B., Rühlmann, C., & Plötz, C. (1993) · PubMed · Cited by 52
Use of multiple correspondence analysis and cluster analysis to study dietary behaviour: Food consumption questionnaire in the SU.VI.MAX. cohort
Guinot, C., Latreille, J., Malvy, D. J.-M., Preziosi, P., Galan, P., Herçberg, S., & Tenenhaus, M. (2001) · European Journal of Epidemiology · doi:10.1023/a:1014586129113 · Cited by 52
[Selenium administration in patients with sepsis syndrome. A prospective randomized study].
Zimmermann, T., Albrecht, S., Kühne, H., Vogelsang, U., Grützmann, R., & Kopprasch, S. (1997) · Medizinische Klinik · doi:10.1007/bf03041947 · Cited by 52
Oral antioxidant supplementation for fatigue associated with primary biliary cirrhosis: results of a multicentre, randomized, placebo‐controlled, cross‐over trial
Prince, M. I., Mitchison, H. C., Ashley, D., Burke, D., Edwards, N., Bramble, M. G., James, O., & Jones, D. E. J. (2002) · Alimentary Pharmacology & Therapeutics · doi:10.1046/j.1365-2036.2003.01398.x · Cited by 52
Cost-Effectiveness Analysis of n-3 Polyunsaturated Fatty Acids (PUFA) after Myocardial Infarction
Franzosi, M. G., Brunetti, M., Marchioli, R., Marfisi, R. M., Tognoni, G., & Valagussa, F. (2001) · PharmacoEconomics · doi:10.2165/00019053-200119040-00008 · Cited by 52
Randomized, Double-Blind, Placebo-Controlled Study of the Preventive Effect of Supplemental Oral Vitamin C on Attenuation of Development of Nitrate Tolerance
Watanabe, H., Kakihana, M., Ohtsuka, S., & Sugishita, Y. (1998) · Journal of the American College of Cardiology · doi:10.1016/s0735-1097(98)00085-0 · Cited by 52
Intervention trial with selenium for the prevention of lung cancer among tin miners in Yunnan, China
Yu, S.-Y., Mao, B., Xiao, P., Yu, W., Wang, Y.-L., Huang, C., Chen, W., & Xuan, X.-Z. (1990) · Biological Trace Element Research · doi:10.1007/bf02917199 · Cited by 52
Antioxidant Supplementation and Immunoendocrine Responses to Prolonged Exercise
Davison, G., Gleeson, M., & Phillips, S. (2007) · Medicine & Science in Sports & Exercise · doi:10.1249/mss.0b013e318031303d · Cited by 52
Failure of Vitamin E in Clinical Trials: Is Gamma-Tocopherol the Answer?
Devaraj, S., & Jialal, I. (2005) · Nutrition Reviews · doi:10.1111/j.1753-4887.2005.tb00143.x · Cited by 52
Supplementation with vitamins C, E, β‐carotene and selenium has no effect on anti‐oxidant status and immune responses in allergic adults: a randomized controlled trial
Dunstan, J. A., Breckler, L., Hale, J., et al. (2007) · Clinical & Experimental Allergy · doi:10.1111/j.1365-2222.2007.02657.x · Cited by 52
A double-blind trial of vitamin E in angina pectoris1,2
Anderson, T. W., & Reid, D. B. W. (1974) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/27.8.1174 · Cited by 52
Effect of vitamin C supplementation on lipid peroxidation, muscle damage and inflammation after 30-min exercise at 75% VO2max.
Nakhostin-Roohi, B., Babaei, P., Rahmaninia, F., & Bohlooli, S. (2008) · PubMed · Cited by 52
Antioxidative efficacy of parallel and combined supplementation with coenzyme Q10 and d-α-Tocopherol in mildly hypercholesterolemic subjects: a randomized placebo-controlled clinical study
Kaikkonen, J., Nyyssönen, K., Tomasi, A., Iannone, A., Tuomainen, T., Porkkala-Sarataho, E., & Salonen, J. T. (2000) · Free Radical Research · doi:10.1080/10715760000301501 · Cited by 51
“THE SU.VI.MAX STUDY”: A Primary Prevention Trial using Nutritional Doses of Antioxidant Vitamins and Minerals in Cardiovascular Diseases and Cancers
Herçberg, S., Preziosi, P., Galan, P., Faure, H., Arnaud, J., Duport, N., Malvy, D. J.-M., Roussel, A. M., Briançon, S., & Favier, A. E. (1999) · Food and Chemical Toxicology · doi:10.1016/s0278-6915(99)00078-2 · Cited by 51
Effect of a nutritional supplement on premenstrual symptomatology in women with premenstrual syndrome: a double-blind longitudinal study.
London, R. S., Bradley, L., & Chiamori, N. (1991) · Journal of the American College of Nutrition · doi:10.1080/07315724.1991.10718176 · Cited by 51
Effect of vitamin E supplementation on post-exercise plasma lipid peroxidation and blood antioxidant status in smokers: with special reference to haemoconcentration effect
Sürmen-Gür, E., �zt�rk, E., G�r, H., et al. (1999) · European Journal of Applied Physiology · doi:10.1007/s004210050539 · Cited by 51
Short-Term Vitamin A Supplementation Does Not Affect Bone Turnover in Men
Kawahara, T. N., Krueger, D. C., Engelke, J. A., Harke, J. M., & Binkley, N. (2002) · Journal of Nutrition · doi:10.1093/jn/132.6.1169 · Cited by 51
The effect of five-year zinc supplementation on serum zinc, serum cholesterol and hematocrit in persons randomly assigned to treatment group in the age-related eye disease study: AREDS Report No. 7.
The Age-Related Eye Disease Study Research Group (2002) · Journal of NutriLife · doi:10.1093/jn/132.4.697 · Cited by 51
Community-based recruitment strategies for a longitudinal interventional study
Garrett, S. K. M., Thomas, A. P., Cicuttini, F., Silagy, C. A., Taylor, H. R., & McNeil, J. J. (2000) · Journal of Clinical Epidemiology · doi:10.1016/s0895-4356(99)00153-5 · Cited by 50
Treatment of Alzheimer's Disease — Searching for a Breakthrough, Settling for Less
Drachman, D. A., & Leber, P. D. (1997) · New England Journal of Medicine · doi:10.1056/nejm199704243361710 · Cited by 50
Safety and Efficacy of Dose-Intensive Oral Vitamin A in Subjects with Sun-Damaged Skin
Alberts, D. S., Ranger‐Moore, J., Einspahr, J. G., et al. (2004) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-03-0188 · Cited by 50
Supplementation with an antioxidant cocktail containing coenzyme Q prevents plasma oxidative damage induced by soccer
Tauler, P., Ferrer, M. D., Sureda, A., Pujol, P., Drobnic, F., Tur, J. A., & Pons, A. (2008) · European Journal of Applied Physiology · doi:10.1007/s00421-008-0831-6 · Cited by 50
Prevalence of precancerous lesions of the stomach in Venezuela.
Muñóz, N., Kato, I., Peraza, S., López, G., Carrillo, E., Ramírez, H. A. C., Vivas, J. H., Castro, D. J., Sánchez, V., Andrade, O., et al. (1996) · PubMed · Cited by 50
The effect of vitamin E on mammary dysplasia: a double-blind study.
London, R. S., Sundaram, G. S., Murphy, L., et al. (1985) · PubMed · Cited by 49
Mortality in the CHAOS trial
Mitchinson, M. J., Stephens, N. G., Parsons, A., Bligh, E., Schofield, P. M., & Brown, M. J. (1999) · The Lancet · doi:10.1016/s0140-6736(05)74955-2 · Cited by 49
Dietary Antioxidant Supplementation and DNA Damage in Smokers and Nonsmokers
Welch, R., Turley, E., Sweetman, S. F., et al. (1999) · Nutrition and Cancer · doi:10.1207/s15327914nc3402_7 · Cited by 49
Reduction of cancer mortality and incidence by selenium supplementation
Combs, G. F., Clark, L. C., & Turnbull, B. W. (1997) · Medizinische Klinik · doi:10.1007/bf03041964 · Cited by 49
Effect of long-term selenium yeast intervention on activity and gene expression of antioxidant and xenobiotic metabolising enzymes in healthy elderly volunteers from the Danish Prevention of Cancer by Intervention by Selenium (PRECISE) Pilot Study
Ravn‐Haren, G., Krath, B. N., Overvad, K., Cold, S., Moesgaard, S., Larsen, E. H., & Dragsted, L. O. (2007) · British Journal Of Nutrition · doi:10.1017/s0007114507882948 · Cited by 49
Minority recruitment to the Selenium and Vitamin E Cancer Prevention Trial (SELECT)
Cook, E. D., Moody‐Thomas, S., Anderson, K. B., Campbell, R. D., Hamilton, S. J., Harrington, J. M., Lippman, S. M., Minasian, L. M., Paskett, E. D., Craine, S., et al. (2005) · Clinical Trials · doi:10.1191/1740774505cn111oa · Cited by 49
Clinical Neuromythology IX — Pyramid sale in the bucket shop
Landau, W. M. (1990) · Neurology · doi:10.1212/wnl.40.9.1337 · Cited by 49
Long-term effects of nutrient intervention on markers of bone remodeling and calciotropic hormones in late-postmenopausal women
Jensen, C. D., Holloway, L., Block, G., Spiller, G. A., Gildengorin, G. L., Gunderson, E. P., Butterfield, G. E., & Marcus, R. (2002) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/75.6.1114 · Cited by 48
Vitamin E supplementation effect on human platelet function, arachidonic acid metabolism, and plasma prostacyclin levels
Stampfer, M., Jakubowski, J. A., Faigel, D. O., et al. (1988) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/47.4.700 · Cited by 48
Effects of a 'healthy' diet and of acute and long-term vitamin C on vascular function in healthy older subjects
Singh, N. (2002) · Cardiovascular Research · doi:10.1016/s0008-6363(02)00514-x · Cited by 48
Vitamin supplementation does not protect against symptoms in ozone-responsive subjects
Mudway, I., Behndig, A., Helleday, R., Pourazar, J., Frew, A. J., Kelly, F. J., & Blomberg, A. (2005) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2005.10.050 · Cited by 48
Vitamin C improves endothelial dysfunction in renal allograft recipients
Williams, M. J. A., Sutherland, W. H. F., McCormick, M. P., de Jong, S. A., McDonald, J. R., & Walker, R. J. (2001) · Nephrology Dialysis Transplantation · doi:10.1093/ndt/16.6.1251 · Cited by 48
Effect of niacin, warfarin, and antioxidant therapy on coagulation parameters in patients with peripheral arterial disease in the Arterial Disease Multiple Intervention Trial (ADMIT)
Chesney, C. M., Elam, M. B., Herd, J. A., Davis, K. B., Garg, R., Hunninghake, D. B., Kennedy, J. W., & Applegate, W. B. (2000) · American Heart Journal · doi:10.1067/mhj.2000.109648 · Cited by 48
Vitamin E and Vitamin C Supplementation in Patients with Chronic Obstructive Pulmonary Disease
Wu, Huang, Y., Hsu, Wang, & Yeh, Y. (2007) · International Journal for Vitamin and Nutrition Research · doi:10.1024/0300-9831.77.4.272 · Cited by 48
The Carotene and Retinol Efficacy Trial (CARET) to prevent lung cancer in high-risk populations: pilot study with asbestos-exposed workers.
Omenn, G. S., Goodman, G. E., Thornquist, M. D., Rosenstock, L., Barnhart, S., Gylys-Colwell, I., Metch, B. J., & Lund, B. (1993) · PubMed · Cited by 48
Administration of Ascorbic Acid and an Aldose Reductase Inhibitor (Tolrestat) in Diabetes: Effect on Urinary Albumin Excretion
McAuliffe, A. V., Brooks, B. A., Fisher, E. J., Molyneaux, L. M., & Yue, D. K. (1998) · The Nephron journals/Nephron journals · doi:10.1159/000045187 · Cited by 47
The Women's Antioxidant Cardiovascular Study: Design and Baseline Characteristics of Participants
Bassuk, S. S., Albert, C. M., Cook, N. R., Zaharris, E., MacFadyen, J. G., Danielson, E., Denburgh, M. V., Buring, J. E., & Manson, J. E. (2004) · Journal of Women s Health · doi:10.1089/154099904322836519 · Cited by 47
Effect of UV Exposure and β-Carotene Supplementation on Delayed-Type Hypersensitivity Response in Healthy Older Men
Herraiz, L. A., Hsieh, W.-C., Parker, R. S., Swanson, J. E., Bendich, A., & Roe, D. A. (1998) · Journal of the American College of Nutrition · doi:10.1080/07315724.1998.10718811 · Cited by 47
Beta Carotene Fails to Prevent Cancer in Two Major Studies; CARET Intervention Stopped
Smigel, K. (1996) · JNCI Journal of the National Cancer Institute · doi:10.1093/jnci/88.3-4.145 · Cited by 47
A double-blind trial of vitamin E in angina pectoris
Anderson, T. W., & Reid, D. B. W. (1974) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/27.10.1174 · Cited by 47
The effect of folic acid on the development of stomach and other gastrointestinal cancers.
Shunshi, Z., Mason, J. B., Shi, Y., et al. (2003) · PubMed · Cited by 46
Effect of Multivitamin and Mineral Supplementation on Episodes of Infection in Nursing Home Residents: A Randomized, Placebo‐Controlled Study
Liu, B. A., McGeer, A., McArthur, M., Simor, A. E., Aghdassi, E., Davis, L., & Allard, J. P. (2007) · Journal of the American Geriatrics Society · doi:10.1111/j.1532-5415.2006.01033.x · Cited by 46
Serum beta-carotene before and after beta-carotene supplementation.
Albanes, D., Virtamo, J. R. K., Rautalahti, M. T., et al. (1992) · PubMed · Cited by 46
Dietary Modification and Moderate Antioxidant Supplementation Differentially Affect Serum Carotenoids, Antioxidant Levels and Markers of Oxidative Stress in Older Humans
Peterman, J. N., Schmidt, M. C., Askew, E. W., Bernstein, P. S., & Tress, M. S. V. (2003) · Journal of Nutrition · doi:10.1093/jn/133.10.3117 · Cited by 46
Effect of supplementation of smoking men with plain or slow release ascorbic acid on lipoprotein oxidation
Nyyssönen, K., Poulsen, H. E., Hayn, M., Agerbo, P., Porkkala-Sarataho, E., Kaikkonen, J., Salonen, R. M., & Salonen, J. T. (1997) · European Journal of Clinical Nutrition · doi:10.1038/sj.ejcn.1600376 · Cited by 46
Supplementation with vitamin E but not with vitamin C lowers lipid peroxidationin vivoin mildly hypercholesterolemic men
Kaikkonen, J., Porkkala-Sarataho, E., Morrow, J. D., Roberts, L. J., Nyyssönen, K., Salonen, R. M., Tuomainen, T., Ristonmaa, U., Poulsen, H. E., & Salonen, J. T. (2001) · Free Radical Research · doi:10.1080/10715760100301461 · Cited by 46
Vitamin and Mineral Supplementation and Neuromuscular Recovery after a Running Race
Gauche, E. S., Lepers, R., Rabita, G., Lévêque, J.-M., Bishop, D. J., Brisswalter, J., & Hausswirth, C. (2006) · Medicine & Science in Sports & Exercise · doi:10.1249/01.mss.0000235351.01438.5a · Cited by 46
Effects of antioxidant supplementation on blood cyclosporin A and glomerular filtration rate in renal transplant recipients
Blackhall, M. L., Fassett, R. G., Sharman, J. E., et al. (2005) · Nephrology Dialysis Transplantation · doi:10.1093/ndt/gfh875 · Cited by 46
Effects of elevated d-alpha (RRR)-tocopherol dosage in man.
北川, 真., & Makoto, M. I. N. D. (1989) · Journal of Nutritional Science and Vitaminology · doi:10.3177/jnsv.35.133 · Cited by 46
Relationships between changes in weight and changes in cardiovascular risk factors in middle-aged French subjects: effect of dieting
Czernichow, S., Mennen, L. I., Bertrais, S., Preziosi, P., Herçberg, S., & Oppert, J. (2002) · International Journal of Obesity · doi:10.1038/sj.ijo.0802059 · Cited by 46
Drugs for preventing lung cancer in healthy people
Hernández, M. C., Sacristán, M., Serra, C., & Bonfill, X. (2003) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd002141 · Cited by 46
Effect of vitamin E on the immune response to influenza virus vaccine and the incidence of infectious disease in man
Harman, D., & Miller, R. W. (1986) · AGE · doi:10.1007/bf02431896 · Cited by 45
Incidence of skin cancers during 5-year follow-up after stopping antioxidant vitamins and mineral supplementation
Ezzedine, K., Latreille, J., Kesse‐Guyot, E., Galan, P., Herçberg, S., Guinot, C., & Malvy, D. J.-M. (2010) · European Journal of Cancer · doi:10.1016/j.ejca.2010.06.008 · Cited by 45
Vitamin C supplementation in normal subjects reduces constitutive ICAM-1 expression
Rayment, S. J., Shaw, J., Woollard, K. J., Lunec, J., & Griffiths, H. R. (2003) · Biochemical and Biophysical Research Communications · doi:10.1016/s0006-291x(03)01383-4 · Cited by 45
Mutations, tissue accumulations, and serum levels of p53 in patients with occupational cancers from asbestos and silica exposure
Husgafvel‐Pursiainen, K., Kannio, A., Oksa, P., Suitiala, T., Koskinen, H., Partanen, R., Hemminki, K., Smith, S., Rosenstock‐Leibu, R., & Brandt‐Rauf, P. W. (1997) · Environmental and Molecular Mutagenesis · doi:10.1002/(sici)1098-2280(1997)30:2 · Cited by 45
Hypoxia/reoxygenation and vitamin c intake influence no synthesis and antioxidant defenses of neutrophils
Sureda, A., Batle, J. M., Tauler, P., Aguiló, A., Cases, N., Tur, J. A., & Pons, A. (2004) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2004.07.033 · Cited by 45
Impact of Vitamin A Supplementation on the Incidence of Infection in Elderly Nursing-home Residents: A Randomized Controlled Trial
MURPHY, S., West, K. P., Greenough, W. B., Cherot, E., Katz, J., & Clement, L. (1992) · Age and Ageing · doi:10.1093/ageing/21.6.435 · Cited by 45
Blood pressure and plasma lipids during ascorbic acid supplementation in borderline hypertensive and normotensive adults
Osilesi, O., Trout, D. L., Ogunwole, J. G., et al. (1991) · Nutrition Research · doi:10.1016/s0271-5317(05)80002-8 · Cited by 45
Mild Cognitive Impairment — No Benefit from Vitamin E, Little from Donepezil
Blacker, D. (2005) · New England Journal of Medicine · doi:10.1056/nejme058086 · Cited by 44
Effects of a Vitamin E‐Modified Dialysis Membrane and Vitamin C Infusion on Oxidative Stress in Hemodialysis Patients
Eiselt, J., Ráček, J., Trefil, L., & Opatrný, K., Jr. (2001) · Artificial Organs · doi:10.1046/j.1525-1594.2001.025006430.x · Cited by 44
Methodologic considerations in the design and conduct of randomized trials: the U.S. Physicians' Health Study
Hennekens, C. H., & Buring, J. E. (1989) · Controlled Clinical Trials · doi:10.1016/0197-2456(89)90053-6 · Cited by 44
The effect of alpha-tocopherol on premenstrual symptomatology: a double-blind study.
London, R. S., Sundaram, G. S., Murphy, L., et al. (1983) · Journal of the American College of Nutrition · doi:10.1080/07315724.1983.10719916 · Cited by 44
Selenium supplementation, soluble tumor necrosis factor-α receptor type 1, and C-reactive protein during psoriasis therapy with narrowband ultraviolet B
Serwin, A. B., Wąsowicz, W., & Chodynicka, B. (2006) · Nutrition · doi:10.1016/j.nut.2006.05.011 · Cited by 44
Low-dose supplementation with lycopene or β-carotene does not enhance cell-mediated immunity in healthy free-living elderly humans
Corridan, B. M., O’Donoghue, M., HUGHES, D. A., & Morrissey, P. (2001) · European Journal of Clinical Nutrition · doi:10.1038/sj.ejcn.1601187 · Cited by 44
Mailing Strategies and Costs of Recruiting Heavy Smokers in CARET, a Large Chemoprevention Trial
VALANIS, B. G., Blank, J. D., & Glass, A. G. (1998) · Controlled Clinical Trials · doi:10.1016/s0197-2456(97)00027-5 · Cited by 44
α-Tocopherol (vitamin E) and β-carotene supplementation does not affect the risk for large abdominal aortic aneurysm in a controlled trial
Törnwall, M. E. (2001) · Atherosclerosis · doi:10.1016/s0021-9150(00)00694-8 · Cited by 43
Effects of Large Dose Vitamin E Supplementation on Anemia in Hemodialysis Patients
Ono, K. (2008) · The Nephron journals/Nephron journals · doi:10.1159/000183516 · Cited by 43
A randomized factorial study of the effects of long-term garlic and micronutrient supplementation and of 2-wk antibiotic treatment for Helicobacter pylori infection on serum cholesterol and lipoproteins
Zhang, L., Gail, M. H., Wang, Y.-Q., Brown, L. M., Pan, K., Ma, J., Amagase, H., You, W., & Moslehi, R. (2006) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/84.4.912 · Cited by 43
Effect of a mixture of micronutrients, but not of bovine colostrum concentrate, on immune function parameters in healthy volunteers: a randomized placebo-controlled study
Wolvers, D. A. W., Broekmans, W. M. R., Logman, M. H., van der Wielen, R. P. J., & Albers, R. (2006) · Nutrition Journal · doi:10.1186/1475-2891-5-28 · Cited by 43
Prevention of endemic arsenism with selenium
Wang, W. Y., Yang, L., Hou, S., et al. (2001) · Institute of Geographic Sciences and Natural Resources Research, CAS Institutional Repository · Cited by 43
Effect of selenium supplementation after acute myocardial infarction.
Korpela, H., Kumpulainen, J. T., Jussila, E., Kemilä, S. J., Kääriäinen, M., Kääriäinen, T., & Sotaniemi, E. A. (1989) · PubMed · Cited by 43
Effects of vitamin E supplementation on oxidative stress at rest and after exercise to exhaustion in athletic students.
Gaeini, A. A., Rahnama, N., & Hamedınıa, M. R. (2006) · PubMed · Cited by 42
Vitamin E Supplementation Reduces Plasma Vascular Cell Adhesion Molecule-1 and von Willebrand Factor Levels and Increases Nitric Oxide Concentrations in Hypercholesterolemic Patients
Desideri, G., Marinucci, M. C., Tomassoni, G., Masci, P. G., Santucci, A., & Ferri, C. (2002) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.87.6.8545 · Cited by 42
Vitamin C and E Supplements to Lansoprazole‐Amoxicillin‐Metronidazole Triple Therapy May Reduce the Eradication Rate of Metronidazole‐Susceptible Helicobacter pylori Infection
Chuang, C., Sheu, B., Huang, A., Yang, H., & Wu, J. (2002) · Helicobacter · doi:10.1046/j.1523-5378.2002.00095.x · Cited by 42
The effect of vitamin and mineral supplementation on esophageal cytology: Results from the linxian dysplasia trial
Mark, S. D., Liu, S. F., Li, J. Y., et al. (1994) · International Journal of Cancer · doi:10.1002/ijc.2910570205 · Cited by 42
Efficacy and safety of oral versus intravenous ascorbic acid for anaemia in haemodialysis patients
Chan, D., Irish, A. B., & Dogra, G. K. (2005) · Nephrology · doi:10.1111/j.1440-1797.2005.00424.x · Cited by 42
Effect of vitamin E supplementation on the regular treatment of seasonal allergic rhinitis
Shahar, E., Hassoun, G., & Pollack, S. (2004) · Annals of Allergy Asthma & Immunology · doi:10.1016/s1081-1206(10)61432-9 · Cited by 42
Response of Selenium Status Indicators to Supplementation of Healthy North American Men with High-Selenium Yeast
Hawkes, W. C., Richter, B. D., Alkan, Z., et al. (2008) · Biological Trace Element Research · doi:10.1007/s12011-007-8066-7 · Cited by 42
On the Reanalysis of the GISSI-Prevenzione
Leaf, A. (2002) · Circulation · doi:10.1161/01.cir.0000015344.46176.99 · Cited by 42
Blood Pressure and Risk of Secondary Cardiovascular Events in Women
Mason, P. J., Manson, J. E., Sesso, H. D., Albert, C. M., Chown, M. J., Cook, N. R., Greenland, P., Ridker, P. M., & Glynn, R. J. (2004) · Circulation · doi:10.1161/01.cir.0000124488.06377.77 · Cited by 42
Nutritional Supplementation in Elderly Medical In-patients: A Double-blind Placebo-controlled Trial
Hogarth, M., MARSHALL, P., Lovat, L. B., Palmer, A. J., FROST, C. G., Fletcher, A. E., Nicholl, C., & Bulpitt, C. J. (1996) · Age and Ageing · doi:10.1093/ageing/25.6.453 · Cited by 42
Effects of a 6-month vitamin intervention on DNA damage in heavy smokers.
Jacobson, J. S., Begg, M. D., Wang, L. W., Wang, Q., Agarwal, M., Norkus, E. P., Singh, V. N., Young, T., Yang, D. D., & Santella, R. M. (2000) · PubMed · Cited by 42
Chemoprevention of lung cancer: the beta-Carotene and Retinol Efficacy Trial (CARET) in high-risk smokers and asbestos-exposed workers.
Omenn, G. S., Goodman, G. E., Thornquist, M. D., et al. (1996) · PubMed · Cited by 42
Exercise and Mononuclear Cell DNA Damage: The Effects of Antioxidant Supplementation
Davison, G. W., Hughes, C., & BELL, R. A. (2005) · International Journal of Sport Nutrition and Exercise Metabolism · doi:10.1123/ijsnem.15.5.480 · Cited by 41
High-dose fish oil and antioxidants in Crohn's disease and the response of bone turnover: a randomised controlled trial
Trebble, T. M., Stroud, M. A., Wootton, S. A., Calder, P. C., Fine, D. R., Mullee, M., Moniz, C. F., & Arden, N. (2005) · British Journal Of Nutrition · doi:10.1079/bjn20051466 · Cited by 41

Flagged first, then by citations

Research works printed but not linked: 26

Pincus, 1997, Alpha-tocopherol and Alzheimer's disease, New England Journal of Medicine, 337, 572, 10.1056/NEJM199708213370814 · DOI
Age-Related Macular Degeneration Study Group, 1996, Multicenter ophthalmic and nutritional age-related macular degeneration study - Part 1: design, subjects and procedures, Journal of the American Optometric Association, 67, 12
Brodkin, 1997, Lobe of origin and histologic type of lung cancer associated with asbestos exposure in the Carotene and Retinol Efficacy Trial (CARET), American Journal of Industrial Medicine, 32, 582, 10.1002/(SICI)1097-0274(199712)32:6<582::AID-AJIM2>3.0.CO;2-S · DOI
Stone, 2000, The Gruppo Italiano per lo Studio della Sopravvivenza nell'Infarto Miocardio (GISSI) - Prevenzione trial on fish oil and vitamin E supplementation in myocardial infarction survivors, Current Cardiology Reports, 2, 445, 10.1007/s11886-000-0059-5 · DOI
Lonn, 2002, Effects of vitamin E on cardiovascular and microvascular outcomes in high-risk patients with diabetes: results of the HOPE study and MICRO-HOPE substudy, Diabetets Care, 25, 1919, 10.2337/diacare.25.11.1919 · DOI
MRC/BHF Heart Protection Study Collaborative Group, 1999, MRC/BHF Heart Protection Study of cholesterol-lowering therapy and of antioxidant vitamin supplementation in a wide range of patients at increased risk of coronary heart disease death: early safety and efficacy experience, European Heart Journal, 20, 725, 10.1053/euhj.1998.1350 · DOI
Li, 1998, Vitamins and minerals in cancer: The Nutrition Intervention Trials in Linxian, China, Medecine Biologie Environnement, 26, 187
Sanjose, 1996, Antioxidants, Helicobacter pylori and stomach cancer in Venezuela, European Journal of Cancer Prevention, 5, 57
Vazquez Martinez, 1998, The SUVIMAX (France) study: the role of antioxidants in the prevention of cancer and cardiovascular disorders, Revista Espanola de Salud Publica, 72, 173
Buring, 1992, The Women's Health Study: rationale and background, The Journal of Myocardial Ischemia, 4, 30
Buring, 1992, The Women's Health Study: summary of study design, The Journal of Myocardial Ischemia, 4, 27
Avery, 2003, Effects of vitamin E supplementation on recovery from repeated bouts of resistance exercise, Journal of Strength and Conditioning Research, 17, 801
Bierenbaum, 1985, The effect of supplemental vitamin E on serum parameters in diabetics, postcoronary and normal subjects, Nutrition Reports International, 31, 1171
Crary, 1987, Antioxidant treatment of macular degeneration of the aging and macular edema in diabetic retinopathy, Southern Medical Journal, 80, 38
Sanjose, 1996, Antioxidants, Helicobacter pylori and stomach cancer in Venezuela, European Journal of Cancer Prevention, 5, 57
Greul, 2002, Photoprotection of UV-irradiated human skin: an antioxidative combination of vitamins E and C, carotenoids, selenium and proanthocyanidins, Skin Pharmacology and Applied Skin Physiology, 15, 307, 10.1159/000064534 · DOI
Jantti, 1991, Treatment of rheumatoid arthritis with fish oil, selenium, vitamins A and E, and placebo, Scandinavian Journal of Rheumatology, 20, 225
Tam, 2005, Effects of vitamins C and E on oxidative stress markers and endothelial function in patients with systemic lupus erythematosus: a double blind, placebo controlled pilot study, Journal of Rheumatology, 32, 275
Cote, 1997, Prevention de la restenose post-angioplastie par la therapie antioxydante, Annales de Cardiologie et D'Angeiologie, 4, 223
Wesnes, 2003, The effects of a combination of Panax ginseng, vitamins and minerals on mental performance, mood and physical fatigue in nurses working night shifts: a double-blind, placebo controllled trial, Current Topics in Nutraceutical Research, 1, 169
Zhu S Mason J Shi Y Hu Y Li R Wang M The interventional effect of folic acid on the development of gastric and other gastrointestinal cancers - Clinical trial and follow-up for seven years Chinese Journal of Gastroenterology 2002 73 8
Zielinski, 1978, On the treatment of arteriosclerotic retinopathy with Cosaldon A+E, Klinische Monatsblatter fur Augenheilkunde, 173, 857
Panel on Dietary Antioxidants and Related Compounds, Subcommittees on Upper Reference Levels of Nutrients and Interpretation and Uses of DRIs, Standing Committee on the Scientific Evaluation of Dietary Reference Intakes, Food and Nutrition Board. Institute of Medicine. Dietary reference intakes for Vitamin C, Vitamin E, Selenium, and Carotenoids National Academy Press, Washington, DC 2000 1 529
Halliwell, 1998, Free Radicals, 89
Copenhagen: The Nordic Cochrane Centre, The Cochrane Collaboration Review Manager (RevMan) 2008
Stranges, 2007, Effects of long-term selenium supplementation on the incidence of type 2 diabetes: a randomized trial, Annals of Internal Medicine, 147, 217, 10.7326/0003-4819-147-4-200708210-00175 · DOI

Sorted by citations

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Petersen, M. C., & Shulman, G. I. (2018) · Physiological Reviews · doi:10.1152/physrev.00063.2017 · Cited by 3,028
Defeating Alzheimer's disease and other dementias: a priority for European science and society
Winblad, B., Amouyel, P., Andrieu, S., Ballard, C., Brayne, C., Brodaty, H., Cedazo-Minguez, A., Dubois, B., Edvardsson, D., Feldman, H., et al. (2016) · The Lancet Neurology · doi:10.1016/s1474-4422(16)00062-4 · Cited by 1,676
13 reasons why the brain is susceptible to oxidative stress
Cobley, J. N., Fiorello, M. L., & Bailey, D. M. (2018) · Redox Biology · doi:10.1016/j.redox.2018.01.008 · Cited by 1,215
The relation between different dimensions of alcohol consumption and burden of disease: an overview
Rehm, J., Baliunas, D., Borges, G. L. G., Graham, K., Irving, H., Kehoe, T., Parry, C. D., Patra, J., Popova, S., Poznyak, V., et al. (2010) · Addiction · doi:10.1111/j.1360-0443.2010.02899.x · Cited by 1,174
The role of mitochondria in aging
Bratic, A., & Larsson, N.-G. (2013) · Journal of Clinical Investigation · doi:10.1172/jci64125 · Cited by 1,087

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Authors: Bjelakovic, G., Nikolova, D., Gluud, L. L., Simonetti, R. G., & Gluud, C.
Affiliations: Medical Faculty, University of Nis; Department of Internal Medicine; Zorana Djindjica 81 Nis Serbia 18000
Copenhagen University Hospital (DK)
Gentofte Hospital (DK)
Ospedale Vincenzo Cervello (IT)
ORCID: Nikolova, Dimitrinka
Gluud, Lise Lotte
Simonetti, Rosa G
Gluud, Christian
Venue: Cochrane Database of Systematic Reviews
Publisher: Wiley
Published: 2012-03-14
Volume: 2012
Issue: 3
Pages: CD007176-CD007176
ISSN: 1361-6137 (ISSN-L)
1465-1858
DOI: 10.1002/14651858.cd007176.pub2
PMC: PMC8407395
OpenAlex: W2174121794
Cited by: 924
References: 1,161
Citations by year: 2026: 19 · 2025: 35 · 2024: 25 · 2023: 43 · 2022: 47 · 2021: 43 · 2020: 54 · 2019: 46 · 2018: 69 · 2017: 54 · 2016: 59 · 2015: 78 · 2014: 65 · 2013: 95 · 2012: 65
FWCI: 10.26
Type: journal article
Language: en
Open access: green
www.ncbi.nlm.nih.gov
Locations: Cochrane Database of Systematic Reviews (publishedVersion)
PubMed Central (publishedVersion)
PubMed (publishedVersion)
Työväentutkimus Vuosikirja (submittedVersion, other-oa)
Topics: Health Sciences › Medicine › Biochemistry (medical) › Antioxidant Activity and Oxidative Stress
Health Sciences › Nursing › Nutrition and Dietetics › Vitamin C and Antioxidants Research
Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Nutrition and Health Studies
Keywords: antioxidant supplements, mortality, beta-carotene, vitamin A, vitamin C, vitamin E, selenium, primary prevention, secondary prevention, healthy adults, disease prevention, trial sequential analysis, risk of bias, heterogeneity, subgroup analysis
MeSH terms: Antioxidants, Ascorbic Acid, Female, Health Status, Humans, Male, Mortality, Primary Prevention, Selenium, Vitamin A, Vitamin E, Randomized Controlled Trials as Topic, beta Carotene, Secondary Prevention

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Antioxidant supplements for prevention of mortality in healthy participants and patients with various diseases

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