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Antidepressants for the treatment of depression in people with cancer
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Antidepressants for the treatment of depression in people with cancer (Review)
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“Evidence of enduring effects of conventional psycho-or pharmacotherapy is limited or ambiguous (Akechi et al., 2008;Ostuzzi et al., 2018).”
From Psychedelics for the treatment of depression, anxiety, and existential distress in patients with a terminal illness: a systematic review (2022) · cites this paper as Ostuzzi et al., 2018
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“The Cochrane review concluded that the evidence for medications compared with placebo was of low certainty based on the limited number and low quality of studies.”
From Management of Anxiety and Depression in Adult Survivors of Cancer: ASCO Guideline Update (2023) · cites this paper as [57]
Experimental — accuracy not yet measuredThe source backs part of the claim, not all of it — or backs it for a different population, condition or comparison.
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“Pharmacologic management was investigated in a 2018 Cochrane review of antidepressant use in cancer patients with MDD and no difference between antidepressants (as a class) and placebo on symptoms of depression at 6-12 weeks was found.57”
From Management of Anxiety and Depression in Adult Survivors of Cancer: ASCO Guideline Update (2023) · cites this paper as [57]
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“Also, head-to-head comparisons of selective serotonin reuptake inhibitors versus tricyclic antidepressants showed no difference.57”
From Management of Anxiety and Depression in Adult Survivors of Cancer: ASCO Guideline Update (2023) · cites this paper as [57]
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“a conclusion informed by the 2018 Cochrane review of null findings for antidepressant use for MDD in patients with cancer at 6-12 weeks, a sufficient interval in pharmacologic trials for effects to be detected.57”
From Management of Anxiety and Depression in Adult Survivors of Cancer: ASCO Guideline Update (2023) · cites this paper as [57]
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“es el tratamiento de elección en depresión por delante del tratamiento farmacológico, por la mala tolerabilidad e interacciones farmacológicas de los antidepresivos en estos pacientes (27 ,28) , porque se han encontrado resultados similares entre la medicación y el placebo en personas con cáncer (29) , y porque los pacientes, tanto oncológicos como no oncológicos, suelen preferirla a la medicación”
From AVANZACT: protocolo e intervención psicoterapéutica en cáncer avanzado basados en Terapia de Aceptación y Compromiso. (2025) · cites this paper as [30]
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3 retracted
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Antidepressants for the treatment of depression in people with cancer
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BackgroundMethodAntidepressants for the treatment of depression in people with cancer
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“…as sertraline and fluoxetine, serotonin and norepinephrine reuptake inhibitors (SNRI) like duloxetine and milnacipran, tricyclic antidepressants (TCA) such as amitriptyline and imipramine, monoamine oxidase inhibitors (MAOI) like moclobemide and phenelzine (Zhao et al., 2015; Ostuzzi et al., 2018).”
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“On the other hand, another meta-analysis suggested that antidepressants can reduce the acute depressive symptoms of cancer patients, but only with limited quality of evidence (Vita et al., 2023).”
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“15 Thus, alternative treatment approaches are needed.”
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Metadata
- Authors
- Ostuzzi, G., Matcham, F., Dauchy, S., Barbui, C., & Hotopf, M.
- Affiliations
- University of Verona (IT)
- King's College London (GB)
- Institut Gustave Roussy (FR)
- Venue
- Cochrane Database of Systematic Reviews
- Publisher
- Wiley
- Published
- 2018-04-23
- Volume
- 2018
- Issue
- 4
- ISSN
- 1361-6137 (ISSN-L)
- 1465-1858
- OpenAlex
- W2940589604
- Cited by
- 158
- References
- 157
- Citations by year
- 2026: 9 · 2025: 16 · 2024: 44 · 2023: 21 · 2022: 29 · 2021: 18 · 2020: 8 · 2019: 9 · 2018: 2
- FWCI
- 0.96
- Type
- journal article
- Language
- en
- Update notices
- new_version (2023-03-31)
- Open access
- bronze
- doi.org
- Locations
- Cochrane Database of Systematic Reviews (publishedVersion)
- Funders
- National Institute for Health and Care Research (NF-SI-0515-10102)
- King's College London
- Evidence Synthesis Programme
- Topics
- Health Sciences › Medicine › Oncology › Cancer survivorship and care
- Health Sciences › Medicine › Pharmacology (medical) › Treatment of Major Depression
- Health Sciences › Medicine › Psychiatry and Mental health › Mental Health Treatment and Access
- Keywords
- antidepressants, depression, cancer, cancer-related depression, antidepressant efficacy, antidepressant safety
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