Cited by 779Bone Tissue Engineering MaterialsCalcium Carbonate Crystallization and InhibitionPolymer Surface Interaction Studies

The DOI matches its Crossref record; 41 of the 42 references it cites were found in a registry or an index.

Mussel‐Inspired Polydopamine Coating as a Universal Route to Hydroxyapatite Crystallization

Ryu, Jungki, Ku, Sook Hee, Lee, Haeshin, Park, Chan Beum·2010·Advanced Functional Materials

Abstract

Bone tissue is a complex biocomposite material with a variety of organic (e.g., proteins, cells) and inorganic (e.g., hydroxyapatite crystals) components hierarchically organized with nano/microscale precision. Based on the understanding of such hierarchical organization of bone tissue and its unique mechanical properties, efforts are being made to mimic these organic–inorganic hybrid biocomposites. A key factor for the successful designing of complex, hybrid biomaterials is the facilitation and control of adhesion at the interfaces, as many current synthetic biomaterials are inert, lacking interfacial bioactivity. In this regard, researchers have focused on controlling the interface by surface modifications, but the development of a simple, unified way to biofunctionalize diverse organic and inorganic materials remains a critical challenge. Here, a universal biomineralization route, called polydopamine‐assisted hydroxyapatite formation (pHAF), that can be applied to virtually any type and morphology of scaffold materials is demonstrated. Inspired by the adhesion mechanism of mussels, the pHAF method can readily integrate hydroxyapatites on ceramics, noble metals, semiconductors, and synthetic polymers, irrespective of their size and morphology (e.g., porosity and shape). Surface‐anchored catecholamine moieties in polydopamine enriches the interface with calcium ions, facilitating the formation of hydroxyapatite crystals that are aligned to the c‐axes, parallel to the polydop…

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Crossref · 10.1002/adfm.200902347

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  1. Ohring M., 2002, Materials Science of Thin Films: Deposition & Structure

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Metadata

Authors
Ryu, J., Ku, S. H., Lee, H., & Park, C. B.
Affiliations
Korea Advanced Institute of Science and Technology (KR)
Corresponding author
  • Lee, Haeshin
  • Park, Chan Beum
Venue
Advanced Functional Materials
Publisher
Wiley
Published
2010-07-05
Volume
20
Issue
13
Pages
2132-2139
ISSN
  • 1616-301X (ISSN-L)
  • 1616-3028
OpenAlex
W2063261010
Cited by
778
References
42
Citations by year
2026: 19 · 2025: 30 · 2024: 44 · 2023: 38 · 2022: 54 · 2021: 53 · 2020: 70 · 2019: 65 · 2018: 76 · 2017: 54 · 2016: 68 · 2015: 57 · 2014: 54 · 2013: 35 · 2012: 30
FWCI
17.94
Type
journal article
Language
en
Open access
closed
Locations
  • Advanced Functional Materials (publishedVersion)
  • Scholarworks@UNIST (Ulsan National Institute of Science and Technology) (submittedVersion)
Funders
Korea Advanced Institute of Science and Technology
Topics
  • Physical Sciences › Engineering › Biomedical Engineering › Bone Tissue Engineering Materials
  • Physical Sciences › Materials Science › Biomaterials › Calcium Carbonate Crystallization and Inhibition
  • Physical Sciences › Materials Science › Surfaces, Coatings and Films › Polymer Surface Interaction Studies
Keywords
polydopamine coating, hydroxyapatite crystallization, catecholamines, biomineralization, surface functionalization, scaffold materials, tissue engineering

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