The DOI matches its Crossref record; 41 of the 42 references it cites were found in a registry or an index.
Mussel‐Inspired Polydopamine Coating as a Universal Route to Hydroxyapatite Crystallization
Abstract
Bone tissue is a complex biocomposite material with a variety of organic (e.g., proteins, cells) and inorganic (e.g., hydroxyapatite crystals) components hierarchically organized with nano/microscale precision. Based on the understanding of such hierarchical organization of bone tissue and its unique mechanical properties, efforts are being made to mimic these organic–inorganic hybrid biocomposites. A key factor for the successful designing of complex, hybrid biomaterials is the facilitation and control of adhesion at the interfaces, as many current synthetic biomaterials are inert, lacking interfacial bioactivity. In this regard, researchers have focused on controlling the interface by surface modifications, but the development of a simple, unified way to biofunctionalize diverse organic and inorganic materials remains a critical challenge. Here, a universal biomineralization route, called polydopamine‐assisted hydroxyapatite formation (pHAF), that can be applied to virtually any type and morphology of scaffold materials is demonstrated. Inspired by the adhesion mechanism of mussels, the pHAF method can readily integrate hydroxyapatites on ceramics, noble metals, semiconductors, and synthetic polymers, irrespective of their size and morphology (e.g., porosity and shape). Surface‐anchored catecholamine moieties in polydopamine enriches the interface with calcium ions, facilitating the formation of hydroxyapatite crystals that are aligned to the c‐axes, parallel to the polydop…
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“These groups function as effective “anchoring sites” for subsequent chemical reactions and can readily undergo covalent coupling with a wide range of biofunctional molecules bearing nucleophilic groups, such as primary amines (–NH2) and thiols (–SH), through simple immersion or co-incubation processes.”
From Polydopamine-Based Biomaterials in Oral Medicine: Applications, Mechanisms, and Translational Challenges (2026) · cites this paper as [10]
In the citing paper
“As a precursor of PDA, DA has functional groups (catechol and phenethylamine) and adhesive mechanism similar to DOPA, which offers DA the potential as a versatile surface modifier in various biomedical applications [21–23].”
From Polydopamine-Assisted Surface Modification for Bone Biosubstitutes (2016) · cites this paper as [23]
In the citing paper
“The formation of PDA coating layer on the silicon-based biosubstitutes has been found to assist in the mineralization [23].”
From Polydopamine-Assisted Surface Modification for Bone Biosubstitutes (2016) · cites this paper as [23]
In the citing paper
“In addition, the PDA-assisted surface modification to Ti and Ti alloys can also offer the osteoinductivity and osteoconductivity to bioinert metallic bone biosubstitutes and enhance their bioactivities regarding the viability, proliferation, and differentiation of cell and material mineralization [23, 71, 72, 88].”
From Polydopamine-Assisted Surface Modification for Bone Biosubstitutes (2016) · cites this paper as [23]
In the citing paper
“In addition, the PDA-assisted surface modification to Ti and Ti alloys can also offer the osteoinductivity and osteoconductivity to bioinert metallic bone biosubstitutes and enhance their bioactivities regarding the viability, proliferation, and differentiation of cell and material mineralization [23, 71, 72, 88].”
From Polydopamine-Assisted Surface Modification for Bone Biosubstitutes (2016) · cites this paper as [23]
In the citing paper
“In addition, the PDA-assisted surface modification to Ti and Ti alloys can also offer the osteoinductivity and osteoconductivity to bioinert metallic bone biosubstitutes and enhance their bioactivities regarding the viability, proliferation, and differentiation of cell and material mineralization [23, 71, 72, 88].”
From Polydopamine-Assisted Surface Modification for Bone Biosubstitutes (2016) · cites this paper as [23]
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Metadata
- Authors
- Ryu, J., Ku, S. H., Lee, H., & Park, C. B.
- Affiliations
- Korea Advanced Institute of Science and Technology (KR)
- Corresponding author
- Lee, Haeshin
- Park, Chan Beum
- Venue
- Advanced Functional Materials
- Publisher
- Wiley
- Published
- 2010-07-05
- Volume
- 20
- Issue
- 13
- Pages
- 2132-2139
- ISSN
- 1616-301X (ISSN-L)
- 1616-3028
- OpenAlex
- W2063261010
- Cited by
- 778
- References
- 42
- Citations by year
- 2026: 19 · 2025: 30 · 2024: 44 · 2023: 38 · 2022: 54 · 2021: 53 · 2020: 70 · 2019: 65 · 2018: 76 · 2017: 54 · 2016: 68 · 2015: 57 · 2014: 54 · 2013: 35 · 2012: 30
- FWCI
- 17.94
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Advanced Functional Materials (publishedVersion)
- Scholarworks@UNIST (Ulsan National Institute of Science and Technology) (submittedVersion)
- Funders
- Korea Advanced Institute of Science and Technology
- Topics
- Physical Sciences › Engineering › Biomedical Engineering › Bone Tissue Engineering Materials
- Physical Sciences › Materials Science › Biomaterials › Calcium Carbonate Crystallization and Inhibition
- Physical Sciences › Materials Science › Surfaces, Coatings and Films › Polymer Surface Interaction Studies
- Keywords
- polydopamine coating, hydroxyapatite crystallization, catecholamines, biomineralization, surface functionalization, scaffold materials, tissue engineering
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