Microbubbles in combination with focused ultrasound for the delivery of quercetin-modified sulfur nanoparticles through the blood brain barrier into the brain parenchyma and relief of endoplasmic reticulum stress to treat Alzheimer's disease
Abstract
The delivery of drugs across the blood–brain barrier (BBB) effectively and safely is one of the major challenges in the treatment of neurodegenerative diseases.
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Qc@SNPs-MB with ultrasound accumulates in brain and promotes drug delivery because of transient BBB opening.
“In combination with ultrasound, this system could accumulate in the brain and promote drug delivery because of the transient opening of the BBB.”
From The blood–brain barrier: Structure, regulation and drug delivery (2023) · cites this paper as [224]
Qc@SNPs-MB effectively treats Alzheimer's disease by protecting nerve cells and reducing endoplasmic reticulum stress from oxidative stress, inflammatory response, calcium homeostasis imbalance, and neuronal apoptosis.
“Qc@SNPs-MB effectively treated Alzheimer’s disease by protecting nerve cells and reducing endoplasmic reticulum stress which comes from oxidative stress, inflammatory response, calcium homeostasis imbalance, and neuronal apoptosis.”
From The blood–brain barrier: Structure, regulation and drug delivery (2023) · cites this paper as [224]
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- Authors
- Liu, Y., Gong, Y., Xie, W., Huang, A., Yuan, X., Zhou, H., Zhu, X., Chen, X., Liu, J., Liu, J., & Qin, X.
- Affiliations
- Jinan University (CN)
- College of Pharmacy
- Corresponding author
- Liu, Jie
- Venue
- Nanoscale
- Publisher
- Royal Society of Chemistry (RSC)
- Published
- 2020
- Volume
- 12
- Issue
- 11
- Pages
- 6498-6511
- ISSN
- 2040-3364 (ISSN-L)
- 2040-3372
- OpenAlex
- W3003203987
- Cited by
- 123
- References
- 52
- Citations by year
- 2026: 18 · 2025: 20 · 2024: 22 · 2023: 15 · 2022: 25 · 2021: 16 · 2020: 7
- FWCI
- 4.95
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Nanoscale (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Natural Science Foundation of China (81803027, 21877051, 21701034)
- Natural Science Foundation of Guangdong Province (2018A030310628)
- Topics
- Physical Sciences › Engineering › Biomedical Engineering › Ultrasound and Hyperthermia Applications
- Life Sciences › Neuroscience › Neurology › Barrier Structure and Function Studies
- Physical Sciences › Materials Science › Biomaterials › Nanoparticle-Based Drug Delivery
- Keywords
- microbubbles, focused ultrasound, blood-brain barrier, sonoporation, quercetin, sulfur nanoparticles, Alzheimer's disease, endoplasmic reticulum stress, brain drug delivery, neuroprotection, oxidative stress, memory impairment, neuroinflammation, calcium homeostasis
- MeSH terms
- Ultrasonic Waves, Alzheimer Disease, Animals, Blood-Brain Barrier, Cell Line, Disease Models, Animal, Humans, Quercetin, Drug Delivery Systems, Microbubbles, Mice, Nanoparticles, Endoplasmic Reticulum Stress
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