Cited by 123Ultrasound and Hyperthermia ApplicationsBarrier Structure and Function StudiesNanoparticle-Based Drug Delivery

Microbubbles in combination with focused ultrasound for the delivery of quercetin-modified sulfur nanoparticles through the blood brain barrier into the brain parenchyma and relief of endoplasmic reticulum stress to treat Alzheimer's disease

Liu, Yanan, Gong, Youcong, Xie, Wenjie, Huang, Anlian, Yuan, Xiaoyu, Zhou, Hui, Zhu, Xufeng, Chen, Xu +3 more·2020·Nanoscale

Abstract

The delivery of drugs across the blood–brain barrier (BBB) effectively and safely is one of the major challenges in the treatment of neurodegenerative diseases.

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Registry

Crossref · 10.1039/c9nr09713a

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52 of 52 references verified0 citation errors · 0 not checkable

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  • Qc@SNPs-MB with ultrasound accumulates in brain and promotes drug delivery because of transient BBB opening.

    “In combination with ultrasound, this system could accumulate in the brain and promote drug delivery because of the transient opening of the BBB.”
  • Qc@SNPs-MB effectively treats Alzheimer's disease by protecting nerve cells and reducing endoplasmic reticulum stress from oxidative stress, inflammatory response, calcium homeostasis imbalance, and neuronal apoptosis.

    “Qc@SNPs-MB effectively treated Alzheimer’s disease by protecting nerve cells and reducing endoplasmic reticulum stress which comes from oxidative stress, inflammatory response, calcium homeostasis imbalance, and neuronal apoptosis.”

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Authors
Liu, Y., Gong, Y., Xie, W., Huang, A., Yuan, X., Zhou, H., Zhu, X., Chen, X., Liu, J., Liu, J., & Qin, X.
Affiliations
  • Jinan University (CN)
  • College of Pharmacy
Corresponding author
Liu, Jie
Venue
Nanoscale
Published
2020
Volume
12
Issue
11
Pages
6498-6511
ISSN
  • 2040-3364 (ISSN-L)
  • 2040-3372
OpenAlex
W3003203987
Cited by
123
References
52
Citations by year
2026: 18 · 2025: 20 · 2024: 22 · 2023: 15 · 2022: 25 · 2021: 16 · 2020: 7
FWCI
4.95
Type
journal article
Language
en
Open access
closed
Locations
  • Nanoscale (publishedVersion)
  • PubMed (publishedVersion)
Funders
  • National Natural Science Foundation of China (81803027, 21877051, 21701034)
  • Natural Science Foundation of Guangdong Province (2018A030310628)
Topics
  • Physical Sciences › Engineering › Biomedical Engineering › Ultrasound and Hyperthermia Applications
  • Life Sciences › Neuroscience › Neurology › Barrier Structure and Function Studies
  • Physical Sciences › Materials Science › Biomaterials › Nanoparticle-Based Drug Delivery
Keywords
microbubbles, focused ultrasound, blood-brain barrier, sonoporation, quercetin, sulfur nanoparticles, Alzheimer's disease, endoplasmic reticulum stress, brain drug delivery, neuroprotection, oxidative stress, memory impairment, neuroinflammation, calcium homeostasis
MeSH terms
Ultrasonic Waves, Alzheimer Disease, Animals, Blood-Brain Barrier, Cell Line, Disease Models, Animal, Humans, Quercetin, Drug Delivery Systems, Microbubbles, Mice, Nanoparticles, Endoplasmic Reticulum Stress

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