Enzymatically cross-linked poly(γ-glutamic acid) hydrogel with enhanced tissue adhesive property
Open accessAbstract
Enzymatic cross-linking of polymer-catechol conjugates in the presence of horseradish peroxidase (HRP) and H 2 O 2 has emerged as an important method to fabricate in situ -forming, injectable hydrogels. Subsequently, tissue adhesion studies using catechol-containing polymers were extensively reported. However, because of the presence of numerous variables such as polymer concentration, oxidizing agent/enzyme, and stoichiometry, the design of the polymer with optimized tissue adhesive property is still challenging. In this study, a poly(γ-glutamic acid) (γ-PGA)-dopamine (PGADA) conjugate was synthesized, and in situ hydrogels were fabricated via enzymatic cross-linking of a catechol moiety. To optimize the tissue adhesive property of the PGADA hydrogel, the effect of various factors, such as polymer concentration, catechol substitution degree (DS), HRP concentration, and H 2 O 2 content, on the gelation behavior and mechanical strength was investigated. The gelation behavior of PGADA hydrogels was characterized using a rheometer and rotational viscometer. Also, the possibility of its use as a tissue adhesive was examined by evaluating the tissue adhesion strength in vitro and ex vivo .
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Kim and coworkers found that PGADA was able to gel in the presence of horseradish peroxidase (HRP) and hydrogen peroxide (H2O2).
“For example, Kim and coworkers synthesized catechol-modified poly (γ-glutamic acid) (PGADA). They found that PGADA was able to gel in the presence of horseradish peroxidase (HRP) and hydrogen peroxide (H2O2) [68].”
From Mussel-Inspired Injectable Adhesive Hydrogels for Biomedical Applications (2024) · cites this paper as [68]
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- Authors
- Kim, M. H., Lee, J. N., Lee, J., Lee, H., & Park, W. H.
- Affiliations
- Chungnam National University (KR)
- Korea Advanced Institute of Science and Technology (KR)
- Corresponding author
- Lee, Haeshin
- Park, Won Ho
- Venue
- ACS Biomaterials Science & Engineering
- Publisher
- American Chemical Society (ACS)
- Published
- 2020-04-22
- Volume
- 6
- Issue
- 5
- Pages
- 3103-3113
- ISSN
- 2373-9878 (ISSN-L)
- OpenAlex
- W3018132833
- Cited by
- 45
- References
- 54
- Citations by year
- 2026: 5 · 2025: 2 · 2024: 5 · 2023: 9 · 2022: 11 · 2021: 12 · 2020: 1
- FWCI
- 2.75
- Type
- journal article
- Language
- en
- Open access
- green
- doi.org
- Licence
- Locations
- ACS Biomaterials Science & Engineering (publishedVersion)
- SSRN Electronic Journal (acceptedVersion)
- PubMed (publishedVersion)
- Funders
- National Research Foundation of Korea (2018R1A2A2A05021100)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Medicine › Hydrogels: synthesis, properties, applications
- Health Sciences › Medicine › Surgery › Surgical Sutures and Adhesives
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Biopolymer Synthesis and Applications
- Keywords
- poly-γ-glutamic acid, catechol-containing polymers, enzymatic crosslinking, horseradish peroxidase, hydrogen peroxide, injectable hydrogel, tissue adhesion, in situ gelation, gelation behavior, mechanical strength, degree of substitution
- MeSH terms
- Hydrogen Peroxide, Polyglutamic Acid, Tissue Adhesives, Glutamic Acid, Hydrogels
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Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
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