Mussel-inspired bisphosphonated injectable nanocomposite hydrogels with adhesive, self-healing, and osteogenic properties for bone regeneration
Abstract
Injectable hydrogels have received much attention because of the advantages of simulation of the natural extracellular matrix, microinvasive implantation, and filling and repairing of complex shape defects. Yet, for bone repair, the current injectable hydrogels have shown significant limitations such as the lack of tissue adhesion, deficiency of self-healing ability, and absence of osteogenic activity. Herein, a strategy to construct mussel-inspired bisphosphonated injectable nanocomposite hydrogels with adhesive, self-healing, and osteogenic properties is developed. The nano-hydroxyapatite/poly(l-glutamic acid)-dextran (nHA/PLGA-Dex) dually cross-linked (DC) injectable hydrogels are fabricated via Schiff base cross-linking and noncovalent nHA-BP chelation. The chelation between bisphosphonate ligands (alendronate sodium, BP) and nHA favors the uniform dispersion of the latter. Moreover, multiple adhesion ligands based on catechol motifs, BP, and aldehyde groups endow the hydrogels with good tissue adhesion. The hydrogels possess excellent biocompatibility and the introduction of BP and nHA both can effectively promote viability, proliferation, migration, and osteogenesis differentiation of MC3T3-E1 cells. The incorporation of BP groups and HA nanoparticles could also facilitate the angiogenic property of endothelial cells. The nHA/PLGA-Dex DC hydrogels exhibited considerable biocompatibility despite the presence of a certain degree of inflammatory response in the early stage…
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The fascinating properties of mussel-inspired injectable hydrogels benefit their application in numerous biomedical fields, such as wound closure and healing, hemostasis, bone repair, drug delivery, smart sensors, and biological coatings.
“Their fascinating properties benefit their application in numerous biomedical fields, such as wound closure and healing [36,37], hemostasis [38,39], bone repair [40,41], drug delivery [42,43], smart sensors [44], biological coatings [45], etc. (Figure 2).”
From Mussel-Inspired Injectable Adhesive Hydrogels for Biomedical Applications (2024) · cites this paper as [41]
These hydrogels are mainly designed as tissue adhesives, hemostatic sealants, nanocomposite gels, drug carriers, hydrogel bioelectrodes, and anti-adhesion gel coatings.
“These hydrogels are mainly designed as tissue adhesives [61,87] (for wound closure and healing), hemostatic sealants [75,88] (for hemostasis), nanocomposite gels [41,89] (for bone repair), drug carriers [42,90] (for drug delivery), hydrogel bioelectrodes [44] (for smart sensors), and anti-adhesion gel coatings [45] (for biological coatings) (Figure 7).”
From Mussel-Inspired Injectable Adhesive Hydrogels for Biomedical Applications (2024) · cites this paper as [41]
The nHA/PLGA-BP-Dex DC hydrogel has tissue adhesive properties, self-healing capacity, and osteoconductivity due to catechol and BP groups.
“The incorporation of catechol and BP groups endowed the composite hydrogel with tissue adhesive properties, self-healing capacity, and osteoconductivity.”
From Mussel-Inspired Injectable Adhesive Hydrogels for Biomedical Applications (2024) · cites this paper as [41]
In vivo cranial bone regeneration experiments confirmed the efficacy of nHA/PLGA-BP-Dex DC hydrogel in bone repair.
“In vivo cranial bone regeneration experiments confirmed the efficacy of the nHA/PLGA-BP-Dex DC hydrogel in bone repair.”
From Mussel-Inspired Injectable Adhesive Hydrogels for Biomedical Applications (2024) · cites this paper as [41]
Compared with untreated controls, the nHA/PLGA-BP-Dex DC hydrogel-treated group showed higher bone volume percentage, bone mineral density, and trabecular number.
“Compared with the control group (untreated), the nHA/PLGA-BP-Dex DC hydrogel-treated group showed a higher percentage of bone volume, bone mineral density, and trabecular number [41].”
From Mussel-Inspired Injectable Adhesive Hydrogels for Biomedical Applications (2024) · cites this paper as [41]
Cites
Biomechanics. Mechanical Properties of Living Tissues
Fung, Y. C., & Skalak, R. (1982) · Journal of Applied Mechanics · doi:10.1115/1.3162171 · Cited by 6,045 · see citing works
Qu, J., Zhao, X., Liang, Y., Zhang, T., Ma, P. X., & Guo, B. (2018) · Biomaterials · doi:10.1016/j.biomaterials.2018.08.044 · Cited by 1,815 · see citing works
Biomimetic materials for tissue engineering
Shin, H., Jo, S., & Mikos, A. G. (2003) · Biomaterials · doi:10.1016/s0142-9612(03)00339-9 · Cited by 1,616 · see citing works
Tough adhesives for diverse wet surfaces
Li, J., Celiz, A. D., Yang, J., Yang, Q., Wamala, I., Whyte, W., Seo, B. R., Vasilyev, N. V., Vlassak, J. J., Suo, Z., et al. (2017) · Science · doi:10.1126/science.aah6362 · Cited by 1,610 · see citing works
Nanoscale hydroxyapatite particles for bone tissue engineering
Zhou, H., & Lee, J. (2011) · Acta Biomaterialia · doi:10.1016/j.actbio.2011.03.019 · Cited by 1,544 · see citing works
Adaptable Hydrogel Networks with Reversible Linkages for Tissue Engineering
Wang, H., & Heilshorn, S. C. (2015) · Advanced Materials · doi:10.1002/adma.201501558 · Cited by 723 · see citing works
Synthesis of hydroxyapatite for biomedical applications
Szcześ, A., Hołysz, L., & Chibowski, E. (2017) · Advances in Colloid and Interface Science · doi:10.1016/j.cis.2017.04.007 · Cited by 722 · see citing works
Novel Biocompatible Polysaccharide‐Based Self‐Healing Hydrogel
Zhao, W., Yang, J., Liu, Z. Q., Xu, F., Zhou, J., Zrı́nyi, M., Osada, Y., & Chen, Y. M. (2015) · Advanced Functional Materials · doi:10.1002/adfm.201401502 · Cited by 662 · see citing works
An Injectable, Self‐Healing Hydrogel to Repair the Central Nervous System
Tseng, T.-C., Tao, L., Hsieh, F.-Y., Wei, Y., Chiu, I., & Hsu, S. (2015) · Advanced Materials · doi:10.1002/adma.201500762 · Cited by 585 · see citing works
Tough, self-healable and tissue-adhesive hydrogel with tunable multifunctionality
Han, L., Yan, L.-W., Wang, K.-F., Fang, L.-M., Zhang, H., Tang, Y.-H., Ding, Y.-H., Weng, L., Xu, J., Weng, J., et al. (2017) · NPG Asia Materials · doi:10.1038/am.2017.33 · Cited by 532 · see citing works
Mussel protein adhesion depends on interprotein thiol-mediated redox modulation
Yu, J., Wei, W., Danner, E., Ashley, R. K., Israelachvili, J. N., & Waite, J. H. (2011) · Nature Chemical Biology · doi:10.1038/nchembio.630 · Cited by 463 · see citing works
Perspectives on Mussel-Inspired Wet Adhesion
Ahn, B. K. (2017) · Journal of the American Chemical Society · doi:10.1021/jacs.6b13149 · Cited by 444 · see citing works
A systematic review of persistence and compliance with bisphosphonates for osteoporosis
Cramer, J. A., Gold, D. T., Silverman, S. L., & Lewiecki, E. M. (2007) · Osteoporosis International · doi:10.1007/s00198-006-0322-8 · Cited by 443 · see citing works
Shin, J., Lee, J. S., Lee, C., Park, H., Yang, K., Jin, Y., Ryu, J. H., Hong, K. S., Moon, S., Chung, H., et al. (2015) · Advanced Functional Materials · doi:10.1002/adfm.201500006 · Cited by 432 · see citing works
Zhu, J., Liu, B., Wang, Z., Wang, D., Ni, H., Zhang, L., & Wang, Y. (2019) · Theranostics · doi:10.7150/thno.37357 · Cited by 429 · see citing works
Zhao, H., & Heindel, N. D. (1991) · Pharmaceutical Research · doi:10.1023/a:1015866104055 · Cited by 422 · see citing works
Chen, H., Cheng, J., Ran, L., Yu, K., Lu, B., Lan, G., Dai, F., & Lu, F. (2018) · Carbohydrate Polymers · doi:10.1016/j.carbpol.2018.08.090 · Cited by 364 · see citing works
Yu, F., Cao, X., Du, J., Wang, G., & Chen, X. (2015) · ACS Applied Materials & Interfaces · doi:10.1021/acsami.5b06896 · Cited by 360 · see citing works
Injectable bioadhesive hydrogels with innate antibacterial properties
Giano, M. C., Ibrahim, Z., Medina, S. H., Sarhane, K. A., Christensen, J. M., Yamada, Y., Brandacher, G., & Schneider, J. P. (2014) · Nature Communications · doi:10.1038/ncomms5095 · Cited by 353 · see citing works
Liu, B., Wang, Y., Miao, Y., Zhang, X., Fan, Z., Singh, G., Zhang, X., Xu, K., Li, B., Hu, Z., et al. (2018) · Biomaterials · doi:10.1016/j.biomaterials.2018.04.023 · Cited by 338 · see citing works
An engineered cell-laden adhesive hydrogel promotes craniofacial bone tissue regeneration in rats
Hasani‐Sadrabadi, M. M., Sarrión, P., Pouraghaei, S., Chau, Y., Ansari, S., Li, S., Aghaloo, T. L., & Moshaverinia, A. (2020) · Science Translational Medicine · doi:10.1126/scitranslmed.aay6853 · Cited by 337 · see citing works
Han, L., Wang, M., Li, P., Gan, D., Yan, L., Xu, J., Wang, K., Fang, L., Chan, C. W., Zhang, H., et al. (2018) · ACS Applied Materials & Interfaces · doi:10.1021/acsami.8b05314 · Cited by 312 · see citing works
Chen, F., Wang, Z., & Lin, C. (2002) · Materials Letters · doi:10.1016/s0167-577x(02)00885-6 · Cited by 305 · see citing works
Shi, L., Ding, P., Wang, Y., Zhang, Y., Ossipov, D. A., & Hilborn, J. G. (2019) · Macromolecular Rapid Communications · doi:10.1002/marc.201800837 · Cited by 305 · see citing works
Zhou, W., Lü, C., Guo, X., Chen, F.-R., Yang, H., & Wang, X. (2009) · Journal of Materials Chemistry · doi:10.1039/b916619j · Cited by 272 · see citing works
Shi, L., Wang, F., Zhu, W., Xu, Z., Fuchs, S., Hilborn, J. G., Zhu, L., Ma, Q., Wang, Y., Weng, X., et al. (2017) · Advanced Functional Materials · doi:10.1002/adfm.201700591 · Cited by 271 · see citing works
Su, W., Chen, Y., & Lin, F. (2010) · Acta Biomaterialia · doi:10.1016/j.actbio.2010.02.037 · Cited by 248 · see citing works
Pectin-based injectable biomaterials for bone tissue engineering
Munarin, F., Guerreiro, S. G., Grellier, M. A., Tanzi, M. C., Barbosa, M. A., Petrini, P., & Granja, P. L. (2011) · Biomacromolecules · doi:10.1021/bm101110x · Cited by 242 · see citing works
Xu, X., Xia, X., Zhang, K., Rai, A., Li, Z. Y., Zhao, P., Wei, K., Zou, L., Yang, B., Wong, W., et al. (2020) · Science Translational Medicine · doi:10.1126/scitranslmed.aba8014 · Cited by 234 · see citing works
Self-citationYan, S., Wang, T., Feng, L., Zhu, J., Zhang, K., Chen, X., Cui, L., & Yin, J. (2014) · Biomacromolecules · doi:10.1021/bm501313t · Cited by 215 · see citing works
Self-citationZhang, K., Jia, Z., Yang, B., Feng, Q., Xu, X. G., Yuan, W., Li, X., Chen, X., Duan, L., Wang, D., et al. (2018) · Advanced Science · doi:10.1002/advs.201800875 · Cited by 193 · see citing works
Self-citationDesigning Injectable, Covalently Cross‐Linked Hydrogels for Biomedical Applications
Patenaude, M., Smeets, N. M. B., & Hoare, T. R. (2014) · Macromolecular Rapid Communications · doi:10.1002/marc.201300818 · Cited by 185 · see citing works
Bioresponsive Phosphoester Hydrogels for Bone Tissue Engineering
Wang, D., Williams, C. G., Yang, F., Cher, N., Lee, H., & Elisseeff, J. H. (2005) · Tissue Engineering · doi:10.1089/ten.2005.11.201 · Cited by 182 · see citing works
Yu, L., Zhang, Z., Zhang, H., & Ding, J. (2010) · Biomacromolecules · doi:10.1021/bm100549q · Cited by 179 · see citing works
Injectable Self-Healing Hydrogel with Antimicrobial and Antifouling Properties
Li, L., Yan, B., Yang, J., Huang, W., Chen, L., & Zeng, H. (2017) · ACS Applied Materials & Interfaces · doi:10.1021/acsami.6b16192 · Cited by 167 · see citing works
Yan, S., Wang, W., Li, X., Ren, J., Yun, W., Zhang, K., Li, G., & Yin, J. (2018) · Journal of Materials Chemistry B · doi:10.1039/c8tb01928b · Cited by 141 · see citing works
Self-citationComposite Double-Network Hydrogels To Improve Adhesion on Biological Surfaces
Karami, P., Wyss, C. S., Khoushabi, A., Schmocker, A. M., Broome, M., Moser, C., Bourban, P. ‐., & Pioletti, D. P. (2018) · ACS Applied Materials & Interfaces · doi:10.1021/acsami.8b10735 · Cited by 120 · see citing works
Bioactive Polymer/Hydroxyapatite (Nano)composites for Bone Tissue Regeneration
Pielichowska, K., & Błażewicz, S. (2010) · Advances in polymer science · doi:10.1007/12_2010_50 · Cited by 114 · see citing works
Xu, Y. X., Patsis, P. A., Hauser, S., Voigt, D., Rothe, R., Günther, M., Cui, M., Yang, X., Wieduwild, R., Eckert, K., et al. (2019) · Advanced Science · doi:10.1002/advs.201802077 · Cited by 113 · see citing works
A mussel-inspired poly(γ-glutamic acid) tissue adhesive with high wet strength for wound closure
Chen, W., Wang, R., Xu, T., Ma, X., Yao, Z., Chi, B., & Xu, H. L. (2017) · Journal of Materials Chemistry B · doi:10.1039/c7tb00813a · Cited by 110 · see citing works
Kaur, G., Wang, C., Sun, J., & Wang, Q. (2010) · Biomaterials · doi:10.1016/j.biomaterials.2010.04.017 · Cited by 102 · see citing works
Ye, W.-L., Zhao, Y.-P., Li, H.-Q., Na, R., Li, F., Mei, Q., Zhao, M., & Zhou, S.-Y. (2015) · Scientific Reports · doi:10.1038/srep14614 · Cited by 96 · see citing works
Bisphosphonate-Based Strategies for Bone Tissue Engineering and Orthopedic Implants
Cattalini, J. P., Boccaccini, A. R., Lucangioli, S. E., & Mouriño, V. (2012) · Tissue Engineering Part B Reviews · doi:10.1089/ten.teb.2011.0737 · Cited by 88 · see citing works
Li, Y., Su, J., Sun, W., Cai, L., & Deng, Z. (2018) · International Journal of Molecular Medicine · doi:10.3892/ijmm.2018.3498 · Cited by 87 · see citing works
Biocompatible Injectable Magnetic Hydrogel Formed by Dynamic Coordination Network
Shi, L., Zeng, Y., Zhao, Y., Yang, B., Ossipov, D. A., Tai, C., Dai, J., & Xu, C. (2019) · ACS Applied Materials & Interfaces · doi:10.1021/acsami.9b17627 · Cited by 80 · see citing works
Layer‐by‐Layer Buildup of Poly( L ‐glutamic acid)/Chitosan Film for Biologically Active Coating
Song, Z., Yin, J., Luo, K., Zheng, Y., Yang, Y. G., Li, Q., Yan, S., & Chen, X. (2008) · Macromolecular Bioscience · doi:10.1002/mabi.200800164 · Cited by 79 · see citing works
Self-citationWang, R., Xu, D., Liang, L., Xu, T., Liu, W., Ouyang, P., Chi, B., & Xu, H. L. (2016) · RSC Advances · doi:10.1039/c5ra15616e · Cited by 71 · see citing works
Shi, L., Han, Y., Hilborn, J. G., & Ossipov, D. (2016) · Chemical Communications · doi:10.1039/c6cc05565f · Cited by 70 · see citing works
Dan, Y., Liu, O., Liu, Y., Zhang, Y., Li, S., Feng, X., Shao, Z., Cao, Y., Yang, S., & Hong, J.-B. (2016) · Nanoscale Research Letters · doi:10.1186/s11671-016-1669-1 · Cited by 67 · see citing works
Wei, K., Senturk, B., Matter, M. T., Wu, X., Herrmann, I. K., Rottmar, M., & Toncelli, C. (2019) · ACS Applied Materials & Interfaces · doi:10.1021/acsami.9b16465 · Cited by 66 · see citing works
Wang, Y., Zhu, G., Li, N., Song, J., Wang, L., & Shi, X. (2015) · Biotechnology Advances · doi:10.1016/j.biotechadv.2015.08.005 · Cited by 65 · see citing works
Wang, X., Jiang, Z., Shi, J., Zhang, C., Zhang, W., & Wu, H. (2013) · Industrial & Engineering Chemistry Research · doi:10.1021/ie401239e · Cited by 62 · see citing works
Bose, S., Vu, A. A., Emshadi, K., & Bandyopadhyay, A. K. (2018) · Materials Science and Engineering C · doi:10.1016/j.msec.2018.02.019 · Cited by 60 · see citing works
Amirthalingam, S., Lee, S. S., Pandian, M., Ramu, J., Iyer, S., Hwang, N. S.-Y., & Jayakumar, R. (2020) · Biomaterials Science · doi:10.1039/d0bm01496f · Cited by 57 · see citing works
Sun, J., Zhang, Y., Li, B., Gu, Y., & Chen, L. (2017) · Journal of Materials Chemistry B · doi:10.1039/c7tb02043k · Cited by 50 · see citing works
A low‐toxic and efficient gene vector: Carboxymethyl dextran‐graft‐polyethylenimine
Sun, Y., Zhang, X., Cheng, H. L., Cheng, S., & Zhuo, R. (2007) · Journal of Biomedical Materials Research Part A · doi:10.1002/jbm.a.31520 · Cited by 50 · see citing works
Wang, S., Yang, Y., Zhao, Z., Wang, X., Mikos, A. G., Qiu, Z., Song, T., Sun, X., Zhao, L., Zhang, C., et al. (2017) · ACS Biomaterials Science & Engineering · doi:10.1021/acsbiomaterials.7b00159 · Cited by 47 · see citing works
The osteochondral dilemma: Review of current management and future trends
Ye, K., Di Bella, C., Myers, D. E., & Choong, P. F. M. (2014) · ANZ Journal of Surgery · doi:10.1111/ans.12108 · Cited by 44 · see citing works
Terpene and Dextran Renewable Resources for the Synthesis of Amphiphilic Biopolymers
Alves, M.-H., Huda, S., Tranchant, J., Gombart, E., Sagorin, G., Caillol, S., Billon, L., & Save, M. (2013) · Biomacromolecules · doi:10.1021/bm401521f · Cited by 36 · see citing works
Diba, M., An, J., Schmidt, S., Hembury, M., Ossipov, D. A., Boccaccini, A. R., & Leeuwenburgh, S. C. G. (2016) · Macromolecular Rapid Communications · doi:10.1002/marc.201600353 · Cited by 31 · see citing works
Chiu, C., Ferreira, J. N., Luo, T. M., Geng, H., Lin, F., & Ko, C. (2012) · Journal of Materials Science Materials in Medicine · doi:10.1007/s10856-012-4691-6 · Cited by 31 · see citing works
Gao, L., Huang, Z., Yan, S., Zhang, K., Xu, S., Li, G., Cui, L., & Yin, J. (2017) · Biomacromolecules · doi:10.1021/acs.biomac.7b01101 · Cited by 29 · see citing works
Self-citationNatural microshells of alginate–chitosan: Unexpected stability and permeability
Tao, X., Sun, X., Su, J., Chen, J., & Roa, W. (2006) · Polymer · doi:10.1016/j.polymer.2006.06.038 · Cited by 23 · see citing works
Senarath-Yapa, K., Li, S., Walmsley, G. G., Zielins, E., Paik, K., Britto, J. A., Grigoriadis, A. E., Wan, D. C., Liu, K. J., Longaker, M. T., et al. (2016) · Tissue Engineering Part A · doi:10.1089/ten.tea.2015.0527 · Cited by 22 · see citing works
Chimpibul, W., Nagashima, T., Hayashi, F., Nakajima, N., Hyon, S., & Matsumura, K. (2016) · Journal of Polymer Science Part A Polymer Chemistry · doi:10.1002/pola.28099 · Cited by 21 · see citing works
George, M. N., Liu, X., Miller, A. L., Xu, H., & Lu, L. (2019) · Journal of Biomedical Materials Research Part A · doi:10.1002/jbm.a.36832 · Cited by 20 · see citing works
Migianu‐Griffoni, E., Chebbi, I., Kachbi, S., Monteil, M., Sainte‐Catherine, O., Chaubet, F., Oudar, O., & Lecouvey, M. (2014) · Bioconjugate Chemistry · doi:10.1021/bc400317h · Cited by 20 · see citing works
Modifying collagen with alendronate sodium for bone regeneration applications
He, Y., Zhu, T., Liu, L., Shi, X., & Lin, Z. (2018) · RSC Advances · doi:10.1039/c8ra01872c · Cited by 15 · see citing works
Moustafa, A. F., Fang, Z., & Kennedy, J. P. (2002) · Polymer Bulletin · doi:10.1007/s00289-002-0037-8 · Cited by 15 · see citing works
Flagged first, then by citations
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Bertsch, P., Diba, M., Mooney, D. J., & Leeuwenburgh, S. C. G. (2022) · Chemical Reviews · doi:10.1021/acs.chemrev.2c00179 · Cited by 926 · see citing works
Evolution of Hybrid Hydrogels: Next-Generation Biomaterials for Drug Delivery and Tissue Engineering
Rana, M. M., & Siegler, H. D. L. H. (2024) · Gels · doi:10.3390/gels10040216 · Cited by 230 · see citing works
Liu, F., Liu, X., Chen, F., & Fu, Q. (2021) · Progress in Polymer Science · doi:10.1016/j.progpolymsci.2021.101472 · Cited by 183 · see citing works
Chen, Y., Sheng, W., Lin, J., Fang, C., Deng, J., Zhang, P., Zhou, M., Liu, P., Weng, J., Yu, F., et al. (2022) · ACS Applied Materials & Interfaces · doi:10.1021/acsami.1c21260 · Cited by 176 · see citing works
Bone/cartilage targeted hydrogel: Strategies and applications
Zhang, H., Wu, S., Chen, W., Hu, Y., Geng, Z., & Su, J. (2022) · Bioactive Materials · doi:10.1016/j.bioactmat.2022.10.028 · Cited by 161 · see citing works
Marine Polysaccharides for Wound Dressings Application: An Overview
Shen, S., Chen, X., Shen, Z., & Chen, H. (2021) · Pharmaceutics · doi:10.3390/pharmaceutics13101666 · Cited by 150 · see citing works
Advances in materials-based therapeutic strategies against osteoporosis
Chen, L., Song, J., Li, S., Zhu, Y., Liu, M., Wan, M., 高木, 昭., Tay, F. R., & Niu, L. (2023) · Biomaterials · doi:10.1016/j.biomaterials.2023.122066 · Cited by 126 · see citing works
Injectable hydrogels for cartilage and bone tissue regeneration: A review
Ghandforoushan, P., Alehosseini, M., Golafshan, N., Castilho, M. D., Dolatshahi‐Pirouz, A., Hanaee, J., Davaran, S., & Orive, G. (2023) · International Journal of Biological Macromolecules · doi:10.1016/j.ijbiomac.2023.125674 · Cited by 103 · see citing works
Review on the biomedical and sensing applications of nanomaterial-incorporated hydrogels
Kailasa, S. K., Joshi, D. J., Kateshiya, M. R., Koduru, J. R., & Malek, N. I. (2022) · Materials Today Chemistry · doi:10.1016/j.mtchem.2021.100746 · Cited by 101 · see citing works
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Kim, S., Jeon, H., Koo, J. M., Oh, D. X., & Park, J. (2024) · Advanced Science · doi:10.1002/advs.202302463 · Cited by 76 · see citing works
Exploring the potential of hydroxyapatite-based materials in biomedicine: A comprehensive review
Liu, C., Xu, M., Wang, Y., Yin, Q., Hu, J., Chen, H., Sun, Z., Liu, C., Li, X., Zhou, W., et al. (2024) · Materials Science and Engineering R Reports · doi:10.1016/j.mser.2024.100870 · Cited by 76 · see citing works
Hydrogel Drug Delivery Systems for Bone Regeneration
Bai, L., Tao, G., Feng, M., Xie, Y., Cai, S., Peng, S., & Xiao, J. (2023) · Pharmaceutics · doi:10.3390/pharmaceutics15051334 · Cited by 70 · see citing works
Hydrogel Tissue Bioengineered Scaffolds in Bone Repair: A Review
Ding, Q., Zhang, S., Liu, X., Zhao, Y., Yang, J., Chai, G., Wang, N., Ma, S., Liu, W., & Ding, C. (2023) · Molecules · doi:10.3390/molecules28207039 · Cited by 65 · see citing works
Bio-inspired dual-adhesive particles from microfluidic electrospray for bone regeneration
Yang, L., Wang, X., Yu, Y., Shang, L., Xu, W., & Zhao, Y. (2022) · Nano Research · doi:10.1007/s12274-022-5202-9 · Cited by 58 · see citing works
Mussel‐mimetic polysaccharide‐based injectable hydrogels for biomedical applications
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Wu, S., Gai, T., Chen, J., Chen, X., & Chen, W. (2024) · Frontiers in Bioengineering and Biotechnology · doi:10.3389/fbioe.2024.1389733 · Cited by 54 · see citing works
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Tan, L., Li, M., Chen, H., Zhang, Y., Liu, Y., Chen, M., Luo, Z. Y., Cai, K., & Hu, Y. (2023) · Nano Today · doi:10.1016/j.nantod.2023.101962 · Cited by 52 · see citing works
Electrospun nanofibers for bone regeneration: from biomimetic composition, structure to function
Zhao, T., Zhang, J., Gao, X., Yuan, D., Gu, Z., & Xu, Y. (2022) · Journal of Materials Chemistry B · doi:10.1039/d2tb01182d · Cited by 51 · see citing works
Zhou, T., Zhou, H., Wang, F., Zhang, P., Shang, J. D., & Shi, L. (2023) · Carbohydrate Polymers · doi:10.1016/j.carbpol.2023.121466 · Cited by 50 · see citing works
Bordini, E. A. F., Ferreira, J. A., Dubey, N., Ribeiro, J. S., Costa, C. A. D. S., Soares, D. G., & Bottino, M. C. (2021) · ACS Applied Bio Materials · doi:10.1021/acsabm.1c00620 · Cited by 47 · see citing works
Advances in the Synthesis and Applications of Mussel-Inspired Polymers
Mu, Y.-B., Sun, Q., Li, B.-W., & Wan, X.-B. (2022) · Polymer Reviews · doi:10.1080/15583724.2022.2041032 · Cited by 39 · see citing works
Bio-inspired adhesive hydrogel for wound healing
Li, W., Zheng, Y., Pang, W., & Lai, P. (2022) · Biomedical Technology · doi:10.1016/j.bmt.2022.11.009 · Cited by 44 · see citing works
Synthesis of Poly-γ-Glutamic Acid and Its Application in Biomedical Materials
CAI, M. L., Han, Y., Zheng, X., Xue, B., Zhang, X., Mahmut, Z., Wang, Y., Dong, B., Zhang, C., Gao, D., et al. (2023) · Materials · doi:10.3390/ma17010015 · Cited by 43 · see citing works
Polydopamine-based polysaccharide materials for water treatment
Liu, F., Jamal, R., Abdiryim, T., & Liu, X. (2022) · Cellulose · doi:10.1007/s10570-022-04787-0 · Cited by 42 · see citing works
Sun, B., Wang, H., Xiao, B., Yan, H., Wu, H., Zhang, Y., Zhang, Y., Yuan, W., Wang, X., & Shi, C. (2023) · Chemical Engineering Journal · doi:10.1016/j.cej.2023.146743 · Cited by 40 · see citing works
Ma, W., Chen, H., Cheng, S., Wu, C., Wang, L., & Du, M. (2023) · International Journal of Biological Macromolecules · doi:10.1016/j.ijbiomac.2023.124287 · Cited by 39 · see citing works
Zhang, X., Ning, F., Li, Y., Lu, J., He, Y., Feng, C., & Dong, C. (2024) · Journal of Controlled Release · doi:10.1016/j.jconrel.2024.11.027 · Cited by 39 · see citing works
Meng, J., Boschetto, F., Yagi, S., Marin, E., Adachi, T., Chen, X.-F., Pezzotti, G., Sakurai, S., Yamane, H., & Xu, H. (2022) · Materials & Design · doi:10.1016/j.matdes.2022.110781 · Cited by 38 · see citing works
Advances in Bioadhesive Hydrogels for Musculoskeletal Tissue Application
Zhang, F., Chien, M., Fan, Q., & Jiang, D. (2024) · Advanced Functional Materials · doi:10.1002/adfm.202316540 · Cited by 37 · see citing works
A gentamicin-thioctic acid multifunctional hydrogel for accelerating infected wound healing
Gao, Y. S., Zhan, X., Huo, S., Fu, L. L., Tang, Z., Qi, K., Lv, C., Liu, C., Zhu, Y., Ding, S., et al. (2022) · Journal of Materials Chemistry B · doi:10.1039/d1tb02761a · Cited by 37 · see citing works
Progress in self-healing hydrogels and their applications in bone tissue engineering
Erezuma, I., Lukin, I., Desimone, M. F., Zhang, Y. S., Dolatshahi‐Pirouz, A., & Orive, G. (2022) · Biomaterials Advances · doi:10.1016/j.bioadv.2022.213274 · Cited by 37 · see citing works
Polycatechols: Promising Materials for Biomedical Applications
Zhu, F., Sun, Z.-H., Li, Y., Chen, C., & Cheng, Y.-Y. (2024) · Progress in polymer science · doi:10.1016/j.progpolymsci.2024.101857 · Cited by 31 · see citing works
El‐Sayed, N. S., & Kamel, S. M. (2022) · Colloids and Interfaces · doi:10.3390/colloids6040078 · Cited by 33 · see citing works
Propelling Minimally Invasive Tissue Regeneration With Next‐Era Injectable Pre‐Formed Scaffolds
Liao, J., Timoshenko, A. B., Cordova, D. J., Potes, M. D. A., Gaihre, B., Liu, X., Elder, B. D., Lu, L., & Tilton, M. (2024) · Advanced Materials · doi:10.1002/adma.202400700 · Cited by 32 · see citing works
Shaygani, H., Mofrad, Y. M., Demneh, S. M. H. R., Hafezi, S., Almasi-Jaf, A., & Shamloo, A. (2024) · International Journal of Biological Macromolecules · doi:10.1016/j.ijbiomac.2024.136689 · Cited by 32 · see citing works
Li, A., Nicolas, J., & Mura, S. (2024) · Advanced Functional Materials · doi:10.1002/adfm.202409670 · Cited by 30 · see citing works
Recent advances in biomaterials for bone regeneration: Bridging innovation and clinical translation
Sabouri, Z., Dequeecker, M., Anees, H., Adib, F. R., Jamous, R., Zheng, J., Lyu, X., Stoetzel, S., Heiss, C., Khassawna, T. E., et al. (2025) · Materials Today Bio · doi:10.1016/j.mtbio.2025.102685 · Cited by 30 · see citing works
Li, J., Li, W., Kong, M., Li, Z., Yang, T., Wang, Q., & Teng, W. (2023) · Journal of Nanobiotechnology · doi:10.1186/s12951-023-01811-8 · Cited by 30 · see citing works
Li, S., Niu, D., Shi, T., Yun, W., Yan, S., Xu, G., & Yin, J. (2023) · ACS Biomaterials Science & Engineering · doi:10.1021/acsbiomaterials.3c00041 · Cited by 30 · see citing works
Self-citationProgress of polysaccharide-based tissue adhesives
Han, G., Kwack, H. S., Kim, Y., Je, Y. H., Kim, H., & Cho, C. (2023) · Carbohydrate Polymers · doi:10.1016/j.carbpol.2023.121634 · Cited by 30 · see citing works
Wang, S., Lei, H., Mi, Y., Ma, P., & Fan, D. (2024) · International Journal of Biological Macromolecules · doi:10.1016/j.ijbiomac.2024.133124 · Cited by 29 · see citing works
Nanocomposite Hydrogels in Regenerative Medicine: Applications and Challenges
Chen, W., Ming, Y., Wang, M., Huang, M., Liu, H., Huang, Y., Huang, Z., Qing, L., Wang, Q. L., & Jia, B. (2023) · Macromolecular Rapid Communications · doi:10.1002/marc.202300128 · Cited by 29 · see citing works
Targeted delivery of anti-osteoporosis therapy: Bisphosphonate-modified nanosystems and composites
Shi, S., Duan, H., & Ou, X. (2024) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2024.116699 · Cited by 28 · see citing works
Yao, J., Huang, C., Yao, J., Hui, J., Shen, S., Zheng, X., Shen, L., & Fan, D. (2024) · Chemical Engineering Journal · doi:10.1016/j.cej.2024.151789 · Cited by 27 · see citing works
A Drug‐Mineralized Hydrogel Orchestrated by Spontaneous Dynamic Mineralization
Liu, J., Zhang, X., Xiao, C., & Chen, X. (2023) · Advanced Functional Materials · doi:10.1002/adfm.202311844 · Cited by 27 · see citing works
Self-citationNanomaterial-integrated injectable hydrogels for craniofacial bone reconstruction
Xia, Y., Chen, Z., Zheng, Z., Chen, H., & Chen, Y. (2024) · Journal of Nanobiotechnology · doi:10.1186/s12951-024-02801-0 · Cited by 26 · see citing works
Li, Y., Zhao, D., Wang, Z., Meng, Y., Liu, B., Li, L., Liu, R., Dong, S., & Wei, F. (2023) · International Journal of Biological Macromolecules · doi:10.1016/j.ijbiomac.2023.123232 · Cited by 26 · see citing works
Schoonraad, S. A., Jaimes, A. A., Singh, A., Croland, K. J., & Bryant, S. J. (2023) · Acta Biomaterialia · doi:10.1016/j.actbio.2023.08.045 · Cited by 24 · see citing works
A tough injectable self‐setting cement‐based hydrogel for noninvasive bone augmentation
Jin, P. F., Xia, M., Hasany, M., Feng, P., Bai, J., Gao, J., Zhang, W., Mehrali, M., & Wang, R. (2023) · Interdisciplinary materials · doi:10.1002/idm2.12119 · Cited by 24 · see citing works
Qiu, B., Cheng, Q., Chen, R., Liu, C., Qin, J., & Jiang, Q. (2024) · Biomacromolecules · doi:10.1021/acs.biomac.4c00201 · Cited by 24 · see citing works
Advances of Mussel-Inspired Nanocomposite Hydrogels in Biomedical Applications
Ma, H., Qiao, X., & Han, L. (2023) · Biomimetics · doi:10.3390/biomimetics8010128 · Cited by 24 · see citing works
Wang, F., Gu, Z., Yin, Z., Zhang, W., Bai, L., & Su, J. (2023) · Journal of Nanobiotechnology · doi:10.1186/s12951-023-02003-0 · Cited by 24 · see citing works
Lian, S., Mu, Z., Yuan, Z., Shafiq, M., Mo, X., & Mu, W. (2024) · Regenerative Biomaterials · doi:10.1093/rb/rbae022 · Cited by 24 · see citing works
Application of adhesives in the treatment of cartilage repair
Feng, H., Ang, K., Guan, P., Li, J., Meng, H., Yang, J. Z., Fan, L., & Sun, Y. (2024) · Interdisciplinary medicine · doi:10.1002/inmd.20240015 · Cited by 23 · see citing works
Wet-adhesive materials of oral and maxillofacial region: From design to application
Mao, Y., Xu, Z., He, Z., Wang, J., & Zhu, Z. (2022) · Chinese Chemical Letters · doi:10.1016/j.cclet.2022.04.059 · Cited by 23 · see citing works
Zhang, W., Sun, T., Zhang, J., Hu, X., Yang, M., Han, L., Xu, G., Zhao, Y., & Li, Z. (2022) · Materials Today Bio · doi:10.1016/j.mtbio.2022.100528 · Cited by 22 · see citing works
Self-citationShi, T., Niu, D., You, J., Li, S., Li, G., Ren, K., Yan, S., Xu, G., & Yin, J. (2023) · International Journal of Biological Macromolecules · doi:10.1016/j.ijbiomac.2023.123541 · Cited by 22 · see citing works
Self-citationAdvances of mussel-inspired hydrogels for Bone/Cartilage regeneration
Li, H., Wang, J., Yang, G., Pei, X., & Zhang, X. (2024) · Chemical Engineering Journal · doi:10.1016/j.cej.2024.150560 · Cited by 22 · see citing works
Functional Hydrogels and Their Applications in Craniomaxillofacial Bone Regeneration
Yu, Y., Yu, T., Wang, X., & Liu, D. (2022) · Pharmaceutics · doi:10.3390/pharmaceutics15010150 · Cited by 21 · see citing works
Chawla, V., Bundel, P., & Singh, Y. (2025) · Biomacromolecules · doi:10.1021/acs.biomac.4c01484 · Cited by 20 · see citing works
Advances in Self‐Healing Polymers: Mechanisms, Applications, and Future Perspectives
Jain, A., Goswami, S., & Banerjee, S. (2025) · Macromolecular Chemistry and Physics · doi:10.1002/macp.202500159 · Cited by 20 · see citing works
Wang, B., Liu, J. S., Guo, C., Bao, X., Qi, L., Yin, J., Xu, G., & Yan, S. (2024) · Composites Part B Engineering · doi:10.1016/j.compositesb.2024.111492 · Cited by 20 · see citing works
Self-citationZou, Y., Yan, F., Tong, R., Mo, M., & Li, Z. (2024) · Journal of Polymer Science · doi:10.1002/pol.20230975 · Cited by 19 · see citing works
Intelligent Self‐Healing Polymeric Systems for Functional and Durable Coatings
Paul, S., Kaushik, A. K., Jain, A., & Banerjee, S. (2025) · Chemistry - An Asian Journal · doi:10.1002/asia.70290 · Cited by 19 · see citing works
Sinna, J., Jeencham, R., Mueangkhot, P., Sophon, S., Noralak, P., Raksapakdee, R., Numpaisal, P.-O., & Ruksakulpiwat, Y. (2023) · Polymers · doi:10.3390/polym15214230 · Cited by 19 · see citing works
Biopolymer Derived Gel Polymer Electrolytes: Current Status and Future Perspectives
Jain, A., Mahata, K., Onkarnath, & Banerjee, S. (2025) · Macromolecular Rapid Communications · doi:10.1002/marc.202500472 · Cited by 18 · see citing works
Advances in Adhesive Materials for Oral and Maxillofacial Soft Tissue Diseases
Cheng, Q., Xu, P., Luo, S., & Chen, A. (2024) · Macromolecular Bioscience · doi:10.1002/mabi.202400494 · Cited by 16 · see citing works
Jeencham, R., Tawonsawatruk, T., Numpaisal, P.-O., & Ruksakulpiwat, Y. (2023) · Polymers · doi:10.3390/polym15092092 · Cited by 16 · see citing works
Nanocomposite hyaluronic acid adhesive hydrogel with controllable drug release for bone regeneration
Liu, J., Liu, Z., Zhang, X., Yang, R., Xu, D., Li, X., Yan, Q., & Luan, S. (2024) · International Journal of Biological Macromolecules · doi:10.1016/j.ijbiomac.2024.133362 · Cited by 15 · see citing works
Self-citationKang, B., Yan, X., Tang, H., Zhao, Z., & Song, S. (2022) · ACS Applied Polymer Materials · doi:10.1021/acsapm.1c01436 · Cited by 15 · see citing works
A sustained release of alendronate from an injectable tetra-PEG hydrogel for efficient bone repair
Chang, S., Li, C., Xu, N., Wang, J., Jing, Z., Cai, H., Tian, Y., Wang, S., Liu, Z., & Wang, X. (2022) · Frontiers in Bioengineering and Biotechnology · doi:10.3389/fbioe.2022.961227 · Cited by 14 · see citing works
Jeencham, R., Sinna, J., Ruksakulpiwat, Y., Tawonsawatruk, T., Numpaisal, P.-O., & Ruksakulpiwat, Y. (2024) · Polymers · doi:10.3390/polym16081093 · Cited by 14 · see citing works
Recent advances in injectable nanocomposite hydrogels
Abdolahinia, E. D., Amiryaghoubi, N., Fathi, M., Barar, J., & Omidi, Y. (2024) · Nano-Structures & Nano-Objects · doi:10.1016/j.nanoso.2024.101254 · Cited by 14 · see citing works
Pereira, A. R., Pires, P. C., Hameed, H., Lopes, D., Lopes, J., Sousa‐Oliveira, I., Babaie, S., Mazzola, P. G., Veiga, F., & Paiva‐Santos, A. C. (2025) · Drug Delivery and Translational Research · doi:10.1007/s13346-025-01864-2 · Cited by 14 · see citing works
Omar, N. A., Amédée, J., Letourneur, D., Fricain, J., & Fénelon, M. (2022) · Frontiers in Bioengineering and Biotechnology · doi:10.3389/fbioe.2022.889481 · Cited by 14 · see citing works
Yang, L., Chen, X., Chen, L., Li, S., Li, J., Li, Z., Sun, T. S., Li, J., & Weng, J. (2024) · Macromolecular Bioscience · doi:10.1002/mabi.202300416 · Cited by 10 · see citing works
Gong, Z., Xiao, T., Wu, D., Yu, H. W., Xing, X., Li, Y., Cai, Y., Chen, C., Liu, J., Duan, D., et al. (2025) · ACS Nano · doi:10.1021/acsnano.5c11716 · Cited by 10 · see citing works
Self-citationXue, F., Liang, Z., Zhang, J., Wen, M., Zhang, Z., Pan, Q., Fan, Z., Wang, L., Wang, X., & Ren, W. (2025) · Chemical Engineering Journal · doi:10.1016/j.cej.2025.164688 · Cited by 9 · see citing works
Guo, Y., Wang, Y., Guo, Y., Dai, X., Yang, M., Wang, D., Jiang, R., Liang, Y., Cui, Q., Zheng, X., et al. (2025) · Advanced Functional Materials · doi:10.1002/adfm.202502329 · Cited by 8 · see citing works
Lee, S. J., Kim, H., Choi, E., Kim, H., Lee, D., An, S., Min, S. J., Ko, W., Lee, J. S., Nah, H., et al. (2024) · Carbohydrate Polymer Technologies and Applications · doi:10.1016/j.carpta.2024.100625 · Cited by 6 · see citing works
Edward, E. B., Zhou, E., Zhang, J., Lok, T., Zhang, J., Yusoff, N. I. S. M., Low, J. T., Lim, Z.-X., Woon, M.-R., Wahab, A. A., et al. (2025) · International Journal of Smart and Nano Materials · doi:10.1080/19475411.2025.2517561 · Cited by 4 · see citing works
Natural Polymer-Based Nanocomposite Hydrogels for Biomedical Applications
Sethi, S., Medha, Thakur, S., Singh, A., & Kaith, B. S. (2022) · Springer eBooks · doi:10.1007/978-3-030-69023-6_107-1 · Cited by 4 · see citing works
Jolly, R., Mahapatra, S., Kuldeep, Basheed, G. A., Mohanty, S., Shakir, M., & Singh, N. (2025) · Journal of Drug Delivery Science and Technology · doi:10.1016/j.jddst.2025.107051 · Cited by 3 · see citing works
Han, L., Feng, H., Yuan, Z., Shafiq, M., Lou, S., El-Newehy, M. H., Abdulhameed, M. M., Xiong, Y., Zhao, X., Mo, X., et al. (2026) · Journal of Nanobiotechnology · doi:10.1186/s12951-026-04179-7 · Cited by 3 · see citing works
Versatile Hydrogels in Regenerative Medicine
Li, Y., Su, P., Wang, Y., Ye, T., Nowaczyk, G., & Wang, W. (2023) · Springer eBooks · doi:10.1007/978-981-99-6948-7_3 · Cited by 2 · see citing works
Self-citationAnitasari, S., Belem, W. F., & Wahab, D. E. (2024) · AMPLITUDO Journal of Science & Technology Innovation · doi:10.56566/amplitudo.v3i1.155 · Cited by 2 · see citing works
CHEN, S., Li, D., Fan, M., Liu, Y., & Wang, R. (2026) · ACS Applied Materials & Interfaces · doi:10.1021/acsami.5c25084 · Cited by 2 · see citing works
Emerging bone adhesives for early fixation and enhanced healing of fractures
Li, W., Sun, S., Tian, Y., Yin, W., Yuan, B., Wu, D., & Peng, C. (2026) · Materials & Design · doi:10.1016/j.matdes.2026.116207 · Cited by 2 · see citing works
Metal-coordinated hydrogels for tissue engineering: A cross-class perspective on ligand design
Mieloch, A. A., Cywoniuk, P., Tuszyńska, M., Porzucek, F., Rybka, J. D., & Woźniak-Budych, M. (2026) · Coordination Chemistry Reviews · doi:10.1016/j.ccr.2026.218164 · Cited by 2 · see citing works
Natural Polymer-Based Nanocomposite Hydrogels for Biomedical Applications
Sethi, S., Medha, Thakur, S., Singh, A., & Kaith, B. S. (2023) · Springer eBooks · doi:10.1007/978-3-031-16101-8_107 · Cited by 2 · see citing works
Multifunctional, green, and aqueous adhesive from grape seed protein and tannic acid
Li, R., Wang, Z., Ge, Z., & Luo, C. (2025) · The Journal of Adhesion · doi:10.1080/00218464.2025.2581688 · Cited by 1 · see citing works
Bakir, M. A., Alkhatib, A. R., Mustafa, A. R., Raddaoui, M., Al-Kattan, W., & Mohammad, K. S. (2026) · Pharmaceutics · doi:10.3390/pharmaceutics18050571 · Cited by 1 · see citing works
Wang, S., Wang, J., Liang, Z., Li, Z., Wang, J., He, M., Wu, Q., Wei, Y., & Huang, D. (2026) · Colloids and Surfaces A Physicochemical and Engineering Aspects · doi:10.1016/j.colsurfa.2026.140939 · Cited by 1 · see citing works
Zhu, Y., Yan, R., Wang, T., & Wang, Q. (2025) · Journal of Biomaterials Science Polymer Edition · doi:10.1080/09205063.2025.2480881
The role of nanotechnology-based implants in musculoskeletal system and oncology
Ribeiro, A. M., Mascarenhas‐Melo, F., Flores‐Sahagun, T. H. S., Jarak, I., Domingues, C., Veiga, F., & Figueiras, A. (2025) · Elsevier eBooks · doi:10.1016/b978-0-443-27378-0.00017-9
Murugan, D., Kumar, A., Dhayalan, A., & Kannan, S. (2025) · Carbohydrate Polymers · doi:10.1016/j.carbpol.2025.124396
- Authors
- Wang, B., Liu, J., Niu, D., Wu, N., Yun, W., Wang, W., Zhang, K., Li, G., Yan, S., Xu, G., & Yin, J.
- Affiliations
- Shanghai University (CN)
- Second Military Medical University (CN)
- Corresponding author
- Yan, Shifeng
- Xu, Guohua
- Yin, Jingbo
- Venue
- ACS Applied Materials & Interfaces
- Publisher
- American Chemical Society (ACS)
- Published
- 2021-07-06
- Volume
- 13
- Issue
- 28
- Pages
- 32673-32689
- ISSN
- 1944-8244 (ISSN-L)
- 1944-8252
- OpenAlex
- W3181057449
- Cited by
- 109
- References
- 69
- Citations by year
- 2026: 11 · 2025: 17 · 2024: 30 · 2023: 25 · 2022: 22 · 2021: 4
- FWCI
- 6.15
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- Locations
- ACS Applied Materials & Interfaces (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Natural Science Foundation of China (51773113, 51873101, 81972076)
- Topics
- Physical Sciences › Engineering › Biomedical Engineering › Bone Tissue Engineering Materials
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Medicine › Hydrogels: synthesis, properties, applications
- Health Sciences › Medicine › Urology › Periodontal Regeneration and Treatments
- Keywords
- injectable hydrogel, bone regeneration, mussel-inspired materials, bisphosphonates, hydroxyapatite nanoparticles, self-healing hydrogels, tissue adhesion, catechol, osteogenic differentiation, angiogenesis, cranial defects, Schiff base crosslinking, alendronate
- MeSH terms
- Adhesives, Animals, Biocompatible Materials, Bone and Bones, Bone Regeneration, Cell Line, Cell Physiological Phenomena, Dextrans, Female, Male, Osteogenesis, Polyglutamic Acid, Swine, Rats, Sprague-Dawley, Durapatite, Alendronate, Hydrogels, Tissue Engineering, Biomimetic Materials, Mice, Rats, Nanocomposites, Tissue Scaffolds
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