Cited by 109Bone Tissue Engineering MaterialsHydrogels: synthesis, properties, applicationsPeriodontal Regeneration and Treatments

Mussel-inspired bisphosphonated injectable nanocomposite hydrogels with adhesive, self-healing, and osteogenic properties for bone regeneration

Wang, Bo, Liu, Jia, Niu, Dongyang, Wu, Nianqi, Yun, Wentao, Wang, Weidong, Zhang, Kunxi, Li, Guifei +3 more·2021·ACS Applied Materials & Interfaces

Abstract

Injectable hydrogels have received much attention because of the advantages of simulation of the natural extracellular matrix, microinvasive implantation, and filling and repairing of complex shape defects. Yet, for bone repair, the current injectable hydrogels have shown significant limitations such as the lack of tissue adhesion, deficiency of self-healing ability, and absence of osteogenic activity. Herein, a strategy to construct mussel-inspired bisphosphonated injectable nanocomposite hydrogels with adhesive, self-healing, and osteogenic properties is developed. The nano-hydroxyapatite/poly(l-glutamic acid)-dextran (nHA/PLGA-Dex) dually cross-linked (DC) injectable hydrogels are fabricated via Schiff base cross-linking and noncovalent nHA-BP chelation. The chelation between bisphosphonate ligands (alendronate sodium, BP) and nHA favors the uniform dispersion of the latter. Moreover, multiple adhesion ligands based on catechol motifs, BP, and aldehyde groups endow the hydrogels with good tissue adhesion. The hydrogels possess excellent biocompatibility and the introduction of BP and nHA both can effectively promote viability, proliferation, migration, and osteogenesis differentiation of MC3T3-E1 cells. The incorporation of BP groups and HA nanoparticles could also facilitate the angiogenic property of endothelial cells. The nHA/PLGA-Dex DC hydrogels exhibited considerable biocompatibility despite the presence of a certain degree of inflammatory response in the early stage…

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Crossref · 10.1021/acsami.1c06058

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  • The fascinating properties of mussel-inspired injectable hydrogels benefit their application in numerous biomedical fields, such as wound closure and healing, hemostasis, bone repair, drug delivery, smart sensors, and biological coatings.

    “Their fascinating properties benefit their application in numerous biomedical fields, such as wound closure and healing [36,37], hemostasis [38,39], bone repair [40,41], drug delivery [42,43], smart sensors [44], biological coatings [45], etc. (Figure 2).”
  • These hydrogels are mainly designed as tissue adhesives, hemostatic sealants, nanocomposite gels, drug carriers, hydrogel bioelectrodes, and anti-adhesion gel coatings.

    “These hydrogels are mainly designed as tissue adhesives [61,87] (for wound closure and healing), hemostatic sealants [75,88] (for hemostasis), nanocomposite gels [41,89] (for bone repair), drug carriers [42,90] (for drug delivery), hydrogel bioelectrodes [44] (for smart sensors), and anti-adhesion gel coatings [45] (for biological coatings) (Figure 7).”
  • The nHA/PLGA-BP-Dex DC hydrogel has tissue adhesive properties, self-healing capacity, and osteoconductivity due to catechol and BP groups.

    “The incorporation of catechol and BP groups endowed the composite hydrogel with tissue adhesive properties, self-healing capacity, and osteoconductivity.”
  • In vivo cranial bone regeneration experiments confirmed the efficacy of nHA/PLGA-BP-Dex DC hydrogel in bone repair.

    “In vivo cranial bone regeneration experiments confirmed the efficacy of the nHA/PLGA-BP-Dex DC hydrogel in bone repair.”
  • Compared with untreated controls, the nHA/PLGA-BP-Dex DC hydrogel-treated group showed higher bone volume percentage, bone mineral density, and trabecular number.

    “Compared with the control group (untreated), the nHA/PLGA-BP-Dex DC hydrogel-treated group showed a higher percentage of bone volume, bone mineral density, and trabecular number [41].”

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Authors
Wang, B., Liu, J., Niu, D., Wu, N., Yun, W., Wang, W., Zhang, K., Li, G., Yan, S., Xu, G., & Yin, J.
Affiliations
  • Shanghai University (CN)
  • Second Military Medical University (CN)
Corresponding author
  • Yan, Shifeng
  • Xu, Guohua
  • Yin, Jingbo
Venue
ACS Applied Materials & Interfaces
Published
2021-07-06
Volume
13
Issue
28
Pages
32673-32689
ISSN
  • 1944-8244 (ISSN-L)
  • 1944-8252
OpenAlex
W3181057449
Cited by
109
References
69
Citations by year
2026: 11 · 2025: 17 · 2024: 30 · 2023: 25 · 2022: 22 · 2021: 4
FWCI
6.15
Type
journal article
Language
en
Open access
closed
Locations
  • ACS Applied Materials & Interfaces (publishedVersion)
  • PubMed (publishedVersion)
Funders
National Natural Science Foundation of China (51773113, 51873101, 81972076)
Topics
  • Physical Sciences › Engineering › Biomedical Engineering › Bone Tissue Engineering Materials
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Medicine › Hydrogels: synthesis, properties, applications
  • Health Sciences › Medicine › Urology › Periodontal Regeneration and Treatments
Keywords
injectable hydrogel, bone regeneration, mussel-inspired materials, bisphosphonates, hydroxyapatite nanoparticles, self-healing hydrogels, tissue adhesion, catechol, osteogenic differentiation, angiogenesis, cranial defects, Schiff base crosslinking, alendronate
MeSH terms
Adhesives, Animals, Biocompatible Materials, Bone and Bones, Bone Regeneration, Cell Line, Cell Physiological Phenomena, Dextrans, Female, Male, Osteogenesis, Polyglutamic Acid, Swine, Rats, Sprague-Dawley, Durapatite, Alendronate, Hydrogels, Tissue Engineering, Biomimetic Materials, Mice, Rats, Nanocomposites, Tissue Scaffolds

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