The DOI matches its Crossref record; 39 of the 39 references it cites were found in a registry or an index.
Ultrafast Self‐Gelling and Wet Adhesive Powder for Acute Hemostasis and Wound Healing
Abstract
Achieving rapid and effective hemostasis on irregularly shaped, non‐compressible visceral, and high‐pressure arterial bleeding wounds remains a critical clinical challenge. Herein, an ultrafast self‐gelling and wet adhesive polyethyleneimine/polyacrylic acid/quaternized chitosan (PEI/PAA/QCS) powder is reported as the hemostatic material and wound dressing. PEI/PAA/QCS powder deposited on bleeding wounds can rapidly absorb a large amount of blood to concentrate coagulation factors. Meanwhile, the powder can form an adhesive hydrogel in situ within 4 s upon hydration to form a pressure‐resistant physical barrier. Furthermore, PEI/PAA/QCS hydrogels can aggregate blood cells and platelets to enhance hemostasis. Depositing PEI/PAA/QCS powder on various bleeding wounds, including at the liver and heart, high‐pressure femoral artery and tail vein of rats, arrests the bleeding around 10 s with no rebleeding after ten minutes. Excellent hemostasis of PEI/PAA/QCS powder is further demonstrated against massive hemorrhage in porcine spleen and liver in vivo, which are non‐compressible organs with abundant blood supply. In addition, the powder can be used as a wound dressing to promote the healing of the full‐thickness skin wounds. The advantages of PEI/PAA/QCS powder including rapid and effective hemostasis, effective wound healing, easy usage, low cost, and adaptability to fit complex target sites make it a promising biomaterial for surgical applications.
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Cites
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A strongly adhesive hemostatic hydrogel for the repair of arterial and heart bleeds
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Biomaterials and Advanced Technologies for Hemostatic Management of Bleeding
Hickman, D. A., Pawlowski, C. L., Sekhon, U. D. S., Marks, J., & Gupta, A. S. (2018) · Advanced Materials · doi:10.1002/adma.201700859 · Cited by 583
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Shear-Thinning Nanocomposite Hydrogels for the Treatment of Hemorrhage
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Cited by
Engineered Hemostatic Biomaterials for Sealing Wounds
Montazerian, H., Davoodi, E., Baidya, A., Baghdasarian, S., Sarikhani, E., Meyer, C. E., Haghniaz, R., Badv, M., Annabi, N., Khademhosseini, A., et al. (2022) · Chemical Reviews · doi:10.1021/acs.chemrev.1c01015 · Cited by 291
A natural biological adhesive from snail mucus for wound repair
Deng, T., Gao, D., Song, X., Zhou, Z., Zhou, L., Tao, M., Jiang, Z., Yang, L., Luo, L., Zhou, A., et al. (2023) · Nature Communications · doi:10.1038/s41467-023-35907-4 · Cited by 289
Pan, G., Li, F., He, S., Li, W., Wu, Q., He, J., Ruan, R., Xiao, Z., Zhang, J., & Yang, H. (2022) · Advanced Functional Materials · doi:10.1002/adfm.202200908 · Cited by 275
Yang, W., Kang, X., Gao, X., Zhuang, Y., Fan, C., Shen, H., Chen, Y., & Dai, J. (2023) · Advanced Functional Materials · doi:10.1002/adfm.202211340 · Cited by 188
Emerging materials for hemostasis
Li, X.-F., Lu, P., Jia, H.-R., Li, G., Zhu, B., Wang, X., & Wu, F.-G. (2023) · Coordination Chemistry Reviews · doi:10.1016/j.ccr.2022.214823 · Cited by 164
Metadata
- Authors
- Peng, X., Xu, X., Deng, Y., Xie, X., Xu, L., Xu, X., Yuan, W., Yang, B., Yang, X., Xia, X., Duan, L., & Bian, L.
- Venue
- Advanced Functional Materials
- Publisher
- Wiley
- Published
- 2021-06-17
- Volume
- 31
- Issue
- 33
- ISSN
- 1616-301X (ISSN-L)
- 1616-3028
- OpenAlex
- W3176613104
- Cited by
- 361
- References
- 39
- FWCI
- 29.56
- Type
- journal article
- Language
- en
- Open access
- closed
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- Peng, X., Xu, X., Deng, Y., Xie, X., Xu, L., Xu, X., Yuan, W., Yang, B., Yang, X., Xia, X., Duan, L., & Bian, L. (2021). Ultrafast Self‐Gelling and Wet Adhesive Powder for Acute Hemostasis and Wound Healing. Advanced Functional Materials. https://doi.org/10.1002/adfm.202102583
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