Microfluidic Organ‐on‐a‐Chip Technology for Advancement of Drug Development and Toxicology
Abstract
In recent years, the exploitation of phenomena surrounding microfluidics has seen an increase in popularity, as researchers have found a way to use their unique properties to create superior design alternatives. One such application is representing the properties and functions of different organs on a microscale chip for the purpose of drug testing or tissue engineering. With the introduction of “organ‐on‐a‐chip” systems, researchers have proposed various methods on various organ‐on‐a‐chip systems to mimic their in vivo counterparts. In this article, a systematic approach is taken to review current technologies pertaining to organ‐on‐a‐chip systems. Design processes with attention to the particular instruments, cells, and materials used are presented.
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MPS features are critical to investigate the absorption, distribution, metabolism, excretion, and toxicity (ADME-T) of drug candidates and for disease modeling.
“These features are critical to investigate the absorption, distribution, metabolism, excretion, and toxicity (ADME-T) of the drug candidate and for disease modeling as well.6”
From Gut-liver-axis microphysiological system for studying cellular fluidic shear stress and inter-tissue interaction (2022) · cites this paper as [6]
MPSs provide interconnecting organs via flow channels and controls.
“and interconnecting organs via flow channels and controls.6”
From Gut-liver-axis microphysiological system for studying cellular fluidic shear stress and inter-tissue interaction (2022) · cites this paper as [6]
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- Authors
- Caplin, J. D., Granados, N. G., James, M. R., Montazami, R., & Hashemi, N.
- Affiliations
- Department of Mechanical Engineering Iowa State University Ames IA 50011 USA
- Venue
- Advanced Healthcare Materials
- Publisher
- Wiley
- Published
- 2015-03-26
- Volume
- 4
- Issue
- 10
- Pages
- 1426-1450
- ISSN
- 2192-2640
- 2192-2659
- Cited by
- 195
- References
- 9
- Language
- en
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