The DOI matches its Crossref record; 26 of the 26 references it cites were found in a registry or an index.
Biodistribution, Clearance, and Long‐Term Fate of Clinically Relevant Nanomaterials
Abstract
Realization of the immense potential of nanomaterials for biomedical applications will require a thorough understanding of how they interact with cells, tissues, and organs. There is evidence that, depending on their physicochemical properties and subsequent interactions, nanomaterials are indeed taken up by cells. However, the subsequent release and/or intracellular degradation of the materials, transfer to other cells, and/or translocation across tissue barriers are still poorly understood. The involvement of these cellular clearance mechanisms strongly influences the long‐term fate of used nanomaterials, especially if one also considers repeated exposure. Several nanomaterials, such as liposomes and iron oxide, gold, or silica nanoparticles, are already approved by the American Food and Drug Administration for clinical trials; however, there is still a huge gap of knowledge concerning their fate in the body. Herein, clinically relevant nanomaterials, their possible modes of exposure, as well as the biological barriers they must overcome to be effective are reviewed. Furthermore, the biodistribution and kinetics of nanomaterials and their modes of clearance are discussed, knowledge of the long‐term fates of a selection of nanomaterials is summarized, and the critical points that must be considered for future research are addressed.
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Cites
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Self-citationMesoporous Silica Nanoparticles for Drug Delivery
Manzano, M., & Vallet‐Regí, M. (2020) · Advanced Functional Materials · doi:10.1002/adfm.201902634 · Cited by 939
Nanomedicine review: clinical developments in liposomal applications
Beltrán-Gracia, E., López-Camacho, A., Higuera-Ciapara, I., Velázquez-Fernández, J. B., & Vallejo-Cardona, A. A. (2019) · Cancer Nanotechnology · doi:10.1186/s12645-019-0055-y · Cited by 513
Inorganic nanomaterials with rapid clearance for biomedical applications
Wang, X., Zhong, X., Li, J., Liu, Z., & Cheng, L. (2021) · Chemical Society Reviews · doi:10.1039/d0cs00461h · Cited by 509
Engineered Extracellular Vesicles for Cancer Therapy
Zhang, X., Zhang, H., Gu, J., Zhang, J., Shi, H., Qian, H., Wang, D., Xu, W., Pan, J., & Santos, H. A. (2021) · Advanced Materials · doi:10.1002/adma.202005709 · Cited by 428
Metadata
- Authors
- Bourquin, J., Milosevic, A., Hauser, D., Lehner, R., Blank, F., Petri‐Fink, A., & Rothen‐Rutishauser, B.
- Venue
- Advanced Materials
- Publisher
- Wiley
- Published
- 2018-02
- Volume
- 30
- Issue
- 19
- Pages
- e1704307-e1704307
- ISSN
- 0935-9648 (ISSN-L)
- 1521-4095
- OpenAlex
- W2792549134
- Cited by
- 461
- References
- 26
- FWCI
- 11.18
- Type
- journal article
- Language
- en
- Open access
- closed
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- Bourquin, J., Milosevic, A., Hauser, D., Lehner, R., Blank, F., Petri‐Fink, A., & Rothen‐Rutishauser, B. (2018). Biodistribution, Clearance, and Long‐Term Fate of Clinically Relevant Nanomaterials. Advanced Materials. https://doi.org/10.1002/adma.201704307
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