The DOI matches its Crossref record; 6 of the 6 references it cites were found in a registry or an index.
Precise Deciphering of Brain Vasculatures and Microscopic Tumors with Dual NIR‐II Fluorescence and Photoacoustic Imaging
Abstract
Diagnostics of cerebrovascular structures and microscopic tumors with intact blood–brain barrier (BBB) significantly contributes to timely treatment of patients bearing neurological diseases. Dual NIR‐II fluorescence and photoacoustic imaging (PAI) is expected to offer powerful strength, including good spatiotemporal resolution, deep penetration, and large signal‐to‐background ratio (SBR) for precise brain diagnostics. Herein, biocompatible and photostable conjugated polymer nanoparticles (CP NPs) are reported for dual‐modality brain imaging in the NIR‐II window. Uniform CP NPs with a size of 50 nm are fabricated from microfluidics devices, which show an emission peak at 1156 nm with a large absorptivity of 35.2 L g−1 cm−1 at 1000 nm. The NIR‐II fluorescence imaging resolves hemodynamics and cerebral vasculatures with a spatial resolution of 23 µm at a depth of 600 µm. The NIR‐II PAI enables successful noninvasive mapping of deep microscopic brain tumors (<2 mm at a depth of 2.4 mm beneath dense skull and scalp) with an SBR of 7.2 after focused ultrasound‐induced BBB opening. This study demonstrates that CP NPs are promising contrast agents for brain diagnostics.
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Cites
A small-molecule dye for NIR-II imaging
Antaris, A. L., Chen, H., Cheng, K., Sun, Y., Hong, G., Qu, C., Diao, S., Deng, Z., Hu, X., Zhang, B., et al. (2016) · Nature Materials · doi:10.1038/nmat4476 · Cited by 1,778
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Self-citationSheng, Z., Guo, B., Hu, D., Xu, S., Wu, W., Liew, W. H., Yao, K., Jiang, J., Liu, C., Zheng, H., et al. (2018) · Advanced Materials · doi:10.1002/adma.201800766 · Cited by 445
Self-citationQi, J., Sun, C., Zebibula, A., Zhang, H., Kwok, R. T. K., Zhao, X., Xi, W., Lam, J. W. Y., Qian, J., & Tang, B. Z. (2018) · Advanced Materials · doi:10.1002/adma.201706856 · Cited by 418
Self-citationExploring the origin of high optical absorption in conjugated polymers
Vezie, M. S., Few, S., Meager, I., Pieridou, G., Dörling, B., Ashraf, R. S., Goñi, A. R., Bronstein, H., McCulloch, I., Hayes, S. C., et al. (2016) · Nature Materials · doi:10.1038/nmat4645 · Cited by 387
Traumatic Brain Injury Imaging in the Second Near‐Infrared Window with a Molecular Fluorophore
Zhang, X., Wang, H., Antaris, A. L., Li, L., Diao, S., Ma, R., Nguyen, A., Hong, G., Ma, Z., Wang, J., et al. (2016) · Advanced Materials · doi:10.1002/adma.201600706 · Cited by 386
Cited by
Advanced Fluorescence Imaging Technology in the Near-Infrared-II Window for Biomedical Applications
Li, C., Chen, G., Zhang, Y., Wu, F., & Wang, Q. (2020) · Journal of the American Chemical Society · doi:10.1021/jacs.0c07022 · Cited by 1,037
Perfecting and extending the near-infrared imaging window
Feng, Z., Tang, T., Wu, T., Yu, X., Zhang, Y., Wang, M., Zheng, J., Ying, Y., Chen, S., Zhou, J., et al. (2021) · Light: Science & Applications · doi:10.1038/s41377-021-00628-0 · Cited by 394
Self-citationActivity‐Based NIR Enzyme Fluorescent Probes for the Diagnosis of Tumors and Image‐Guided Surgery
Li, H., Kim, D., Yao, Q., Ge, H., Chung, J., Fan, J., Wang, J., Peng, X., & Yoon, J. (2021) · Angewandte Chemie International Edition · doi:10.1002/anie.202009796 · Cited by 363
Recent Progress in NIR-II Contrast Agent for Biological Imaging
Cao, J., Zhu, B., Zheng, K., He, S., Meng, L., Song, J., & Yang, H. (2020) · Frontiers in Bioengineering and Biotechnology · doi:10.3389/fbioe.2019.00487 · Cited by 313
NIR-II bioluminescence for in vivo high contrast imaging and in situ ATP-mediated metastases tracing
Lu, L., Li, B., Ding, S., Fan, Y., Wang, S., Sun, C., Zhao, M., Zhao, C.-X., & Zhang, F. (2020) · Nature Communications · doi:10.1038/s41467-020-18051-1 · Cited by 274
Metadata
- Authors
- Guo, B., Feng, Z., Hu, D., Xu, S., Middha, E., Pan, Y., Liu, C., Zheng, H., Qian, J., Sheng, Z., & Liu, B.
- Venue
- Advanced Materials
- Publisher
- Wiley
- Published
- 2019-06-06
- Volume
- 31
- Issue
- 30
- Pages
- e1902504-e1902504
- ISSN
- 0935-9648 (ISSN-L)
- 1521-4095
- OpenAlex
- W2958176707
- Cited by
- 227
- References
- 6
- FWCI
- 11.28
- Type
- journal article
- Language
- en
- Open access
- closed
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- The paper
- Guo, B., Feng, Z., Hu, D., Xu, S., Middha, E., Pan, Y., Liu, C., Zheng, H., Qian, J., Sheng, Z., & Liu, B. (2019). Precise Deciphering of Brain Vasculatures and Microscopic Tumors with Dual NIR‐II Fluorescence and Photoacoustic Imaging. Advanced Materials. https://doi.org/10.1002/adma.201902504
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