The DOI matches its Crossref record; 5 of the 5 references it cites were found in a registry or an index.
An NIR‐II‐Emissive Photosensitizer for Hypoxia‐Tolerant Photodynamic Theranostics
Abstract
As a common feature in a majority of malignant tumors, hypoxia has become the Achilles’ heel of photodynamic therapy (PDT). The development of type‐I photosensitizers that show hypoxia‐tolerant PDT efficiency provides a straightforward way to address this issue. However, type‐I PDT materials have rarely been discovered. Herein, a π‐conjugated molecule with A–D–A configuration, COi6‐4Cl, is reported. The H 2 O‐dispersible nanoparticle of COi6‐4Cl can be activated by an 880 nm laser, and displays hypoxia‐tolerant type I/II combined PDT capability, and more notably, a high NIR‐II fluorescence with a quantum yield over 5%. Moreover, COi6‐4Cl shows a negligible photothermal conversion effect. The non‐radiative decay of COi6‐4Cl is suppressed in the dispersed and aggregated state due to the restricted molecular vibrations and distinct intermolecular steric hindrance induced by its four bulky side chains. These features make COi6‐4Cl a distinguished single‐NIR‐wavelength‐activated phototheranostic material, which performs well in NIR‐II fluorescence‐guided PDT treatment and shows an enhanced in vivo anti‐tumor efficiency over the clinically approved Chlorin e6, by the equal stresses on hypoxia‐tolerant anti‐tumor therapy and deep‐penetration imaging. Therefore, the great potential of COi6‐4Cl in precise PDT cancer therapy against hypoxia challenges is demonstrated.
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Hong, G., Zou, Y., Antaris, A. L., Diao, S., Wu, D., Cheng, K., Zhang, X., Chen, C., Liu, B., He, Y., et al. (2014) · Nature Communications · doi:10.1038/ncomms5206 · Cited by 563
Self-citationZheng, Z., Zhang, T., Liu, H., Chen, Y., Kwok, R. T. K., Ma, C., Zhang, P., Sung, H. H. Y., Williams, I. D., Lam, J. W. Y., et al. (2018) · ACS Nano · doi:10.1021/acsnano.8b03138 · Cited by 340
Strategies to Enhance the Photosensitization: Polymerization and the Donor–Acceptor Even–Odd Effect
Liu, S., Zhang, H., Li, Y., Liu, J., Du, L., Chen, M., Kwok, R. T. K., Lam, J. W. Y., Phillips, D. L., & Tang, B. Z. (2018) · Angewandte Chemie International Edition · doi:10.1002/anie.201810326 · Cited by 277
Huang, J., Xie, C., Zhang, X., Jiang, Y., Li, J., Fan, Q., & Pu, K. (2019) · Angewandte Chemie International Edition · doi:10.1002/anie.201909560 · Cited by 258
Self-citationSwitching between H- and J-type electronic coupling in single conjugated polymer aggregates
Eder, T., Stangl, T., Gmelch, M., Remmerssen, K., Laux, D., Höger, S., Lupton, J. M., & Vogelsang, J. (2017) · Nature Communications · doi:10.1038/s41467-017-01773-0 · Cited by 135
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Pham, T. C., Nguyen, V.-N., Choi, Y., Lee, S., & Yoon, J. (2021) · Chemical Reviews · doi:10.1021/acs.chemrev.1c00381 · Cited by 1,813
The principles, design and applications of fused-ring electron acceptors
Wang, J., Xue, P., Jiang, Y., Huo, Y., & Zhan, X. (2022) · Nature Reviews Chemistry · doi:10.1038/s41570-022-00409-2 · Cited by 454
Phototherapy in cancer treatment: strategies and challenges
Cai, Y., Chai, T., Nguyen, W., Liu, J., Xiao, E., Ran, X., Ran, Y., Du, D., Chen, W., & Chen, X. (2025) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-025-02140-y · Cited by 453
BODIPY‐Based Photodynamic Agents for Exclusively Generating Superoxide Radical over Singlet Oxygen
Teng, K., Chen, W., Niu, L., Fang, W., Cui, G., & Yang, Q. (2021) · Angewandte Chemie International Edition · doi:10.1002/anie.202106748 · Cited by 445
NIR-II light in clinical oncology: opportunities and challenges
Zhang, Z., Du, Y., Shi, X., Wang, K., Qu, Q., Liang, Q., Ma, X., He, K., Chi, C., Tang, J., et al. (2024) · Nature Reviews Clinical Oncology · doi:10.1038/s41571-024-00892-0 · Cited by 341
Metadata
- Authors
- Li, L., Shao, C., Liu, T., Chao, Z., Chen, H., Xiao, F., He, H., Wei, Z., Zhu, Y., Wang, H., Zhang, X., Wen, Y., Yang, B., He, F., & Tian, L.
- Venue
- Advanced Materials
- Publisher
- Wiley
- Published
- 2020-10-07
- Volume
- 32
- Issue
- 45
- Pages
- e2003471-e2003471
- ISSN
- 0935-9648 (ISSN-L)
- 1521-4095
- OpenAlex
- W3092372334
- Cited by
- 254
- References
- 5
- FWCI
- 16.75
- Type
- journal article
- Language
- en
- Open access
- closed
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- Li, L., Shao, C., Liu, T., Chao, Z., Chen, H., Xiao, F., He, H., Wei, Z., Zhu, Y., Wang, H., Zhang, X., Wen, Y., Yang, B., He, F., & Tian, L. (2020). An NIR‐II‐Emissive Photosensitizer for Hypoxia‐Tolerant Photodynamic Theranostics. Advanced Materials. https://doi.org/10.1002/adma.202003471
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