Cited by 27Neuroscience and Neural EngineeringSilk-based biomaterials and applicationsAdvanced Sensor and Energy Harvesting Materials

Tissue/Organ Adaptable Bioelectronic Silk‐Based Implants

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Zhu, Ziyi, Yan, Zhiwen, Ni, Siyuan, Yang, Huiran, Xie, Yating, Wang, Xueying, Zou, Dujuan, Tao, Chen +11 more·2024·Advanced Materials

Abstract

Implantable bioelectronic devices, designed for both monitoring and modulating living organisms, require functional and biological adaptability. Pure silk is innovatively employed, which is known for its excellent biocompatibility, to engineer water‐triggered, geometrically reconfigurable membranes, on which functions can be integrated by Micro Electro Mechanical System (MEMS) techniques and specially functionalized silk. These devices can undergo programmed shape deformations within 10 min once triggered by water, and thus establishing stable bioelectronic interfaces with natively fitted geometries. As a testament to the applicability of this approach, a twining peripheral nerve electrode is designed, fabricated, and rigorously tested, demonstrating its efficacy in nerve modulation while ensuring biocompatibility for successful implantation.

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Authors
Zhu, Z., Yan, Z., Ni, S., Yang, H., Xie, Y., Wang, X., Zou, D., Tao, C., Jiang, W., Jiang, J., Su, Z., Xia, Y., Zhou, Z., Sun, L., Fan, C., Tao, T. H., Wei, X., Qian, Y., & Liu, K.
Affiliations
  • Chinese Academy of Sciences (CN)
  • Shanghai Jiao Tong University (CN)
  • State Key Laboratory of Transducer Technology Shanghai Institute of Microsystem and Information Technology Chinese Academy of Sciences 865 Changning Rd. Shanghai 200050 China
Corresponding author
  • Wei, Xiaoling
  • Qian, Yun
  • Liu, Keyin
Venue
Advanced Materials
Publisher
Wiley
Published
2024-07-22
Volume
36
Issue
38
Pages
e2405892-e2405892
ISSN
  • 0935-9648 (ISSN-L)
  • 1521-4095
OpenAlex
W4400891314
Cited by
27
References
62
Citations by year
2026: 7 · 2025: 17 · 2024: 3
FWCI
4.74
Type
journal article
Language
en
Open access
Locations
  • Advanced Materials (publishedVersion)
  • PubMed (publishedVersion)
Funders
National Natural Science Foundation of China (61 974 154, 82 372 409)
Topics
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neural Engineering
  • Physical Sciences › Materials Science › Biomaterials › Silk-based biomaterials and applications
  • Physical Sciences › Engineering › Biomedical Engineering › Advanced Sensor and Energy Harvesting Materials
Keywords
bioelectronic implants, MEMS integration, biocompatibility, biomedical implants
MeSH terms
Animals, Biocompatible Materials, Electrodes, Implanted, Prostheses and Implants, Silk

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