Hyperbaric Oxygen Boosts PD‐1 Antibody Delivery and T Cell Infiltration for Augmented Immune Responses Against Solid Tumors
Open accessAbstract
Aberrant mechanical properties and immunosuppression are the two key factors that limit the antitumor efficacy of T cell immune checkpoint blockade inhibitors, e.g., programmed cell death‐1 antibody (PD‐1 Ab), against solid tumors in the clinic. This study leverages hyperbaric oxygen (HBO) for the first time to address these two issues and reports the PD‐1‐Ab‐mediated immune responses against various stroma‐rich solid malignancies. The results demonstrate that HBO promoted PD‐1 Ab delivery and T cells infiltration into tumor parenchyma by depleting the extracellular matrix's main components, such as collagen and fibronectin. Furthermore, HBO disrupts hypoxia‐mediated immunosuppression and helps PD‐1 Ab trigger robust cytotoxic T lymphocytes and long‐lasting immunological memory to inhibit tumor relapses. Such enhanced immune responses are effective in solid tumors from rodents and the cancer cells from hepatocellular carcinoma patients. The results illustrate that HBO bolsters antitumor efficacy of PD‐1 Ab, and the HBO–PD‐1 Ab combination is a promising stroma‐rich solid tumors’ treatment in the clinic.
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HBO promotes PD-1 Ab delivery and T-cell infiltration into the tumor parenchyma by depleting major components of the ECM, such as collagen and fibronectin.
“HBO also promoted PD‐1 Ab delivery and T‐cell infiltration into the tumor parenchyma by depleting major components of the ECM, such as collagen and fibronectin.”
From Hypoxia signaling in cancer: Implications for therapeutic interventions (2023) · cites this paper as [423]
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Hypoxic microenvironment in cancer: molecular mechanisms and therapeutic interventions
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- Authors
- Liu, X., Ye, N., Liu, S., Guan, J., Deng, Q., Zhang, Z., Xiao, C., Ding, Z., Zhang, B., Chen, X., Li, Z., & Yang, X.
- Affiliations
- Huazhong University of Science and Technology (CN)
- Tongji Hospital (CN)
- Hepatic Surgery Center and Hubei Key Laboratory of Hepatic‐Biliary‐Pancreatic Diseases National Medical Center for Major Public Events Tongji Hospital Tongji Medical College Huazhong University of Science and Technology Wuhan 430030 P. R. China
- Wuhan Institute of Bioengineering (CN)
- Corresponding author
- Li, Zifu
- Venue
- Advanced Science
- Publisher
- Wiley
- Published
- 2021-06-03
- Volume
- 8
- Issue
- 15
- Pages
- e2100233-e2100233
- ISSN
- 2198-3844 (ISSN-L)
- PMC
- PMC8336507
- OpenAlex
- W3165232211
- Cited by
- 83
- References
- 46
- Citations by year
- 2026: 5 · 2025: 17 · 2024: 24 · 2023: 16 · 2022: 18 · 2021: 3
- FWCI
- 5.54
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- Locations
- Advanced Science (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Funders
- National Key Research and Development Program of China (2020YFA0211200, 2020YFA0710700, 2018YFA0208900)
- Huazhong University of Science and Technology (the HCP Program)
- National Natural Science Foundation of China (31972927)
- Topics
- Health Sciences › Medicine › Oncology › Cancer Immunotherapy and Biomarkers
- Life Sciences › Immunology and Microbiology › Immunology › Immunotherapy and Immune Responses
- Physical Sciences › Engineering › Biomedical Engineering › Nanoplatforms for cancer theranostics
- Keywords
- hyperbaric oxygen therapy, anti-PD-1, immune checkpoint blockade, solid tumors, tumor stroma, extracellular matrix, collagen, fibronectin, tumor hypoxia, immunosuppression, T cell infiltration, cytotoxic T lymphocytes, immunological memory, hepatocellular carcinoma, antitumor immunity
- MeSH terms
- Animals, Disease Models, Animal, Hyperbaric Oxygenation, Immunity, Liver Neoplasms, Mice, Inbred BALB C, T-Lymphocytes, Cell Line, Tumor, Mice, Programmed Cell Death 1 Receptor
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