Dynamic Adjust of Non‐Radiative and Radiative Attenuation of AIE Molecules Reinforces NIR‐II Imaging Mediated Photothermal Therapy and Immunotherapy
Open accessAbstract
Due to the aggregation‐caused quenching effect and near‐infrared I poor penetration capabilities of common fluorescent molecules, their applications in visualized imaging and photoactivated treatment are limited. Therefore, new near‐infrared II (NIR‐II) molecule (named TST), which had the abilities of aggregation‐induced emission (AIE) and photothermal therapy are synthesized. Moreover, in order to further improve its fluorescent yield and therapeutic effect, camptothecin prodrug (CPT‐S‐PEG) and novel immune checkpoint inhibitor AZD4635 are used to co‐assemble with TST into nanoparticles for drug delivery. On account of the strong interaction of camptothecin and TST, the intramolecular rotation of TST is limited, thereby inhibiting non‐radiation attenuation and promoting fluorescence generation when the nanoparticles are intact. As nanoparticles uptake by cancer cells, redox sensitive CPT‐S‐PEG is degraded and the nanoparticles disintegrate. The released TST enhances non‐radiative attenuation and expedites photothermal conversion because of the removal of the constraint of camptothecin. Furthermore, photothermal therapy induces immunogenic cell death of cancer cells and releases abundant ATP into the tumor microenvironment to recruit immune cells. However, superfluous ATP is converted into immunosuppressive adenosine through the CD39‐CD73‐A2AR pathway. The AZD4635 released by photothermal disintegration of the nanoparticles just blocks this pathway timely, achieving favorable synergistic effect of photothermal therapy, chemotherapy, and immunotherapy.
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Within intact nanoparticles, the strong CPT-TST interaction restricts the intramolecular rotation of TST, suppressing non-radiative decay and endowing CAT-NP with exceptional NIR-II imaging performance (emission: 1050 nm; quantum yields: 15.32%).
“Within intact nanoparticles, the strong CPT-TST interaction restricts the intramolecular rotation of TST, suppressing non-radiative decay and endowing CAT-NP with exceptional NIR-II imaging performance (emission: 1050 nm; quantum yields: 15.32%).”
From Organic small-molecule NIR-II fluorophores for tumor phototheranostics (2026) · cites this paper as [127]
Yu et al. successfully synthesized a novel AIE molecule (TST) with both NIR-II imaging and PTT capabilities.
“Yu et al. successfully synthesized a novel AIE molecule (TST) with both NIR-II imaging and PTT capabilities (Fig. 22b)127.”
From Organic small-molecule NIR-II fluorophores for tumor phototheranostics (2026) · cites this paper as [127]
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“PTPE3 NPs, formed through assembly with Pluronic F127, exhibited exceptional optical properties, deep imaging penetration depth, and ultrahigh photochemical stability.”
InfluentialSelf-citation
- Authors
- Wang, Z., Yu, L., Wang, Y., Wang, C., Mu, Q., Liu, X., Yu, M., Wang, K., Yao, G., & Yu, Z.
- Affiliations
- Gaozhou People's Hospital (CN)
- Guangzhou University of Chinese Medicine (CN)
- TCM-Intigrated Cancer Center of Southern Medical University (CN)
- Fuzhou University (CN)
- Southern Medical University (CN)
- The First People's Hospital of Shunde (CN)
- Nanfang Hospital (CN)
- Corresponding author
- Wang, Kang‐Nan
- Yao, Guangyu
- Yu, Zhiqiang
- ORCID
- Venue
- Advanced Science
- Publisher
- Wiley
- Published
- 2022-01-22
- Volume
- 9
- Issue
- 8
- Pages
- e2104793-e2104793
- ISSN
- 2198-3844 (ISSN-L)
- PMC
- PMC8922098
- OpenAlex
- W4207028123
- Cited by
- 125
- References
- 36
- Citations by year
- 2026: 14 · 2025: 30 · 2024: 33 · 2023: 30 · 2022: 18
- FWCI
- 8.05
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- Locations
- Advanced Science (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- Funders
- National Natural Science Foundation of China (81773642, 52073139, F121310008)
- Natural Science Foundation of Guangdong Province (2019A1515011498, 2019A1515011619)
- Topics
- Physical Sciences › Engineering › Biomedical Engineering › Nanoplatforms for cancer theranostics
- Physical Sciences › Materials Science › Materials Chemistry › Luminescence and Fluorescent Materials
- Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Photodynamic Therapy Research Studies
- Keywords
- aggregation-induced emission, NIR-II fluorescence imaging, photothermal therapy, camptothecin prodrug, immune checkpoint inhibitors, nanoparticle drug delivery, internal rotation, redox-responsive drug release, immunogenic cell death, adenosine, synergistic cancer therapy
- MeSH terms
- Photothermal Therapy, Immunotherapy, Phototherapy, Prodrugs, Nanoparticles
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