CoChat
Sign Up
Cited by 65Genetic and Clinical Aspects of Sex Determination and Chromosomal AbnormalitiesAortic Disease and Treatment ApproachesConnective tissue disorders research

Aortic dimensions in Turner syndrome

Quezada, Emilio, Lapidus, Jodi, Shaughnessy, Robin, Chen, Zunqiu, Silberbach, Michael·2015·American Journal of Medical Genetics Part A
DOI 10.1002/ajmg.a.37208
Open this paper in CoChat — free account

Abstract

In Turner syndrome, linear growth is less than the general population. Consequently, to assess stature in Turner syndrome, condition-specific comparators have been employed. Similar reference curves for cardiac structures in Turner syndrome are currently unavailable. Accurate assessment of the aorta is particularly critical in Turner syndrome because aortic dissection and rupture occur more frequently than in the general population. Furthermore, comparisons to references calculated from the taller general population with the shorter Turner syndrome population can lead to over-estimation of aortic size causing stigmatization, medicalization, and potentially over-treatment. We used echocardiography to measure aortic diameters at eight levels of the thoracic aorta in 481 healthy girls and women with Turner syndrome who ranged in age from two to seventy years. Univariate and multivariate linear regression analyses were performed to assess the influence of karyotype, age, body mass index, bicuspid aortic valve, blood pressure, history of renal disease, thyroid disease, or growth hormone therapy. Because only bicuspid aortic valve was found to independently affect aortic size, subjects with bicuspid aortic valve were excluded from the analysis. Regression equations for aortic diameters were calculated and Z-scores corresponding to 1, 2, and 3 standard deviations from the mean were plotted against body surface area. The information presented here will allow clinicians and other caregivers to calculate aortic Z-scores using a Turner-based reference population. © 2015 Wiley Periodicals, Inc.

Integrity signals

Registry

Crossref · 10.1002/ajmg.a.37208

Cites

16 of 16 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

This paper’s full text isn’t openly available, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

  • In one study, AHI showed greater predictive value compared to the absolute diameter, Z-score, or ASI.

    “In practice, AHI is easiest to use and in one study showed greater predictive value compared to the absolute diameter, Z-score, or ASI. This is probably due to the prevalence of obesity, which can deflate the ASI or Z-score (Table 13).233,234,445”

    From Clinical practice guidelines for the care of girls and women with Turner syndrome. (2024) · cites this paper as [234]

  • The greater predictive value of AHI is probably due to the prevalence of obesity, which can deflate the ASI or Z-score.

    “In practice, AHI is easiest to use and in one study showed greater predictive value compared to the absolute diameter, Z-score, or ASI. This is probably due to the prevalence of obesity, which can deflate the ASI or Z-score (Table 13).233,234,445”

    From Clinical practice guidelines for the care of girls and women with Turner syndrome. (2024) · cites this paper as [234]

Cites

Flagged first, then by citations

Cited by

Sorted by citations

Related

Authors
Quezada, E., Lapidus, J., Shaughnessy, R., Chen, Z., & Silberbach, M.
Affiliations
Oregon Health & Science University (US)
Corresponding author
Quezada, Emilio
ORCID
Venue
American Journal of Medical Genetics Part A
Publisher
Wiley
Published
2015-06-27
Volume
167
Issue
11
Pages
2527-2532
ISSN
  • 1552-4825 (ISSN-L)
  • 1552-4833
DOI
10.1002/ajmg.a.37208
OpenAlex
W1584515765
Cited by
65
References
16
Citations by year
2026: 5 · 2025: 8 · 2024: 7 · 2023: 4 · 2022: 8 · 2021: 5 · 2020: 6 · 2019: 9 · 2018: 9 · 2017: 3 · 2016: 1
FWCI
2.96
Type
journal article
Language
en
Open access
closed
Licence
onlinelibrary.wiley.com/termsAndConditions#vor (vor)
Locations
  • American Journal of Medical Genetics Part A (publishedVersion)
  • PubMed (publishedVersion)
Funders
Oregon Clinical and Translational Research Institute
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetic and Clinical Aspects of Sex Determination and Chromosomal Abnormalities
  • Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Aortic Disease and Treatment Approaches
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Connective tissue disorders research
Keywords
Turner syndrome, aortic dimensions, aortic diameter, reference curves, bicuspid aortic valve, aortic dissection, aortic rupture, body surface area, echocardiography, growth hormone therapy, body mass index
MeSH terms
Adolescent, Adult, Aged, Aorta, Body Surface Area, Child, Child, Preschool, Demography, Electrocardiography, Humans, Middle Aged, Turner Syndrome, Ultrasonography, Young Adult

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review