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Cognitive resilience to Alzheimer's disease characterized by cell‐type abundance

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The AD odyssey 2023: Tales of single cell

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A factor-based analysis of individual human microglia uncovers regulators of an Alzheimer-related transcriptional signaturePreprint

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APOE- ε4-induced Fibronectin at the blood-brain barrier is a conserved pathological mediator of disrupted astrocyte-endothelia interaction in Alzheimer’s diseasePreprint

Bhattarai, P., Yılmaz, E., Cakir, E. Ö., Yüceer, H., Lee, A., Ma, Y., Çelikkaya, H., Coşacak, M. İ., Haage, V. C., Wang, X., et al. (2025) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2025.01.24.634732 · Cited by 12 · see citing works

Cell-death pathways and tau-associated neuronal vulnerability in Alzheimer’s disease

Lin, G., Chancellor, S. E., Kwon, T., Woodbury, M. E., Doering, A., Abdourahman, A., Bennett, R. E., Liao, F., Pastika, T., Tamm, J. A., et al. (2025) · Cell Reports · doi:10.1016/j.celrep.2025.115758 · Cited by 13 · see citing works

Rodent models of Alzheimer's disease: Critical analysis of current hypotheses and pathways for future research

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Copy Number Variation and Haplotype Analysis of 17q21.31 Reveals Increased Risk Associated with Progressive Supranuclear Palsy and Gene Expression Changes in Neuronal Cells

Wang, H., Chang, T. S., Dombroski, B. A., Cheng, P., Si, Y., Tucci, A. A., Patil, V., Valiente‐Banuet, L., Li, C., Farrell, K. W., et al. (2025) · Movement Disorders · doi:10.1002/mds.30150 · Cited by 7 · see citing works

Human disease-specific cell signatures in non-lesional tissue in Multiple Sclerosis detected by single-cell and spatial transcriptomicsPreprint

Lam, M., Lee, D. I., Kosater, I. M., Khairallah, A., Taga, M. F., Zhang, Y., Fujita, M., Nag, S., Bennett, D. A., Jager, P. L. D., et al. (2023) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2023.12.20.572491 · Cited by 7 · see citing works

A lifespan transcriptomic atlas of the human prefrontal cortex at single-cell resolutionPreprint

Yang, H., Clarence, T., Scott, M. R., Wang, X., Prashant, N. M., Pjanic, M., Venkatesh, S., Hong, A., Casey, C., Murphy, S. R., et al. (2024) · medRxiv · doi:10.1101/2024.11.06.24316592 · Cited by 7 · see citing works

In Silico Identification of a Potential TNF-Alpha Binder Using a Structural Similarity: A Potential Drug Repurposing Approach to the Management of Alzheimer’s Disease

Tettevi, E. J., Kuevi, D. N. O., Sumabe, B. K., Simpong, D. L., Maina, M. B., Dongdem, J. T., Osei-Atweneboana, M. Y., & Ocloo, A. (2024) · BioMed Research International · doi:10.1155/2024/9985719 · Cited by 6 · see citing works

High-resolution omics of vascular ageing and inflammatory pathways in neurodegeneration

Kwok, A. J., Lu, J., Huang, J., Ip, B. Y. M., Mok, V., Lai, H. M., & Ko, H. (2023) · Seminars in Cell and Developmental Biology · doi:10.1016/j.semcdb.2023.06.005 · Cited by 6 · see citing works

Population Diversity at the Single-Cell Level

Gordon, M. G., Kathail, P., Choy, B., Kim, M. C., Mazumder, T., Gearing, M., & Ye, C. (2024) · Annual Review of Genomics and Human Genetics · doi:10.1146/annurev-genom-021623-083207 · Cited by 4 · see citing works

Single-Cell Analysis in Cerebrovascular Research: Primed for Breakthroughs and Clinical Impact

Albertson, A. J., Winkler, E. A., Yang, A. C., Buckwalter, M. S., Dingman, A., Fan, H., Herson, P. S., McCullough, L. D., Pérez‐Pinzón, M. A., Sansing, L. H., et al. (2024) · Stroke · doi:10.1161/strokeaha.124.049001 · Cited by 4 · see citing works

Ensemble deep learning model for early diagnosis and classification of Alzheimer's disease using MRI scans

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Generation of hiPSC-Derived Brain Microvascular Endothelial Cells Using Directed Differentiation and Transcriptional Reprogramming

Cui, A., Patel, R., Bosco, P., Akcan, U., Richters, E., Delgado, P. B., Agalliu, D., & Sproul, A. A. (2025) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/atvbaha.125.323397 · Cited by 4 · see citing works

Hippocampus Glutathione S Reductase Potentially Confers Genetic Resilience to Cognitive Decline in the AD-BXD Mouse PopulationPreprint

Saul, M. C., LITKOWSKI, E. M., Hadad, N., Dunn, A. R., Boas, S. M., Willcox, J. A. L., Robbins, J. E., Wu, Y., Philip, V. M., Merrihew, G. E., et al. (2024) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2024.01.09.574219 · Cited by 4 · see citing works

Lifespan single-cell transcriptomic atlas of the human prefrontal cortex

Yang, H., Clarence, T., Scott, M. R., Wang, X., Prashant, N. M., Pjanic, M., Venkatesh, S., Hong, A., Casey, C., Murphy, S. E., et al. (2026) · Nature · doi:10.1038/s41586-026-10271-7 · Cited by 12 · see citing works

The potential of circulating nonesterified fatty acids and sphingolipids in the biological understanding of cognitive decline and dementia

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G-protein coupled estrogen receptor 1, amyloid-β, and tau tangles in older adults

Oveisgharan, S., Yu, L., Lopes, K. D. P., Petyuk, V., Tasaki, S., Vialle, R. A., Menon, V., Wang, Y., Jager, P. L. D., Schneider, J. A., et al. (2024) · Communications Biology · doi:10.1038/s42003-024-06272-9 · Cited by 3 · see citing works

An image segmentation pipeline optimized for human microglia uncovers sources of morphological diversity in Alzheimer’s diseasePreprint

Jager, R. M. D., Lee, A., Sigalov, A., & Taga, M. F. (2024) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2024.02.01.577128 · Cited by 3 · see citing works

Genetic architecture of epigenetic cortical clock age in brain tissue from older individuals: alterations in CD46 and other loci

Grodstein, F., Lemos, B., Yang, J., Lopes, K. D. P., Vialle, R. A., Seyfried, N. T., Wang, Y., Shireby, G. L., Hannon, E. J., Thomas, A. J., et al. (2024) · Epigenetics · doi:10.1080/15592294.2024.2392050 · Cited by 2 · see citing works

Annotation Comparison Explorer (ACE): connecting brain cell types across studies of health and Alzheimer’s DiseasePreprint

Miller, J. A., Travaglini, K. J., Luquez, T., Hostetler, R. E., Oster, A., Daniel, S. F., Tasic, B., & Menon, V. (2025) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2025.02.11.637559 · Cited by 3 · see citing works

Uncovering the Signatures of Cellular Senescence in the Human Dorsolateral Prefrontal CortexPreprint

Sloan, N., Mares, J. A., Daly, A. C., Coie, L. A., Grier, S., Barretto, N., Casel, O., Kang, K., Jackson, C., Pedersen, M., et al. (2025) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2025.02.19.639091 · Cited by 2 · see citing works

Single-nucleus multiomics in brains from Hispanic individuals reveal APOE-ε4 -driven disruption of focal adhesion signaling in the presence of cerebrovascular pathologyPreprint

Yılmaz, E., Chen, K. W., Cakir, E. Ö., Bhattarai, P., Liu, M., Ciener, B., Qiao, M., Lantigua, R., Medrano, M. Z., Rivera, D., et al. (2025) · medRxiv · doi:10.1101/2025.05.21.25328040 · Cited by 3 · see citing works

Integration of genomic and transcriptomic layers in RNA‐Seq data leads to protein interaction modules with improved Alzheimer's disease associations

Düz, E., İlgün, A., Bozkurt, F. B., & Çakır, T. (2024) · European Journal of Neuroscience · doi:10.1111/ejn.16600 · Cited by 1 · see citing works

Underestimation of mitochondrial respiratory capacity in gray matter voxels of the human brain map due to limited OXPHOS and TCA cycle in astrocytes

Chinopoulos, C. (2025) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2025.1661231 · Cited by 1 · see citing works

Association of 10 VEGF Family Genes with Alzheimer’s Disease Endophenotypes at Single Cell ResolutionPreprint

Wu, Y., Libby, J. B., Dumitrescu, L. C., Jager, P. L. D., Menon, V., Schneider, J. A., Bennett, D. A., & Hohman, T. J. (2024) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2024.04.12.589221 · Cited by 1 · see citing works

Single-nucleus and spatial transcriptomic profiling of human temporal cortex and white matter reveals novel associations with AD pathologyPreprint

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Immunogenetics of neurological disease

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Additional file 2 of APOE2 protects against Aβ pathology by improving neuronal mitochondrial function through ERRα signaling

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Additional file 1 of APOE2 protects against Aβ pathology by improving neuronal mitochondrial function through ERRα signaling

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The Caudate Nucleus Exhibits Distinct Pathology and Cell Type-Specific Responses Across Alzheimer’s DiseasePreprint

Kana, O. Z., Postupna, N. O., Agrawal, A., Long, B., Travaglini, K. J., Gabitto, M. I., Lai, H.-Y., Mahoney, J. T., Xiao, M., Bajwa, T. S., et al. (2026) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.64898/2026.01.10.694705 · Cited by 1 · see citing works

A diagnostic plasma omics‐biomarker for Alzheimer's disease informed by microglial single‐cell transcriptomics: A pilot study

Lutz, M. W., Man, Z., Zheng, Y., Venkatesan, S., & Chiba‐Falek, O. (2026) · Alzheimer s & Dementia Translational Research & Clinical Interventions · doi:10.1002/trc2.70273

Cellular communities reveal trajectories of brain ageing and Alzheimer’s disease

Green, G. S., Fujita, M., Yang, H.-S., Taga, M., Cain, A., McCabe, C., Comandante-Lou, N., White, C. C., Schmidtner, A. K., Zeng, L., et al. (2024) · Nature · doi:10.1038/s41586-024-07871-6 · Cited by 204 · see citing works

Cellular network perturbations point to a new microglia‐astrocyte community accelerating Alzheimer’s disease progression

Green, G. S., Fujita, M., Yang, H., Aubin, C., Taga, M. F., Cain, A., Zeng, L., Regev, A., Bennett, D. A., Menon, V., et al. (2022) · Alzheimer s & Dementia · doi:10.1002/alz.067511 · Cited by 2 · see citing works

Multicellular communities are perturbed in the aging human brain and Alzheimer’s disease

Cain, A., Taga, M., McCabe, C., Green, G. S., Hekselman, I., White, C. C., Lee, D. I., Gaur, P., Rozenblatt-Rosen, O., Zhang, F., et al. (2023) · Nature Neuroscience · doi:10.1038/s41593-023-01356-x · Cited by 142 · see citing works

Hepatitis C Behind and Beyond Bars

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Integrated multimodal cell atlas of Alzheimer’s disease

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