The impact of diabetes on cognitive impairment and its progression to dementia
Open accessAbstract
Introduction: Diabetes is a well‐established risk factor for dementia, but its impact on the prodromal phase of dementia is unclear. Methods: Cohorts of older adults who were cognitively healthy (n = 1840) or had cognitive impairment‐no dementia (CIND; n = 682) were followed over 12 years to detect incident CIND and dementia, respectively. Results: Poorly controlled diabetes (glycated hemoglobin [HbA1c] ≥7.5%; reference = normoglycemia) was associated with double the risk of CIND (Cox regression multi‐adjusted hazard ratio [HR] 2.01, 95% confidence interval [CI] 1.13‐3.58) and triple the risk CIND progressing to dementia (HR 2.87, 95% CI 1.20‐6.85). Co‐morbid diabetes and heart disease doubled the risk of incident CIND and dementia, although neither disease conferred a significant risk of either outcome alone. Elevated systemic inflammation contributed to the diabetes‐associated increased dementia risk. Conclusions: Diabetes characterized by poor glycemic control or cardiovascular complications is related to a greater risk of the development and progression of cognitive impairment. Inflammation may play a role in these relationships.
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Diabetes is a well-established risk factor for cognitive impairment and dementia.
“Diabetes is a well-established risk factor for cognitive impairment and dementia”
From Microbiota–gut–brain axis and its therapeutic applications in neurodegenerative diseases (2024) · cites this paper as [603]
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- Authors
- Dove, A., Shang, Y., Xu, W., Grande, G., Laukka, E. J., Fratiglioni, L., & Marseglia, A.
- Affiliations
- Karolinska Institutet (SE)
- Corresponding author
- Dove, Abigail
- ORCID
- Venue
- Alzheimer's & Dementia
- Publisher
- Wiley
- Published
- 2021-10-12
- Volume
- 17
- Issue
- 11
- Pages
- 1769-1778
- ISSN
- 1552-5260 (ISSN-L)
- 1552-5279
- OpenAlex
- W3206442136
- Cited by
- 252
- References
- 49
- Citations by year
- 2026: 46 · 2025: 70 · 2024: 79 · 2023: 42 · 2022: 15
- FWCI
- 24.57
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- Locations
- Alzheimer s & Dementia (publishedVersion, cc-by-nc-nd)
- PubMed (publishedVersion)
- Funders
- Vetenskapsrådet
- National Natural Science Foundation of China
- Alzheimerfonden
- Gun och Bertil Stohnes Stiftelse
- Stiftelsen för Gamla Tjänarinnor
- Topics
- Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
- Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Cancer-related cognitive impairment studies
- Health Sciences › Medicine › Physiology › Alzheimer's disease research and treatments
- Keywords
- diabetes mellitus, cognitive impairment
- MeSH terms
- Aged, Aged, 80 and over, Dementia, Diabetes Mellitus, Type 2, Female, Humans, Longitudinal Studies, Male, Middle Aged, Risk Factors, Comorbidity, Disease Progression, Cognitive Dysfunction, Prodromal Symptoms
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