Cited by 253Dementia and Cognitive Impairment ResearchCancer-related cognitive impairment studiesAlzheimer's disease research and treatments

The impact of diabetes on cognitive impairment and its progression to dementia

Open access
Dove, Abigail, Shang, Ying, Xu, Weili, Grande, Giulia, Laukka, Erika J., Fratiglioni, Laura, Marseglia, Anna·2021·Alzheimer's & Dementia

Abstract

Introduction: Diabetes is a well‐established risk factor for dementia, but its impact on the prodromal phase of dementia is unclear. Methods: Cohorts of older adults who were cognitively healthy (n = 1840) or had cognitive impairment‐no dementia (CIND; n = 682) were followed over 12 years to detect incident CIND and dementia, respectively. Results: Poorly controlled diabetes (glycated hemoglobin [HbA1c] ≥7.5%; reference = normoglycemia) was associated with double the risk of CIND (Cox regression multi‐adjusted hazard ratio [HR] 2.01, 95% confidence interval [CI] 1.13‐3.58) and triple the risk CIND progressing to dementia (HR 2.87, 95% CI 1.20‐6.85). Co‐morbid diabetes and heart disease doubled the risk of incident CIND and dementia, although neither disease conferred a significant risk of either outcome alone. Elevated systemic inflammation contributed to the diabetes‐associated increased dementia risk. Conclusions: Diabetes characterized by poor glycemic control or cardiovascular complications is related to a greater risk of the development and progression of cognitive impairment. Inflammation may play a role in these relationships.

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Crossref · 10.1002/alz.12482

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Authors
Dove, A., Shang, Y., Xu, W., Grande, G., Laukka, E. J., Fratiglioni, L., & Marseglia, A.
Affiliations
Karolinska Institutet (SE)
Corresponding author
Dove, Abigail
Venue
Alzheimer's & Dementia
Publisher
Wiley
Published
2021-10-12
Volume
17
Issue
11
Pages
1769-1778
ISSN
  • 1552-5260 (ISSN-L)
  • 1552-5279
OpenAlex
W3206442136
Cited by
252
References
49
Citations by year
2026: 46 · 2025: 70 · 2024: 79 · 2023: 42 · 2022: 15
FWCI
24.57
Type
journal article
Language
en
Open access
Locations
  • Alzheimer s & Dementia (publishedVersion, cc-by-nc-nd)
  • PubMed (publishedVersion)
Funders
  • Vetenskapsrådet
  • National Natural Science Foundation of China
  • Alzheimerfonden
  • Gun och Bertil Stohnes Stiftelse
  • Stiftelsen för Gamla Tjänarinnor
Topics
  • Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
  • Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Cancer-related cognitive impairment studies
  • Health Sciences › Medicine › Physiology › Alzheimer's disease research and treatments
Keywords
diabetes mellitus, cognitive impairment
MeSH terms
Aged, Aged, 80 and over, Dementia, Diabetes Mellitus, Type 2, Female, Humans, Longitudinal Studies, Male, Middle Aged, Risk Factors, Comorbidity, Disease Progression, Cognitive Dysfunction, Prodromal Symptoms

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