Diabetes, impaired fasting glucose, and development of cognitive impairment in older women
Abstract
OBJECTIVE: To investigate the association between diabetes and impaired fasting glucose (IFG) and cognition and risk of developing both dementia and mild cognitive impairment (MCI) in older women. METHODS: The authors analyzed data from a 4-year randomized trial of raloxifene among 7,027 osteoporotic postmenopausal women (mean age, 66.3 years) at 178 sites. Diabetes was defined by history, fasting blood glucose > or =7.0 mmol/L (> or =126 mg/dL), or use of hypoglycemic agents; IFG was defined as fasting glucose <7.0 mmol/L but >6.11 mmol/L (110 mg/dL); all others were considered to have normal glucose (NG). The main outcome was baseline and 4-year change on five standardized cognitive tests (z scores with lower scores indicating worse performance) and risk of developing clinically significant impairment (dementia, mild cognitive impairment, or very low cognitive score). RESULTS: A total of 267 (3.8%) women had diabetes and 297 (4.2%) had IFG. Women with IFG had worse baseline cognitive scores compared to women with NG but better scores than diabetics (age-adjusted composite z score based on five tests: NG 0.40, 95% CI 0.30 to 0.49; IFG 0.14, 95% CI -0.36 to 0.64; diabetics -0.78, 95% CI -1.23 to -0.33; p < 0.001). There was greater 4-year decline among diabetics (age and treatment-adjusted composite z score: NG -0.05, 95% CI -0.16 to 0.05; IFG 0.11, 95% CI -0.53 to 0.75; diabetics -1.00, 95% CI -1.50 to -0.50; p = 0.001). Further adjustment for education, race, and depression led to similar results. Risk of developing cognitive impairment among women with IFG or diabetes was increased by almost twofold (age and treatment-adjusted OR = 1.64; 95% CI 1.03 to 2.61 for IFG; OR = 1.79; 95% CI 1.14 to 2.81 for diabetics). CONCLUSIONS: Diabetic as well as pre-diabetic women have impaired cognitive performance and greater risk of developing cognitive impairment.
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Two included studies reported that participants with impaired fasting glucose or impaired glucose tolerance experience more cognitive decline than participants without.
“Moreover, two of the studies included in this review reported that participants with impaired fasting glucose or impaired glucose tolerance experience more cognitive decline than participants without, further supporting a link between cognitive decline and hyperglycaemia [51, 69, 70].”
From Cognitive decline and dementia in diabetes—systematic overview of prospective observational studies (2005) · cites this paper as [70]
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- Authors
- Yaffe, K., Blackwell, T., Kanaya, A. M., Davidowitz, N., Barrett-Connor, E., & Krueger, K.
- Affiliations
- San Francisco VA Medical Center (US)
- Venue
- Neurology
- Published
- 2004-08-24
- Volume
- 63
- Issue
- 4
- Pages
- 658-663
- ISSN
- 0028-3878 (ISSN-L)
- 1526-632X
- OpenAlex
- W2114456718
- Cited by
- 520
- References
- 35
- Citations by year
- 2026: 11 · 2025: 12 · 2024: 12 · 2023: 9 · 2022: 14 · 2021: 22 · 2020: 24 · 2019: 21 · 2018: 22 · 2017: 16 · 2016: 28 · 2015: 32 · 2014: 31 · 2013: 25 · 2012: 37
- FWCI
- 11.25
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Neurology (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institute on Aging (R01AG021918)
- Topics
- Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Menopause: Health Impacts and Treatments
- Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Cancer-related cognitive impairment studies
- Keywords
- diabetes mellitus, impaired fasting glucose, cognitive impairment, dementia, mild cognitive impairment, older women, postmenopausal women, cognitive decline, glucose metabolism, osteoporosis
- MeSH terms
- Age Factors, Aged, Blood Glucose, Brain, Cardiovascular Diseases, Cognition Disorders, Dementia, Depression, Diabetes Mellitus, Fasting, Female, Follow-Up Studies, Humans, Hypoglycemic Agents, Magnetic Resonance Imaging, Middle Aged, Obesity, Prediabetic State, Psychological Tests, Risk, Tomography, X-Ray Computed, Osteoporosis, Postmenopausal, Comorbidity, Odds Ratio, Randomized Controlled Trials as Topic, Raloxifene Hydrochloride
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