Cited by 34Dementia and Cognitive Impairment ResearchNeurological Disease Mechanisms and TreatmentsCancer-related cognitive impairment studies

Poor pulmonary function is associated with mild cognitive impairment, its progression to dementia, and brain pathologies: A community‐based cohort study

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Wang, Jiao, Dove, Abigail, Song, Ruixue, Qi, Xiuying, Ma, Jun, Bennett, David A., Xu, Weili·2022·Alzheimer's & Dementia

Abstract

Introduction: The relationship between pulmonary function (PF) and mild cognitive impairment (MCI), dementia, and brain pathologies remains unclear. Methods: A total of 1312 dementia‐free participants, including a cognitively intact group (n = 985) and an MCI group (n = 327), were followed for up to 21 years to detect incident MCI and dementia. PF was assessed at baseline with a composite score and tertiled. Over follow‐up, 540 participants underwent autopsies for neuropathological assessment. Results: Compared to the highest PF, the hazard ratios (95% confidence intervals [CIs]) of the lowest PF were 1.95 (1.43‐2.66) for MCI in the cognitively intact group and 1.55 (1.03‐2.33) for dementia in the MCI group. Low PF was further related to Alzheimer's disease pathology (odds ratio [OR] 1.32, 95% CI 1.19‐1.47) and vascular pathology (OR 3.05, 95% CI 1.49‐6.25). Discussion: Low PF increases MCI risk and accelerates MCI progression to dementia. Both neurodegenerative and vascular mechanisms may underlie the PF‐dementia association.

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  • Autopsy investigations revealed that decreased pulmonary function is associated with a greater burden of Alzheimer's disease pathologies, including amyloid deposition and neurofibrillary tangles.

    “Autopsy investigations revealed that decreased PF is associated with a greater burden of AD pathologies, including amyloid deposition and neurofibrillary tangles.263”

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  1. [8]WHO. Risk Reduction of Cognitive Decline and Dementia: WHO Guidelines. Geneva: World Health Organization. 2019. 31219687

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Authors
Wang, J., Dove, A., Song, R., Qi, X., Ma, J., Bennett, D. A., & Xu, W.
Affiliations
  • Tianjin Medical University (CN)
  • Karolinska Institutet (SE)
  • Shandong University (CN)
  • Rush University Medical Center (US)
Corresponding author
Xu, Weili
Venue
Alzheimer's & Dementia
Publisher
Wiley
Published
2022-02-20
Volume
18
Issue
12
Pages
2551-2559
ISSN
  • 1552-5260 (ISSN-L)
  • 1552-5279
OpenAlex
W4213152334
Cited by
34
References
55
Citations by year
2026: 7 · 2025: 11 · 2024: 6 · 2023: 6 · 2022: 4
FWCI
4.40
Type
journal article
Language
en
Open access
Locations
  • Alzheimer s & Dementia (publishedVersion, cc-by-nc)
  • PubMed Central (publishedVersion, cc-by-nc)
  • PubMed (publishedVersion)
Funders
  • Stiftelsen för Gamla Tjänarinnor (2021‐2022)
  • National Natural Science Foundation of China (R01AG17917, 2017-00981, 81771519, 2021–2022)
  • Karolinska Institutet (2020-01660)
  • Vetenskapsrådet (2020-01660, 81771519, 2021-01647, 2017-00981)
  • Alzheimerfonden (2021‐2022)
  • Demensfonden
  • National Institutes of Health
  • National Institute on Aging (R01AG017917)
  • National Institute of Neurological Disorders and Stroke (UH2NS100599)
Topics
  • Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
  • Life Sciences › Neuroscience › Neurology › Neurological Disease Mechanisms and Treatments
  • Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Cancer-related cognitive impairment studies
Keywords
lung function, mild cognitive impairment
MeSH terms
Alzheimer Disease, Brain, Humans, Cohort Studies, Proportional Hazards Models, Disease Progression, Cognitive Dysfunction

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