The DOI matches its Crossref record; 14 of the 14 references it cites were found in a registry or an index.
Dopaminergic influences on formation of a motor memory
Open accessAbstract
The ability of the central nervous system to form motor memories, a process contributing to motor learning and skill acquisition, decreases with age. Dopaminergic activity, one of the mechanisms implicated in memory formation, experiences a similar decline with aging. It is possible that restoring dopaminergic function in elderly adults could lead to improved formation of motor memories with training. We studied the influence of a single oral dose of levodopa (100mg) administered preceding training on the ability to encode an elementary motor memory in the primary motor cortex of elderly and young healthy volunteers in a randomized, double‐blind, placebo‐controlled design. Attention to the task and motor training kinematics were comparable across age groups and sessions. In young subjects, encoding a motor memory under placebo was more prominent than in older subjects, and the encoding process was accelerated by intake of levodopa. In the elderly group, diminished motor memory encoding under placebo was enhanced by intake of levodopa to levels present in younger subjects. Therefore, upregulation of dopaminergic activity accelerated memory formation in young subjects and restored the ability to form a motor memory in elderly subjects; possible mechanisms underlying the beneficial effects of dopaminergic agents on motor learning in neurorehabilitation. Ann Neurol 2005;58:121–130
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Functional architecture of basal ganglia circuits: neural substrates of parallel processing
Alexander, G. E., & Crutcher, M. D. (1990) · Trends in Neurosciences · doi:10.1016/0166-2236(90)90107-l · Cited by 4,131
Dopamine, learning and motivation.
Wise, R. A. (2004) · Nature Reviews Neuroscience · doi:10.1038/nrn1406 · Cited by 3,379 · cited 1×
“Thus, it is conceivable that agedependent decline in brain dopamine function might contribute to the decreased ability to encode new memories in elderly adults.(8,9,14) Motor training(4,15,16) leads to formation of motor memories, which are crucial for skill acquisition and are influential in the process of functional…”
BackgroundInsights into the ageing mind: a view from cognitive neuroscience
Hedden, T., & Gabrieli, J. D. E. (2004) · Nature Reviews Neuroscience · doi:10.1038/nrn1323 · Cited by 2,223
Depression of motor cortex excitability by low-frequency transcranial magnetic stimulation
Chen, R., Classen, J., Gerloff, C., Celnik, P., Wassermann, E. M., Hallett, M., & Cohen, L. G. (1997) · Neurology · doi:10.1212/wnl.48.5.1398 · Cited by 2,128 · cited 1×
“1Hz, a rate that does not affect cortical excitability.(29) Subjects occasionally realized that the thumb had moved but could not determine its direction.”
BackgroundSelf-citationNudo, R. J., Wise, B. M., SiFuentes, F., & Milliken, G. W. (1996) · Science · doi:10.1126/science.272.5269.1791 · Cited by 1,911
Functional MRI evidence for adult motor cortex plasticity during motor skill learning
Kami, A., Meyer, G., Jezzard, P., Adams, M. M., Turner, R., & Ungerleider, L. G. (1995) · Nature · doi:10.1038/377155a0 · Cited by 1,883
Modulation of memory fields by dopamine Dl receptors in prefrontal cortex
Williams, G. V., & Goldman-Rakic, P. S. (1995) · Nature · doi:10.1038/376572a0 · Cited by 1,593
Models of Information Processing in the Basal Ganglia
(1994) · doi:10.7551/mitpress/4708.001.0001 · Cited by 1,190
Rapid plasticity of human cortical movement representation induced by practice
Classen, J., Liepert, J., Wise, S. P., Hallett, M., & Cohen, L. G. (1998) · Journal of Neurophysiology · doi:10.1152/jn.1998.79.2.1117 · Cited by 1,156
Self-citationIs Heterosynaptic modulation essential for stabilizing hebbian plasiticity and memory
Bailey, C. H., Giustetto, M., Huang, Y.-Y., Hawkins, R. D., & Kandel, E. R. (2000) · Nature Reviews Neuroscience · doi:10.1038/35036191 · Cited by 382
Cited by
Physical activity and memory functions: An interventional study
Ruscheweyh, R., Willemer, C., Krüger, K., Duning, T., Warnecke, T., Sommer, J., Völker, K., Ho, H. V., Mooren, F., Knecht, S., et al. (2011) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2009.08.001 · Cited by 499
Self-citationDi Lazzaro, V., Pilato, F., Saturno, E., Oliviero, A., Dileone, M., Mazzone, P., Insola, A., Tonali, P. A., Ranieri, F., Huang, Y. Z., et al. (2005) · The Journal of Physiology · doi:10.1113/jphysiol.2005.087288 · Cited by 423
Nitsche, M. A., Lampe, C., Antal, A., Liebetanz, D., Lang, N., Tergau, F., & Paulus, W. (2006) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.2006.04676.x · Cited by 339
Boosting focally-induced brain plasticity by dopamine
Kuo, M.-F., Paulus, W., & Nitsche, M. A. (2008) · Cerebral Cortex · doi:10.1093/cercor/bhm098 · Cited by 269
Levodopa ameliorates learning and memory deficits in a murine model of Alzheimer’s disease
Ambrée, O., Richter, H., Sachser, N., Lewejohann, L., Dere, E., de Souza Silva, M. A., Herring, A., Keyvani, K., Paulus, W., & Schäbitz, W.-R. (2009) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2007.11.010 · Cited by 115
Metadata
- Authors
- Flöel, A., Breitenstein, C., Hummel, F., Celnik, P., Gingert, C., Sawaki, L., Knecht, S., & Cohen, L. G.
- Venue
- Annals of Neurology
- Publisher
- Wiley
- Published
- 2005-06-27
- Volume
- 58
- Issue
- 1
- Pages
- 121-130
- ISSN
- 0364-5134 (ISSN-L)
- 1531-8249
- OpenAlex
- W2134353679
- Cited by
- 189
- References
- 14
- FWCI
- 6.69
- Type
- journal article
- Language
- en
- Open access
- green
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
How to cite
Cite CoChat for the checks on this page, and the paper for its own findings.
- This page
- CoChat. (2026). Citation check: Dopaminergic influences on formation of a motor memory. https://app.cochat.ai/papers/10.1002/ana.20536
- The paper
- Flöel, A., Breitenstein, C., Hummel, F., Celnik, P., Gingert, C., Sawaki, L., Knecht, S., & Cohen, L. G. (2005). Dopaminergic influences on formation of a motor memory. Annals of Neurology. https://doi.org/10.1002/ana.20536
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
