The DOI matches its Crossref record; 50 of the 50 references it cites were found in a registry or an index.
Dopaminergic modulation of long‐lasting direct current‐induced cortical excitability changes in the human motor cortex
Open accessAbstract
Dopaminergic mechanisms participate in N‐methyl‐d‐aspartate (NMDA) receptor‐dependent neuroplasticity, as animal experiments have shown. This may be similar in humans, where dopamine influences learning and memory. We tested the role of dopamine in human cortical neuroplasticity. Changes of excitability were induced by transcranial direct current stimulation (tDCS). D2 receptor blocking by sulpiride abolished the induction of after‐effects nearly completely. D1 activation alone in the presence of D2 receptor blocking induced by co‐administration of sulpiride and pergolide did not re‐establish the excitability changes induced by tDCS. This suggests that D2 receptors play a major supporting role in inducing neuroplasticity in the human motor cortex. Enhancement of D2 and, to a lesser degree, D1 receptors by pergolide consolidated tDCS‐generated excitability diminution until the morning after stimulation. The readiest explanation for this pattern of results is that D2 receptor activation has a consolidation‐enhancing effect on tDCS‐induced changes of excitability in the human cortex. The results of this study underscore the importance of the dopaminergic system for human neuroplasticity, suggest a first pharmacological add‐on mechanism to prolong the excitability‐diminishing effects of cathodal tDCS for up to 24 h after stimulation, and thus render the application of tDCS practicable in diseases displaying enhanced cortical excitability, e.g. migraine and epilepsy.
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Cites
Nitsche, M. A., & Paulus, W. (2000) · The Journal of Physiology · doi:10.1111/j.1469-7793.2000.t01-1-00633.x · Cited by 5,656
Self-citationSustained excitability elevations induced by transcranial DC motor cortex stimulation in humans
Nitsche, M. A., & Paulus, W. (2001) · Neurology · doi:10.1212/wnl.57.10.1899 · Cited by 2,617
Self-citationNitsche, M. A., Fricke, K., Henschke, U., Schlitterlau, A., Liebetanz, D., Lang, N., Henning, S., Tergau, F., & Paulus, W. (2003) · The Journal of Physiology · doi:10.1113/jphysiol.2003.049916 · Cited by 1,514
Self-citationLiebetanz, D. (2002) · Brain · doi:10.1093/brain/awf238 · Cited by 1,383
Self-citationEffects of non-invasive cortical stimulation on skilled motor function in chronic stroke
Hummel, F. (2005) · Brain · doi:10.1093/brain/awh369 · Cited by 1,114
Nitsche, M. A., Schauenburg, A., Lang, N., Liebetanz, D., Exner, C., Paulus, W., & Tergau, F. (2003) · Journal of Cognitive Neuroscience · doi:10.1162/089892903321662994 · Cited by 1,032
Self-citationLearning-Induced LTP in Neocortex
Rioult-Pedotti, M.-S., Friedman, D., & Donoghue, J. P. (2000) · Science · doi:10.1126/science.290.5491.533 · Cited by 1,015
Loss of bidirectional striatal synaptic plasticity in L-DOPA-induced dyskinesia
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Level of action of cathodal DC polarisation induced inhibition of the human motor cortex
Nitsche, M. A., Nitsche, M. S., Klein, C. C., Tergau, F., Rothwell, J. C., & Paulus, W. (2003) · Clinical Neurophysiology · doi:10.1016/s1388-2457(02)00412-1 · Cited by 736
Self-citationStrengthening of horizontal cortical connections following skill learning
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Cited by
Transcranial direct current stimulation: State of the art 2008
Nitsche, M. A., Cohen, L. G., Wassermann, E. M., Priori, A., Lang, N., Antal, A., Paulus, W., Hummel, F., Boggio, P. S., Fregni, F., et al. (2008) · Brain Stimulation · doi:10.1016/j.brs.2008.06.004 · Cited by 3,057
Self-citationPhysiological basis of transcranial direct current stimulation
Stagg, C. J., & Nitsche, M. A. (2011) · The Neuroscientist · doi:10.1177/1073858410386614 · Cited by 1,719
Self-citationRidding, M. C., & Ziemann, U. (2010) · The Journal of Physiology · doi:10.1113/jphysiol.2010.190314 · Cited by 787
Physiology of Transcranial Direct Current Stimulation
Stagg, C. J., Antal, A., & Nitsche, M. A. (2018) · The Journal of ECT · doi:10.1097/yct.0000000000000510 · Cited by 478
Self-citationNeurobiological after-effects of non-invasive brain stimulation
Cirillo, G., Di Pino, G., Capone, F., Ranieri, F., Florio, L., Todisco, V., Tedeschi, G., Funke, K., & Di Lazzaro, V. (2017) · Brain Stimulation · doi:10.1016/j.brs.2016.11.009 · Cited by 446
Metadata
- Authors
- Nitsche, M. A., Lampe, C., Antal, A., Liebetanz, D., Lang, N., Tergau, F., & Paulus, W.
- Venue
- European Journal of Neuroscience
- Publisher
- Wiley
- Published
- 2006-03
- Volume
- 23
- Issue
- 6
- Pages
- 1651-1657
- ISSN
- 0953-816X (ISSN-L)
- 1460-9568
- OpenAlex
- W2134464143
- Cited by
- 339
- References
- 50
- FWCI
- 7.92
- Type
- journal article
- Language
- en
- Open access
- green
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- Nitsche, M. A., Lampe, C., Antal, A., Liebetanz, D., Lang, N., Tergau, F., & Paulus, W. (2006). Dopaminergic modulation of long‐lasting direct current‐induced cortical excitability changes in the human motor cortex. European Journal of Neuroscience. https://doi.org/10.1111/j.1460-9568.2006.04676.x
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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