The DOI matches its Crossref record; 4 of the 4 references it cites were found in a registry or an index.
Age and energy intake interact to modify cell stress pathways and stroke outcome
Open accessAbstract
Objective: Age and excessive energy intake/obesity are risk factors for cerebrovascular disease, but it is not known if and how these factors affect the extent of brain damage and outcome in ischemic stroke. We therefore determined the interactions of age and energy intake on the outcome of ischemic brain injury, and elucidated the underlying mechanisms. Methods: We utilized a novel microchip‐based immunoaffinity capillary electrophoresis technology to measure a panel of neurotrophic factors, cytokines, and cellular stress resistance proteins in brain tissue samples from young, middle‐aged, and old mice that had been maintained on control or energy‐restricted diets prior to middle cerebral artery occlusion and reperfusion. Results: Mortality from focal ischemic stroke was increased with advancing age and reduced by an intermittent fasting (IF) diet. Brain damage and functional impairment were reduced by IF in young and middle‐aged mice, but not in old mice. The basal and poststroke levels of neurotrophic factors (brain‐derived neurotrophic factor and basic fibroblast growth factor), protein chaperones (heat shock protein 70 and glucose regulated protein 78), and the antioxidant enzyme heme oxygenase‐1 were decreased, whereas levels of inflammatory cytokines were increased in the cerebral cortex and striatum of old mice compared with younger mice. IF coordinately increased levels of protective proteins and decreased inflammatory cytokines in young, but not in old mice. Interpretation: Reduction in dietary energy intake differentially modulates neurotrophic and inflammatory pathways to protect neurons against ischemic injury, and these beneficial effects of IF are compromised during aging, resulting in increased brain damage and poorer functional outcome. ANN NEUROL 2010;67:41–52
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Self-citationHalagappa, V. K. M., Guo, Z., Pearson, M., Matsuoka, Y., Cutler, R. G., LaFerla, F. M., & Mattson, M. P. (2007) · Neurobiology of Disease · doi:10.1016/j.nbd.2006.12.019 · Cited by 580
Self-citationDuan, W., Guo, Z., Jiang, H., Ware, M., Li, X.-J., & Mattson, M. P. (2003) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0536856100 · Cited by 428
Self-citationCaloric restriction alone and with exercise improves CVD risk in healthy non-obese individuals
Lefevre, M., Redman, L. M., Heilbronn, L. K., Smith, J. V., Martin, C. K., Rood, J. C., Greenway, F. L., Williamson, D. A., Smith, S. R., & Ravussin, E. (2009) · Atherosclerosis · doi:10.1016/j.atherosclerosis.2008.05.036 · Cited by 217
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Vasconcelos, A. R., Yshii, L. M., Viel, T. A., Buck, H. S., Mattson, M. P., Scavone, C., & Kawamoto, E. M. (2014) · Journal of Neuroinflammation · doi:10.1186/1742-2094-11-85 · Cited by 210
Zeb, F., Wu, X., Chen, L., Fatima, S., Haq, I.-U., Chen, A., Majeed, F., Feng, Q., & Li, M. (2020) · British Journal of Nutrition · doi:10.1017/s0007114519003428 · Cited by 202
Rothman, S. M., Griffioen, K. J., Wan, R., & Mattson, M. P. (2012) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.2012.06525.x · Cited by 185
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“…as fasting and exercise can be beneficial for neurons and brain health (Mattson 2012), and are neuroprotective in animal models of stroke, Parkinson’s disease, and Alzheimer’s disease (Halagappa et al. 2007; Arumugam et al. 2010; Zhang et al. 2011; Griffioen et al. 2013; Meller and Simon 2013).”
BackgroundBeneficial effects of dietary restriction in aging brain
Hadem, I. K. H., Majaw, T., Kharbuli, B., & Sharma, R. (2019) · Journal of Chemical Neuroanatomy · doi:10.1016/j.jchemneu.2017.10.001 · Cited by 59
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Metadata
- Authors
- Arumugam, T. V., Phillips, T. M., Cheng, A., Morrell, C. H., Mattson, M. P., & Wan, R.
- Venue
- Annals of Neurology
- Publisher
- Wiley
- Published
- 2010-01
- Volume
- 67
- Issue
- 1
- Pages
- 41-52
- ISSN
- 0364-5134 (ISSN-L)
- 1531-8249
- OpenAlex
- W2111402656
- Cited by
- 281
- References
- 4
- FWCI
- 9.45
- Type
- journal article
- Language
- en
- Open access
- green
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