Cited by 434Dietary Effects on HealthGenetics, Aging, and Longevity in Model OrganismsAutophagy in Disease and Therapy

Energy intake and exercise as determinants of brain health and vulnerability to injury and disease

Open access
Mattson, Mark P.·2012·Cell Metabolism

Abstract

Evolution favored individuals with superior cognitive and physical abilities under conditions of limited food sources, and brain function can therefore be optimized by intermittent dietary energy restriction (ER) and exercise. Such energetic challenges engage adaptive cellular stress-response signaling pathways in neurons involving neurotrophic factors, protein chaperones, DNA-repair proteins, autophagy, and mitochondrial biogenesis. By suppressing adaptive cellular stress responses, overeating and a sedentary lifestyle may increase the risk of Alzheimer's and Parkinson's diseases, stroke, and depression. Intense concerted efforts of governments, families, schools, and physicians will be required to successfully implement brain-healthy lifestyles that incorporate ER and exercise.

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Crossref · 10.1016/j.cmet.2012.08.012

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  • Exercise influences neurogenesis in the dentate gyrus and increases synapse plasticity.

    “In particular, exercise has been shown to influence neurogenesis in the dentate gyrus (67, 68) and to increase synapse plasticity (67, 68).”

    From Muscle–Organ Crosstalk: The Emerging Roles of Myokines (2020) · cites this paper as [68]

  • Physical exercise has positive health effects on cognitive function and brain health.

    “Evidence is accumulating that physical exercise has positive health effects on cognitive function and brain health (67, 68).”

    From Muscle–Organ Crosstalk: The Emerging Roles of Myokines (2020) · cites this paper as [68]

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Authors
Mattson, M. P.
Affiliations
Johns Hopkins University (US)
Corresponding author
Mattson, Mark P.
Venue
Cell Metabolism
Publisher
Elsevier BV
Published
2012-12
Volume
16
Issue
6
Pages
706-722
ISSN
1550-4131 (ISSN-L)
OpenAlex
W2015620326
Cited by
434
References
196
Citations by year
2026: 23 · 2025: 26 · 2024: 26 · 2023: 31 · 2022: 35 · 2021: 39 · 2020: 33 · 2019: 34 · 2018: 23 · 2017: 34 · 2016: 38 · 2015: 41 · 2014: 36 · 2013: 14 · 2012: 1
FWCI
3.12
Type
journal article
Language
en
Open access
Locations
  • Cell Metabolism (publishedVersion)
  • PubMed (publishedVersion)
  • Europe PMC (PubMed Central) (acceptedVersion)
  • PubMed Central (acceptedVersion)
Funders
  • National Institutes of Health
  • National Institute on Aging (ZIAAG000313, ZIAAG000314, ZIAAG000330, ZIAAG000331, ZIAAG000312, ZIAAG000324, ZIAAG000315, ZIAAG000317)
Topics
  • Health Sciences › Medicine › Physiology › Dietary Effects on Health
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Aging › Genetics, Aging, and Longevity in Model Organisms
  • Health Sciences › Medicine › Epidemiology › Autophagy in Disease and Therapy
Keywords
caloric restriction, physical activity, brain health, neurodegeneration, Alzheimer's disease, Parkinson's disease, stroke, depression, cellular stress response, neurotrophic factors, autophagy, mitochondrial biogenesis, molecular chaperones, DNA repair, overeating, sedentary lifestyle
MeSH terms
Brain, Energy Intake, Humans, Neurons, Exercise, Neurodegenerative Diseases, Caloric Restriction

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