Cited by 242Diet and metabolism studiesMitochondrial Function and PathologyNeuroscience and Neuropharmacology Research

3‐Hydroxybutyrate regulates energy metabolism and induces BDNF expression in cerebral cortical neurons

Open access
Marosi, Krisztina, Kim, Sang Woo, Moehl, Keelin, Scheibye‐Knudsen, Morten, Cheng, Aiwu, Cutler, Roy, Camandola, Simonetta, Mattson, Mark P.·2016·Journal of Neurochemistry

Abstract

During fasting and vigorous exercise, a shift of brain cell energy substrate utilization from glucose to the ketone 3‐hydroxybutyrate (3 OHB ) occurs. Studies have shown that 3 OHB can protect neurons against excitotoxicity and oxidative stress, but the underlying mechanisms remain unclear. Neurons maintained in the presence of 3 OHB exhibited increased oxygen consumption and ATP production, and an elevated NAD + / NADH ratio. We found that 3 OHB metabolism increases mitochondrial respiration which drives changes in expression of brain‐derived neurotrophic factor ( BDNF ) in cultured cerebral cortical neurons. The mechanism by which 3 OHB induces Bdnf gene expression involves generation of reactive oxygen species, activation of the transcription factor NF ‐κB, and activity of the histone acetyltransferase p300/ EP 300. Because BDNF plays important roles in synaptic plasticity and neuronal stress resistance, our findings suggest cellular signaling mechanisms by which 3 OHB may mediate adaptive responses of neurons to fasting, exercise, and ketogenic diets. image

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

A few free checks a day · papers already verified open instantly · results are public

Integrity signals

Registry

Crossref · 10.1111/jnc.13868

Cites

83 of 83 references verified0 citation errors · 0 not checkable

Statistics

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

A few free checks a day · papers already verified open instantly · results are public

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

  • The ketone β-hydroxybutyrate raises NAD+ in neurons and suppresses Aβ and p-Tau pathologies and ameliorates behavioral deficits in a mouse model of AD.

    “the ketone β-hydroxybutyrate, which elevates NAD+ levels in neurons and has been shown to suppress Aβ and p-Tau pathologies and ameliorate behavioral deficits in a mouse model of AD”

    From NAD+ in Brain Aging and Neurodegenerative Disorders (2019) · cites this paper as Marosi et al., 2016

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

Cites

Flagged first, then by citations

1 of the 84 references couldn’t be matched to a known paper.

Cited by

Sorted by citations

Authors
Marosi, K., Kim, S. W., Moehl, K., Scheibye‐Knudsen, M., Cheng, A., Cutler, R., Camandola, S., & Mattson, M. P.
Affiliations
  • National Institute on Aging (US)
  • University of Copenhagen (DK)
  • Johns Hopkins University (US)
Corresponding author
Mattson, Mark P.
Venue
Journal of Neurochemistry
Publisher
Wiley
Published
2016-11-14
Volume
139
Issue
5
Pages
769-781
ISSN
  • 0022-3042 (ISSN-L)
  • 1471-4159
OpenAlex
W2531271987
Cited by
242
References
84
Citations by year
2026: 16 · 2025: 21 · 2024: 25 · 2023: 24 · 2022: 34 · 2021: 32 · 2020: 27 · 2019: 25 · 2018: 19 · 2017: 17 · 2016: 2
FWCI
16.91
Type
journal article
Language
en
Open access
Locations
  • Journal of Neurochemistry (publishedVersion)
  • PubMed (publishedVersion)
  • Europe PMC (PubMed Central) (acceptedVersion)
  • PubMed Central (acceptedVersion)
  • Research at the University of Copenhagen (University of Copenhagen) (submittedVersion)
Funders
National Institute on Aging
Topics
  • Health Sciences › Medicine › Physiology › Diet and metabolism studies
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Mitochondrial Function and Pathology
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
Keywords
beta-hydroxybutyrate, brain-derived neurotrophic factor, cortical neurons, brain energy metabolism, ketone bodies, mitochondrial respiration, reactive oxygen species, NF-κB, NAD+/NADH ratio, fasting, physical activity, ketogenic diet
MeSH terms
Animals, Cell Survival, Cells, Cultured, Cerebral Cortex, Energy Metabolism, Humans, Male, Mice, Inbred C57BL, Neurons, Gene Expression, Rats, Sprague-Dawley, Brain-Derived Neurotrophic Factor, 3-Hydroxybutyric Acid, Mice, Rats, HEK293 Cells

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review