The DOI matches its Crossref record.
Temporal profile of neuronal damage in a model of transient forebrain ischemia
Abstract
This study examined the temporal profile of ischemic neuronal damage following transient bilateral forebrain ischemia in the rat model of four‐vessel occlusion. Wistar rats were subjected to transient but severe forebrain ischemia by permanently occluding the vertebral arteries and 24 hours later temporarily occluding the common carotid arteries for 10, 20, or 30 minutes. Carotid artery blood flow was restored and the rats were killed by perfusion‐fixation after 3, 6, 24, and 72 hours. Rats with postischemic convulsions were discarded. Ischemic neuronal damage was graded in accordance with conventional neuropathological criteria. Ten minutes of four‐vessel occlusion produced scattered ischemic cell change in the cerebral hemispheres of most rats. The time to onset of visible neuronal damage varied among brain regions and in some regions progressively worsened with time. After 30 minutes of ischemia, small to medium‐sized striatal neurons were damaged early while the initiation of visible damage to hippocampal neurons in the h1 zone was delayed for 3 to 6 hours. The number of damaged neurons in neocortex (layer 3, layers 5 and 6, or both) and hippocampus (h1, h3–5, paramedian zone) increased significantly (p < 0.01) between 24 and 72 hours. The unique delay in onset of ischemic cell change and the protracte increase in its incidence between 24 and 72 hours could reflect either delayed‐appearance of ischemic change in previously killed neurons or a delayed insult that continued to jeopardize compromised but otherwise viable neurons during the postischemic period.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cited by
Ischemic Cell Death in Brain Neurons
Lipton, P. (1999) · Physiological Reviews · doi:10.1152/physrev.1999.79.4.1431 · Cited by 3,043
Siesjö, B. K., & Bengtsson, F. (1989) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1038/jcbfm.1989.20 · Cited by 1,231
Magarin˜os, A. M., & McEwen, B. S. (1995) · Neuroscience · doi:10.1016/0306-4522(95)00259-l · Cited by 863
Calcium in Ischemic Cell Death
Kristián, T., & Siesjö, B. K. (1998) · Stroke · doi:10.1161/01.str.29.3.705 · Cited by 825
Brain ischemia and reperfusion: molecular mechanisms of neuronal injury
White, B. C., Sullivan, J. M., DeGracia, D. J., O’Neil, B. J., Neumar, R. W., Grossman, L. I., Rafols, J. A., & Krause, G. S. (2000) · Journal of the Neurological Sciences · doi:10.1016/s0022-510x(00)00386-5 · Cited by 796
Gervais, F. G., Xu, D., Robertson, G. S., Vaillancourt, J. P., Zhu, Y., Huang, J., LeBlanc, A., Smith, D., Rigby, M., Shearman, M. S., et al. (1999) · Cell · doi:10.1016/s0092-8674(00)80748-5 · Cited by 674
Oxygen radical mechanisms of brain injury following ischemia and reperfusion
Traystman, R. J., Kirsch, J. R., & Koehler, R. C. (1991) · Journal of Applied Physiology · doi:10.1152/jappl.1991.71.4.1185 · Cited by 653
Hypoxia facilitates Alzheimer's disease pathogenesis by up-regulating BACE1 gene expression
Sun, X., He, G., Qing, H., Zhou, W., Dobie, F., Cai, F., Staufenbiel, M., Huang, L. E., & Song, W. (2006) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0606298103 · Cited by 605
Lindvall, O., Ernfors, P., Bengzon, J., Kokaia, Z., Smith, M. L., Siesjö, B. K., & Persson, H. (1992) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.89.2.648 · Cited by 514
Choroid plexus and the blood–cerebrospinal fluid barrier in disease
Solár, P., Zamani, A., Kubíčková, L., Dubový, P., & Joukal, M. (2020) · Fluids and Barriers of the CNS · doi:10.1186/s12987-020-00196-2 · Cited by 365
Yang, G., Kitagawa, K., Matsushita, K., Mabuchi, T., Yagita, Y., Yanagihara, T., & Matsumoto, M. (1997) · Brain Research · doi:10.1016/s0006-8993(96)01453-9 · Cited by 246
Blasco‐Ibáñez, J. M., & Freund, T. F. (1995) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.1995.tb00638.x · Cited by 212
The Choroid Plexus in Healthy and Diseased Brain
Kaur, C., Rathnasamy, G., & Ling, E.-A. (2016) · Journal of Neuropathology & Experimental Neurology · doi:10.1093/jnen/nlv030 · Cited by 176
Waters, F., Chiu, V., Atkinson, A., & Blom, J. D. (2018) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2018.00303 · Cited by 165
Neuroprotective effects of the green tea components theanine and catechins
Kakuda, T. (2002) · Biological & Pharmaceutical Bulletin · doi:10.1248/bpb.25.1513 · Cited by 165
Wie�ner, C., Gehrmann, J., Lindholm, D., T�pper, R., Kreutzberg, G. W., & Hossmann, K. A. (1993) · Acta Neuropathologica · doi:10.1007/bf00228578 · Cited by 151
Astrocytic contributions to bioenergetics of cerebral ischemia
Dienel, G. A., & Hertz, L. (2005) · Glia · doi:10.1002/glia.20157 · Cited by 150
Yin, H. Z., Sensi, S. L., Ogoshi, F., & Weiss, J. H. (2002) · The Journal of Neuroscience · doi:10.1523/jneurosci.22-04-01273.2002 · Cited by 143
Neuroprotection by two polyphenols following excitotoxicity and experimental ischemia
Gottlieb, M., Leal-Campanario, R., Campos-Esparza, M. R., Sánchez-Gómez, M. V., Alberdi, E., Arranz, A., Delgado-García, J. M., Gruart, A., & Matute, C. (2006) · Neurobiology of Disease · doi:10.1016/j.nbd.2006.03.017 · Cited by 141
Heiss, W.-D., Graf, R., Löttgen, J., Ohta, K., Fujita, T., Wagner, R., Grond, M., & Weinhard, K. (1997) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1097/00004647-199704000-00004 · Cited by 132
White matter lesions and brain atrophy: more than shared risk factors? A systematic review
Appelman, A. P. A., Exalto, L. G., van der Graaf, Y., Biessels, G. J., Mali, W. P. T. M., & Geerlings, M. I. (2009) · Cerebrovascular Diseases · doi:10.1159/000226774 · Cited by 130
Neuroprotective effects of theanine and its preventive effects on cognitive dysfunction
Kakuda, T. (2011) · Pharmacological Research · doi:10.1016/j.phrs.2011.03.010 · Cited by 124
BALDWIN, S. A., GIBSON, T., CALLIHAN, C. T., SULLIVAN, P. G., PALMER, E., & SCHEFF, S. W. (1997) · Journal of Neurotrauma · doi:10.1089/neu.1997.14.385 · Cited by 120
Protection against ischemic hippocampal CAI damage in the rat with a new non-NMDA antagonist, NBQX
Diemer, N. H., Jørgensen, M. B., Johansen, F. F., Sheardown, M., & Honoré, T. (1992) · Acta Neurologica Scandinavica · doi:10.1111/j.1600-0404.1992.tb08052.x · Cited by 106
Incomplete lacunar infarction (Type I b lacunes)
Lammie, G. A., Brannan, F., & Wardlaw, J. M. (1998) · Acta Neuropathologica · doi:10.1007/s004010050877 · Cited by 87
Brain damage in a mouse model of global cerebral ischemia
Olsson, T., Wieloch, T., & Smith, M.-L. (2003) · Brain Research · doi:10.1016/s0006-8993(03)03014-2 · Cited by 87
Schwartz-Bloom, R. D., Miller, K. A., Evenson, D. A., Crain, B. J., & Nadler, J. V. (2000) · Neuroscience · doi:10.1016/s0306-4522(00)00144-5 · Cited by 80
Dehydroepiandrosterone (DHEA) reduces neuronal injury in a rat model of global cerebral ischemia.
Li, H., Klein, G., Sun, P., & Buchan, A. M. (2001) · Brain Research · doi:10.1016/s0006-8993(00)03077-8 · Cited by 70
Enhanced Hypoxia Susceptibility in Hippocampal Slices From a Mouse Model of Rett Syndrome
Fischer, M., Reuter, J., Gerich, F. J., Hildebrandt, B., Hägele, S., Katschinski, D., & Müller, M. (2009) · Journal of Neurophysiology · doi:10.1152/jn.91124.2008 · Cited by 65
Jarvis, C. R., Lilge, L., Vipond, G. J., & Andrew, R. D. (1999) · NeuroImage · doi:10.1006/nimg.1999.0473 · Cited by 58
Gao, T.-M., Pulsinelli, W. A., & Xu, Z. C. (1998) · Neuroscience · doi:10.1016/s0306-4522(98)00150-x · Cited by 43
Self-citationTomimoto, H., & Yanagihara, T. (1992) · Brain Research · doi:10.1016/0006-8993(92)90171-5 · Cited by 34
Ohk, T. G., Yoo, K.-Y., Park, S. M., Shin, B. N., Kim, I. H., Park, J. H., Ahn, H. C., Lee, Y. J., Kim, M. J., Kim, T. Y., et al. (2012) · Neurochemical Research · doi:10.1007/s11064-011-0678-9 · Cited by 29
Jin, J., Kang, H.-M., Jung, J., Jeong, J.-W., & Park, C. (2014) · NeuroReport · doi:10.1097/wnr.0000000000000046 · Cited by 21
Metadata
- Authors
- Pulsinelli, W. A., Brierley, J. B., & Plum, F.
- Venue
- Annals of Neurology
- Publisher
- Wiley
- Published
- 1982-05
- Volume
- 11
- Issue
- 5
- Pages
- 491-498
- ISSN
- 0364-5134 (ISSN-L)
- 1531-8249
- OpenAlex
- W1982892406
- Cited by
- 2,675
- References
- 0
- FWCI
- 28.04
- Type
- journal article
- Language
- en
- Open access
- closed
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
